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Muscle stress relief SIGNED

Muscle Stress Relief: An integrated research program linking together basic research on secondary myopathies in stress states to innovative translation in applied myology.

Total Cost €

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EC-Contrib. €

0

Partnership

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 Muscle stress relief project word cloud

Explore the words cloud of the Muscle stress relief project. It provides you a very rough idea of what is the project "Muscle stress relief" about.

myofibril    animal    progressive    lung    lifestyles    diverse    ultimately    vice    expertise    unbalanced    multidisciplinary    inter    talk    seconded    translation    versa    contractility    ageing    stages    complementary    collaborative    interdisciplinary    south    six    variety    teams    secondary    clinical    disease    impairing    functionally    preventive    endemic    translational    organ    liver    nutrition    groups    strategies    stage    causing    metabolism    capacities    myofilament    academic    underlying    muscle    chronic    kidney    myopathy    stress    regenerative    cross    countries    africa    myopathies    edge    incidence    innovative    weakness    proteins    mechanisms    thereby    nine    detection    lifestyle    team    network    organs    participate    university    predicted    scheme    force    interventions    sme    smes    joint    therapeutic    models    heart    regulation    cutting    humoral    innovation    socioeconomic    monitoring    risk    inactive    medical   

Project "Muscle stress relief" data sheet

The following table provides information about the project.

Coordinator
PANEPISTIMIO THESSALIAS 

Organization address
address: ARGONAFTON FILELLINON
city: VOLOS
postcode: 38221
website: www.uth.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Project website http://www.musclestressrelief.eu
 Total cost 1˙606˙500 €
 EC max contribution 1˙458˙000 € (91%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2014
 Funding Scheme MSCA-RISE
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    PANEPISTIMIO THESSALIAS EL (VOLOS) coordinator 144˙000.00
2    UNIVERSITY OF ST MARK & ST JOHN UK (PLYMOUTH) participant 189˙000.00
3    STICHTING VUMC NL (AMSTERDAM) participant 180˙000.00
4    TZARTOS - DIAGNOSIS & RESEARCH IN NEUROIMMUNOLOGY MEDICAL LIMITED LIABILITY COMPANY EL (Athens) participant 166˙500.00
5    RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG DE (HEIDELBERG) participant 139˙500.00
6    ASSOCIATION GENETHON FR (EVRY) participant 130˙500.00
7    MYOMEDIX GMBH DE (NECKARGEMUEND) participant 126˙000.00
8    CHRISTOS PAPADOPOULOS & SIA OE EL (KARDITSA) participant 117˙000.00
9    FONDAZIONE PER LA RICERCA BIOMEDICA AVANZATA ONLUS IT (PADOVA) participant 94˙500.00
10    UNIVERSITAT KONSTANZ DE (KONSTANZ) participant 90˙000.00
11    KNIGHT SCIENTIFIC LIMITED UK (PLYMOUTH DEVON) participant 40˙500.00
12    DLD GESELLSCHAFT FUR DIAGNOSTIKA UND MEDIZINISCHE GERATE MBH DE (HAMBURG) participant 31˙500.00
13    ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT DE (MANNHEIM) participant 9˙000.00
14    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) participant 0.00
15    IMMUNDIAGNOSTIK AG DE (BENSHEIM) participant 0.00
16    STICHTING VU NL (AMSTERDAM) participant 0.00
17    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) participant 0.00
18    STELLENBOSCH UNIVERSITY ZA (STELLENBOSCH) partner 0.00
19    University of Arizona College of Medicine-Phoenix US (Gilbert) partner 0.00
20    University of California San Francisco School of Medicine US (San Francisco) partner 0.00
21    UNIVERSITY OF FLORIDA US (GAINESVILLE) partner 0.00

