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Eliciting Mucosal Immunity to Tuberculosis

Total Cost €


EC-Contrib. €






Project "EMI-TB" data sheet

The following table provides information about the project.


Organization address
city: LONDON
postcode: SW17 0RE

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 7˙999˙920 €
 EC max contribution 7˙993˙660 € (100%)
 Programme 1. H2020-EU.3.1.2. (Preventing disease)
 Code Call H2020-PHC-2014-single-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2019-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ST GEORGE'S HOSPITAL MEDICAL SCHOOL UK (LONDON) coordinator 2˙235˙080.00
2    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 970˙037.00
3    Department of Health UK (Leeds) participant 824˙657.00
4    UNIVERSIDAD DE VIGO ES (VIGO PONTEVEDRA) participant 670˙000.00
5    Instituto Nacional de Saúde MZ (Maputo) participant 454˙593.00
6    SPOREGEN LIMITED UK (READING BERKSHIRE) participant 436˙047.00
7    LIONEX GMBH DE (BRAUNSCHWEIG) participant 408˙350.00
8    KING'S COLLEGE LONDON UK (LONDON) participant 363˙586.00
9    STOCKHOLMS UNIVERSITET SE (STOCKHOLM) participant 333˙350.00
14    MIKROBIOLOGICKY USTAV AV CR V.V.I CZ (PRAHA 4) participant 150˙000.00


 Project objective

Tuberculosis (TB) is a global health problem, killing 1.5 million of people every year. The only currently available vaccine, Mycobacterium bovis BCG, is effective against severe childhood forms, but it demonstrates a variable efficacy against the pulmonary form of TB in adults. Many of these adult TB cases result from the reactivation of an initially controlled, latent Mycobacterium tuberculosis (MTB) infection. Effective prophylactic vaccination remains the key long-term strategy for combating TB. Continued belief in reaching this goal requires unrelenting innovation in the formulation and delivery of candidate vaccines. It is also based on the assumption, that the failure of recent human vaccine trials could have been due to a sub-optimal vaccine design and delivery, and therefore should not erode the key principle that a TB vaccine is an attainable target. This proposal focuses on mucosal vaccination, which has been considered in the past, but not implemented efficiently. The innovation of the proposal is focused on several important aspects of vaccine development and testing, including the use of novel technologies for vaccine delivery, novel ways of specific targeting of mucosal immune cells and tissues, the use of polypeptides incorporating early and latent MTB antigens and putative CD8 T cell epitopes, and application of novel tools for identifying early predictors and correlates of vaccine-induced protection. The overall objective is to design a vaccine that will induce a broad-ranging immune response to MTB both systemically and in the mucosa of the lungs, and provide the currently missing links in protective immunity to this pathogen.


List of deliverables.
Publication of primary research articles in high impact journals Demonstrators, pilots, prototypes 2020-02-21 11:08:43

Take a look to the deliverables list in detail:  detailed list of EMI-TB deliverables.


