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EMI-TB SIGNED

Eliciting Mucosal Immunity to Tuberculosis

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

EMI-TB project word cloud

Explore the words cloud of the EMI-TB project. It provides you a very rough idea of what is the project "EMI-TB" about.

tuberculosis innovation demonstrates epitopes mucosa cells vaccination tb ways adults mtb belief technologies links human adult mycobacterium combating global pulmonary missing antigens trials attainable unrelenting bcg efficacy systemically immune reaching assumption sub reactivation bovis infection people form optimal broad putative tools ranging cd8 mucosal initially vaccine pathogen correlates vaccines killing candidate tissues million lungs severe protection erode prophylactic latent cell continued predictors immunity forms childhood formulation health induce strategy protective incorporating polypeptides

Project "EMI-TB" data sheet

The following table provides information about the project.

Coordinator	ST GEORGE'S HOSPITAL MEDICAL SCHOOL Organization address address: CRANMER TERRACE city: LONDON postcode: SW17 0RE website: http://www.sgul.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.emi-tb.org
Total cost	7˙999˙920 €
EC max contribution	7˙993˙660 € (100%)
Programme	1. H2020-EU.3.1.2. (Preventing disease)
Code Call	H2020-PHC-2014-single-stage
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-01-01 to 2019-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ST GEORGE'S HOSPITAL MEDICAL SCHOOL ST GEORGE'S HOSPITAL MEDICAL SCHOOL Organization address address: CRANMER TERRACE city: LONDON postcode: SW17 0RE website: http://www.sgul.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	2˙235˙080.00
2	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	970˙037.00
3	Department of Health Department of Health Organization address address: Quarry House, Quarry Hill city: Leeds postcode: LS2 7UE website: www.dh.gov.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Leeds)	participant	824˙657.00
4	UNIVERSIDAD DE VIGO UNIVERSIDAD DE VIGO Organization address address: LG CAMPUS LAGOAS MARCOSENDE city: VIGO PONTEVEDRA postcode: 36310 website: www.uvigo.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (VIGO PONTEVEDRA)	participant	670˙000.00
5	Instituto Nacional de Saúde Instituto Nacional de Saúde Organization address address: Avenida Eduardo Mondlane 1008 city: Maputo postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	MZ (Maputo)	participant	454˙593.00
6	SPOREGEN LIMITED SPOREGEN LIMITED Organization address address: QUEENS ROAD 3 WESTLEY GATE city: READING BERKSHIRE postcode: RG1 4AP website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (READING BERKSHIRE)	participant	436˙047.00
7	LIONEX GMBH LIONEX GMBH Organization address address: Salzdahlumer Strasse 196 city: BRAUNSCHWEIG postcode: 38126 website: www.lionex.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BRAUNSCHWEIG)	participant	408˙350.00
8	KING'S COLLEGE LONDON KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	363˙586.00
9	STOCKHOLMS UNIVERSITET STOCKHOLMS UNIVERSITET Organization address address: UNIVERSITETSVAGEN 10 city: STOCKHOLM postcode: 10691 website: www.su.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	333˙350.00
10	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	323˙036.00
11	UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA Organization address address: VIA CRACOVIA 50 city: ROMA postcode: 133 website: www.uniroma2.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	320˙132.00
12	AZIENDA OSPEDALIERA UNIVERSITARIA POLICLINICO PAOLO GIACCONE DI PALERMO AZIENDA OSPEDALIERA UNIVERSITARIA POLICLINICO PAOLO GIACCONE DI PALERMO Organization address address: VIA DEL VESPRO 129 city: PALERMO postcode: 90127 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PALERMO)	participant	320˙000.00
13	INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL Organization address address: CTRA DE CANYET S/N city: BADALONA BARCELONA postcode: 8916 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BADALONA BARCELONA)	participant	184˙792.00
14	MIKROBIOLOGICKY USTAV AV CR V.V.I MIKROBIOLOGICKY USTAV AV CR V.V.I Organization address address: VIDENSKA 1083 city: PRAHA 4 postcode: 142 00 website: http://www.biomed.cas.cz/mbu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (PRAHA 4)	participant	150˙000.00

Map

Project objective

Tuberculosis (TB) is a global health problem, killing 1.5 million of people every year. The only currently available vaccine, Mycobacterium bovis BCG, is effective against severe childhood forms, but it demonstrates a variable efficacy against the pulmonary form of TB in adults. Many of these adult TB cases result from the reactivation of an initially controlled, latent Mycobacterium tuberculosis (MTB) infection. Effective prophylactic vaccination remains the key long-term strategy for combating TB. Continued belief in reaching this goal requires unrelenting innovation in the formulation and delivery of candidate vaccines. It is also based on the assumption, that the failure of recent human vaccine trials could have been due to a sub-optimal vaccine design and delivery, and therefore should not erode the key principle that a TB vaccine is an attainable target. This proposal focuses on mucosal vaccination, which has been considered in the past, but not implemented efficiently. The innovation of the proposal is focused on several important aspects of vaccine development and testing, including the use of novel technologies for vaccine delivery, novel ways of specific targeting of mucosal immune cells and tissues, the use of polypeptides incorporating early and latent MTB antigens and putative CD8 T cell epitopes, and application of novel tools for identifying early predictors and correlates of vaccine-induced protection. The overall objective is to design a vaccine that will induce a broad-ranging immune response to MTB both systemically and in the mucosa of the lungs, and provide the currently missing links in protective immunity to this pathogen.

