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MeTABLE

Advanced bioinformatics for genome and metagenome analyses and discovery of novel biocatalists from extremophiles: implications for improving industrial bioprocesses

Total Cost €

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EC-Contrib. €

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Partnership

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Project "MeTABLE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI CAMERINO 

Organization address
address: PIAZZA CAVOUR 19F
city: CAMERINO
postcode: 62032
website: www.unicam.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://www.metable.eu/metable/
 Total cost 337˙500 €
 EC max contribution 337˙500 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2014
 Funding Scheme MSCA-RISE
 Starting year 2014
 Duration (year-month-day) from 2014-12-01   to  2018-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI CAMERINO IT (CAMERINO) coordinator 81˙000.00
2    EPIGENETIKS GENETIK BIYOINFORMATIK YAZILIM AS TR (ISTANBUL) participant 130˙500.00
3    UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA IT (MILANO) participant 58˙500.00
4    BIOMOLECULAR RESEARCH GENOMICS SRL IT (PADOVA) participant 45˙000.00
5    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 22˙500.00
6    ELVESYS FR (PARIS) participant 0.00
7    COMSATS INSTITUTE OF INFORMATION TECHNOLOGY PK (Islamabad) partner 0.00

Map

 Project objective

The aim of this proposal is to acquire new insights about the mechanisms of environmental adaptation, particularly for cold-adapted organisms, and to discover novel metabolic pathways and enzymes with potential industrial value. We intend to accomplish this goal by establishing a collaboration and a knowledge-exchange network between industrial and academic partners aiming at developing bioinformatic tools for genomic analysis and biotechnology tools for directed evolution. The partners present high complementarity: UNICAM holds genomic sequences from psychrophilic and mesophilic ciliates that need to be annotated and analysed. Sabanci provides environmental samples for the isolation and characterization of new extremophiles. CAMBRIDGE provides the know-how for the discovery of new metabolic pathways valuable for understanding environmental adaptation. BMR Genomics and COMSATS possess all the facilities for genome sequencing and annotation and bioinformatic expertise with the purpose of developing new tools to analyse genomes of microorganisms from extreme environment. UNIMIB owns the facilities for the heterologous expression of gene sequences in bacteria and yeasts and technologies to assess and implement the properties of novel enzymes towards industrial application. We are confident that the establishment of the international research network proposed, with its synergistic effects, will significantly contribute to push all the involved laboratories to the top level in the field of production of active biomolecules and in the discovery of mechanisms of molecular adaptation under extreme environmental conditions. These discoveries may help the manufacturing of a new generation of ordinary facilities, as cleaning agents, biofuels, with a significant impact on the everyday life of European citizens.

 Deliverables

List of deliverables.
Optimized biomolecules Other 2019-08-06 18:17:09
Patents Websites, patent fillings, videos etc. 2019-08-06 18:17:09
optimized molecules for bioremediation Other 2019-08-06 18:17:09
patent on optimized biomolecules Websites, patent fillings, videos etc. 2019-08-06 18:17:09
Characterized new biocatalists Other 2019-08-06 18:17:08
genome annotations Other 2019-08-06 18:17:07
E. focardii genome database and identification of sequences encoding molecules of interest for industrial applications. Documents, reports 2019-08-06 18:17:08
proposals for new projects Documents, reports 2019-08-06 18:17:08
Web page ,Twitter and Facebook account Documents, reports 2019-08-06 18:17:07
reports on new biocatalists Documents, reports 2019-08-06 18:17:06
Isolation of microbes that can survive to extreme environments for cultivation when possible that can survive to extreme environments for cultivation when possibles Other 2019-08-06 18:17:07
characterization of biocatalysts of interest Other 2019-08-06 18:17:07
Characterized new metabolic pathways Other 2019-08-06 18:17:08
Improved bioinformatics tools Documents, reports 2019-08-06 18:17:07
Joint publications concerning WP1-WP5 Documents, reports 2019-08-06 18:17:08
New insight on the molecular mechanisms responsible for cold-adaptation and/or environmental adaptation Documents, reports 2019-08-06 18:17:07
metagenome sequence and annotation Documents, reports 2019-08-06 18:17:07
New rules for system biology Documents, reports 2019-08-06 18:17:07
patenting and industrial applications Documents, reports 2019-08-06 18:17:07
trained researchers on bioinformatics Other 2019-08-06 18:17:07

