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TIME

Time of damage in classic galactosemia: is prenatal toxicity a determinant factor?

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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Project "TIME" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT MAASTRICHT 

Organization address
address: Minderbroedersberg 4-6
city: MAASTRICHT
postcode: 6200 MD
website: http://www.maastrichtuniversity.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website https://www.galactosemianetwork.org/research-within-galnet
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2018-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) coordinator 177˙598.00

Map

 Project objective

The TIME project aims to ascertain the time at which the toxicity observed in classic galactosemia begins, particularly if it begins prenatally. Recent advances in the molecular bases of classic galactosemia have taken research a step further towards therapy development. Therefore, it is of utmost importance to elucidate when the damage accurately begins, in order to define the time at which therapy should be initiated so that it can effectively prevent the development of long-term complications. The Galactosemia Research Group (GRG) in Maastricht has recently developed a zebrafish model of classic galactosemia, which is particularly indicated for studying developmental processes. I will use transient embryological- and whole life-knockout galt-zebrafish to analyze damage in target-organs at different stages of pre- and post-natal development and compare them to the wild-type fish, which will allow determining the exact time of damage onset in classic galactosemia. The GRG is a world-renowned multidisciplinary group that will strongly enhance my professional and personal qualifications as a researcher. In turn, I will contribute with my expertise in molecular bases of rare metabolic disorders. This project constitutes a major milestone for this disorder, as it will allow the development of an effective treatment, which in turn will decrease galactosemic patients' requirement for medical assistance and by making them fit to work and to fully engage in the society. Prof. Patrick Cunningham (Trinity College, Dublin) once said: To be a researcher is not just to be in the laboratory, you work for the world, you work for the society. This sentence illustrates what I have always felt to be my purpose as a researcher. Ever since I initiated my scientific career that I am fully committed in taking research in rare disorders towards the improvement of patients’ health and lives, and this fellowship constitutes an important step towards that commitment.

 Publications

year authors and title journal last update
List of publications.
2018 Didem Demirbas, Ana I. Coelho, M. Estela Rubio-Gozalbo, Gerard T. Berry
Hereditary galactosemia
published pages: 188-196, ISSN: 0026-0495, DOI: 10.1016/j.metabol.2018.01.025
Metabolism 83 2019-06-14
2017 Ana I. Coelho, M. Estela Rubio-Gozalbo, João B. Vicente, Isabel Rivera
Sweet and sour: an update on classic galactosemia
published pages: 325-342, ISSN: 0141-8955, DOI: 10.1007/s10545-017-0029-3
Journal of Inherited Metabolic Disease 40/3 2019-06-14
2018 Jo M. Vanoevelen, Britt van Erven, Jörgen Bierau, Xiaoping Huang, Gerard T. Berry, Rein Vos, Ana I. Coelho, M. Estela Rubio-Gozalbo
Impaired fertility and motor function in a zebrafish model for classic galactosemia
published pages: 117-127, ISSN: 0141-8955, DOI: 10.1007/s10545-017-0071-1
Journal of Inherited Metabolic Disease 41/1 2019-06-14

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The information about "TIME" are provided by the European Opendata Portal: CORDIS opendata.

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