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IMMUNOSHAPE

Development of Selective Carbohydrate Immunomodulators Targeting C-type Lectin Receptors on Antigen Presenting Cells

Total Cost €

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EC-Contrib. €

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Partnership

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Project "IMMUNOSHAPE" data sheet

The following table provides information about the project.

Coordinator
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE 

Organization address
address: PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C
city: SAN SEBASTIAN
postcode: 20009
website: www.cicbiomagune.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://www.immunoshape.eu/
 Total cost 3˙811˙581 €
 EC max contribution 3˙811˙581 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2014
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE ES (SAN SEBASTIAN) coordinator 495˙745.00
2    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) participant 273˙287.00
3    GLYCODIAG FR (CHEVILLY) participant 262˙875.00
4    UNIVERSITE GRENOBLE ALPES FR (SAINT MARTIN D'HERES) participant 262˙875.00
5    UNIVERSITA DEGLI STUDI DI MILANO IT (MILANO) participant 258˙061.00
6    DC4U NL (BREUKELEN) participant 255˙374.00
7    STICHTING VUMC NL (AMSTERDAM) participant 255˙374.00
8    UNIVERSITEIT LEIDEN NL (LEIDEN) participant 255˙374.00
9    DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG DE (HEIDELBERG) participant 249˙216.00
10    GLYCOUNIVERSE GMBH & CO. KOMMANDITGESELLSCHAFT AUF AKTIEN DE (POTSDAM) participant 249˙216.00
11    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 249˙216.00
12    STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER DE (HANNOVER) participant 249˙216.00
13    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 247˙872.00
14    MIDATECH PHARMA ESPANA SL ES (DERIO) participant 247˙872.00
15    STICHTING VU NL (AMSTERDAM) participant 0.00
16    UNIVERSITE JOSEPH FOURIER GRENOBLE 1 FR (GRENOBLE) participant 0.00
17    GLAXOSMITHKLINE VACCINES SRL IT (SIENA) partner 0.00

Map

 Project objective

IMMUNOSHAPE aims at training a new generation of scientists that will be capable of combining state of the art synthesis and screening technology to develop new lead structures for highly selective glycan based multivalent immunotherapeutics for the treatment of cancer, autoimmune diseases and allergy. To this end, we have set up a training program in a unique academic-industrial environment that will educate young researchers in scientific and practical biomedical glycoscience with the final aim to produce new talent and innovation in the field and improve their career perspectives in both academic and non-academic sectors. The unique combination of 10 academic groups with expertise in automated solid-phase carbohydrate synthesis, microarray based highthroughput screening technology, tumour immunology, structural glycobiology, multivalent systems and medicinal chemistry along with 4 industrial partners active in nanomedicine, immunotherapy, medicinal device development and the fabrication of scientific instrumentation will provide a multidisciplinary and multisectorial training to 15 ESRs in biomedical glycoscience and its industrial applications.

 Deliverables

List of deliverables.
Website online Websites, patent fillings, videos etc. 2019-09-06 08:37:36
Murine and human CLRs Documents, reports 2019-09-06 08:37:36
Neoglycoproteins Documents, reports 2019-09-06 08:37:36
Glycan antigen library Documents, reports 2019-09-06 08:37:36
Glycan binding of CLRs Documents, reports 2019-09-06 08:37:36
Cell surface binding Documents, reports 2019-09-06 08:37:36
Glycodendrimers Documents, reports 2019-09-06 08:37:36

