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SymPathInfect

Symbiont-mediated defense of amoebae against Legionella pneumophila - molecular mechanisms and pathogen ecology

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

SymPathInfect project word cloud

Explore the words cloud of the SymPathInfect project. It provides you a very rough idea of what is the project "SymPathInfect" about.

occurs protecting experiments co borne legionella techniques route disease interactions endosymbionts bacteria interfere infecting host symbiont replication human ubiquitous light transmission biofilms transcriptomics implications defense microbes first pathogens containing spread intracellularly chemical simulating talk vectors imaging water pneumophila organisms physiological frequently generally understand mediated mechanism lysis amoebae isotope survive perspective association metabolomics thousands infection annually variety competition ecology shed people legionellae profiling performed proteomics bacterial opportunistic man protozoa molecular cross symbionts amoeba phenomenon humans laboratory interaction outbreaks thereby free made natural mesocosm environmental suggests living subsequently data environment

Project "SymPathInfect" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAT WIEN Organization address address: UNIVERSITATSRING 1 city: WIEN postcode: 1010 website: www.univie.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Austria [AT]
Project website	http://www.microbial-ecology.net/research/symbiont-mediated-defense-of-amoebae-against-legionella-pneumophila-sympathinfect
Total cost	178˙156 €
EC max contribution	178˙156 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-10-01 to 2018-09-24

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAT WIEN UNIVERSITAT WIEN Organization address address: UNIVERSITATSRING 1 city: WIEN postcode: 1010 website: www.univie.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	coordinator	178˙156.00

Map

Project objective

Legionellae are opportunistic human pathogens infecting thousands of people annually in Europe. These bacteria are ubiquitous in many natural and man-made water systems, where they survive as free-living organisms in biofilms or intracellularly within a variety of protozoa. Free-living amoebae are the main route for spread and replication of legionellae in the environment, and infection of humans generally occurs via amoebae as vectors. Amoebae are frequently associated with bacterial endosymbionts, and recent data suggests that these symbionts interfere with replication of legionellae in amoebae thereby protecting the amoeba host from legionellae-induced lysis. The aim of this proposal is to further investigate this phenomenon of symbiont-mediated defense in protozoa, and to assess its implications for the ecology and transmission of legionellae. To shed light on the molecular and physiological interactions during infection of symbiont-containing amoebae with Legionella pneumophila, co-infection experiments will be performed and analyzed by state-of-the-art molecular methods including transcriptomics, proteomics and metabolomics, isotope profiling and chemical imaging techniques. Infection experiments will first be performed under controlled laboratory conditions to understand the interaction between amoeba, their bacterial symbionts and L. pneumophila, to analyse the molecular cross-talk, and to determine the mechanism of competition between the bacterial partners in this association. Subsequently, mesocosm experiments simulating environmental conditions will help to understand the impact of bacterial symbionts of amoebae on L. pneumophila spread and replication in the environment. Taken together, the comprehensive analysis of symbiont-mediated defense in amoebae will provide a new perspective on the ecology of L. pneumophila and lead to a better understanding of the role of amoebae and other microbes in water-borne disease outbreaks.

Publications

List of publications.
year	authors and title	journal	last update
2018	C. Bergin, C. Wentrup, N. Brewig, A. Blazejak, C. ErsÃ©us, O. Giere, M. Schmid, P. De Wit, N. Dubilier Acquisition of a Novel Sulfur-Oxidizing Symbiont in the Gutless Marine Worm Inanidrilus exumae published pages: , ISSN: 0099-2240, DOI: 10.1128/AEM.02267-17	Applied and Environmental Microbiology 84/7	2019-04-18
2018	Bela Hausmann, Claus Pelikan, Craig W. Herbold, Stephan KÃ¶stlbacher, Mads Albertsen, Stephanie A. Eichorst, Tijana Glavina del Rio, Martin Huemer, Per H. Nielsen, Thomas Rattei, Ulrich Stingl, Susannah G. Tringe, Daniela Trojan, Cecilia Wentrup, Dagmar Woebken, Michael Pester, Alexander Loy Peatland Acidobacteria with a dissimilatory sulfur metabolism published pages: 1729-1742, ISSN: 1751-7362, DOI: 10.1038/s41396-018-0077-1	The ISME Journal 12/7	2019-04-18

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The information about "SYMPATHINFECT" are provided by the European Opendata Portal: CORDIS opendata.