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TOTIPOTENCY2014

Dissecting the epigenetic control of totipotency.

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 TOTIPOTENCY2014 project word cloud

Explore the words cloud of the TOTIPOTENCY2014 project. It provides you a very rough idea of what is the project "TOTIPOTENCY2014" about.

researcher    murine    newly    analysed    determined    biology    innovative    stage    genes    vitro    host    experimentally    escs    am    potentially    epigenetics    expands    mode    extra    regulation    somatic    eel    regenerative    contribution    mechanisms    expertise    therapy    fidelity    cell    validating    model    shortlisted    embryo    gene    medicine    screened    poorly    fertilization    reprogramming    mechanistic    insights    34    implantation    edge    enhancer    differentiation    additional    efficiency    personalised    cells    shortly    epigenetic    single    restoring    mechanistically    interaction    critical    firstly    developmental    restricted    combines    validated    data    one    technologies    uses    contain    interdependencies    normally    population    sub    enhancers    enhanced    embryonic    capability    totipotency    rare    occurs    chromatin    confirmed    expressing    cutting    lab    regulators    lack    action    stem    expression    remodelling    bioinformatic    transcriptome    previously    tractable    limited    mammalian    systematically    proteins    relevance   

Project "TOTIPOTENCY2014" data sheet

The following table provides information about the project.

Coordinator		 THE BABRAHAM INSTITUTE 

Organization address
address: Babraham Hall
city: CAMBRIDGE
postcode: CB22 3AT
website: www.babraham.ac.uk

contact info
title: n.a.
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surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website https://www.babraham.ac.uk/our-research/epigenetics/wolf-reik
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2017-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE BABRAHAM INSTITUTE UK (CAMBRIDGE) coordinator 183˙454.00

Map

 Project objective

One of the most critical epigenetic and chromatin remodelling processes in mammalian development occurs shortly after fertilization restoring totipotency. Due to limited cell numbers and lack of experimentally tractable systems, the mechanisms and regulation of this developmental stage are poorly understood. This proposal will provide important mechanistic insights into the epigenetic control of early embryonic gene expression, and its relevance to somatic reprogramming.

Murine embryonic stem cells (ESCs) contain a rare sub-population of early embryonic like (EEL) cells expressing genes normally restricted to the pre-implantation embryo, with enhanced extra-embryonic differentiation capability. Firstly, using novel single-cell technologies, I will characterize the EEL cells in detail, validating them as an in vitro model of pre-implantation development. On-going research in the host lab that I am involved in has identified an epigenetic enhancer that expands this EEL sub-population. Through bioinformatic analysis of pre-implantation transcriptome data, I have shortlisted 34 epigenetic and chromatin-associated proteins, including the previously identified factor, which will be systematically screened to identify new enhancers of totipotency. Validated EEL regulators, including two additional newly confirmed factors, will be analysed mechanistically determining their interaction partners, interdependencies, and mode of action. Finally, the contribution of the totipotency regulators towards the efficiency and fidelity of somatic reprogramming will be determined, potentially improving the use of this technology for personalised gene therapy and regenerative medicine.

This state-of-the-art proposal uses innovative and novel cutting-edge technologies and combines the expertise of the researcher and the host. It has the potential for significant impact across several fields from epigenetics and stem cell biology to reprogramming and regenerative medicine.

 Publications

year authors and title journal last update
List of publications.
2016 Mélanie A. Eckersley-Maslin, Valentine Svensson, Christel Krueger, Thomas M. Stubbs, Pascal Giehr, Felix Krueger, Ricardo J. Miragaia, Charalampos Kyriakopoulos, Rebecca V. Berrens, Inês Milagre, Jörn Walter, Sarah A. Teichmann, Wolf Reik
MERVL/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs
published pages: 179-192, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.08.087 		Cell Reports 17/1 2019-06-14

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