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NChIP SIGNED

Chromatin dynamics during DNA replication

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

NChIP project word cloud

Explore the words cloud of the NChIP project. It provides you a very rough idea of what is the project "NChIP" about.

tetramers fundamental positioning establishment newly h4 posttranslational histones se few kinetics shown encoded unmarked fold h3 synthesized disease facts movements histone smaller previously strand transcriptional protein chromatin stay driver epigenetic 1kb thought binding accepted lagging maintenance effect blocs genomic split influence prerequisite predispositions components nucleosome nucleosomes integrity diluted original differentiation theory marks potentially environmental equally cellular gene proteins heritable cerevisiae footprint replication cancer daughter domains inherited perturbations assembly locus programs dynamics site throughput spread inheritance distribute bulk survive implying 400bp dna re measuring strands differences reassembly activation regulators genome maternal majority demonstrated later phenomena renewal

Project "NChIP" data sheet

The following table provides information about the project.

Coordinator	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	1˙984˙677 €
EC max contribution	1˙984˙677 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-CoG
Funding Scheme	ERC-COG
Starting year	2015
Duration (year-month-day)	from 2015-06-01 to 2020-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	1˙984˙677.00

Map

Project objective

Chromatin assembly is a fundamental cellular process necessary for the maintenance of genome integrity and transcriptional programs. Understanding the effect of DNA replication on histone protein dynamics is also a prerequisite for understanding the role of chromatin in epigenetic inheritance. Epigenetic phenomena are thought to influence cellular differentiation and cancer formation, as well as the impact of environmental factors on early development and later predispositions to disease. While epigenetic inheritance of chromatin components is, in theory, accepted as the driver of such phenomena, chromatin state inheritance per se has only been demonstrated for a few specific cases. Not much is known about histone “inheritance” beyond the facts that bulk maternal histones distribute equally among the daughter strands and are diluted two-fold after replication with newly synthesized “unmarked” histones, and that the majority of H3/H4 tetramers do not split before reassembly. We have shown previously that maternal nucleosomes stay on average within 400bp of their original binding site, implying that any potentially heritable chromatin encoded information, has to be inherited in ~1kb blocs, as smaller nucleosome domains would rapidly be diluted by new nucleosomes. I propose to develop high throughput systems for directly measuring movements of histones and chromatin regulators during genomic replication in S.cerevisiae to determine, how chromatin states survive the perturbations associated with replication. We will determine locus specific differences in the spread of maternal nucleosomes after replication, the effects of leading and lagging strand replication on nucleosome positioning and maternal nucleosome distribution, the renewal dynamics of posttranslational histone marks and chromatin binding proteins, and the kinetics of chromatin footprint re-establishment and gene (re)activation.

Publications

List of publications.
year	authors and title	journal	last update
2019	Rahima Ziane, Alain Camasses, Marta Radman-Livaja Mechanics of DNA Replication and Transcription Guide the Asymmetric Distribution of RNAPol2 and New Nucleosomes on Replicated Daughter Genomes published pages: , ISSN: , DOI: 10.1101/553669	biorxiv	2020-02-05
2019	Hrvoje Galic, Pauline Vasseur,Marta Radman-Livaja The budding yeast heterochromatic SIR complex resets upon exit from stationary phase published pages: , ISSN: , DOI: 10.1101/603613	biorxiv	2020-02-05
2016	Pauline Vasseur, Saphia Tonazzini, Rahima Ziane, Alain Camasses, OliverÂ J. Rando, Marta Radman-Livaja Dynamics of Nucleosome Positioning Maturation following Genomic Replication published pages: 2651-2665, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.07.083	Cell Reports 16/10	2019-06-06

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