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RncRNAA

Functions of non-coding RNAs in protein synthesis and homeostasis during aging

Total Cost €

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EC-Contrib. €

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Partnership

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Project "RncRNAA" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.age.mpg.de/science/research-labs/partridge/research/
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 159˙460.00

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 Project objective

Because old age is the largest risk factor for many human diseases, it is one of the key challenges of our time to find ways to increase healthy lifespan and reduce the loss of health in later life. Inhibition of protein synthesis is capable of extending the lifespan of a number of organisms and has been shown to ameliorate symptoms in models of several age related diseases.

Recent studies have shown that non-coding (nc) RNAs frequently interact with translating ribosomes, although little is known about their function there. In previous work, I discovered a ribosome-bound ncRNA to be required for both the inhibition of translation and the increase in lifespan seen in insulin signaling (IIS) mutant worms. However, due to a nematode-specific RNA trans-splicing mechanism, affecting post-transcriptional gene regulation, the relevance of these results to others organisms remains unclear.

Given the crucial role protein synthesis plays in lifespan determination and the unexplored functions of ncRNAs in this process, I propose to systematically investigate the role of ncRNAs in translation and longevity. My goal is to identify ncRNAs that interact with ribosomes that have an effect on proteostasis or post-transcriptional gene regulation and consequently on lifespan extension and understanding their function.

 Publications

year authors and title journal last update
List of publications.
2016 Paul Essers, Luke S. Tain, Tobias Nespital, Joana Goncalves, Jenny Froehlich, Linda Partridge
Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice
published pages: 30290, ISSN: 2045-2322, DOI: 10.1038/srep30290
Scientific Reports 6 2019-07-23

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The information about "RNCRNAA" are provided by the European Opendata Portal: CORDIS opendata.

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