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CARDIS

Early stage CARdio Vascular Disease Detection with Integrated Silicon Photonics

Total Cost €

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EC-Contrib. €

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Partnership

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 CARDIS project word cloud

Explore the words cloud of the CARDIS project. It provides you a very rough idea of what is the project "CARDIS" about.

care    medtronic    tools    intervention    social    size    volumes    transfer    subsystems    integrate    stenosis    apwv    ge    integration    model    flow    signals    esc    micro    met    specs    moving    silicon    clinical    skin    photonics    disseminate    economic    point    create    components    cardiac    heart    ip    detectors    individuals    volume    sub    prediction    moderate    wave    protect    scalable    setting    weight    parts    pulse    translate    cvd    identification    besides    underlying    velocity    classification    device    abnormalities    commercially    optics    biomechanical    invasive    screening    fabricate    doppler    population    driver    too    small    cardis    stiffness    laser    physiological    primary    guidelines    chip    whenever    interferometer    screen    halt    contraction    bench    vibrometer    validate    aortic    events    vibrations    risk    latest    optical    mobile    reverse    undiagnosed    detection    array    commit    arterial    esh    early    pathological    fast   

Project "CARDIS" data sheet

The following table provides information about the project.

Coordinator
INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM 

Organization address
address: KAPELDREEF 75
city: LEUVEN
postcode: 3001
website: www.imec.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website http://www.cardis-h2020.eu
 Total cost 3˙629˙207 €
 EC max contribution 3˙629˙206 € (100%)
 Programme 1. H2020-EU.2.1.1.6. (Micro- and nanoelectronics and photonics: Key enabling technologies related to micro- and nanoelectronics and to photonics, covering also quantum technologies)
 Code Call H2020-ICT-2014-1
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-02-01   to  2019-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM BE (LEUVEN) coordinator 721˙413.00
2    SIOS MESSTECHNIK DE (ILMENAU) participant 662˙750.00
3    MEDTRONIC BAKKEN RESEARCH CENTER B.V. NL (MAASTRICHT) participant 602˙990.00
4    UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK IE (Cork) participant 426˙579.00
5    UNIVERSITEIT GENT BE (GENT) participant 399˙500.00
6    QUEEN MARY UNIVERSITY OF LONDON UK (LONDON) participant 274˙059.00
7    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 215˙000.00
8    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) participant 176˙915.00
9    FUNDICO BVBA BE (OOSTKAMP) participant 150˙000.00

Map

 Project objective

Early identification of individuals at risk for CVD allows early intervention to halt or reverse the pathological process. This is the driver of Medtronic and partners to develop a mobile, low-cost, non-invasive, point-of-care screening device for CVD.

Assessment of arterial stiffness by measurement of the aortic pulse wave velocity (aPWV) is included in the latest ESC/ESH guidelines for CVD risk prediction. Besides aPWV, early identification of arterial stenosis and cardiac contraction abnormalities can be used to improve CVD risk classification. However, no tools are available today to screen a large population at primary care on these parameters, and individuals that are considered to be at low or moderate risk are too often undiagnosed.

The objective of CARDIS is to investigate and demonstrate the concept of a mobile, low-cost device based on a silicon photonics integrated laser Doppler vibrometer and validate the concept for the screening of arterial stiffness, detection of stenosis and heart failure. We will: •Investigate, design and fabricate the optical subsystems and components: silicon photonics chip with integrated Ge-detectors, micro-optics, micro-optical laser bench, optical package •Integrate the subsystems and build a multi-array laser interferometer system •Develop a process flow scalable to high volumes for all sub-systems and their integration steps •Investigate and develop the biomechanical model to translate optical signals related to skin-level vibrations into underlying CVD physiological events •Validate the system in a clinical setting

Photonics integration is needed to enable a device that is mobile (small size, small weight, robust (no moving parts), low cost (high volume scalable process flow) and allows fast screening (laser array).

The partners commit to protect IP whenever possible, disseminate results via open access and, if target specs are met, commercially exploit and transfer the technology to create social and economic impact.

 Deliverables

List of deliverables.
Evaluation of the clinical feasibility and validation of LDV for measurement of aortic and local PWV Documents, reports 2020-02-07 12:45:49
Final Report Documents, reports 2020-02-07 12:45:49
Press release at project end Websites, patent fillings, videos etc. 2020-02-07 12:45:50
Evaluation of the clinical feasibility and validation of LDV for measurement of coronary stenosis Documents, reports 2020-02-07 12:45:50
Evaluation of LDV measurements to assess cardiac pump function, globally and locally Documents, reports 2020-02-07 12:45:50
Website online Websites, patent fillings, videos etc. 2020-02-07 12:45:49
Press release at project start Websites, patent fillings, videos etc. 2020-02-07 12:45:49

Take a look to the deliverables list in detail:  detailed list of CARDIS deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Yanlu Li, Jinghao Zhu, Matthieu Duperron, Peter O’Brien, Ralf Schüler, Soren Aasmul, Mirko de Melis, Mathias Kersemans, Roel Baets
Six-beam homodyne laser Doppler vibrometry based on silicon photonics technology
published pages: 3638, ISSN: 1094-4087, DOI: 10.1364/oe.26.003638
Optics Express 26/3 2020-02-07
2019 Viviana Mancini, Aslak W. Bergersen, Jan Vierendeels, Patrick Segers, Kristian Valen-Sendstad
High-Frequency Fluctuations in Post-stenotic Patient Specific Carotid Stenosis Fluid Dynamics: A Computational Fluid Dynamics Strategy Study
published pages: , ISSN: 1869-408X, DOI: 10.1007/s13239-019-00410-9
Cardiovascular Engineering and Technology 2020-02-07
2017 Matthieu Duperron, Lee Carroll, Marc Rensing, Sean Collins, Yan Zhao, Yanlu Li, Roel Baets, Peter O\'Brien
Hybrid integration of laser source on silicon photonic integrated circuit for low-cost interferometry medical device
published pages: 1010915, ISSN: , DOI: 10.1117/12.2250921
Optical Interconnects XVII 2020-02-07

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The information about "CARDIS" are provided by the European Opendata Portal: CORDIS opendata.

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