Map

 Project objective

A diverse variety of medical or lifestyle conditions lead to a progressive loss of muscle force by functionally impairing myofibril contractility and causing ultimately myofibril loss. Major underlying risk factors of chronic muscle force loss are ageing, inactive lifestyles, and unbalanced nutrition. Together, these factors are predicted to lead to an endemic incidence of muscle weakness both in the developed countries. Clinical research on the mechanisms involved requires a multidisciplinary approach covering aspects of ageing, metabolism, and on the humoral cross-talk of muscle with other key organs including heart, liver, kidney, and lung. To achieve this, six European groups with complementary expertise in inter-organ-cross-talk during stress-induced secondary myopathies will team-up with three leading teams in the U.S. with expertise in myopathy animal models, myofilament proteins and translation of muscle research into therapeutic interventions, and with one team from South Africa with cutting-edge expertise in the regulation of regenerative capacities in muscle. Importantly, five SMEs will participate in this RISE network that provide expertise in early muscle disease detection, monitoring, and the developing preventive strategies: Their knowledge on muscle disease detection at early stages and their monitoring during interventions will promote translational innovation. To implement innovation and our joint research program, both early stage and advanced researchers will be seconded from the academic nine teams to these five SMEs and vice versa. Thereby, this RISE scheme will establish a long-term collaborative University-SME driven translational innovative research program innovation in our interdisciplinary field of growing socioeconomic medical importance.

 Deliverables

List of deliverables.
Management Websites, patent fillings, videos etc. 2020-01-28 10:54:17
Workshop Other 2020-01-28 10:54:17