Deliverables

List of deliverables.
Publication of primary research articles in high impact journals	Demonstrators, pilots, prototypes	2020-02-21 11:08:43

Take a look to the deliverables list in detail: detailed list of EMI-TB deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Katarzyna Kuczkowska, Alastair Copland, Lise Ã˜verland, Geir Mathiesen, Andy C. Tran, Mathew J. Paul, Vincent G. H. Eijsink, Rajko Reljic Inactivated Lactobacillus plantarum Carrying a Surface-Displayed Ag85B-ESAT-6 Fusion Antigen as a Booster Vaccine Against Mycobacterium tuberculosis Infection published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01588	Frontiers in Immunology 10	2020-02-21
2019	Alastair Copland, Adam Sparrow, Peter Hart, Gil Reynolds Diogo, Mathew Paul, Miyuki Azuma, Rajko Reljic Bacillus Calmette-GuÃ©rin Induces PD-L1 Expression on Antigen-Presenting Cells via Autocrine and Paracrine Interleukin-STAT3 Circuits published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-40145-0	Scientific Reports 9/1	2020-02-21
2019	Andy C. Tran, Mi-Young Kim, Rajko Reljic Emerging Themes for the Role of Antibodies in Tuberculosis published pages: , ISSN: 1598-2629, DOI: 10.4110/in.2019.19.e24	Immune Network 19/4	2020-02-21
2018	Lucille Adam, MoisÃ©s LÃ³pez-GonzÃ¡lez, Albin BjÃ¶rk, Sandra PÃ¥lsson, Candice Poux, Marie Wahren-Herlenius, Carmen FernÃ¡ndez, Anna-Lena Spetz Early Resistance of Non-virulent Mycobacterial Infection in C57BL/6 Mice Is Associated With Rapid Up-Regulation of Antimicrobial Cathelicidin Camp published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01939	Frontiers in Immunology 9	2020-02-21
2019	Berit Carow, Thomas Hauling, Xiaoyan Qian, Igor Kramnik, Mats Nilsson, Martin E. Rottenberg Spatial and temporal localization of immune transcripts defines hallmarks and diversity in the tuberculosis granuloma published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09816-4	Nature Communications 10/1	2020-02-21
2018	Marco Pio La Manna, Valentina Orlando, Paolo Li Donni, Guido Sireci, Paola Di Carlo, Antonio Cascio, Francesco Dieli, Nadia Caccamo Identification of plasma biomarkers for discrimination between tuberculosis infection/disease and pulmonary non tuberculosis disease published pages: e0192664, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0192664	PLOS ONE 13/3	2020-02-21
2019	Gil R. Diogo, Peter Hart, Alastair Copland, Mi-Young Kim, Andy C. Tran, Noemi Poerio, Mahavir Singh, Matthew J. Paul, Maurizio Fraziano, Rajko Reljic Immunization With Mycobacterium tuberculosis Antigens Encapsulated in Phosphatidylserine Liposomes Improves Protection Afforded by BCG published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01349	Frontiers in Immunology 10	2020-02-21
2018	Valentina Orlando, Marco P. La Manna, Delia Goletti, Fabrizio Palmieri, Elena Lo Presti, Simone A. Joosten, Carmela La Mendola, Simona Buccheri, Tom H. M. Ottenhoff, Francesco Dieli, Nadia Caccamo Human CD4 T-Cells With a Naive Phenotype Produce Multiple Cytokines During Mycobacterium Tuberculosis Infection and Correlate With Active Disease published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01119	Frontiers in Immunology 9	2020-02-21
2018	Juraj Ivanyi Vaccine development might be handled more effectively in biotech companies than in academia published pages: k758, ISSN: 0959-8138, DOI: 10.1136/bmj.k758	BMJ	2020-02-21
2018	Gina R Webster, Craig van Dolleweerd, Thais Guerra, Szymon Stelter, Sven Hofmann, Mi-Young Kim, Audrey Y-H Teh, Gil Reynolds Diogo, Alastair Copland, Mathew Paul, Peter Hart, Rajko Reljic, Julian K-C Ma A polymeric immunoglobulin - antigen fusion protein strategy for enhancing vaccine immunogenicity published pages: , ISSN: 1467-7644, DOI: 10.1111/pbi.12932	Plant Biotechnology Journal	2020-02-21