year authors and title journal last update
List of publications.
2019 Katarzyna Kuczkowska, Alastair Copland, Lise Øverland, Geir Mathiesen, Andy C. Tran, Mathew J. Paul, Vincent G. H. Eijsink, Rajko Reljic
Inactivated Lactobacillus plantarum Carrying a Surface-Displayed Ag85B-ESAT-6 Fusion Antigen as a Booster Vaccine Against Mycobacterium tuberculosis Infection
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01588
Frontiers in Immunology 10 2020-02-21
2019 Alastair Copland, Adam Sparrow, Peter Hart, Gil Reynolds Diogo, Mathew Paul, Miyuki Azuma, Rajko Reljic
Bacillus Calmette-Guérin Induces PD-L1 Expression on Antigen-Presenting Cells via Autocrine and Paracrine Interleukin-STAT3 Circuits
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-40145-0
Scientific Reports 9/1 2020-02-21
2019 Andy C. Tran, Mi-Young Kim, Rajko Reljic
Emerging Themes for the Role of Antibodies in Tuberculosis
published pages: , ISSN: 1598-2629, DOI: 10.4110/in.2019.19.e24
Immune Network 19/4 2020-02-21
2018 Lucille Adam, Moisés López-González, Albin Björk, Sandra Pålsson, Candice Poux, Marie Wahren-Herlenius, Carmen Fernández, Anna-Lena Spetz
Early Resistance of Non-virulent Mycobacterial Infection in C57BL/6 Mice Is Associated With Rapid Up-Regulation of Antimicrobial Cathelicidin Camp
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01939
Frontiers in Immunology 9 2020-02-21
2019 Berit Carow, Thomas Hauling, Xiaoyan Qian, Igor Kramnik, Mats Nilsson, Martin E. Rottenberg
Spatial and temporal localization of immune transcripts defines hallmarks and diversity in the tuberculosis granuloma
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09816-4
Nature Communications 10/1 2020-02-21
2018 Marco Pio La Manna, Valentina Orlando, Paolo Li Donni, Guido Sireci, Paola Di Carlo, Antonio Cascio, Francesco Dieli, Nadia Caccamo
Identification of plasma biomarkers for discrimination between tuberculosis infection/disease and pulmonary non tuberculosis disease
published pages: e0192664, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0192664
PLOS ONE 13/3 2020-02-21
2019 Gil R. Diogo, Peter Hart, Alastair Copland, Mi-Young Kim, Andy C. Tran, Noemi Poerio, Mahavir Singh, Matthew J. Paul, Maurizio Fraziano, Rajko Reljic
Immunization With Mycobacterium tuberculosis Antigens Encapsulated in Phosphatidylserine Liposomes Improves Protection Afforded by BCG
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01349
Frontiers in Immunology 10 2020-02-21
2018 Valentina Orlando, Marco P. La Manna, Delia Goletti, Fabrizio Palmieri, Elena Lo Presti, Simone A. Joosten, Carmela La Mendola, Simona Buccheri, Tom H. M. Ottenhoff, Francesco Dieli, Nadia Caccamo
Human CD4 T-Cells With a Naive Phenotype Produce Multiple Cytokines During Mycobacterium Tuberculosis Infection and Correlate With Active Disease
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01119
Frontiers in Immunology 9 2020-02-21
2018 Juraj Ivanyi
Vaccine development might be handled more effectively in biotech companies than in academia
published pages: k758, ISSN: 0959-8138, DOI: 10.1136/bmj.k758
BMJ 2020-02-21
2018 Gina R Webster, Craig van Dolleweerd, Thais Guerra, Szymon Stelter, Sven Hofmann, Mi-Young Kim, Audrey Y-H Teh, Gil Reynolds Diogo, Alastair Copland, Mathew Paul, Peter Hart, Rajko Reljic, Julian K-C Ma
A polymeric immunoglobulin - antigen fusion protein strategy for enhancing vaccine immunogenicity
published pages: , ISSN: 1467-7644, DOI: 10.1111/pbi.12932
Plant Biotechnology Journal 2020-02-21
2018 Roberto Nisini, Noemi Poerio, Sabrina Mariotti, Federica De Santis, Maurizio Fraziano
The Multirole of Liposomes in Therapy and Prevention of Infectious Diseases
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.00155
