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SELMA SIGNED

Trial Ready Small Vessel MRI Markers: Proof of Concept

Total Cost €

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EC-Contrib. €

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Partnership

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 SELMA project word cloud

Explore the words cloud of the SELMA project. It provides you a very rough idea of what is the project "SELMA" about.

scanners    image    automated    pharmaceutical    imaging    solution    group    sequences    lack    itself    drugs    trials    first    flow    patients    small    pilot    experiments    agent    serious    7t    problem    reflect    drug    brain    35    reflecting    smallvesselmri    selma    markers    healthy    ambition    engagement    3t    vessels    15    proof    pulsation    perforating    clinical    treatment    337333    measuring    quality    newly    ubiquitous    business    plan    secondary    trial    gap    invasive    time    mri    individuals    cerebral    dementia    diseases    scan    acute    data    yielded    macroscopic    biomarkers    platforms    abnormalities    blood    vascular    industry    stroke    ready    shift    rescan    software    society    port    informs    life    vessel    administration    erc    themselves    paradigm    hampers    stiffness    pulse    velocity    disease    tool    damage    healthcare    ageing    irreversible    reproducibility    clinically    svd    bridge    hallmark   

Project "SELMA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

Organization address
address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX
website: www.umcutrecht.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 149˙979 €
 EC max contribution 149˙979 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) coordinator 149˙979.00

Map

 Project objective

Problem: Cerebral small vessel disease (SVD) is a hallmark of serious brain diseases such as acute stroke and dementia. It has a major impact on society, since it affects quality of life of many ageing individuals, and increasingly challenges the healthcare resources. Current image-based biomarkers do not reflect SVD itself, but rather macroscopic, irreversible brain damage, secondary to the abnormalities of the small vessels. This greatly hampers development of new drugs as clinical trials lack effective biomarkers directly reflecting SVD. Solution: The SmallVesselMRI ERC project (337333), yielded 7T MRI methods with the potential to offer a paradigm shift in SVD research. We have developed new MRI measures that, for the first time, allow non-invasive assessment of the condition of the small vessels themselves, including blood flow velocity pulsation in small perforating vessels, which informs on vessel stiffness. The current proof-of-concept project ‘trial-ready Small vEsseL MRI MArkers (SELMA) aims to make these novel promising vascular parameters ready for use in phase II/III clinical trials. Our ambition is to bridge the gap between high end imaging research platforms and widespread clinical MRI, in order to enable drug-target engagement studies in clinical trials for newly developed drugs. SELMA will: 1) Port the small-vessel 7T MRI pulse sequences to clinically ubiquitous 3T MRI scanners. 2) Develop a software tool that can provide robust, automated data analysis. 3) Determine the reproducibility of the SELMA biomarkers in a group of 35 healthy individuals with scan-rescan experiments. 4) Provide clinical proof of concept by a pilot study in 15 patients with SVD, measuring the vascular parameters before and after administration of a pharmaceutical agent. Using results of our proof of concept study, we will develop a business plan to approach the pharmaceutical industry to change the paradigm in drug development for SVD treatment.

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The information about "SELMA" are provided by the European Opendata Portal: CORDIS opendata.

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