Explore the words cloud of the SingMet project. It provides you a very rough idea of what is the project "SingMet" about.
The following table provides information about the project.
UNIVERSITY OF SOUTHAMPTON
|Coordinator Country||United Kingdom [UK]|
|Total cost||183˙454 €|
|EC max contribution||183˙454 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2015-08-01 to 2017-07-31|
Take a look of project's partnership.
|1||UNIVERSITY OF SOUTHAMPTON||UK (SOUTHAMPTON)||coordinator||183˙454.00|
The goal of the project is the development of new contrast agents for magnetic resonance imaging (MRI) based on the concepts of hyperpolarization and singlet state nuclear magnetic resonance (NMR). Hyperpolarization boosts the detectable NMR signal of the contrast agents by up to 4 orders magnitude and the generation of singlet states conserves the enhanced polarization for a long time, while not giving a directly detectable signal. The NMR signal can subsequently be obtained by chemically breaking the molecular symmetry or by applying radiofrequency pulses. This technique therefore allows for the detection of a NMR signal after minutes instead of seconds compared to state-of-the-art metabolic tracers. A combination of these techniques leads to a nanomolar detection limit of the tracers, which is a remarkable sensitivity for MRI. The chemical transformation which triggers the generation of a hyperpolarized NMR signal may be due to enzymes which are diagnostic of cancer cells. The project leads towards new agents for the in vivo detection and imaging of cancer without the use of ionizing radiation or contrast agents containing dangerous heavy metals. Overall it is planned to develop molecules with nanomolar detection limits upon hyperpolarization, that maintain their traceability for minutes and undergo chemical transformation induced by enzymes, which can be tracked utilizing MRI.
|year||authors and title||journal||last update|
James Eills, Gabriele Stevanato, Christian Bengs, Stefan GlÃ¶ggler, Stuart J. Elliott, Javier Alonso-Valdesueiro, Giuseppe Pileio, Malcolm H. Levitt
Singlet order conversion and parahydrogen-induced hyperpolarization of 13C nuclei in near-equivalent spin systems
published pages: 163-172, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2016.11.010
|Journal of Magnetic Resonance 274||2019-07-23|
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The information about "SINGMET" are provided by the European Opendata Portal: CORDIS opendata.
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