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MedPlant SIGNED

Harnessing the Molecules of Medicinal Plants

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MedPlant project word cloud

Explore the words cloud of the MedPlant project. It provides you a very rough idea of what is the project "MedPlant" about.

plants    metabolomic    expertise    inexpensive    diverse    potentially    accelerated    vincristine    dramatically    plant    unnatural    data    monoterpene    defense    bioinformatics    expensive    synthetic    bioinformatic    malaria    mechanisms    rapid    3000    extraordinary    signaling    morphine    nature    laboratory    pursue    identification    harnessing    ca    alleviates    poppy    sessile    sweet    treat    pain    strategy    exploited    selecting    biology    chemical    molecules    platforms    overproduce    alkaloid    members    cancer    metabolism    artemisinin    wormwood    biosynthetically    biosynthetic    strategically    uncover    seq    diversity    metabolites    humans    periwinkle    evolutionarily    found    gene    generate    indole    rna    discovery    potent    understand    organisms    group    medicinal    tools    sequencing    levels    unlock    chemically    bottleneck    chemistry    biochemical    candidates    unprecedented    cure    natural    combination    power    synthesize    madagascar    metabolomics   

Project "MedPlant" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙499˙999 €
 EC max contribution 2˙499˙999 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2023-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 2˙399˙999.00
2    JOHN INNES CENTRE UK (NORWICH) participant 100˙000.00

Map

 Project objective

Plants, as sessile organisms, synthesize complex molecules for defense and signaling. Humans have long exploited the potent medicinal activities of these plant natural products: artemisinin from sweet wormwood is used to cure malaria, vincristine from Madagascar periwinkle is used to treat cancer, and morphine from poppy alleviates pain. Synthetic biology approaches are being used with increasing success to overproduce these expensive molecules, which are often present at low levels in the plant. However, to pursue such approaches effectively, we must fully understand the biosynthetic pathways that generate these molecules. This pathway discovery process has been a major bottleneck in harnessing the chemical power of plants.

Recent advances in sequencing, bioinformatics and metabolomics have provided the tools to address plant natural product metabolism on an unprecedented scale: we can now use inexpensive RNA-seq data, in combination with bioinformatic analyses and metabolomic data, for rapid identification of pathway-specific biosynthetic gene candidates.

Here we use these advances, along with our expertise in chemistry, to unlock the extraordinary chemical diversity that is found within the ca. 3000 members of the plant-derived monoterpene indole alkaloid metabolites. By strategically selecting a group of molecules that are chemically diverse, yet biosynthetically and evolutionarily related, the gene discovery process will be dramatically accelerated (Objective 1). Moreover, using this strategy, we will uncover new biochemical mechanisms by which chemical diversity is generated in plants (Objective 2). Understanding these mechanisms will allow us to generate “unnatural” chemical diversity in the laboratory by creating production platforms that produce new-to-nature molecules that may potentially have important applications (Objective 3).

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The information about "MEDPLANT" are provided by the European Opendata Portal: CORDIS opendata.

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