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TIME

Time of damage in classic galactosemia: is prenatal toxicity a determinant factor?

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

TIME project word cloud

Explore the words cloud of the TIME project. It provides you a very rough idea of what is the project "TIME" about.

developmental treatment dublin organs renowned fish grg bases decrease career wild constitutes assistance always post onset qualifications felt fellowship ascertain rare natal metabolic classic toxicity multidisciplinary am maastricht initiated accurately compare milestone laboratory complications turn zebrafish galactosemic group molecular sentence stages lives engage indicated personal prenatally society prevent knockout fit therapy galt patients model scientific said disorder requirement elucidate researcher disorders once expertise illustrates cunningham prof commitment galactosemia utmost medical patrick begins improvement embryological committed college exact purpose world analyze life trinity transient health damage time professional

Project "TIME" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	https://www.galactosemianetwork.org/research-within-galnet
Total cost	177˙598 €
EC max contribution	177˙598 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-10-01 to 2018-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITEIT MAASTRICHT UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	coordinator	177˙598.00

Map

Project objective

The TIME project aims to ascertain the time at which the toxicity observed in classic galactosemia begins, particularly if it begins prenatally. Recent advances in the molecular bases of classic galactosemia have taken research a step further towards therapy development. Therefore, it is of utmost importance to elucidate when the damage accurately begins, in order to define the time at which therapy should be initiated so that it can effectively prevent the development of long-term complications. The Galactosemia Research Group (GRG) in Maastricht has recently developed a zebrafish model of classic galactosemia, which is particularly indicated for studying developmental processes. I will use transient embryological- and whole life-knockout galt-zebrafish to analyze damage in target-organs at different stages of pre- and post-natal development and compare them to the wild-type fish, which will allow determining the exact time of damage onset in classic galactosemia. The GRG is a world-renowned multidisciplinary group that will strongly enhance my professional and personal qualifications as a researcher. In turn, I will contribute with my expertise in molecular bases of rare metabolic disorders. This project constitutes a major milestone for this disorder, as it will allow the development of an effective treatment, which in turn will decrease galactosemic patients' requirement for medical assistance and by making them fit to work and to fully engage in the society. Prof. Patrick Cunningham (Trinity College, Dublin) once said: To be a researcher is not just to be in the laboratory, you work for the world, you work for the society. This sentence illustrates what I have always felt to be my purpose as a researcher. Ever since I initiated my scientific career that I am fully committed in taking research in rare disorders towards the improvement of patients’ health and lives, and this fellowship constitutes an important step towards that commitment.

Publications

List of publications.
year	authors and title	journal	last update
2018	Didem Demirbas, Ana I. Coelho, M. Estela Rubio-Gozalbo, Gerard T. Berry Hereditary galactosemia published pages: 188-196, ISSN: 0026-0495, DOI: 10.1016/j.metabol.2018.01.025	Metabolism 83	2019-06-14
2017	Ana I. Coelho, M. Estela Rubio-Gozalbo, JoÃ£o B. Vicente, Isabel Rivera Sweet and sour: an update on classic galactosemia published pages: 325-342, ISSN: 0141-8955, DOI: 10.1007/s10545-017-0029-3	Journal of Inherited Metabolic Disease 40/3	2019-06-14
2018	Jo M. Vanoevelen, Britt van Erven, JÃ¶rgen Bierau, Xiaoping Huang, Gerard T. Berry, Rein Vos, Ana I. Coelho, M. Estela Rubio-Gozalbo Impaired fertility and motor function in a zebrafish model for classic galactosemia published pages: 117-127, ISSN: 0141-8955, DOI: 10.1007/s10545-017-0071-1	Journal of Inherited Metabolic Disease 41/1	2019-06-14

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The information about "TIME" are provided by the European Opendata Portal: CORDIS opendata.