Take a look to the deliverables list in detail:  detailed list of IMMUNOSHAPE deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Andreas Geissner, Anika Reinhardt, Christoph Rademacher, Timo Johannssen, João Monteiro, Bernd Lepenies, Michel Thépaut, Franck Fieschi, Jana Mrázková, Michaela Wimmerova, Frank Schuhmacher, Sebastian Götze, Dan Grünstein, Xiaoqiang Guo, Heung Sik Hahm, Jeyakumar Kandasamy, Daniele Leonori, Christopher E. Martin, Sharavathi G. Parameswarappa, Sandip Pasari, Mark K. Schlegel, Hidenori Tanaka,
Microbe-focused glycan array screening platform
published pages: 1958-1967, ISSN: 0027-8424, DOI: 10.1073/pnas.1800853116
Proceedings of the National Academy of Sciences 116/6 2019-10-08
2018 Athanasios Blanas, Neha M. Sahasrabudhe, Ernesto Rodríguez, Yvette van Kooyk, Sandra J. van Vliet
Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy
published pages: , ISSN: 2234-943X, DOI: 10.3389/fonc.2018.00039
Frontiers in Oncology 8 2019-09-06
2018 Alonso Pardo-Vargas, Martina Delbianco, Peter H Seeberger
Automated glycan assembly as an enabling technology
published pages: 48-55, ISSN: 1367-5931, DOI: 10.1016/j.cbpa.2018.04.007
Current Opinion in Chemical Biology 46 2019-09-06
2017 Joao T. Monteiro and Bernd Lepenies
Multivalent Lectin-Glycan Interactions in the Immune System
published pages: 325-344, ISSN: , DOI:
Multivalency: Concepts, Research and Applications 2019-09-06
2018 Laura Medve, Silvia Achilli, Sonia Serna, Fabio Zuccotto, Norbert Varga, Michel Thépaut, Monica Civera, Corinne Vivès, Franck Fieschi, Niels Reichardt, Anna Bernardi
On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin
published pages: 14448-14460, ISSN: 0947-6539, DOI: 10.1002/chem.201802577
Chemistry - A European Journal 24/54 2019-09-06
2017 Anthony Troegeler, Ingrid Mercier, Céline Cougoule, Danilo Pietretti, André Colom, Carine Duval, Thien-Phong Vu Manh, Florence Capilla, Renaud Poincloux, Karine Pingris, Jérôme Nigou, Jörg Rademann, Marc Dalod, Frank A. W. Verreck, Talal Al Saati, Geanncarlo Lugo-Villarino, Bernd Lepenies, Denis Hudrisier, Olivier Neyrolles
C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells
published pages: E540-E549, ISSN: 0027-8424, DOI: 10.1073/pnas.1613254114
Proceedings of the National Academy of Sciences 114/4 2019-09-06
2018 Joanna Grabowska, Miguel A. Lopez-Venegas, Alsya J. Affandi, Joke M. M. den Haan
CD169+ Macrophages Capture and Dendritic Cells Instruct: The Interplay of the Gatekeeper and the General of the Immune System
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02472
Frontiers in Immunology 9 2019-09-06
2018 Laura Medve, Silvia Achilli, Sonia Serna, Fabio Zuccotto, Norbert Varga, Michel Thépaut, Monica Civera, Corinne Vivès, Franck Fieschi, Niels Reichardt, Anna Bernardi
On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin
published pages: 14448-14460, ISSN: 0947-6539, DOI: 10.1002/chem.201802577
Chemistry - A European Journal 24/54 2019-09-06
2018 Joyce Lübbers, Ernesto Rodríguez, Yvette van Kooyk
Modulation of Immune Tolerance via Siglec-Sialic Acid Interactions
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02807
Frontiers in Immunology 9 2019-09-06
2016 José J. Reina, Antonio Di Maio, Javier Ramos-Soriano, Rute C. Figueiredo, Javier Rojo
Rapid and efficient synthesis of α(1–2)mannobiosides
published pages: 2873-2882, ISSN: 1477-0520, DOI: 10.1039/C6OB00083E
Org. Biomol. Chem. 14/10 2019-09-06
2017 Ana Gimeno, Niels-Christian Reichardt, F. Javier Cañada, Lukas Perkams, Carlo Unverzagt, Jesús Jiménez-Barbero, Ana Ardá
NMR and Molecular Recognition of N-Glycans: Remote Modifications of the Saccharide Chain Modulate Binding Features
