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ECMED

The Extracellular Matrix in Epileptogenesis

Total Cost €

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EC-Contrib. €

0

Partnership

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Project "ECMED" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.ecmed-itn.eu
 Total cost 3˙047˙025 €
 EC max contribution 3˙047˙025 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2014
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 273˙287.00
2    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) participant 516˙122.00
3    DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV DE (BONN) participant 498˙432.00
4    ITA-SUOMEN YLIOPISTO FI (KUOPIO) participant 269˙145.00
5    UNIVERSITE D'AIX MARSEILLE FR (Marseille) participant 262˙875.00
6    AMC MEDICAL RESEARCH BV NL (AMSTERDAM ZUIDOOST) participant 255˙374.00
7    UNIVERSITEIT ANTWERPEN BE (ANTWERPEN) participant 250˙560.00
8    LEIBNIZ-INSTITUT FUER NEUROBIOLOGIE DE (MAGDEBURG) participant 249˙216.00
9    IPROTEOS SL ES (BARCELONA) participant 247˙872.00
10    INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK PL (WARSZAWA) participant 224˙137.00
11    ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) participant 0.00

Map

 Project objective

Over 50 million people worldwide have epilepsy and 30% are resistant to our present therapies. Epilepsy, therefore, comprises a major burden to society and so there is a pressing need for new approaches to treatment. The brain extracellular matrix (ECM) plays a critical role in governing brain excitability and function. Although research into the role of the ECM in neuronal signalling and network function has advanced considerably in recent years, its full translational potential has yet to be realised. There is growing evidence for a major role of the ECM in epilepsy including the association between ECM protein mutations and epilepsy, changes in the ECM and associated proteins during the development of epilepsy and the strong association between the ECM and brain diseases associated with epilepsy including stroke, traumatic brain injury, neurodegeneration and autism. This proposal brings together considerable expertise from academic and industry partners in the biology of the ECM with experts in epilepsy research. This, therefore, represents a truly collaborative effort to determine not only the role of the ECM in the development of epilepsy but also novel approaches to treat and to prevent epilepsy. The academic partners will focus on specific research questions, whilst the industrial members will provide diagnostic, treatment and advanced research tools. The project has a strong translational theme and the combination of basic and translational science will be of great benefit for the training of young researchers. Trainees will be exposed to courses, workshops, joint research meetings and inter-laboratory visits. The focus of the training programme is on expanding knowledge and the application of such knowledge to address pertinent question relevant to the diagnosis, prognosis and treatment of epilepsy, so providing an ideal insight into translational neuroscience.

 Deliverables

List of deliverables.
Advanced training course 4 Other 2019-09-06 08:35:51
New data on the mechanisms of epileptogenesis Documents, reports 2019-09-06 08:35:51
New data on the mechanisms of epileptogenesis-2 Documents, reports 2019-09-06 08:35:51
Advanced training course 2 Other 2019-09-06 08:35:51
Advanced training course 3 Other 2019-09-06 08:35:51
New approach for seizure analysis Demonstrators, pilots, prototypes 2019-09-06 08:35:51
ECMED network website and flyer Websites, patent fillings, videos etc. 2019-09-06 08:35:51
Advanced Training course 1 Other 2019-09-06 08:35:51

