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APGAR

Air Pollution, Growing brAin and cognitive disordeR in children

Total Cost €

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EC-Contrib. €

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Partnership

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Project "APGAR" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL 

There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country Spain [ES]
 Project website https://www.isglobal.org/en/-/air-pollution-growing-brain-and-cognitive-disorder-in-children-apgar-proyecto-inma
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-10-15   to  2017-10-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA ES (BARCELONA) coordinator 170˙121.00
2    FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL ES (BARCELONA) coordinator 0.00

Map

 Project objective

Air pollution exposure has been associated with adverse effects on cognition in children. However, the impact of air pollution on the structures and functions of the growing brain in children is unknown. The objectives of the APGAR project are to determine 1) the impact of urban air pollution on the structures and functions of the growing brain in children from the general population, 2) to what extent these structural and functional changes are associated with cognitive performance in children. The APGAR project is a longitudinal study conducted in 400 school age children from the general population, recruited between 2012 and 2013, in different schools in Barcelona, Spain. Psychometric and air pollution measurements were conducted weekly during 2 six-week periods: at the beginning of the school year and 9 months later. Neuroimaging (High-resolution 3-dimensional Magnetic Resonance Imaging (MRI), Diffusion Tensor Images, Fluid Attenuation Inversion Recovery, T2-weighted spin-echo sequences and functional MRI, spectrometry) were also conducted. Interfacing neuroimaging and environmental epidemiology represents an innovative applications of neuroimaging in general population, as previous studies have focused exclusively on effects based on test scores. Using original statistical methods (combination of supervised machine learning methods, feature selection and regression models), we will examine the impact of air pollution on the brain structures correlated with cognitive performance in children. Secondly, we will examine whether profiles of brain changes, specifically related to air pollution exposure, are associated with cognition level in participants. This multidisciplinary project may improve our understanding of the mechanisms that underlie the link between air pollution and cognitive disorder in children, and may lead to public health actions to improve air quality and reduce the burden of disease associated with air pollution in Europe.

 Publications

year authors and title journal last update
List of publications.
2017 Marion Mortamais, Jesus Pujol, Barend L. van Drooge, Didac Maci?, Gerard Mart?nez-Vilavella, Christelle Reynes, Robert Sabatier, Ioar Rivas, Joan Grimalt, Joan Forns, Mar Alvarez-Pedrerol, Xavier Querol, Jordi Sunyer
Effect of exposure to polycyclic aromatic hydrocarbons on basal ganglia and attention-deficit hyperactivity disorder symptoms in primary school children
published pages: 12-19, ISSN: 0160-4120, DOI: 10.1016/j.envint.2017.04.011
Environment International 105 2019-06-13

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The information about "APGAR" are provided by the European Opendata Portal: CORDIS opendata.

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