Opendata, web and dolomites

FLEXGENOME

The Flexible Genome: understanding the genetic regulation of Phenotypic Plasticity.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 FLEXGENOME project word cloud

Explore the words cloud of the FLEXGENOME project. It provides you a very rough idea of what is the project "FLEXGENOME" about.

encoded    environment    opportunity    nevertheless    area    variation    scientific    successfully    evolutionary    pp    desired    alternative    molecular    integrating    expressing    programs    progress    ecologically    phenomenon    interact    bicyclus    track    flexibility    nature    scientist    genomics    mechanisms    fellowship    model    ecological    exposed    obtaining    traits    gene    termed    biology    bioinformatics    seq    expertise    animals    computational    offers    determined    rna    disciplines    multiple    laboratory    co    butterfly    fundamental    precisely    poorly    me    analytical    characterised    basis    environmental    anynana    survive    expression    genomic    phenotypic    techniques    train    question    outstanding    lifespan    insect    career    multicellular    critical    environments    decades    responsible    host    expressed    genome    characterising    phenotypes    combining    plasticity    reproduce    networks    stimuli    single    genetic    unprecedented    form    record    surprisingly    organisms    genes    diseases   

Project "FLEXGENOME" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.vicencio-oostra.dds.nl/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-04-15   to  2017-04-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

Map

 Project objective

In multicellular animals, complex phenotypic traits such as behaviour, lifespan and diseases are not only determined by genetic factors but also in large part by the environment. Understanding how genes and the environment interact to produce fundamental traits is a major question in biology. Many organisms are capable of expressing multiple phenotypes from a single genome when exposed to different environments. This widespread phenomenon is termed phenotypic plasticity (PP). The genetic programs needed to produce alternative phenotypes are encoded within a single genome, and environmental stimuli determine which form is expressed. PP is highly relevant in nature as it allows organisms to survive and reproduce successfully in variable environments. Nevertheless, the molecular and genetic mechanisms responsible for this flexibility are surprisingly poorly understood. Here, I will investigate the genetic basis of PP by applying advanced genomic and computational techniques to an ecological model of PP, the butterfly Bicyclus anynana. In particular, I will 1) identify the genetic programs that produce alternative phenotypes from a single genome; and 2) assess the potential for evolutionary change in PP by characterising genetic variation in these programs. I will do this by applying RNA-Seq and gene co-expression networks to an ecologically well-characterised insect and developing and integrating methods and concepts across disciplines. Combining my significant expertise on the model system with the host laboratory’s outstanding track record in evolutionary genomics and bioinformatics, this project offers a unique opportunity for obtaining an unprecedented and long-desired insight into the genetic mechanisms of PP. This fellowship will train me in precisely the technical and analytical techniques that are critical for scientific progress in decades to come, and for my career development as a scientist within the European Research Area.

 Publications

year authors and title journal last update
List of publications.
2017 Vicencio Oostra, Marjo Saastamoinen, Bas J Zwaan, Christopher W Wheat
Extensive phenotypic plasticity in a seasonal butterfly limits potential for evolutionary responses to environmental change
published pages: , ISSN: , DOI: 10.1101/126177
bioRxiv preprint 126177 2019-07-24

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "FLEXGENOME" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "FLEXGENOME" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

GW (2019)

Analysing the heavy element factories of the Universe : photometric and spectroscopic sample study of kilonovae

Read More  

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

TheaTheor (2018)

Theorizing the Production of 'Comedia Nueva': The Process of Play Configuration in Spanish Golden Age Theater

Read More