Take a look to the deliverables list in detail:  detailed list of ECMED deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 John R. Counsell, Rajvinder Karda, Juan Antinao Diaz, Louise Carey, Tatiana Wiktorowicz, Suzanne M.K. Buckley, Shima Ameri, Joanne Ng, Julien Baruteau, Filipa Almeida, Rohan de Silva, Roberto Simone, Eleonora Lugarà, Gabriele Lignani, Dirk Lindemann, Axel Rethwilm, Ahad A. Rahim, Simon N. Waddington, Steven J. Howe
Foamy Virus Vectors Transduce Visceral Organs and Hippocampal Structures following In Vivo Delivery to Neonatal Mice
published pages: 626-634, ISSN: 2162-2531, DOI: 10.1016/j.omtn.2018.07.006
Molecular Therapy - Nucleic Acids 12 2019-09-06
2018 John R. Counsell, Rajvinder Karda, Juan Antinao Diaz, Louise Carey, Tatiana Wiktorowicz, Suzanne M.K. Buckley, Shima Ameri, Joanne Ng, Julien Baruteau, Filipa Almeida, Rohan de Silva, Roberto Simone, Eleonora Lugarà, Gabriele Lignani, Dirk Lindemann, Axel Rethwilm, Ahad A. Rahim, Simon N. Waddington, Steven J. Howe
Foamy Virus Vectors Transduce Visceral Organs and Hippocampal Structures following In Vivo Delivery to Neonatal Mice
published pages: 626-634, ISSN: 2162-2531, DOI: 10.1016/j.omtn.2018.07.006
Molecular Therapy - Nucleic Acids 12 2019-09-06
2018 Pierluigi Valente, Alessandra Romei, Manuela Fadda, Bruno Sterlini, Davide Lonardoni, Nicola Forte, Floriana Fruscione, Enrico Castroflorio, Caterina Michetti, Giorgia Giansante, Flavia Valtorta, Jin-Wu Tsai, Federico Zara, Thierry Nieus, Anna Corradi, Anna Fassio, Pietro Baldelli, Fabio Benfenati
Constitutive Inactivation of the PRRT2 Gene Alters Short-Term Synaptic Plasticity and Promotes Network Hyperexcitability in Hippocampal Neurons
published pages: , ISSN: 1047-3211, DOI: 10.1093/cercor/bhy079
Cerebral Cortex 2019-09-06
2017 A. Korotkov, J. D. Mills, J. A. Gorter, E. A. van Vliet, E. Aronica
Systematic review and meta-analysis of differentially expressed miRNAs in experimental and human temporal lobe epilepsy
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-11510-8
Scientific Reports 7/1 2019-09-06
2015 Gianpiero Garau, Paola Magotti, Martin Heine, Svetlana Korotchenko, Patricia Marie-Jeanne Lievens, Vladimir Berezin, Alexander Dityatev
Heparin/heparan sulfates bind to and modulate neuronal L-type (Cav1.2) voltage-dependent Ca2+ channels
published pages: 156-165, ISSN: 0014-4886, DOI: 10.1016/j.expneurol.2015.08.006
Experimental Neurology 274 2019-09-06
2018 Floriana Fruscione, Pierluigi Valente, Bruno Sterlini, Alessandra Romei, Simona Baldassari, Manuela Fadda, Cosimo Prestigio, Giorgia Giansante, Jacopo Sartorelli, Pia Rossi, Alicia Rubio, Antonio Gambardella, Thierry Nieus, Vania Broccoli, Anna Fassio, Pietro Baldelli, Anna Corradi, Federico Zara, Fabio Benfenati
PRRT2 controls neuronal excitability by negatively modulating Na+ channel 1.2/1.6 activity
published pages: 1000-1016, ISSN: 0006-8950, DOI: 10.1093/brain/awy051
Brain 141/4 2019-09-06
2016 van Vliet, Erwin A; Potschka, Heidrun; Koepp, Matthias J; Immonen, Riikka; Federico, Paolo; Friedman, Alon; Pitkänen, Asla; Cole, Andrew J.; Dedeurwaerdere, Stefanie
Workshop on neurobiology of epilepsy appraisal: Imaging biomarkers in epilepsy
published pages: , ISSN: 1528-1167, DOI: 10.1111/epi.13621
Epilepsia 1 2019-09-06
2017 A. Korotkov, J. D. Mills, J. A. Gorter, E. A. van Vliet, E. Aronica
Systematic review and meta-analysis of differentially expressed miRNAs in experimental and human temporal lobe epilepsy
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-11510-8
Scientific Reports 7/1 2019-09-06

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