Explore the words cloud of the HyHeat project. It provides you a very rough idea of what is the project "HyHeat" about.
The following table provides information about the project.
CONSIGLIO NAZIONALE DELLE RICERCHE
|Coordinator Country||Italy [IT]|
|Total cost||180˙277 €|
|EC max contribution||180˙277 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2015-09-01 to 2017-08-31|
Take a look of project's partnership.
|1||CONSIGLIO NAZIONALE DELLE RICERCHE||IT (ROMA)||coordinator||180˙277.00|
Hyperthermia (HT) is currently used as a non-invasive technique for cancer therapy, whereby biological tissues are exposed to higher than normal temperatures, for selective ablation of tumoral cells. However, the molecular mechanisms underlying the in vivo cellular responses to heat stress remain unclear to date. The overall aim of the HyHeat project is to use an invertebrate model to screen the heating capabilities of different gold nanoparticles (AuNPs) in vivo, with the grand aim of understanding the cellular responses to heat stress and therefore taking the first steps towards improving nanoparticle (NP) mediated HT efficacy for therapeutic purposes. To this end, plasmonic AuNPs with photothermal capabilities will be surface engineered and supplied to living Hydra by soaking. Upon laser irradiation of the animal, cellular and molecular expression will be profiled to monitor the overall response to NP-mediated HT. A simple invertebrate organism will be used, in line with European strategies aimed to reduce vertebrate experimentation. Once a panel of upregulated genes have been identified, the research will be conducted in mice analyzing those genes found deregulated in Hydra with the final aim to identify genetic markers of HT treatment and speed up the entry of this therapy into clinics. HyHeat is a multidisciplinary project that take advantage of the Fellow´s Dr. Maria Moros knowledge in the synthesis and functionalization of NPs, and the expertise of the host group supervisor (Dr. C. Tortiglione, Instituto di Cibernetica “Eduardo Caianiello” (ICIB), National Research Council (CNR), Italy) in molecular biology using invertebrate models. This project will offer the applicant the possibility to work in a top European institution who pioneered the use of Hydra to test bioactivity and toxicity of NPs, and to develop new skills and knowledge necessary for the progress of her scientific career towards an independent position.
|year||authors and title||journal||last update|
Laura De Matteis, Maria Alleva, InÃ©s Serrano-Sevilla, Sonia GarcÃa-Embid, Grazyna Stepien, MarÃa Moros, JesÃºs de la Fuente
Controlling Properties and Cytotoxicity of Chitosan Nanocapsules by Chemical Grafting
published pages: 175, ISSN: 1660-3397, DOI: 10.3390/md14100175
|Marine Drugs 14/10||2019-07-24|
Gabriel Alfranca, Ãlvaro Artiga, Grazyna Stepien, MarÃa Moros, Scott G Mitchell, JesÃºs M de la Fuente
Gold nanoprismâ€“nanorod face off: comparing the heating efficiency, cellular internalization and thermoablation capacity
published pages: 2903-2916, ISSN: 1743-5889, DOI: 10.2217/nnm-2016-0257
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The information about "HYHEAT" are provided by the European Opendata Portal: CORDIS opendata.