published pages: 1104-1112, ISSN: 1554-8929, DOI: 10.1021/acschembio.6b01116
ACS Chemical Biology 12/4 2019-09-06
2017 Y. Y. Michelle Yang, Xiao Hong Li, Katarzyna Brzezicka, Niels-Christian Reichardt, R. Alan Wilson, Angela van Diepen, Cornelis H. Hokke
Specific anti-glycan antibodies are sustained during and after parasite clearance in Schistosoma japonicum-infected rhesus macaques
published pages: e0005339, ISSN: 1935-2735, DOI: 10.1371/journal.pntd.0005339
PLOS Neglected Tropical Diseases 11/2 2019-09-06
2016 Katarzyna Brzezicka, Uwe Vogel, Sonia Serna, Timo Johannssen, Bernd Lepenies, Niels-Christian Reichardt
Influence of Core β-1,2-Xylosylation on Glycoprotein Recognition by Murine C-type Lectin Receptors and Its Impact on Dendritic Cell Targeting
published pages: 2347-2356, ISSN: 1554-8929, DOI: 10.1021/acschembio.6b00265
ACS Chemical Biology 11/8 2019-09-06
2016 Angela Berzi, Stefania Ordanini, Ben Joosten, Daria Trabattoni, Alessandra Cambi, Anna Bernardi, Mario Clerici
Pseudo-Mannosylated DC-SIGN Ligands as Immunomodulants
published pages: 35373, ISSN: 2045-2322, DOI: 10.1038/srep35373
Scientific Reports 6 2019-09-06
2017 João Monteiro, Bernd Lepenies
Myeloid C-Type Lectin Receptors in Viral Recognition and Antiviral Immunity
published pages: 59, ISSN: 1999-4915, DOI: 10.3390/v9030059
Viruses 9/3 2019-09-06
2017 Luca Unione, Maria Alcalá, Begoña Echeverria, Sonia Serna, Ana Ardá, Antonio Franconetti, F. Javier Cañada, Tammo Diercks, Niels Reichardt, Jesús Jiménez-Barbero
Fluoroacetamide Moieties as NMR Spectroscopy Probes for the Molecular Recognition of GlcNAc-Containing Sugars: Modulation of the CH-Ï€ Stacking Interactions by Different Fluorination Patterns
published pages: 3957-3965, ISSN: 0947-6539, DOI: 10.1002/chem.201605573
Chemistry - A European Journal 23/16 2019-09-06
2017 Ana Gimeno, Niels-Christian Reichardt, F. Javier Cañada, Lukas Perkams, Carlo Unverzagt, Jesús Jiménez-Barbero, Ana Ardá
NMR and Molecular Recognition of N-Glycans: Remote Modifications of the Saccharide Chain Modulate Binding Features
published pages: 1104-1112, ISSN: 1554-8929, DOI: 10.1021/acschembio.6b01116
ACS Chemical Biology 12/4 2019-09-06
2016 Niels-Christian Reichardt, Manuel Martín-Lomas, Soledad Penadés
Opportunities for glyconanomaterials in personalized medicine
published pages: 13430-13439, ISSN: 1359-7345, DOI: 10.1039/C6CC04445J
Chem. Commun. 52/92 2019-09-06
2018 Begoña Echeverria, Sonia Serna, Silvia Achilli, Corinne Vivès, Julie Pham, Michel Thépaut, Cornelis H. Hokke, Franck Fieschi, Niels-Christian Reichardt
Chemoenzymatic Synthesis of N-glycan Positional Isomers and Evidence for Branch Selective Binding by Monoclonal Antibodies and Human C-type Lectin Receptors
published pages: , ISSN: 1554-8929, DOI: 10.1021/acschembio.8b00431
ACS Chemical Biology 2019-09-06
2018 Sabine Mayer, Rebecca Moeller, João T. Monteiro, Kerstin Ellrott, Christine Josenhans, Bernd Lepenies
C-Type Lectin Receptor (CLR)–Fc Fusion Proteins As Tools to Screen for Novel CLR/Bacteria Interactions: An Exemplary Study on Preselected Campylobacter jejuni Isolates
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.00213
Frontiers in Immunology 9 2019-09-06
2018 Chethan D. Shanthamurthy, Prashant Jain, Sharon Yehuda, João T. Monteiro, Shani Leviatan Ben-Arye, Balamurugan Subramani, Bernd Lepenies, Vered Padler-Karavani, Raghavendra Kikkeri
ABO Antigens Active Tri- and Disaccharides Microarray to Evaluate C-type Lectin Receptor Binding Preferences
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-24333-y
Scientific Reports 8/1 2019-09-06

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