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ChloroQuality

Dissecting chloroplast protein quality control specificity for rational plant reprogramming

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ChloroQuality project word cloud

Explore the words cloud of the ChloroQuality project. It provides you a very rough idea of what is the project "ChloroQuality" about.

heat    death    fitness    rational    lack    stress    little    investigation    validating    candidate    shed    refolding    enzymes    hsp70    biology    receiving    degraded    chloroplast    levels    proteases    resistance    losses    specificity    discovering    chaperones    constitute    damaged    strategies    engineering    damage    action    adverse    group    plant    aggregation    fundamental    society    chloroplasts    aggregated    transfer    posttranslationally    metabolism    demand    demands    organisms    survival    toxic    cope    independent    determined    regulated    signaling    misfolding    cellular    gap    ing    productivity    expertise    drought    recognize    interactors    act    salt    environmental    improvement    scientist    recycling    adaptors    photosynthesis    crop    quality    improving    cover    cold    sessile    flexible    substrates    proteins    transgenic    protein    chaperone    light    synergistically    network    alter    background    food    plants    molecular    stresses    line    unfolded    coordinately    chloroplastic    regulate    economy    undesirable   

Project "ChloroQuality" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://plantmolecularbiology.bio.lmu.de/research/plant-acclimation/chloroplast-protein/index.html
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2017-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 159˙460.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

Improving food quality, crop productivity and plant resistance to stresses are major demands of Europe’s society and economy. Plants are sessile organisms that have developed very flexible strategies to cope with adverse environmental conditions as heat, cold, drought and salt stress. These stresses cause protein misfolding and aggregation resulting in plant damage/death and productivity losses. Recycling of damaged proteins is achieved by the action of molecular chaperones. But when recycling is not possible, toxic aggregated proteins have to be degraded by the action of proteases to avoid cellular damage. Chaperones and proteases act coordinately and constitute the protein quality control system that is essential for plant survival. In plant chloroplasts, the chaperone Hsp70 is known to posttranslationally regulate important processes like photosynthesis. It is known that the specificity of Hsp70 is determined by its J-protein partners, adaptors that recognize unfolded substrates and transfer them to the chaperone for refolding. However, little is known about the target proteins of Hsp70, such that there is a large lack of information about how chloroplastic enzymes are regulated at protein levels. This knowledge is crucial for rational engineering of specific molecular pathways and plant fitness improvement. The ability to specifically alter plant metabolism without undesirable effects is a fundamental demand of European society and addresses current concerns about transgenic plants. This proposal aims to cover this gap by discovering and validating interactors of chloroplastic J-proteins. The strong background of the applicant in protein quality control and the expertise in chloroplast biology of the receiving group will synergistically contribute to shed light on the chloroplast signaling network. In addition, this project aims to develop the candidate into an independent scientist and open his own line of investigation.

 Publications

year authors and title journal last update
List of publications.
2017 Nicola Zagari, Omar Sandoval-Ibañez, Niels Sandal, Junyi Su, Manuel Rodriguez-Concepcion, Jens Stougaard, Mathias Pribil, Dario Leister, Pablo Pulido
SNOWY COTYLEDON 2 Promotes Chloroplast Development and Has a Role in Leaf Variegation in Both Lotus japonicus and Arabidopsis thaliana
published pages: 721-734, ISSN: 1674-2052, DOI: 10.1016/j.molp.2017.02.009
Molecular Plant 10/5 2019-06-13
2018 Pablo Pulido, Dario Leister
Novel DNAJ-related proteins in Arabidopsis thaliana
published pages: 480-490, ISSN: 0028-646X, DOI: 10.1111/nph.14827
New Phytologist 217/2 2019-06-13

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