Opendata, web and dolomites


Profiling gene expression in Hydra vulgaris following Gold Nanoparticle-mediated hyperthermia

Total Cost €


EC-Contrib. €






 HyHeat project word cloud

Explore the words cloud of the HyHeat project. It provides you a very rough idea of what is the project "HyHeat" about.

council    final    progress    hyperthermia    tortiglione    clinics    nanoparticles    biological    markers    bioactivity    independent    biology    cancer    screen    analyzing    supplied    cells    cnr    np    animal    skills    scientific    cellular    profiled    moros    maria    purposes    upregulated    temperatures    irradiation    first    expression    mediated    toxicity    cibernetica    selective    vertebrate    living    synthesis    therapy    expertise    position    acute    fellow    panel    deregulated    tissues    plasmonic    tumoral    molecular    vivo    surface    soaking    ablation    reduce    functionalization    career    aunps    group    mechanisms    hyheat    heat    national    model    gold    mice    once    multidisciplinary    speed    caianiello    technique    whereby    ht    supervisor    unclear    grand    icib    nps    advantage    models    host    organism    di    strategies    monitor    efficacy    invasive    therapeutic    genetic    dr    photothermal    experimentation    found    possibility    invertebrate    heating    underlying    normal    engineered    hydra    genes    nanoparticle    laser    italy    date    treatment    instituto    exposed    eduardo    entry    line    stress    pioneered   

Project "HyHeat" data sheet

The following table provides information about the project.


Organization address
city: ROMA
postcode: 185

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website
 Total cost 180˙277 €
 EC max contribution 180˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2017-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Hyperthermia (HT) is currently used as a non-invasive technique for cancer therapy, whereby biological tissues are exposed to higher than normal temperatures, for selective ablation of tumoral cells. However, the molecular mechanisms underlying the in vivo cellular responses to heat stress remain unclear to date. The overall aim of the HyHeat project is to use an invertebrate model to screen the heating capabilities of different gold nanoparticles (AuNPs) in vivo, with the grand aim of understanding the cellular responses to heat stress and therefore taking the first steps towards improving nanoparticle (NP) mediated HT efficacy for therapeutic purposes. To this end, plasmonic AuNPs with photothermal capabilities will be surface engineered and supplied to living Hydra by soaking. Upon laser irradiation of the animal, cellular and molecular expression will be profiled to monitor the overall response to NP-mediated HT. A simple invertebrate organism will be used, in line with European strategies aimed to reduce vertebrate experimentation. Once a panel of upregulated genes have been identified, the research will be conducted in mice analyzing those genes found deregulated in Hydra with the final aim to identify genetic markers of HT treatment and speed up the entry of this therapy into clinics. HyHeat is a multidisciplinary project that take advantage of the Fellow´s Dr. Maria Moros knowledge in the synthesis and functionalization of NPs, and the expertise of the host group supervisor (Dr. C. Tortiglione, Instituto di Cibernetica “Eduardo Caianiello” (ICIB), National Research Council (CNR), Italy) in molecular biology using invertebrate models. This project will offer the applicant the possibility to work in a top European institution who pioneered the use of Hydra to test bioactivity and toxicity of NPs, and to develop new skills and knowledge necessary for the progress of her scientific career towards an independent position.


year authors and title journal last update
List of publications.
2016 Laura De Matteis, Maria Alleva, Inés Serrano-Sevilla, Sonia García-Embid, Grazyna Stepien, María Moros, Jesús de la Fuente
Controlling Properties and Cytotoxicity of Chitosan Nanocapsules by Chemical Grafting
published pages: 175, ISSN: 1660-3397, DOI: 10.3390/md14100175
Marine Drugs 14/10 2019-07-24
2016 Gabriel Alfranca, Álvaro Artiga, Grazyna Stepien, María Moros, Scott G Mitchell, Jesús M de la Fuente
Gold nanoprism–nanorod face off: comparing the heating efficiency, cellular internalization and thermoablation capacity
published pages: 2903-2916, ISSN: 1743-5889, DOI: 10.2217/nnm-2016-0257
Nanomedicine 11/22 2019-07-24

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "HYHEAT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "HYHEAT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

SIMIS (2020)

Strongly Interacting Mass Imbalanced Superfluid with ultracold fermions

Read More  

POMOC (2019)

Charles IV and the power of marvellous objects

Read More  


Limit sets of discrete dynamical systems

Read More