CANCER-TECH
Cervical cancer detection platform based on novel laser processing
Total Cost €
0EC-Contrib. €
0Partnership
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0CANCER-TECH project word cloud
Explore the words cloud of the CANCER-TECH project. It provides you a very rough idea of what is the project "CANCER-TECH" about.
Project "CANCER-TECH" data sheet
The following table provides information about the project.
| Coordinator |
DUBLIN CITY UNIVERSITY
Organization address contact info |
| Coordinator Country | Ireland [IE] |
| Project website | https://www.openaire.eu/search/project |
| Total cost | 175˙866 € |
| EC max contribution | 175˙866 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2014 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-01-01 to 2017-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | DUBLIN CITY UNIVERSITY | IE (DUBLIN) | coordinator | 175˙866.00 |
Map
Project objective
About 10% of all cancers diagnosed in women worldwide, are cancers of the cervix, the organ that connects the uterus and the vagina. Alone in the European Union over 16,000 deaths are reported annually due to cervical cancer effecting women mainly between the ages of 25 and 50. Within the scope of this fellowship, hosted by Dublin City University (Ireland) in collaboration with Arrows Biomedical GMBH (Germany), a highly sensitive platform to detect Human Papillomavirus (HPV), causative agent of about 99.7% of cervical cancer, will be developed. The proposed diagnostic platform will be based on a laser textured biopolymer as device substrate, functionalized with nanoparticles produced via the Pulsed Laser Ablation in Liquid (PLAL) technique. This on-chip immunoassay will allow rapid detection of the HPV. The novelty of this project lies in the high-quality bio-nanostructures as nano-labels via PLAL designed for ultrasensitive detection of HPV. Two major aspects of this project are: (1) the development of complex nano-labels specifically targeting high risk HPV; and (2) improvement in the performance of the developed assay increasing their sensitivity and specificity, relative to current start of the art. Ultrapure HPV-specific nano-labels will be prepared using pulsed laser ablation in liquid, a green synthesis route independent of any chemical processing. The proposed technique is advantageous due to the enhanced surface activity of laser-generated nanoparticles, which will reduce the amount of sample molecules needed for the successful detection by improving the limit of detection and overall detection time. This project aims at making substantial contribution to the advancement of cancer immunosensing based on a novel on-chip immunoassay design for medical applications. Through this project, the applicant aims to develop intellectual property related to the manufacturing of biomedical devices via laser processed surfaces.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
K. Bagga, R. McCann, F. O\'Sullivan, P. Ghosh, S. Krishnamurthy, A. Stalcup, M. Vázquez, D. Brabazon Nanoparticle functionalized laser patterned substrate: an innovative route towards low cost biomimetic platforms published pages: 8060-8069, ISSN: 2046-2069, DOI: 10.1039/C6RA27260F |
RSC Advances 7/13 | 2019-06-13 |
| 2016 |
Ronán McCann, Komal Bagga, Robert Groarke, Apryll Stalcup, Mercedes Vázquez, Dermot Brabazon Microchannel fabrication on cyclic olefin polymer substrates via 1064 nm Nd:YAG laser ablation published pages: 603-608, ISSN: 0169-4332, DOI: 10.1016/j.apsusc.2016.06.059 |
Applied Surface Science 387 | 2019-06-13 |
| 2017 |
Ronán McCann, Cian Hughes, Komal Bagga, Apryll Stalcup, Mercedes Vázquez, Dermot Brabazon Pulsed laser deposition of plasmonic nanostructured gold on flexible transparent polymers at atmospheric pressure published pages: 245303, ISSN: 0022-3727, DOI: 10.1088/1361-6463/aa7193 |
Journal of Physics D: Applied Physics 50/24 | 2019-06-13 |
| 2017 |
McCann, R.; Bagga, K.; McCarthy, E.; Groarke, R.; Al-Hamaoy, A.; Stalcup, A.; Vázquez, M.; Brabazon, D. Carbon Nanoparticle Functionalization of Laser Textured Polymer Surfaces for Chemical and Biological Speciation. published pages: p63-72., ISSN: 0898-1507, DOI: |
Lasers in Engineering Vol. 36 Issue 1-3 | 2019-06-13 |
| 2018 |
Fereshteh Chekin, Komal Bagga, Palaniappan Subramanian, Roxana Jijie, Santosh K. Singh, Sreekumar Kurungot, Rabah Boukherroub, Sabine Szunerits Nucleic aptamer modified porous reduced graphene oxide/MoS 2 based electrodes for viral detection: Application to human papillomavirus (HPV) published pages: 991-1000, ISSN: 0925-4005, DOI: 10.1016/j.snb.2018.02.065 |
Sensors and Actuators B: Chemical 262 | 2019-06-13 |
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