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Symbiont-mediated defense of amoebae against Legionella pneumophila - molecular mechanisms and pathogen ecology

Total Cost €


EC-Contrib. €






 SymPathInfect project word cloud

Explore the words cloud of the SymPathInfect project. It provides you a very rough idea of what is the project "SymPathInfect" about.

infecting    amoeba    profiling    environmental    frequently    biofilms    interfere    ubiquitous    living    chemical    amoebae    man    variety    imaging    host    experiments    spread    outbreaks    lysis    simulating    symbiont    ecology    data    phenomenon    thereby    protozoa    legionellae    interaction    proteomics    transmission    metabolomics    generally    perspective    protecting    competition    subsequently    opportunistic    made    transcriptomics    molecular    environment    annually    route    water    bacterial    survive    replication    free    organisms    co    microbes    suggests    laboratory    talk    implications    humans    bacteria    pathogens    mechanism    occurs    symbionts    mediated    defense    interactions    human    association    disease    containing    isotope    vectors    techniques    people    legionella    intracellularly    natural    cross    mesocosm    endosymbionts    shed    infection    understand    light    first    thousands    pneumophila    borne    performed    physiological   

Project "SymPathInfect" data sheet

The following table provides information about the project.


Organization address
city: WIEN
postcode: 1010

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website
 Total cost 178˙156 €
 EC max contribution 178˙156 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2018-09-24


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT WIEN AT (WIEN) coordinator 178˙156.00


 Project objective

Legionellae are opportunistic human pathogens infecting thousands of people annually in Europe. These bacteria are ubiquitous in many natural and man-made water systems, where they survive as free-living organisms in biofilms or intracellularly within a variety of protozoa. Free-living amoebae are the main route for spread and replication of legionellae in the environment, and infection of humans generally occurs via amoebae as vectors. Amoebae are frequently associated with bacterial endosymbionts, and recent data suggests that these symbionts interfere with replication of legionellae in amoebae thereby protecting the amoeba host from legionellae-induced lysis. The aim of this proposal is to further investigate this phenomenon of symbiont-mediated defense in protozoa, and to assess its implications for the ecology and transmission of legionellae. To shed light on the molecular and physiological interactions during infection of symbiont-containing amoebae with Legionella pneumophila, co-infection experiments will be performed and analyzed by state-of-the-art molecular methods including transcriptomics, proteomics and metabolomics, isotope profiling and chemical imaging techniques. Infection experiments will first be performed under controlled laboratory conditions to understand the interaction between amoeba, their bacterial symbionts and L. pneumophila, to analyse the molecular cross-talk, and to determine the mechanism of competition between the bacterial partners in this association. Subsequently, mesocosm experiments simulating environmental conditions will help to understand the impact of bacterial symbionts of amoebae on L. pneumophila spread and replication in the environment. Taken together, the comprehensive analysis of symbiont-mediated defense in amoebae will provide a new perspective on the ecology of L. pneumophila and lead to a better understanding of the role of amoebae and other microbes in water-borne disease outbreaks.


year authors and title journal last update
List of publications.
2018 C. Bergin, C. Wentrup, N. Brewig, A. Blazejak, C. Erséus, O. Giere, M. Schmid, P. De Wit, N. Dubilier
Acquisition of a Novel Sulfur-Oxidizing Symbiont in the Gutless Marine Worm Inanidrilus exumae
published pages: , ISSN: 0099-2240, DOI: 10.1128/AEM.02267-17
Applied and Environmental Microbiology 84/7 2019-04-18
2018 Bela Hausmann, Claus Pelikan, Craig W. Herbold, Stephan Köstlbacher, Mads Albertsen, Stephanie A. Eichorst, Tijana Glavina del Rio, Martin Huemer, Per H. Nielsen, Thomas Rattei, Ulrich Stingl, Susannah G. Tringe, Daniela Trojan, Cecilia Wentrup, Dagmar Woebken, Michael Pester, Alexander Loy
Peatland Acidobacteria with a dissimilatory sulfur metabolism
published pages: 1729-1742, ISSN: 1751-7362, DOI: 10.1038/s41396-018-0077-1
The ISME Journal 12/7 2019-04-18

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