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ChemoBOOM SIGNED

Development of Palladium-Labile Prodrugs for Bioorthogonally-Activated Chemotherapy

Total Cost €

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EC-Contrib. €

0

Partnership

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 ChemoBOOM project word cloud

Explore the words cloud of the ChemoBOOM project. It provides you a very rough idea of what is the project "ChemoBOOM" about.

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Project "ChemoBOOM" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.boomchemistry.com/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2018-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 183˙454.00

Map

 Project objective

The heterogeneity and capacity to evolve in response to treatment of the most aggressive forms of cancer make the selective inhibition of molecular targets an insufficient strategy to reach complete neoplastic remission. In this context, the unspecificity of classic chemotherapeutic agents becomes an advantage for treatment. Nonetheless, due to dose-limiting adverse effects, chemotherapeutic drugs become ineffective against some late-stage primary tumours, which are typically responsible for the death of the patient. To tackle those difficult to treat cancers, improved chemotherapeutic strategies far beyond the one-pill paradigm are mandatory. To reduce systemic side effects while increasing the levels of drug in the disease area, a number of novel methods originated from the Chemical Biology field (rather than from conventional Medicinal Chemistry approaches) have emerged during the last year to explore the site-specific activation of cytotoxic drugs. One of those novel concepts, pioneered by the Unciti-Broceta’s group in Edinburgh, is based on the use of palladium to activate drug precursors by heterogeneous bioorthogonal organometallic (BOOM) catalysis. Using an O-propargylation strategy to mask functional groups essential for the cytotoxic mode of action of clinically-used drugs, I will investigate the development of novel bioorthogonal palladium-labile prodrugs and their reactivation in cancer cell culture by heterogeneous palladium catalysis. With the support of a MSCA-IF, I intent to explore the full scope of this exciting experimental strategy, including the first ever approach designed to release two cytotoxic drugs with synergistic pharmacological activity from a single prodrug molecule.

 Publications

year authors and title journal last update
List of publications.
2017 Ana M. Pérez-López, Belén Rubio-Ruiz, Víctor Sebastián, Lloyd Hamilton, Catherine Adam, Thomas L. Bray, Silvia Irusta, Paul M. Brennan, Guy C. Lloyd-Jones, Dirk Sieger, Jesús Santamaría, Asier Unciti-Broceta
Gold-Triggered Uncaging Chemistry in Living Systems
published pages: 12548-12552, ISSN: 1433-7851, DOI: 10.1002/anie.201705609
Angewandte Chemie International Edition 56/41 2019-06-14
2016 Belén Rubio-Ruiz, Jason T. Weiss, Asier Unciti-Broceta
Efficient Palladium-Triggered Release of Vorinostat from a Bioorthogonal Precursor
published pages: 9974-9980, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b01426
Journal of Medicinal Chemistry 59/21 2019-06-14
2018 Belén Rubio-Ruiz, Ana M. Pérez-López, Thomas L. Bray, Martin Lee, Alan Serrels, Martín Prieto, Manuel Arruebo, Neil O. Carragher, Víctor Sebastián, Asier Unciti-Broceta
High-Precision Photothermal Ablation Using Biocompatible Palladium Nanoparticles and Laser Scanning Microscopy
published pages: 3341-3348, ISSN: 1944-8244, DOI: 10.1021/acsami.7b17282
ACS Applied Materials & Interfaces 10/4 2019-06-14

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The information about "CHEMOBOOM" are provided by the European Opendata Portal: CORDIS opendata.

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