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SingMet

Development of MRI contrast agents based on long-lived singlet states

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "SingMet" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF SOUTHAMPTON 

Organization address
address: Highfield
city: SOUTHAMPTON
postcode: SO17 1BJ
website: http://www.southampton.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://blog.soton.ac.uk/magres/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-08-01   to  2017-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF SOUTHAMPTON UK (SOUTHAMPTON) coordinator 183˙454.00

Map

 Project objective

The goal of the project is the development of new contrast agents for magnetic resonance imaging (MRI) based on the concepts of hyperpolarization and singlet state nuclear magnetic resonance (NMR). Hyperpolarization boosts the detectable NMR signal of the contrast agents by up to 4 orders magnitude and the generation of singlet states conserves the enhanced polarization for a long time, while not giving a directly detectable signal. The NMR signal can subsequently be obtained by chemically breaking the molecular symmetry or by applying radiofrequency pulses. This technique therefore allows for the detection of a NMR signal after minutes instead of seconds compared to state-of-the-art metabolic tracers. A combination of these techniques leads to a nanomolar detection limit of the tracers, which is a remarkable sensitivity for MRI. The chemical transformation which triggers the generation of a hyperpolarized NMR signal may be due to enzymes which are diagnostic of cancer cells. The project leads towards new agents for the in vivo detection and imaging of cancer without the use of ionizing radiation or contrast agents containing dangerous heavy metals. Overall it is planned to develop molecules with nanomolar detection limits upon hyperpolarization, that maintain their traceability for minutes and undergo chemical transformation induced by enzymes, which can be tracked utilizing MRI.

 Publications

year authors and title journal last update
List of publications.
2017 James Eills, Gabriele Stevanato, Christian Bengs, Stefan Glöggler, Stuart J. Elliott, Javier Alonso-Valdesueiro, Giuseppe Pileio, Malcolm H. Levitt
Singlet order conversion and parahydrogen-induced hyperpolarization of 13C nuclei in near-equivalent spin systems
published pages: 163-172, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2016.11.010
Journal of Magnetic Resonance 274 2019-07-23

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The information about "SINGMET" are provided by the European Opendata Portal: CORDIS opendata.

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