2018	Roberto Nisini, Noemi Poerio, Sabrina Mariotti, Federica De Santis, Maurizio Fraziano The Multirole of Liposomes in Therapy and Prevention of Infectious Diseases published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.00155	Frontiers in Immunology 9	2020-02-21
2018	Alastair Copland1, Peter Hart1, Gil R. Diogo1, Shane Harris1, Mathew Paul1, Mahavir Singh2, Simon M. Cutting3 and Rajko Reljic1* Mucosal Delivery of Fusion Proteins with Bacillus subtilis Spores Enhances Protection against Tuberculosis by BCG published pages: , ISSN: 1664-3224, DOI:	Frontiers in Immunology	2020-02-21
2017	Peter Hart, Alastair Copland, Gil Diogo, Shane Harris, Ralf Spallek, Wulf Oehlmann, Mahavir Singh, Juan Basile, Martin Rottenberg, Matthew Paul, Rajko Reljic Nanoparticle-Fusion protein complexes protect against Mycobacterium tuberculosis infection published pages: , ISSN: 1525-0016, DOI: 10.1016/j.ymthe.2017.12.016	Molecular Therapy	2020-02-21
2016	Nadia Caccamo, Francesco Dieli Inflammation and the coagulation system in tuberculosis: Tissue Factor leads the dance published pages: 303-306, ISSN: 0014-2980, DOI: 10.1002/eji.201546225	European Journal of Immunology 46/2	2020-02-21
2017	Marco Pio La Manna, Valentina Orlando, Francesco Dieli, Paola Di Carlo, Antonio Cascio, Gilda Cuzzi, Fabrizio Palmieri, Delia Goletti, Nadia Caccamo Quantitative and qualitative profiles of circulating monocytes may help identifying tuberculosis infection and disease stages published pages: e0171358, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0171358	PLOS ONE 12/2	2020-02-21
2015	Francesco Taus, Marilina B. Santucci, Emanuela Greco, Matteo Morandi, Ivana Palucci, Sabrina Mariotti, Noemi Poerio, Roberto Nisini, Giovanni Delogu, Maurizio Fraziano Monosodium Urate Crystals Promote Innate Anti-Mycobacterial Immunity and Improve BCG Efficacy as a Vaccine against Tuberculosis published pages: e0127279, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0127279	PLOS ONE 10/5	2020-02-21
2017	Gil R. Diogo, Adam Sparrow, Matthew J. Paul, Alastair Copland, Peter J. Hart, Szymon Stelter, Craig van Dolleweerd, Pascal M.W. Drake, Derek C. Macallan, Rajko Reljic Murine IL-4Î”2 splice variant down-regulates IL-4 activities independently of IL-4RÎ± binding and STAT-6 phosphorylation published pages: 154-162, ISSN: 1043-4666, DOI: 10.1016/j.cyto.2017.09.007	Cytokine 99	2020-02-21
2017	Noemi Poerio, Francesca Bugli, Francesco Taus, Marilina B. Santucci, Carlo Rodolfo, Francesco Cecconi, Riccardo Torelli, Francesco Varone, Riccardo Inchingolo, Fabio Majo, Vincenzina Lucidi, Sabrina Mariotti, Roberto Nisini, Maurizio Sanguinetti, Maurizio Fraziano Liposomes loaded with bioactive lipids enhance antibacterial innate immunity irrespective of drug resistance published pages: 45120, ISSN: 2045-2322, DOI: 10.1038/srep45120	Scientific Reports 7	2020-02-21
2017	Teresa Prezzemolo, Krista E. van Meijgaarden, Kees L.M.C. Franken, Nadia Caccamo, Francesco Dieli, Tom H.M. Ottenhoff, Simone A. Joosten Detailed characterization of human Mycobacterium tuberculosis specific HLA-E restricted CD8 + TÂ cells published pages: , ISSN: 0014-2980, DOI: 10.1002/eji.201747184	European Journal of Immunology	2020-02-21
2019	JesÃºs Mateos, Olivia EstÃ©vez, Ãfrica GonzÃ¡lez-FernÃ¡ndez, Luis Anibarro, Ãngeles PallarÃ©s, Rajko Reljic, JosÃ© M. Gallardo, Isabel Medina, MÃ³nica Carrera High-resolution quantitative proteomics applied to the study of the specific protein signature in the sputum and saliva of active tuberculosis patients and their infected and uninfected contacts published pages: 41-52, ISSN: 1874-3919, DOI: 10.1016/j.jprot.2019.01.010	Journal of Proteomics 195	2020-02-21
2018	Nadia Caccamo, Simone A. Joosten, Tom H. M. Ottenhoff, Francesco Dieli Atypical Human Effector/Memory CD4+ T Cells With a Naive-Like Phenotype published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02832	Frontiers in Immunology 9	2020-02-21

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