Take a look to the deliverables list in detail:  detailed list of Muscle stress relief deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Giulia Favaro, Vanina Romanello, Tatiana Varanita, Maria Andrea Desbats, Valeria Morbidoni, Caterina Tezze, Mattia Albiero, Marta Canato, Gaia Gherardi, Diego De Stefani, Cristina Mammucari, Bert Blaauw, Simona Boncompagni, Feliciano Protasi, Carlo Reggiani, Luca Scorrano, Leonardo Salviati, Marco Sandri
DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-10226-9
Nature Communications 10/1 2020-03-05
2019 Vanina Romanello, Marco Scalabrin, Mattia Albiero, Bert Blaauw, Luca Scorrano, Marco Sandri
Inhibition of the Fission Machinery Mitigates OPA1 Impairment in Adult Skeletal Muscles
published pages: 597, ISSN: 2073-4409, DOI: 10.3390/cells8060597
Cells 8/6 2020-03-05
2020 John S. Tzartos, Katerina Karagiorgou, Dimitrios Tzanetakos, Marianthi Breza, Maria Eleftheria Evangelopoulos, Sygkliti-Henrietta Pelidou, Christos Bakirtzis, Ioannis Nikolaidis, Georgios Koutsis, Konstantinos Notas, Elisabeth Chroni, Ioannis Markakis, Nikolaos C. Grigoriadis, Maria Anagnostouli, Anastasios Orologas, Dimitrios Parisis, Theodoros Karapanayiotides, Dimitra Papadimitriou, Vasiliki Ko
Deciphering anti-MOG IgG antibodies: Clinical and radiological spectrum, and comparison of antibody detection assays
published pages: 116673, ISSN: 0022-510X, DOI: 10.1016/j.jns.2020.116673
Journal of the Neurological Sciences 410 2020-02-20
2019 J.G. Silvestre, I.L. Baptista, W.J. Silva, A. Cruz, M.T. Silva, E.H. Miyabara, S. Labeit, A.S. Moriscot
The E3 ligase MuRF2 plays a key role in the functional capacity of skeletal muscle fibroblasts
published pages: , ISSN: 0100-879X, DOI: 10.1590/1414-431x20198551
Brazilian Journal of Medical and Biological Research 52/9 2020-02-13
2019 Robbert J. van der Pijl, Henk L. Granzier, Coen A. C. Ottenheijm
Diaphragm contractile weakness due to reduced mechanical loading: role of titin
published pages: C167-C176, ISSN: 0363-6143, DOI: 10.1152/ajpcell.00509.2018
American Journal of Physiology-Cell Physiology 317/2 2020-01-28
2019 William José Silva, Flavia Aparecida Graça, André Cruz, João Guilherme Silvestre, Siegfried Labeit, Elen Haruka Miyabara, Chao Yun Irene Yan, Da Zhi Wang, Anselmo Sigari Moriscot
miR‐29c improves skeletal muscle mass and function throughout myocyte proliferation and differentiation and by repressing atrophy‐related genes
published pages: e13278, ISSN: 1748-1708, DOI: 10.1111/apha.13278
Acta Physiologica 2020-01-28
2019 Anselmo Sigari Moriscot, Igor Luchini Baptista, William José Silva, João Guilherme Silvestre, Volker Adams, Alexander Gasch, Julius Bogomolovas, Siegfried Labeit
MuRF1 and MuRF2 are key players in skeletal muscle regeneration involving myogenic deficit and deregulation of the chromatin-remodeling complex
published pages: 1-25, ISSN: 2617-1619, DOI: 10.1002/j.2617-1619.2019.tb00010.x
JCSM Rapid Communications 2/1 2020-01-28
2018 Nikolaos Trakas, Socrates J. Tzartos
Immunostick ELISA for rapid and easy diagnosis of myasthenia gravis
published pages: 107-112, ISSN: 0022-1759, DOI: 10.1016/j.jim.2018.06.016
Journal of Immunological Methods 460 2020-01-28
2017 Mitrou GI, Poulianiti KP, Koutedakis Y, Jamurtas AZ, Maridaki MD, Stefanidis I, Sakkas GK, Karatzaferi C
Functional responses of uremic single skeletal muscle fibers to redox imbalances
published pages: 3-7, ISSN: 1108-4189, DOI:
Hippokratia 21(1) 2020-01-28
2018 Johan Lindqvist, Marloes van den Berg, Robbert van der Pijl, Pleuni E. Hooijman, Albertus Beishuizen, Judith Elshof, Monique de Waard, Armand Girbes, Angelique Spoelstra-de Man, Zhong-Hua Shi, Charissa van den Brom, Sylvia Bogaards, Shengyi Shen, Joshua Strom, Henk Granzier, Jeroen Kole, René J. P. Musters, Marinus A. Paul, Leo M. A. Heunks, Coen A. C. Ottenheijm
Positive End-Expiratory Pressure Ventilation Induces Longitudinal Atrophy in Diaphragm Fibers
published pages: 472-485, ISSN: 1073-449X, DOI: 10.1164/rccm.201709-1917OC
American Journal of Respiratory and Critical Care Medicine 198/4 2020-01-28
