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Continuous self-assembly using enzyme mediated supramolecular switching

Total Cost €


EC-Contrib. €






Project "ASSEMZYME" data sheet

The following table provides information about the project.


Organization address
postcode: 67081

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-03-24   to  2017-03-23


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE STRASBOURG FR (STRASBOURG) coordinator 173˙076.00


 Project objective

Supramolecular chemistry has resulted in truly sophisticated architectures, many of which are able to exert specific functions, as well as to change and adapt in response to external stimuli. So far, however, artificial structures with a similar functional complexity as living self-assembled systems are lacking. This is because nearly all current supramolecular systems are in thermodynamic equilibrium or kinetically trapped states. Living systems, on the other hand, operate far from equilibrium in so-called dissipative steady states, and continuously consume energy to keep their structure and function. Mimicking nature, here we propose to prepare dissipative self-assembled steady states of synthetic discotic molecules, controlled by competitive enzymatic pathways (phosphorylation / dephosphorylation), in which the supramolecular assemblies are kept far from equilibrium by a continuous perturbation i.e. the influx of a chemical fuel. We expect to get fundamentally new insights into non-equilibrium self-assembly, opening the door to truly adaptive, self-healing, life-like complex artificial systems. The candidate will be trained in a promising new research area in one of the hotspots for supramolecular chemistry in Europe, which would be a great stepping stone for his future independent research career.


year authors and title journal last update
List of publications.
2017 Alessandro Sorrenti, Jorge Leira-Iglesias, Akihiro Sato, Thomas M. Hermans
Non-equilibrium steady states in supramolecular polymerization
published pages: 15899, ISSN: 2041-1723, DOI: 10.1038/ncomms15899
Nature Communications 8 2019-07-24
2017 Alessandro Sorrenti, Jorge Leira-Iglesias, Albert J. Markvoort, Tom F. A. de Greef, Thomas M. Hermans
Non-equilibrium supramolecular polymerization
published pages: , ISSN: 0306-0012, DOI: 10.1039/C7CS00121E
Chem. Soc. Rev. 2019-07-24

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