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RAIS

Scalable, point-of-care and label free microarray platform for rapid detection of Sepsis

Total Cost €

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EC-Contrib. €

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Partnership

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 RAIS project word cloud

Explore the words cloud of the RAIS project. It provides you a very rough idea of what is the project "RAIS" about.

hospital    serum    biophotonics    acute    biomarkers    unnecessary    portable    cartridge    insurance    patients    70    sepsis    mobile    free    arrays    proximity    cmos    ml    battery    point    nano    diseases    micrornas    ict    sensitivity    ccd    2014    microfluidic    health    shorter    image    bills    device    measuring    uses    quantifying    covered    ket    put    reader    rate    tests    invasive    technique    interferometric    minimally    savings    care    ultimately    mortality    validate    label    consequence    patient    structured    surface    stays    capture    translate    critical    samples    accurate    market    potentially    line    powered    microliters    photonics    changing    ribonucleic    slide    receptors    proteins    minutes    sensing    micro    pg    individuals    reducing    interleukins    rais    disruptive    consisting    geometry    billion    microscopy    combining    lens    optical    few    detect    area    diagnosis    outcomes    life    blood    proper    acids    detection    microarray    million    fast    bio    treatment    simultaneously    levels    plate    platform    proprietary    drugs    concentration    markers    integration    transparent    lower    perfectly    screening    right   

Project "RAIS" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE CIENCIES FOTONIQUES 

Organization address
address: AVINGUDA CARL FRIEDRICH GAUSS 3
city: Castelldefels
postcode: 8860
website: www.icfo.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://www.rais-project.eu
 Total cost 3˙388˙572 €
 EC max contribution 2˙988˙572 € (88%)
 Programme 1. H2020-EU.2.1.1.6. (Micro- and nanoelectronics and photonics: Key enabling technologies related to micro- and nanoelectronics and to photonics, covering also quantum technologies)
 Code Call H2020-ICT-2014-1
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2018-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE CIENCIES FOTONIQUES ES (Castelldefels) coordinator 812˙945.00
2    TRINEAN NV BE (GENTBRUGGE) participant 416˙660.00
3    FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA ES (BARCELONA) participant 370˙358.00
4    MICROTEC GESELLSCHAFT FUR MIKROTECHNOLOGIE MBH DE (DUISBURG) participant 298˙750.00
5    IXSCIENT LIMITED UK (TWICKENHAM MIDDLESEX) participant 264˙375.00
6    DIESSE DIAGNOSTICA SENESE SPA IT (MILANO) participant 250˙450.00
7    FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA ES (BELLATERRA (BARCELONA)) participant 246˙406.00
8    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 153˙736.00
9    BRAHMS GMBH DE (HENNIGSDORF) participant 144˙000.00
10    INSTITUT CATALA DE LA SALUT ES (BARCELONA) participant 30˙891.00
11    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) participant 0.00

Map

 Project objective

The diagnosis and management of acute Sepsis is a critical area where fast and accurate results can translate into life changing health outcomes for individuals. The overall aim of RAIS is to develop a new point-of-care label-free microarray platform and validate it for quantifying levels of specific Sepsis’ biomarkers. The approach uses a novel interferometric technique ultimately capable of providing very large arrays of tests. Specific objectives and activities include: (i) an optical microarray reader based on a disruptive proprietary design combining interferometric lens-free microscopy and proximity CCD or CMOS image sensing; (ii) a microarray plate, in a proper microfluidic cartridge, consisting of a transparent slide with a novel nano-structured surface geometry to increase the detection sensitivity and covered by specific receptors to capture bio-markers; (iii) their integration in a portable and battery powered label free microarray platform potentially capable of measuring more than 1 million bio-targets simultaneously. The developed technology will be capable to detect micro-ribonucleic acids (microRNAs), interleukins and other specific proteins associated to Sepsis using a few microliters of blood or serum samples, in a concentration of a few pg/ml, within 30 minutes (sample to result) and at a cost per patient of less than 50€. In this way, patients will be put on the right treatment more rapidly, potentially reducing the Sepsis mortality rate of more than 70%, with estimated cost savings of more than €10 billion per year as a consequence of shorter hospital stays, reduced use of unnecessary drugs and lower associated insurance bills. The technical approach, targeted device, application and the addressed market sector are perfectly in line with the call H2020-ICT-2014-1 - Photonics KET - Biophotonics for screening of diseases: Mobile, low-cost point-of-care screening devices for reliable, fast and non- or minimally-invasive detection of diseases.

 Deliverables

List of deliverables.
Business plan Documents, reports 2019-05-30 17:02:34
Report on novel developments and preliminary exploitation plan Documents, reports 2019-05-30 17:02:30
Final exploitation plan and technology roadmap Documents, reports 2019-05-30 17:02:27

Take a look to the deliverables list in detail:  detailed list of RAIS deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 Filiz Yesilkoy, Roland A Terborg, Josselin Pello, Alexander A Belushkin, Yasaman Jahani, Valerio Pruneri, Hatice Altug
Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager
published pages: 17152, ISSN: 2047-7538, DOI: 10.1038/lsa.2017.152
Light: Science & Applications 7/2 2019-05-30
2016 R. A. Terborg, J. Pello, I. Mannelli, J. P. Torres, V. Pruneri
Ultrasensitive interferometric on-chip microscopy of transparent objects
published pages: e1600077-e160007, ISSN: 2375-2548, DOI: 10.1126/sciadv.1600077
Science Advances 2/6 2019-05-30
2016 Odeta Limaj, Dordaneh Etezadi, Nathan J. Wittenberg, Daniel Rodrigo, Daehan Yoo, Sang-Hyun Oh, Hatice Altug
Infrared Plasmonic Biosensor for Real-Time and Label-Free Monitoring of Lipid Membranes
published pages: 1502-1508, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.5b05316
Nano Letters 16/2 2019-05-30

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