Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. totipotency2014

TOTIPOTENCY2014

Dissecting the epigenetic control of totipotency.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0
 Outcomes and results

 TOTIPOTENCY2014 project word cloud

Explore the words cloud of the TOTIPOTENCY2014 project. It provides you a very rough idea of what is the project "TOTIPOTENCY2014" about.

cutting    medicine    determined    proteins    systematically    therapy    firstly    insights    efficiency    expands    bioinformatic    gene    regulators    contribution    cells    contain    lab    experimentally    confirmed    transcriptome    epigenetic    capability    shortly    sub    cell    enhancer    escs    host    chromatin    extra    somatic    data    shortlisted    population    expertise    mechanistically    biology    validating    rare    uses    reprogramming    remodelling    mechanistic    mechanisms    genes    one    epigenetics    single    newly    developmental    stem    fertilization    validated    expression    researcher    implantation    mammalian    eel    lack    additional    restricted    embryo    critical    personalised    expressing    interdependencies    potentially    analysed    technologies    enhancers    regulation    previously    embryonic    stage    regenerative    poorly    model    normally    34    vitro    murine    action    interaction    combines    limited    tractable    edge    totipotency    enhanced    fidelity    am    restoring    mode    innovative    differentiation    screened    occurs    relevance   

Project "TOTIPOTENCY2014" data sheet

The following table provides information about the project.

Coordinator		 THE BABRAHAM INSTITUTE 

Organization address
address: Babraham Hall
city: CAMBRIDGE
postcode: CB22 3AT
website: www.babraham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Project website https://www.babraham.ac.uk/our-research/epigenetics/wolf-reik
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2017-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE BABRAHAM INSTITUTE UK (CAMBRIDGE) coordinator 183˙454.00

Map

 Project objective

One of the most critical epigenetic and chromatin remodelling processes in mammalian development occurs shortly after fertilization restoring totipotency. Due to limited cell numbers and lack of experimentally tractable systems, the mechanisms and regulation of this developmental stage are poorly understood. This proposal will provide important mechanistic insights into the epigenetic control of early embryonic gene expression, and its relevance to somatic reprogramming.

Murine embryonic stem cells (ESCs) contain a rare sub-population of early embryonic like (EEL) cells expressing genes normally restricted to the pre-implantation embryo, with enhanced extra-embryonic differentiation capability. Firstly, using novel single-cell technologies, I will characterize the EEL cells in detail, validating them as an in vitro model of pre-implantation development. On-going research in the host lab that I am involved in has identified an epigenetic enhancer that expands this EEL sub-population. Through bioinformatic analysis of pre-implantation transcriptome data, I have shortlisted 34 epigenetic and chromatin-associated proteins, including the previously identified factor, which will be systematically screened to identify new enhancers of totipotency. Validated EEL regulators, including two additional newly confirmed factors, will be analysed mechanistically determining their interaction partners, interdependencies, and mode of action. Finally, the contribution of the totipotency regulators towards the efficiency and fidelity of somatic reprogramming will be determined, potentially improving the use of this technology for personalised gene therapy and regenerative medicine.

This state-of-the-art proposal uses innovative and novel cutting-edge technologies and combines the expertise of the researcher and the host. It has the potential for significant impact across several fields from epigenetics and stem cell biology to reprogramming and regenerative medicine.

 Publications

year authors and title journal last update
List of publications.
2016 Mélanie A. Eckersley-Maslin, Valentine Svensson, Christel Krueger, Thomas M. Stubbs, Pascal Giehr, Felix Krueger, Ricardo J. Miragaia, Charalampos Kyriakopoulos, Rebecca V. Berrens, Inês Milagre, Jörn Walter, Sarah A. Teichmann, Wolf Reik
MERVL/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs
published pages: 179-192, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.08.087 		Cell Reports 17/1 2019-06-14

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TOTIPOTENCY2014" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "TOTIPOTENCY2014" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

RipGEESE (2020)

Identifying the ripples of gene regulation evolution in the evolution of gene sequences to determine when animal nervous systems evolved

Read More  

DEF2DEV (2019)

Identification of the mode of action of plant defensins during root development and plant defense responses.

Read More  

NarrowbandSSL (2019)

Development of Narrow Band Blue and Red Emitting Macromolecules for Solution-Processed Solid State Lighting Devices

Read More