TARGEPILIVER
Characterization of Key Epigenetic Targets in Hepatic Fibrosis and Hepatocellular Carcinoma Development. Generation of New Antifibrotic and Antitumoral Drugs.
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0TARGEPILIVER project word cloud
Explore the words cloud of the TARGEPILIVER project. It provides you a very rough idea of what is the project "TARGEPILIVER" about.
Project "TARGEPILIVER" data sheet
The following table provides information about the project.
| Coordinator |
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA
Organization address contact info |
| Coordinator Country | Spain [ES] |
| Project website | https://cima.unav.edu/en/investigacion/programas-verticales/hepatologia/respuesta-hepatica-al-dano-agudo-y-cronico-desarrollo-de-estrategias-terapeuticas |
| Total cost | 170˙121 € |
| EC max contribution | 170˙121 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2014 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-12-01 to 2018-03-22 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA | ES (PAMPLONA) | coordinator | 170˙121.00 |
Map
Project objective
Liver fibrosis represents a common pathogenic pathway in most chronic liver diseases (CLDs) and cirrhosis, its end stage, is a huge healthcare burden. The main causes of CLD are chronic viral hepatitis B or C infection, alcohol abuse and obesity-linked steatohepatitis, conditions with increasing global incidence. Hepatocellular carcinoma (HCC) develops on this background of CLD as a multistep process in the context of chronic inflammation and cirrhosis. Among all non-hematological malignancies, HCC has the fastest rising incidence of any neoplasm in USA and Europe. Despite all the progress in understanding the cellular and molecular mechanisms of liver fibrosis and hepatocarcinogenesis, there are no effective therapies to halt fibrosis or quell liver cancer. Exposure to environmental factors triggers adaptative epigenetic mechanisms, including alterations in DNA methylation or post-translational modification of histones, which control gene expression and ultimately cellular behaviour in ways critical for the development of CLD and HCC. From the literature and our preliminary observations it is known that many of the enzymes carrying out these epigenetic events, such as DNA and histone methyltransferases, present altered expression and activity in CLD and HCC. The deposition of methyl marks in histones and DNA are very dynamic enzymatic processes, amenable to pharmacological intervention and therefore constitute attractive therapeutic targets. Our proposal has two main objectives: first the analysis of the expression, activity and pathological significance of DNA and histone-methyltransferases in models of CLD and hepatocarcinogenesis; and second the development of new efficacious DNA and histone-methyltransferase specific inhibitors with a good safety profile, which is critical when treating patients with compromised liver function. These new epigenetic therapies could be used to prevent CLD progression, and to treat HCC alone or in combination with existing drugs.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Gloria Alvarez-Sola, Iker Uriarte, Maria U. Latasa, Maddalen Jimenez, Marina Barcena-Varela, Eva SantamarÃa, Raquel Urtasun, Carlos Rodriguez-Ortigosa, Jesús Prieto, Pedro Berraondo, Maite G. Fernandez-Barrena, Carmen Berasain, MatÃas A. Avila Bile acids, FGF15/19 and liver regeneration: From mechanisms to clinical applications published pages: 1326-1334, ISSN: 0925-4439, DOI: 10.1016/j.bbadis.2017.06.025 |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864/4 | 2019-06-13 |
| 2017 |
M.G. Fernandez-Barrena, M. Barcena-Varela, J.M. Banales New evidence supporting the biliary bicarbonate umbrella theory published pages: 126-128, ISSN: 2210-7401, DOI: 10.1016/j.clinre.2016.09.004 |
Clinics and Research in Hepatology and Gastroenterology 41/2 | 2019-06-13 |
| 2017 |
Gloria Alvarez-Sola, Iker Uriarte, Maria U Latasa, Maddalen Jimenez, Marina Barcena-Varela, Eva SantamarÃa, Raquel Urtasun, Carlos Rodriguez-Ortigosa, Jesús Prieto, Fernando J Corrales, Anna Baulies, Carmen GarcÃa-Ruiz, Jose C Fernandez-Checa, Pedro Berraondo, Maite G Fernandez-Barrena, Carmen Berasain, MatÃas A Avila Engineered fibroblast growth factor 19 protects from acetaminophen-induced liver injury and stimulates aged liver regeneration in mice published pages: e3083, ISSN: 2041-4889, DOI: 10.1038/cddis.2017.480 |
Cell Death and Disease 8/10 | 2019-06-13 |
| 2017 |
Gloria Alvarez-Sola, Iker Uriarte, M Ujue Latasa, Maite G Fernandez-Barrena, Raquel Urtasun, Maria Elizalde, Marina Barcena-Varela, Maddalen Jiménez, Haisul C Chang, Roberto Barbero, Victoria Catalán, Amaia RodrÃguez, Gema Frühbeck, José M Gallego-Escuredo, Aleix Gavaldà -Navarro, Francesc Villarroya, Carlos M Rodriguez-Ortigosa, Fernando J Corrales, Jesus Prieto, Pedro Berraondo, Carmen Berasain, Matias A Avila Fibroblast growth factor 15/19 (FGF15/19) protects from diet-induced hepatic steatosis: development of an FGF19-based chimeric molecule to promote fatty liver regeneration published pages: 1818-1828, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2016-312975 |
Gut 66/10 | 2019-06-13 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TARGEPILIVER" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "TARGEPILIVER" are provided by the European Opendata Portal: CORDIS opendata.