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NChIP SIGNED

Chromatin dynamics during DNA replication

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NChIP project word cloud

Explore the words cloud of the NChIP project. It provides you a very rough idea of what is the project "NChIP" about.

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Project "NChIP" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙984˙677 €
 EC max contribution 1˙984˙677 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙984˙677.00

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 Project objective

Chromatin assembly is a fundamental cellular process necessary for the maintenance of genome integrity and transcriptional programs. Understanding the effect of DNA replication on histone protein dynamics is also a prerequisite for understanding the role of chromatin in epigenetic inheritance. Epigenetic phenomena are thought to influence cellular differentiation and cancer formation, as well as the impact of environmental factors on early development and later predispositions to disease. While epigenetic inheritance of chromatin components is, in theory, accepted as the driver of such phenomena, chromatin state inheritance per se has only been demonstrated for a few specific cases. Not much is known about histone “inheritance” beyond the facts that bulk maternal histones distribute equally among the daughter strands and are diluted two-fold after replication with newly synthesized “unmarked” histones, and that the majority of H3/H4 tetramers do not split before reassembly. We have shown previously that maternal nucleosomes stay on average within 400bp of their original binding site, implying that any potentially heritable chromatin encoded information, has to be inherited in ~1kb blocs, as smaller nucleosome domains would rapidly be diluted by new nucleosomes. I propose to develop high throughput systems for directly measuring movements of histones and chromatin regulators during genomic replication in S.cerevisiae to determine, how chromatin states survive the perturbations associated with replication. We will determine locus specific differences in the spread of maternal nucleosomes after replication, the effects of leading and lagging strand replication on nucleosome positioning and maternal nucleosome distribution, the renewal dynamics of posttranslational histone marks and chromatin binding proteins, and the kinetics of chromatin footprint re-establishment and gene (re)activation.

 Publications

year authors and title journal last update
List of publications.
2019 Rahima Ziane, Alain Camasses, Marta Radman-Livaja
Mechanics of DNA Replication and Transcription Guide the Asymmetric Distribution of RNAPol2 and New Nucleosomes on Replicated Daughter Genomes
published pages: , ISSN: , DOI: 10.1101/553669
biorxiv 2020-02-05
2019 Hrvoje Galic, Pauline Vasseur,Marta Radman-Livaja
The budding yeast heterochromatic SIR complex resets upon exit from stationary phase
published pages: , ISSN: , DOI: 10.1101/603613
biorxiv 2020-02-05
2016 Pauline Vasseur, Saphia Tonazzini, Rahima Ziane, Alain Camasses, Oliver J. Rando, Marta Radman-Livaja
Dynamics of Nucleosome Positioning Maturation following Genomic Replication
published pages: 2651-2665, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.07.083
Cell Reports 16/10 2019-06-06

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