Frontiers in Immunology 9 2020-02-21
2018 Alastair Copland1, Peter Hart1, Gil R. Diogo1, Shane Harris1, Mathew Paul1, Mahavir Singh2, Simon M. Cutting3 and Rajko Reljic1*
Mucosal Delivery of Fusion Proteins with Bacillus subtilis Spores Enhances Protection against Tuberculosis by BCG
published pages: , ISSN: 1664-3224, DOI:
Frontiers in Immunology 2020-02-21
2017 Peter Hart, Alastair Copland, Gil Diogo, Shane Harris, Ralf Spallek, Wulf Oehlmann, Mahavir Singh, Juan Basile, Martin Rottenberg, Matthew Paul, Rajko Reljic
Nanoparticle-Fusion protein complexes protect against Mycobacterium tuberculosis infection
published pages: , ISSN: 1525-0016, DOI: 10.1016/j.ymthe.2017.12.016
Molecular Therapy 2020-02-21
2016 Nadia Caccamo, Francesco Dieli
Inflammation and the coagulation system in tuberculosis: Tissue Factor leads the dance
published pages: 303-306, ISSN: 0014-2980, DOI: 10.1002/eji.201546225
European Journal of Immunology 46/2 2020-02-21
2017 Marco Pio La Manna, Valentina Orlando, Francesco Dieli, Paola Di Carlo, Antonio Cascio, Gilda Cuzzi, Fabrizio Palmieri, Delia Goletti, Nadia Caccamo
Quantitative and qualitative profiles of circulating monocytes may help identifying tuberculosis infection and disease stages
published pages: e0171358, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0171358
PLOS ONE 12/2 2020-02-21
2015 Francesco Taus, Marilina B. Santucci, Emanuela Greco, Matteo Morandi, Ivana Palucci, Sabrina Mariotti, Noemi Poerio, Roberto Nisini, Giovanni Delogu, Maurizio Fraziano
Monosodium Urate Crystals Promote Innate Anti-Mycobacterial Immunity and Improve BCG Efficacy as a Vaccine against Tuberculosis
published pages: e0127279, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0127279
PLOS ONE 10/5 2020-02-21
2017 Gil R. Diogo, Adam Sparrow, Matthew J. Paul, Alastair Copland, Peter J. Hart, Szymon Stelter, Craig van Dolleweerd, Pascal M.W. Drake, Derek C. Macallan, Rajko Reljic
Murine IL-4Δ2 splice variant down-regulates IL-4 activities independently of IL-4Rα binding and STAT-6 phosphorylation
published pages: 154-162, ISSN: 1043-4666, DOI: 10.1016/j.cyto.2017.09.007
Cytokine 99 2020-02-21
2017 Noemi Poerio, Francesca Bugli, Francesco Taus, Marilina B. Santucci, Carlo Rodolfo, Francesco Cecconi, Riccardo Torelli, Francesco Varone, Riccardo Inchingolo, Fabio Majo, Vincenzina Lucidi, Sabrina Mariotti, Roberto Nisini, Maurizio Sanguinetti, Maurizio Fraziano
Liposomes loaded with bioactive lipids enhance antibacterial innate immunity irrespective of drug resistance
published pages: 45120, ISSN: 2045-2322, DOI: 10.1038/srep45120
Scientific Reports 7 2020-02-21
2017 Teresa Prezzemolo, Krista E. van Meijgaarden, Kees L.M.C. Franken, Nadia Caccamo, Francesco Dieli, Tom H.M. Ottenhoff, Simone A. Joosten
Detailed characterization of human Mycobacterium tuberculosis specific HLA-E restricted CD8 + T cells
published pages: , ISSN: 0014-2980, DOI: 10.1002/eji.201747184
European Journal of Immunology 2020-02-21
2019 Jesús Mateos, Olivia Estévez, África González-Fernández, Luis Anibarro, Ángeles Pallarés, Rajko Reljic, José M. Gallardo, Isabel Medina, Mónica Carrera
High-resolution quantitative proteomics applied to the study of the specific protein signature in the sputum and saliva of active tuberculosis patients and their infected and uninfected contacts
published pages: 41-52, ISSN: 1874-3919, DOI: 10.1016/j.jprot.2019.01.010
Journal of Proteomics 195 2020-02-21
2018 Nadia Caccamo, Simone A. Joosten, Tom H. M. Ottenhoff, Francesco Dieli
Atypical Human Effector/Memory CD4+ T Cells With a Naive-Like Phenotype
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02832
Frontiers in Immunology 9 2020-02-21

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