Explore the words cloud of the NterAct project. It provides you a very rough idea of what is the project "NterAct" about.
The following table provides information about the project.
UNIVERSITETET I BERGEN
|Coordinator Country||Norway [NO]|
|Total cost||1˙999˙273 €|
|EC max contribution||1˙999˙273 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2018-06-01 to 2023-05-31|
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|1||UNIVERSITETET I BERGEN||NO (BERGEN)||coordinator||1˙999˙273.00|
In mammalian cells, N-terminal (Nt) acetylation is one of the most abundant protein modifications. It is catalysed by N-terminal acetyltransferases (NATs) and mostly occurs co-translationally. However, in contrast to the defined co-translational NATs, post-translational NATs which have crucial regulatory roles are mostly unexplored. Distinct peptide hormones regulate appetite, metabolism, sexual behaviour and pain, and their biological activity is critically modulated by post-translational Nt-acetylation. However, the identity of the NAT responsible for this modification, ‘HormNat’, is unknown, thus the molecular and physiological ramifications of this regulatory circuit remain elusive. Another example is actin, a key regulator of cell motility and cell division. The actin N-terminus is crucial for actin function and in mammals actin is modified by an unknown post-translational NAT, ‘ActNat’. Hence, the objectives of this project are to identify these human NATs acting post-translationally, and to investigate their molecular mechanisms, regulation and impact.
We will identify the novel NATs by a combination of classical and newly developed in-house tools like in vitro acetylation assays, unique bisubstrate analogues, Nt-acetylation specific antibodies, and targeted mass spectrometry. Interestingly, Nt-acetylation is considered irreversible, but there is reason to believe that specific substrates are Nt-deacetylated. Elucidation of post-translational NATs and the reversible nature of Nt-acetylation would represent a new era in the field of protein and peptide regulation and identify key cellular and organismal switches.
|year||authors and title||journal||last update|
Henriette Aksnes, Rasmus Ree, Thomas Arnesen
Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases
published pages: 1097-1114, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2019.02.007
|Molecular Cell 73/6||2020-01-30|
Henriette Aksnes, Michael Marie, Thomas Arnesen, Adrian Drazic
Actin polymerization and cell motility are affected by NAA80-mediated posttranslational N-terminal acetylation of actin
published pages: e1526572, ISSN: 1942-0889, DOI: 10.1080/19420889.2018.1526572
|Communicative & Integrative Biology 11/4||2020-01-30|
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