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SymPathInfect

Symbiont-mediated defense of amoebae against Legionella pneumophila - molecular mechanisms and pathogen ecology

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SymPathInfect project word cloud

Explore the words cloud of the SymPathInfect project. It provides you a very rough idea of what is the project "SymPathInfect" about.

imaging    vectors    pneumophila    techniques    made    intracellularly    simulating    lysis    infection    bacteria    frequently    molecular    people    thereby    pathogens    protozoa    proteomics    symbiont    metabolomics    symbionts    biofilms    transcriptomics    association    variety    implications    mechanism    isotope    competition    data    infecting    profiling    free    mesocosm    legionellae    mediated    laboratory    annually    organisms    subsequently    containing    shed    survive    borne    protecting    humans    first    human    natural    understand    amoebae    defense    transmission    environment    route    ubiquitous    amoeba    bacterial    ecology    disease    perspective    endosymbionts    legionella    outbreaks    occurs    interfere    host    phenomenon    opportunistic    physiological    thousands    spread    chemical    experiments    light    interaction    replication    performed    suggests    co    talk    interactions    microbes    environmental    generally    man    cross    water    living   

Project "SymPathInfect" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT WIEN 

Organization address
address: UNIVERSITATSRING 1
city: WIEN
postcode: 1010
website: www.univie.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website http://www.microbial-ecology.net/research/symbiont-mediated-defense-of-amoebae-against-legionella-pneumophila-sympathinfect
 Total cost 178˙156 €
 EC max contribution 178˙156 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2018-09-24

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT WIEN AT (WIEN) coordinator 178˙156.00

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 Project objective

Legionellae are opportunistic human pathogens infecting thousands of people annually in Europe. These bacteria are ubiquitous in many natural and man-made water systems, where they survive as free-living organisms in biofilms or intracellularly within a variety of protozoa. Free-living amoebae are the main route for spread and replication of legionellae in the environment, and infection of humans generally occurs via amoebae as vectors. Amoebae are frequently associated with bacterial endosymbionts, and recent data suggests that these symbionts interfere with replication of legionellae in amoebae thereby protecting the amoeba host from legionellae-induced lysis. The aim of this proposal is to further investigate this phenomenon of symbiont-mediated defense in protozoa, and to assess its implications for the ecology and transmission of legionellae. To shed light on the molecular and physiological interactions during infection of symbiont-containing amoebae with Legionella pneumophila, co-infection experiments will be performed and analyzed by state-of-the-art molecular methods including transcriptomics, proteomics and metabolomics, isotope profiling and chemical imaging techniques. Infection experiments will first be performed under controlled laboratory conditions to understand the interaction between amoeba, their bacterial symbionts and L. pneumophila, to analyse the molecular cross-talk, and to determine the mechanism of competition between the bacterial partners in this association. Subsequently, mesocosm experiments simulating environmental conditions will help to understand the impact of bacterial symbionts of amoebae on L. pneumophila spread and replication in the environment. Taken together, the comprehensive analysis of symbiont-mediated defense in amoebae will provide a new perspective on the ecology of L. pneumophila and lead to a better understanding of the role of amoebae and other microbes in water-borne disease outbreaks.

 Publications

year authors and title journal last update
List of publications.
2018 C. Bergin, C. Wentrup, N. Brewig, A. Blazejak, C. Erséus, O. Giere, M. Schmid, P. De Wit, N. Dubilier
Acquisition of a Novel Sulfur-Oxidizing Symbiont in the Gutless Marine Worm Inanidrilus exumae
published pages: , ISSN: 0099-2240, DOI: 10.1128/AEM.02267-17
Applied and Environmental Microbiology 84/7 2019-04-18
2018 Bela Hausmann, Claus Pelikan, Craig W. Herbold, Stephan Köstlbacher, Mads Albertsen, Stephanie A. Eichorst, Tijana Glavina del Rio, Martin Huemer, Per H. Nielsen, Thomas Rattei, Ulrich Stingl, Susannah G. Tringe, Daniela Trojan, Cecilia Wentrup, Dagmar Woebken, Michael Pester, Alexander Loy
Peatland Acidobacteria with a dissimilatory sulfur metabolism
published pages: 1729-1742, ISSN: 1751-7362, DOI: 10.1038/s41396-018-0077-1
The ISME Journal 12/7 2019-04-18

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