Take a look to the deliverables list in detail:  detailed list of MeTABLE deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Alessio Mancini, Sandra Pucciarelli
Antibiotic activity of the antioxidant drink effective Microorganism-X (EM-X) extracts against common nosocomial pathogens: an in vitro study
published pages: 1-6, ISSN: 1478-6419, DOI: 10.1080/14786419.2018.1517344
Natural Product Research 2019-10-08
2018 Alessio Mancini, Filmon Eyassu, Maxwell Conway, Annalisa Occhipinti, Pietro Liò, Claudio Angione, Sandra Pucciarelli
CiliateGEM: an open-project and a tool for predictions of ciliate metabolic variations and experimental condition design
published pages: 1-11, ISSN: 1471-2105, DOI: 10.1186/s12859-018-2422-9
BMC Bioinformatics 19/S15 2019-08-06
2018 Alessandro Pischedda, Kesava Priyan Ramasamy, Marco Mangiagalli, Federica Chiappori, Luciano Milanesi, Cristina Miceli, Sandra Pucciarelli, Marina Lotti
Antarctic marine ciliates under stress: superoxide dismutases from the psychrophilic Euplotes focardii are cold-active yet heat tolerant enzymes
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-33127-1
Scientific Reports 8/1 2019-08-06
2018 Aleksei Kaleda, Lotem Haleva, Guy Sarusi, Tova Pinsky, Marco Mangiagalli, Maya Bar Dolev, Marina Lotti, Marco Nardini, Ido Braslavsky
Saturn-Shaped Ice Burst Pattern and Fast Basal Binding of an Ice-Binding Protein from an Antarctic Bacterial Consortium
published pages: , ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.8b01914
Langmuir 2019-08-06
2019 Tyler D.R. Vance, Maddalena Bayer-Giraldi, Peter L. Davies, Marco Mangiagalli
Ice-binding proteins and the ‘domain of unknown function’ 3494 family
published pages: , ISSN: 1742-464X, DOI: 10.1111/febs.14764
The FEBS Journal 2019-08-06
2018 M. Lotti, S. Brocca, M. Mangiagalli, A. Pischedda, M. Orlando, S. Maione, D. De Pascale, S. Pucciarelli, M. Nardini, I. Braslavsky
Enzymes and ice binding proteins from Antarctic organisms
published pages: S43-S44, ISSN: 1871-6784, DOI: 10.1016/j.nbt.2018.05.091
New Biotechnology 44 2019-08-06
2017 Katre Juganson, Monika Mortimer, Angela Ivask, Sandra Pucciarelli, Cristina Miceli, Kaja Orupõld, Anne Kahru
Mechanisms of toxic action of silver nanoparticles in the protozoan Tetrahymena thermophila : From gene expression to phenotypic events
published pages: , ISSN: 0269-7491, DOI: 10.1016/j.envpol.2017.03.013
Environmental Pollution 2019-08-06
2018 Marco Mangiagalli, Guy Sarusi, Aleksei Kaleda, Maya Bar Dolev, Valentina Nardone, Vittoria Federica Vena, Ido Braslavsky, Marina Lotti, Marco Nardini
Structure of a bacterial ice binding protein with two faces of interaction with ice
published pages: 1653-1666, ISSN: 1742-464X, DOI: 10.1111/febs.14434
The FEBS Journal 285/9 2019-08-06
2017 Guang Yang, Hua Yao, Matteo Mozzicafreddo, Patrizia Ballarini, Sandra Pucciarelli, Cristina Miceli
Rational engineering of a cold-adapted α-amylase from the Antarctic ciliate Euplotes focardii for simultaneous improvement of thermostability and catalytic activity
published pages: AEM.00449-17, ISSN: 0099-2240, DOI: 10.1128/AEM.00449-17
Applied and Environmental Microbiology 2019-08-06

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