Opendata, web and dolomites


Development of MRI contrast agents based on long-lived singlet states

Total Cost €


EC-Contrib. €






Project "SingMet" data sheet

The following table provides information about the project.


Organization address
address: Highfield
postcode: SO17 1BJ

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-08-01   to  2017-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The goal of the project is the development of new contrast agents for magnetic resonance imaging (MRI) based on the concepts of hyperpolarization and singlet state nuclear magnetic resonance (NMR). Hyperpolarization boosts the detectable NMR signal of the contrast agents by up to 4 orders magnitude and the generation of singlet states conserves the enhanced polarization for a long time, while not giving a directly detectable signal. The NMR signal can subsequently be obtained by chemically breaking the molecular symmetry or by applying radiofrequency pulses. This technique therefore allows for the detection of a NMR signal after minutes instead of seconds compared to state-of-the-art metabolic tracers. A combination of these techniques leads to a nanomolar detection limit of the tracers, which is a remarkable sensitivity for MRI. The chemical transformation which triggers the generation of a hyperpolarized NMR signal may be due to enzymes which are diagnostic of cancer cells. The project leads towards new agents for the in vivo detection and imaging of cancer without the use of ionizing radiation or contrast agents containing dangerous heavy metals. Overall it is planned to develop molecules with nanomolar detection limits upon hyperpolarization, that maintain their traceability for minutes and undergo chemical transformation induced by enzymes, which can be tracked utilizing MRI.


year authors and title journal last update
List of publications.
2017 James Eills, Gabriele Stevanato, Christian Bengs, Stefan Glöggler, Stuart J. Elliott, Javier Alonso-Valdesueiro, Giuseppe Pileio, Malcolm H. Levitt
Singlet order conversion and parahydrogen-induced hyperpolarization of 13C nuclei in near-equivalent spin systems
published pages: 163-172, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2016.11.010
Journal of Magnetic Resonance 274 2019-07-23

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SINGMET" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SINGMET" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

ACES (2019)

Antarctic Cyclones: Expression in Sea Ice

Read More  


Contain, Distribute, Obstruct. Governing the Mobility of Asylum Seekers in the European Union

Read More  

UNITE (2019)

Unification Through Law: The Court of Justice of the European Union as Cultural-Moral Agent

Read More