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HyHeat

Profiling gene expression in Hydra vulgaris following Gold Nanoparticle-mediated hyperthermia

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EC-Contrib. €

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 Outcomes and results

 HyHeat project word cloud

Explore the words cloud of the HyHeat project. It provides you a very rough idea of what is the project "HyHeat" about.

animal    once    living    genetic    first    upregulated    biological    heat    vivo    hydra    normal    speed    skills    aunps    profiled    tumoral    dr    monitor    mechanisms    selective    advantage    national    date    np    caianiello    biology    cibernetica    mediated    technique    multidisciplinary    plasmonic    reduce    therapeutic    host    exposed    organism    soaking    expression    molecular    tissues    model    deregulated    maria    position    models    engineered    therapy    grand    pioneered    cnr    hyheat    found    vertebrate    final    instituto    nanoparticles    mice    di    expertise    synthesis    screen    nps    supervisor    functionalization    whereby    group    purposes    fellow    possibility    panel    strategies    career    progress    invasive    moros    markers    ablation    independent    eduardo    entry    experimentation    photothermal    clinics    supplied    council    treatment    cellular    gold    underlying    heating    hyperthermia    toxicity    acute    analyzing    laser    ht    cells    tortiglione    unclear    bioactivity    cancer    line    icib    irradiation    efficacy    genes    nanoparticle    surface    scientific    temperatures    stress    invertebrate    italy   

Project "HyHeat" data sheet

The following table provides information about the project.

Coordinator		 CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Italy [IT]
 Project website http://www.tortiglione.com/nanobiomoleculargroup/Sito/NanoBiomolecular_group.html
 Total cost 180˙277 €
 EC max contribution 180˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2017-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 180˙277.00

Map

 Project objective

Hyperthermia (HT) is currently used as a non-invasive technique for cancer therapy, whereby biological tissues are exposed to higher than normal temperatures, for selective ablation of tumoral cells. However, the molecular mechanisms underlying the in vivo cellular responses to heat stress remain unclear to date. The overall aim of the HyHeat project is to use an invertebrate model to screen the heating capabilities of different gold nanoparticles (AuNPs) in vivo, with the grand aim of understanding the cellular responses to heat stress and therefore taking the first steps towards improving nanoparticle (NP) mediated HT efficacy for therapeutic purposes. To this end, plasmonic AuNPs with photothermal capabilities will be surface engineered and supplied to living Hydra by soaking. Upon laser irradiation of the animal, cellular and molecular expression will be profiled to monitor the overall response to NP-mediated HT. A simple invertebrate organism will be used, in line with European strategies aimed to reduce vertebrate experimentation. Once a panel of upregulated genes have been identified, the research will be conducted in mice analyzing those genes found deregulated in Hydra with the final aim to identify genetic markers of HT treatment and speed up the entry of this therapy into clinics. HyHeat is a multidisciplinary project that take advantage of the Fellow´s Dr. Maria Moros knowledge in the synthesis and functionalization of NPs, and the expertise of the host group supervisor (Dr. C. Tortiglione, Instituto di Cibernetica “Eduardo Caianiello” (ICIB), National Research Council (CNR), Italy) in molecular biology using invertebrate models. This project will offer the applicant the possibility to work in a top European institution who pioneered the use of Hydra to test bioactivity and toxicity of NPs, and to develop new skills and knowledge necessary for the progress of her scientific career towards an independent position.

 Publications

year authors and title journal last update
List of publications.
2016 Laura De Matteis, Maria Alleva, Inés Serrano-Sevilla, Sonia García-Embid, Grazyna Stepien, María Moros, Jesús de la Fuente
Controlling Properties and Cytotoxicity of Chitosan Nanocapsules by Chemical Grafting
published pages: 175, ISSN: 1660-3397, DOI: 10.3390/md14100175 		Marine Drugs 14/10 2019-07-24
2016 Gabriel Alfranca, Álvaro Artiga, Grazyna Stepien, María Moros, Scott G Mitchell, Jesús M de la Fuente
Gold nanoprism–nanorod face off: comparing the heating efficiency, cellular internalization and thermoablation capacity
published pages: 2903-2916, ISSN: 1743-5889, DOI: 10.2217/nnm-2016-0257 		Nanomedicine 11/22 2019-07-24

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The information about "HYHEAT" are provided by the European Opendata Portal: CORDIS opendata.

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