RAIS
Scalable, point-of-care and label free microarray platform for rapid detection of Sepsis
Total Cost €
0EC-Contrib. €
0Partnership
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0RAIS project word cloud
Explore the words cloud of the RAIS project. It provides you a very rough idea of what is the project "RAIS" about.
Project "RAIS" data sheet
The following table provides information about the project.
| Coordinator |
FUNDACIO INSTITUT DE CIENCIES FOTONIQUES
Organization address contact info |
| Coordinator Country | Spain [ES] |
| Project website | http://www.rais-project.eu |
| Total cost | 3˙388˙572 € |
| EC max contribution | 2˙988˙572 € (88%) |
| Programme |
1. H2020-EU.2.1.1.6. (Micro- and nanoelectronics and photonics: Key enabling technologies related to micro- and nanoelectronics and to photonics, covering also quantum technologies) |
| Code Call | H2020-ICT-2014-1 |
| Funding Scheme | RIA |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-01-01 to 2018-03-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | FUNDACIO INSTITUT DE CIENCIES FOTONIQUES | ES (Castelldefels) | coordinator | 812˙945.00 |
| 2 | TRINEAN NV | BE (GENTBRUGGE) | participant | 416˙660.00 |
| 3 | FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA | ES (BARCELONA) | participant | 370˙358.00 |
| 4 | MICROTEC GESELLSCHAFT FUR MIKROTECHNOLOGIE MBH | DE (DUISBURG) | participant | 298˙750.00 |
| 5 | IXSCIENT LIMITED | UK (TWICKENHAM MIDDLESEX) | participant | 264˙375.00 |
| 6 | DIESSE DIAGNOSTICA SENESE SPA | IT (MILANO) | participant | 250˙450.00 |
| 7 | FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA | ES (BELLATERRA (BARCELONA)) | participant | 246˙406.00 |
| 8 | AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS | ES (MADRID) | participant | 153˙736.00 |
| 9 | BRAHMS GMBH | DE (HENNIGSDORF) | participant | 144˙000.00 |
| 10 | INSTITUT CATALA DE LA SALUT | ES (BARCELONA) | participant | 30˙891.00 |
| 11 | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE | CH (LAUSANNE) | participant | 0.00 |
Map
Project objective
The diagnosis and management of acute Sepsis is a critical area where fast and accurate results can translate into life changing health outcomes for individuals. The overall aim of RAIS is to develop a new point-of-care label-free microarray platform and validate it for quantifying levels of specific Sepsis’ biomarkers. The approach uses a novel interferometric technique ultimately capable of providing very large arrays of tests. Specific objectives and activities include: (i) an optical microarray reader based on a disruptive proprietary design combining interferometric lens-free microscopy and proximity CCD or CMOS image sensing; (ii) a microarray plate, in a proper microfluidic cartridge, consisting of a transparent slide with a novel nano-structured surface geometry to increase the detection sensitivity and covered by specific receptors to capture bio-markers; (iii) their integration in a portable and battery powered label free microarray platform potentially capable of measuring more than 1 million bio-targets simultaneously. The developed technology will be capable to detect micro-ribonucleic acids (microRNAs), interleukins and other specific proteins associated to Sepsis using a few microliters of blood or serum samples, in a concentration of a few pg/ml, within 30 minutes (sample to result) and at a cost per patient of less than 50€. In this way, patients will be put on the right treatment more rapidly, potentially reducing the Sepsis mortality rate of more than 70%, with estimated cost savings of more than €10 billion per year as a consequence of shorter hospital stays, reduced use of unnecessary drugs and lower associated insurance bills. The technical approach, targeted device, application and the addressed market sector are perfectly in line with the call H2020-ICT-2014-1 - Photonics KET - Biophotonics for screening of diseases: Mobile, low-cost point-of-care screening devices for reliable, fast and non- or minimally-invasive detection of diseases.
Deliverables
| Business plan | Documents, reports | 2019-05-30 17:02:34 |
| Report on novel developments and preliminary exploitation plan | Documents, reports | 2019-05-30 17:02:30 |
| Final exploitation plan and technology roadmap | Documents, reports | 2019-05-30 17:02:27 |
Take a look to the deliverables list in detail: detailed list of RAIS deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Filiz Yesilkoy, Roland A Terborg, Josselin Pello, Alexander A Belushkin, Yasaman Jahani, Valerio Pruneri, Hatice Altug Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager published pages: 17152, ISSN: 2047-7538, DOI: 10.1038/lsa.2017.152 |
Light: Science & Applications 7/2 | 2019-05-30 |
| 2016 |
R. A. Terborg, J. Pello, I. Mannelli, J. P. Torres, V. Pruneri Ultrasensitive interferometric on-chip microscopy of transparent objects published pages: e1600077-e160007, ISSN: 2375-2548, DOI: 10.1126/sciadv.1600077 |
Science Advances 2/6 | 2019-05-30 |
| 2016 |
Odeta Limaj, Dordaneh Etezadi, Nathan J. Wittenberg, Daniel Rodrigo, Daehan Yoo, Sang-Hyun Oh, Hatice Altug Infrared Plasmonic Biosensor for Real-Time and Label-Free Monitoring of Lipid Membranes published pages: 1502-1508, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.5b05316 |
Nano Letters 16/2 | 2019-05-30 |
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