Explore the words cloud of the DIvA project. It provides you a very rough idea of what is the project "DIvA" about.
The following table provides information about the project.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
|Coordinator Country||France [FR]|
|Total cost||2˙000˙000 €|
|EC max contribution||2˙000˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-07-01 to 2020-12-31|
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|1||CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS||FR (PARIS)||coordinator||2˙000˙000.00|
'Among the types of damage, DNA Double Strands Breaks (DSBs) are the most deleterious, as illustrated by the variety of human diseases associated with DSB repair defects. Repair of DSB into the chromatin context raises several questions that we aim to address in this proposal. Firstly, it is likely that the chromatin environment where a break occurs influences the choice of repair pathway. Since the different DSB repair mechanisms can lead to different 'scar' on the genome, further studies are required to elucidate how chromatin structure regulates the targeting of DSB repair machineries. Secondly, DNA packaging into chromatin hinders detection and repair of DSBs and many chromatin modifications were recently identified as induced around DSBs to facilitate repair. However, a complete picture of the chromatin landscape set up at DSB, and more specifically the set of histone modifications associated with each repair pathway ('repair histone code') is still awaited. In addition, whether and how damaged chromosomes are reorganized within the nucleus is still unknown. Finally, once repair has been completed, the initial chromatin landscape must be faithfully restored in order to maintain epigenome stability and cell fate. Using an experimental system we recently developed (called DIvA for DSB Inducible via AsiSI), that allows the induction of multiple sequence-specific DSBs widespread across the genome, we propose to investigate these uncovered aspects of the relationship between chromatin and DSB repair. By high-throughput genomic and proteomic technologies, we will try (i) to understand the contribution of chromatin in the DSB repair pathway choice (PRIME), (ii) to describe more thoroughly the chromatin remodeling events and the spatial chromosomes reorganization, that occur concomitantly to DSB to promote adequate repair (REPAIR), and (iii) to elucidate the processes at work to restore epigenome integrity after DSB repair (RESTORE). '
|year||authors and title||journal||last update|
Aude GuÃ©nolÃ©, GaÃ«lle Legube
A meeting at risk: Unrepaired DSBs go for broke
published pages: 589-599, ISSN: 1949-1034, DOI: 10.1080/19491034.2017.1380138
Thomas Clouaire, Aline Marnef, GaÃ«lle Legube
Taming Tricky DSBs: ATM on duty
published pages: 84-91, ISSN: 1568-7864, DOI: 10.1016/j.dnarep.2017.06.010
|DNA Repair 56||2020-03-20|
FranÃ§ois Aymard, Marion Aguirrebengoa, Emmanuelle Guillou, Biola M Javierre, Beatrix Bugler, Coline Arnould, Vincent Rocher, Jason S Iacovoni, Anna Biernacka, Magdalena Skrzypczak, Krzysztof Ginalski, Maga Rowicka, Peter Fraser, GaÃ«lle Legube
Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes
published pages: 353-361, ISSN: 1545-9993, DOI: 10.1038/nsmb.3387
|Nature Structural & Molecular Biology 24/4||2020-03-20|
Sarah Cohen, Nadine Puget, Yea-Lih Lin, Thomas Clouaire, Marion Aguirrebengoa, Vincent Rocher, Philippe Pasero, Yvan Canitrot, GaÃ«lle Legube
Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-02894-w
|Nature Communications 9/1||2020-03-20|
Pierre Caron, Jonathan Choudjaye, Thomas Clouaire, BÃ©atrix Bugler, Virginie Daburon, Marion Aguirrebengoa, Thomas Mangeat, JasonÂ S. Iacovoni, Alejandro Ãlvarez-QuilÃ³n, Felipe CortÃ©s-Ledesma, GaÃ«lle Legube
Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks
published pages: 1598-1609, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2015.10.024
|Cell Reports 13/8||2020-03-20|
Francois Aymard, GaÃ«lle Legube
A TAD closer to ATM
published pages: e1134411, ISSN: 2372-3556, DOI: 10.1080/23723556.2015.1134411
|Molecular & Cellular Oncology 3/3||2020-03-20|
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