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The Flexible Genome: understanding the genetic regulation of Phenotypic Plasticity.

Total Cost €


EC-Contrib. €






 FLEXGENOME project word cloud

Explore the words cloud of the FLEXGENOME project. It provides you a very rough idea of what is the project "FLEXGENOME" about.

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Project "FLEXGENOME" data sheet

The following table provides information about the project.


Organization address
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-04-15   to  2017-04-14


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 183˙454.00


 Project objective

In multicellular animals, complex phenotypic traits such as behaviour, lifespan and diseases are not only determined by genetic factors but also in large part by the environment. Understanding how genes and the environment interact to produce fundamental traits is a major question in biology. Many organisms are capable of expressing multiple phenotypes from a single genome when exposed to different environments. This widespread phenomenon is termed phenotypic plasticity (PP). The genetic programs needed to produce alternative phenotypes are encoded within a single genome, and environmental stimuli determine which form is expressed. PP is highly relevant in nature as it allows organisms to survive and reproduce successfully in variable environments. Nevertheless, the molecular and genetic mechanisms responsible for this flexibility are surprisingly poorly understood. Here, I will investigate the genetic basis of PP by applying advanced genomic and computational techniques to an ecological model of PP, the butterfly Bicyclus anynana. In particular, I will 1) identify the genetic programs that produce alternative phenotypes from a single genome; and 2) assess the potential for evolutionary change in PP by characterising genetic variation in these programs. I will do this by applying RNA-Seq and gene co-expression networks to an ecologically well-characterised insect and developing and integrating methods and concepts across disciplines. Combining my significant expertise on the model system with the host laboratory’s outstanding track record in evolutionary genomics and bioinformatics, this project offers a unique opportunity for obtaining an unprecedented and long-desired insight into the genetic mechanisms of PP. This fellowship will train me in precisely the technical and analytical techniques that are critical for scientific progress in decades to come, and for my career development as a scientist within the European Research Area.


year authors and title journal last update
List of publications.
2017 Vicencio Oostra, Marjo Saastamoinen, Bas J Zwaan, Christopher W Wheat
Extensive phenotypic plasticity in a seasonal butterfly limits potential for evolutionary responses to environmental change
published pages: , ISSN: , DOI: 10.1101/126177
bioRxiv preprint 126177 2019-07-24

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The information about "FLEXGENOME" are provided by the European Opendata Portal: CORDIS opendata.

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