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RAIS

Scalable, point-of-care and label free microarray platform for rapid detection of Sepsis

Total Cost €

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EC-Contrib. €

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Partnership

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 RAIS project word cloud

Explore the words cloud of the RAIS project. It provides you a very rough idea of what is the project "RAIS" about.

surface    covered    ultimately    acids    microliters    lower    structured    blood    changing    individuals    geometry    proteins    minimally    proprietary    perfectly    stays    receptors    fast    area    cartridge    slide    rate    critical    potentially    technique    tests    label    minutes    bio    mobile    biophotonics    screening    reader    consisting    measuring    transparent    markers    rais    translate    life    70    concentration    unnecessary    platform    hospital    2014    reducing    right    microscopy    nano    patients    uses    ccd    point    million    micrornas    bills    capture    interferometric    accurate    ribonucleic    photonics    serum    device    disruptive    battery    sensing    ml    validate    integration    optical    combining    sepsis    put    invasive    quantifying    consequence    arrays    detect    line    interleukins    ict    powered    patient    microarray    lens    savings    free    image    insurance    plate    health    pg    mortality    outcomes    market    diseases    micro    proximity    treatment    shorter    microfluidic    sensitivity    care    few    acute    diagnosis    billion    proper    detection    portable    drugs    cmos    biomarkers    simultaneously    levels    ket    samples   

Project "RAIS" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE CIENCIES FOTONIQUES 

Organization address
address: AVINGUDA CARL FRIEDRICH GAUSS 3
city: Castelldefels
postcode: 8860
website: www.icfo.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://www.rais-project.eu
 Total cost 3˙388˙572 €
 EC max contribution 2˙988˙572 € (88%)
 Programme 1. H2020-EU.2.1.1.6. (Micro- and nanoelectronics and photonics: Key enabling technologies related to micro- and nanoelectronics and to photonics, covering also quantum technologies)
 Code Call H2020-ICT-2014-1
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2018-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE CIENCIES FOTONIQUES ES (Castelldefels) coordinator 812˙945.00
2    TRINEAN NV BE (GENTBRUGGE) participant 416˙660.00
3    FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA ES (BARCELONA) participant 370˙358.00
4    MICROTEC GESELLSCHAFT FUR MIKROTECHNOLOGIE MBH DE (DUISBURG) participant 298˙750.00
5    IXSCIENT LIMITED UK (TWICKENHAM MIDDLESEX) participant 264˙375.00
6    DIESSE DIAGNOSTICA SENESE SPA IT (MILANO) participant 250˙450.00
7    FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA ES (BELLATERRA (BARCELONA)) participant 246˙406.00
8    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 153˙736.00
9    BRAHMS GMBH DE (HENNIGSDORF) participant 144˙000.00
10    INSTITUT CATALA DE LA SALUT ES (BARCELONA) participant 30˙891.00
11    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) participant 0.00

Map

 Project objective

The diagnosis and management of acute Sepsis is a critical area where fast and accurate results can translate into life changing health outcomes for individuals. The overall aim of RAIS is to develop a new point-of-care label-free microarray platform and validate it for quantifying levels of specific Sepsis’ biomarkers. The approach uses a novel interferometric technique ultimately capable of providing very large arrays of tests. Specific objectives and activities include: (i) an optical microarray reader based on a disruptive proprietary design combining interferometric lens-free microscopy and proximity CCD or CMOS image sensing; (ii) a microarray plate, in a proper microfluidic cartridge, consisting of a transparent slide with a novel nano-structured surface geometry to increase the detection sensitivity and covered by specific receptors to capture bio-markers; (iii) their integration in a portable and battery powered label free microarray platform potentially capable of measuring more than 1 million bio-targets simultaneously. The developed technology will be capable to detect micro-ribonucleic acids (microRNAs), interleukins and other specific proteins associated to Sepsis using a few microliters of blood or serum samples, in a concentration of a few pg/ml, within 30 minutes (sample to result) and at a cost per patient of less than 50€. In this way, patients will be put on the right treatment more rapidly, potentially reducing the Sepsis mortality rate of more than 70%, with estimated cost savings of more than €10 billion per year as a consequence of shorter hospital stays, reduced use of unnecessary drugs and lower associated insurance bills. The technical approach, targeted device, application and the addressed market sector are perfectly in line with the call H2020-ICT-2014-1 - Photonics KET - Biophotonics for screening of diseases: Mobile, low-cost point-of-care screening devices for reliable, fast and non- or minimally-invasive detection of diseases.

 Deliverables

List of deliverables.
Business plan Documents, reports 2019-05-30 17:02:34
Report on novel developments and preliminary exploitation plan Documents, reports 2019-05-30 17:02:30
Final exploitation plan and technology roadmap Documents, reports 2019-05-30 17:02:27

Take a look to the deliverables list in detail:  detailed list of RAIS deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 Filiz Yesilkoy, Roland A Terborg, Josselin Pello, Alexander A Belushkin, Yasaman Jahani, Valerio Pruneri, Hatice Altug
Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager
published pages: 17152, ISSN: 2047-7538, DOI: 10.1038/lsa.2017.152
Light: Science & Applications 7/2 2019-05-30
2016 R. A. Terborg, J. Pello, I. Mannelli, J. P. Torres, V. Pruneri
Ultrasensitive interferometric on-chip microscopy of transparent objects
published pages: e1600077-e160007, ISSN: 2375-2548, DOI: 10.1126/sciadv.1600077
Science Advances 2/6 2019-05-30
2016 Odeta Limaj, Dordaneh Etezadi, Nathan J. Wittenberg, Daniel Rodrigo, Daehan Yoo, Sang-Hyun Oh, Hatice Altug
Infrared Plasmonic Biosensor for Real-Time and Label-Free Monitoring of Lipid Membranes
published pages: 1502-1508, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.5b05316
Nano Letters 16/2 2019-05-30

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