Explore the words cloud of the SynChI project. It provides you a very rough idea of what is the project "SynChI" about.
The following table provides information about the project.
THE HEBREW UNIVERSITY OF JERUSALEM
|Coordinator Country||Israel [IL]|
|Total cost||2˙000˙000 €|
|EC max contribution||2˙000˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-05-01 to 2021-04-30|
Take a look of project's partnership.
|1||THE HEBREW UNIVERSITY OF JERUSALEM||IL (JERUSALEM)||coordinator||2˙000˙000.00|
Pathological neuronal synchrony is the hallmark of many neurological disorders, including Parkinson’s disease (PD) and Huntington’s disease (HD), which further share deficits in cholinergic signaling. Moreover, recent findings have underscored the therapeutic relevance of the synchrony among striatal cholinergic interneurons (ChI) that orchestrate this signaling. They have shown that excessively synchronous ChI discharge induces di-synaptic release of dopamine, GABA and glutamate. Here, I propose to elucidate how ChI synchronization is generated under normal and pathological conditions and thereby identify novel therapeutic targets to treat PD and HD. This study has only very recently become feasible with the advent of powerful tools that I have mastered to explore ChI synchrony. We will employ a combination of cutting-edge in vitro and in vivo techniques to simultaneously record a far larger population of pre-identified ChIs than is currently possible. We will express GCaMP6, a genetically encoded calcium indicator (GECI), exclusively in ChIs, and use multiphoton microscopy to image calcium transients from several ChIs simultaneously in conjunction with intracellular recording from individual ChIs in acute brain slices and in anesthetized mice. Additionally, we will use endoscopic GECI imaging in freely-moving classically conditioned mice. We will employ modern analyses that reveal low-dimensional structures in large neuronal datasets to quantify synchrony (1) during on-going activity; (2) during optogenetic activation of afferents; and (3), in the freely-moving mice, while presenting conditioned cues. Finally, we will study the origins of pathological synchrony in PD and HD mouse models and explore means to correct this condition. This comprehensive approach should explain the pathological ChI synchrony observed in PD; identify novel targets to treat PD and HD; and create a general methodology to study pathological synchrony in many other neurological disorders.
|year||authors and title||journal||last update|
Jose de Jesus Aceves Buendia, Lior Tiroshi, Wei-Hua Chiu, Joshua A. Goldberg
Selective remodeling of glutamatergic transmission to striatal cholinergic interneurons after dopamine depletion
published pages: , ISSN: 0953-816X, DOI: 10.1111/ejn.13715
|European Journal of Neuroscience||2020-01-21|
Joshua L. Plotkin, Joshua A. Goldberg
Thinking Outside the Box (and Arrow): Current Themes in Striatal Dysfunction in Movement Disorders
published pages: 107385841880788, ISSN: 1073-8584, DOI: 10.1177/1073858418807887
Asami Tanimura, Sean Austin O. Lim, Jose de Jesus Aceves Buendia, Joshua A. Goldberg, D. James Surmeier
Cholinergic Interneurons Amplify Corticostriatal Synaptic Responses in the Q175 Model of Huntingtonâ€™s Disease
published pages: , ISSN: 1662-5137, DOI: 10.3389/fnsys.2016.00102
|Frontiers in Systems Neuroscience 10||2020-01-21|
Lior Tiroshi, Joshua A. Goldberg
Population dynamics and entrainment of basal ganglia pacemakers are shaped by their dendritic arbors
published pages: e1006782, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1006782
|PLOS Computational Biology 15/2||2020-01-21|
Rotem Rehani, Yara Atamna, Lior Tiroshi, Wei-Hua Chiu, JosÃ© de JesÃºs Aceves BuendÃa, Gabriela J. Martins, Gilad A. Jacobson, Joshua A. Goldberg
Activity Patterns in the Neuropil of Striatal Cholinergic Interneurons in Freely Moving Mice Represent Their Collective Spiking Dynamics
published pages: ENEURO.0351-18.2, ISSN: 2373-2822, DOI: 10.1523/eneuro.0351-18.2018
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SYNCHI" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "SYNCHI" are provided by the European Opendata Portal: CORDIS opendata.