2017 Caterina Tezze, Vanina Romanello, Maria Andrea Desbats, Gian Paolo Fadini, Mattia Albiero, Giulia Favaro, Stefano Ciciliot, Maria Eugenia Soriano, Valeria Morbidoni, Cristina Cerqua, Stefan Loefler, Helmut Kern, Claudio Franceschi, Stefano Salvioli, Maria Conte, Bert Blaauw, Sandra Zampieri, Leonardo Salviati, Luca Scorrano, Marco Sandri
Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence
published pages: 1374-1389.e6, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2017.04.021
Cell Metabolism 25/6 2020-01-28
2017 Christina Karatzaferi, Nancy Adamek, Michael A Geeves
Modulators of actin-myosin dissociation: basis for muscle type functional differences during fatigue
published pages: ajpcell.00023.20, ISSN: 0363-6143, DOI: 10.1152/ajpcell.00023.2017
American Journal of Physiology - Cell Physiology 2020-01-28
2015 C. J. Malavaki, G. K. Sakkas, G. I. Mitrou, A. Kalyva, I. Stefanidis, K. H. Myburgh, C. Karatzaferi
Skeletal muscle atrophy: disease-induced mechanisms may mask disuse atrophy
published pages: 405-421, ISSN: 0142-4319, DOI: 10.1007/s10974-015-9439-8
Journal of Muscle Research and Cell Motility 36/6 2020-01-28
2017 Shara Atambayeva, Raigul Niyazova, Anatoliy Ivashchenko, Anna Pyrkova, Ilya Pinsky, Aigul Akimniyazova, Siegfried Labeit
The Binding Sites of miR-619-5p in the mRNAs of Human and Orthologous Genes
published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-017-3811-6
BMC Genomics 18/1 2020-01-28
2016 Julius Bogomolovas, Alexander Gasch, Vilhelmas Bajoras, Dovilė Karčiauskaitė, Pranas Šerpytis, Virginija Grabauskienė, Dittmar Labeit, Siegfried Labeit
Cardiac specific titin N2B exon is a novel sensitive serological marker for cardiac injury
published pages: 232-234, ISSN: 0167-5273, DOI: 10.1016/j.ijcard.2016.03.045
International Journal of Cardiology 212 2020-01-28
2016 C. Stergiou, K. Lazaridis, V. Zouvelou, J. Tzartos, R. Mantegazza, C. Antozzi, F. Andreetta, A. Evoli, F. Deymeer, G. Saruhan-Direskeneli, H. Durmus, T. Brenner, A. Vaknin, S. Berrih-Aknin, A. Behin, T. Sharshar, M. De Baets, M. Losen, P. Martinez-Martinez, K.A. Kleopa, E. Zamba-Papanicolaou, T. Kyriakides, A. Kostera-Pruszczyk, P. Szczudlik, B. Szyluk, D. Lavrnic, I. Basta, S. Peric, C. Tallaksen, A. Maniaol, N.E. Gilhus, C. Casasnovas Pons, J. Pitha, M. Jakubíkova, F. Hanisch, J. Bogomolovas, D. Labeit, S. Labeit, S.J. Tzartos
Titin antibodies in “seronegative” myasthenia gravis — A new role for an old antigen
published pages: 108-115, ISSN: 0165-5728, DOI: 10.1016/j.jneuroim.2016.01.018
Journal of Neuroimmunology 292 2020-01-28
2017 Thomas Scott Bowen, Volker Adams, Sarah Werner, Tina Fischer, Paulien Vinke, Maria Noel Brogger, Norman Mangner, Axel Linke, Peter Sehr, Joe Lewis, Dittmar Labeit, Alexander Gasch, Siegfried Labeit
Small-molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia
published pages: , ISSN: 2190-5991, DOI: 10.1002/jcsm.12233
Journal of Cachexia, Sarcopenia and Muscle 2020-01-28
2019 Konstantina P. Poulianiti, Aggeliki Karioti, Antonia Kaltsatou, Georgia I. Mitrou, Yiannis Koutedakis, Konstantinos Tepetes, Grigoris Christodoulidis, Giannis Giakas, Maria D. Maridaki, Ioannis Stefanidis, Athanasios Z. Jamurtas, Giorgos K. Sakkas, Christina Karatzaferi
Evidence of Blood and Muscle Redox Status Imbalance in Experimentally Induced Renal Insufficiency in a Rabbit Model
published pages: 1-14, ISSN: 1942-0900, DOI: 10.1155/2019/8219283
Oxidative Medicine and Cellular Longevity 2019 2020-01-28
2019 Georgia I. Mitrou, Giorgos K. Sakkas, Konstantina P. Poulianiti, Aggeliki Karioti, Konstantinos Tepetes, Grigorios Christodoulidis, Giannis Giakas, Ioannis Stefanidis, Michael A. Geeves, Yiannis Koutedakis, Christina Karatzaferi
Evidence of functional deficits at the single muscle fiber level in experimentally-induced renal insufficiency
published pages: 259-265, ISSN: 0021-9290, DOI: 10.1016/j.jbiomech.2018.10.035
Journal of Biomechanics 82 2020-01-28

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