EU H2020 Project "HYHEAT (Profiling gene expression in Hydra vulgaris following Gold..)": description, partecipants, costs and EC-fundings

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HyHeat project word cloud

Explore the words cloud of the HyHeat project. It provides you a very rough idea of what is the project "HyHeat" about.

first selective irradiation dr skills nps eduardo molecular exposed nanoparticle advantage monitor toxicity bioactivity np unclear di instituto profiled efficacy invertebrate career expression model nanoparticles ht genetic cells council heating purposes grand strategies multidisciplinary vertebrate vivo tumoral animal treatment maria hyperthermia moros reduce stress hydra scientific once hyheat tortiglione surface screen engineered mechanisms aunps markers national acute living models biology tissues therapy date gold laser icib invasive speed genes line heat cibernetica functionalization group whereby cnr biological therapeutic cellular italy analyzing expertise photothermal synthesis experimentation upregulated mediated ablation fellow possibility supervisor normal progress caianiello pioneered technique independent supplied clinics position panel soaking underlying final plasmonic temperatures entry mice organism deregulated host cancer found

Project "HyHeat" data sheet

The following table provides information about the project.

Coordinator	CONSIGLIO NAZIONALE DELLE RICERCHE Organization address address: PIAZZALE ALDO MORO 7 city: ROMA postcode: 185 website: www.cnr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.tortiglione.com/nanobiomoleculargroup/Sito/NanoBiomolecular_group.html
Total cost	180˙277 €
EC max contribution	180˙277 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-09-01 to 2017-08-31

#	participants	country	role	EC contrib. [€]
1	CONSIGLIO NAZIONALE DELLE RICERCHE	IT (ROMA)	coordinator	180˙277.00

CONSIGLIO NAZIONALE DELLE RICERCHE

IT (ROMA)

coordinator

180˙277.00

Project objective

Hyperthermia (HT) is currently used as a non-invasive technique for cancer therapy, whereby biological tissues are exposed to higher than normal temperatures, for selective ablation of tumoral cells. However, the molecular mechanisms underlying the in vivo cellular responses to heat stress remain unclear to date. The overall aim of the HyHeat project is to use an invertebrate model to screen the heating capabilities of different gold nanoparticles (AuNPs) in vivo, with the grand aim of understanding the cellular responses to heat stress and therefore taking the first steps towards improving nanoparticle (NP) mediated HT efficacy for therapeutic purposes. To this end, plasmonic AuNPs with photothermal capabilities will be surface engineered and supplied to living Hydra by soaking. Upon laser irradiation of the animal, cellular and molecular expression will be profiled to monitor the overall response to NP-mediated HT. A simple invertebrate organism will be used, in line with European strategies aimed to reduce vertebrate experimentation. Once a panel of upregulated genes have been identified, the research will be conducted in mice analyzing those genes found deregulated in Hydra with the final aim to identify genetic markers of HT treatment and speed up the entry of this therapy into clinics. HyHeat is a multidisciplinary project that take advantage of the Fellow´s Dr. Maria Moros knowledge in the synthesis and functionalization of NPs, and the expertise of the host group supervisor (Dr. C. Tortiglione, Instituto di Cibernetica “Eduardo Caianiello” (ICIB), National Research Council (CNR), Italy) in molecular biology using invertebrate models. This project will offer the applicant the possibility to work in a top European institution who pioneered the use of Hydra to test bioactivity and toxicity of NPs, and to develop new skills and knowledge necessary for the progress of her scientific career towards an independent position.

Publications

List of publications.
year	authors and title	journal	last update
2016	Laura De Matteis, Maria Alleva, InÃ©s Serrano-Sevilla, Sonia GarcÃa-Embid, Grazyna Stepien, MarÃa Moros, JesÃºs de la Fuente Controlling Properties and Cytotoxicity of Chitosan Nanocapsules by Chemical Grafting published pages: 175, ISSN: 1660-3397, DOI: 10.3390/md14100175	Marine Drugs 14/10	2019-07-24
2016	Gabriel Alfranca, Ãlvaro Artiga, Grazyna Stepien, MarÃa Moros, Scott G Mitchell, JesÃºs M de la Fuente Gold nanoprismâ€“nanorod face off: comparing the heating efficiency, cellular internalization and thermoablation capacity published pages: 2903-2916, ISSN: 1743-5889, DOI: 10.2217/nnm-2016-0257	Nanomedicine 11/22	2019-07-24

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