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VMHCIRCUITS

Deciphering central role of VMH circuits in regulating energy balance

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 VMHCIRCUITS project word cloud

Explore the words cloud of the VMHCIRCUITS project. It provides you a very rough idea of what is the project "VMHCIRCUITS" about.

monitor    treatment    feeding    disorders    models    relatively    shown    animal    corresponding    brain    combining    significance    basics    glucose    steadily    hypothalamus    obesity    physiological    observations    tightly    metabolic    virus    incidence    least    regions    manipulations    circulating    driving    morphological    human    heavily    retrograde    screens    cardiovascular    decades    vmh    last    electrophysiology    adiposity    dissect    neurons    acute    body    circuits    tracers    weight    food    regulation    signals    collectively    basis    vivo    genetic    central    point    regulate    expressed    diabetes    mediating    connections    genes    behavioral    portion    neuronal    stores    techniques    dramatic    co    mechanisms    alterations    intake    electrical    homeostasis    understand    obese    input    energy    synaptic    downstream    pharmacological    subset    optogenetics    negative    few    mapping    patients    distributed    wiring    ventromedial    altered    morbidities    little    functional    balance    morbidly    underlying    circuit    diseases    diagram    upstream   

Project "VMHCIRCUITS" data sheet

The following table provides information about the project.

Coordinator
ISTANBUL MEDIPOL UNIVERSITESI VAFKI 

Organization address
address: ATATURK BULVARI 27 FAITH KASAPDEMIRHUN MAHALLESI
city: ISTANBUL
postcode: 34083
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Turkey [TR]
 Project website http://denizatasoylab.com
 Total cost 145˙845 €
 EC max contribution 145˙845 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ISTANBUL MEDIPOL UNIVERSITESI VAFKI TR (ISTANBUL) coordinator 145˙845.00

Map

 Project objective

Incidence of obesity has been steadily increasing for the last few decades. A corresponding rise in the obesity associated co-morbidities such as cardiovascular diseases and type-2 diabetes makes it an acute priority to understand the mechanisms underlying body weight regulation. It is well established that distributed brain circuits tightly monitor and regulate energy stores. Of particular interest, electrical and pharmacological manipulations to ventromedial portion of the hypothalamus (VMH), results in dramatic alterations in food intake, adiposity and glucose homeostasis in animal models. Furthermore, human genetic screens have shown that, at least for a subset of morbidly obese patients, genes that are heavily expressed in VMH are altered. Collectively these observations point to a central role for VMH in driving negative energy balance, yet relatively little is known how VMH neurons achieve this. To identify novel mechanisms for controlling energy balance, we propose to determine the following: 1) identify signals that regulate VMH neuronal activity, this includes synaptic input as well as circulating signals, 2) dissect out immediate downstream and upstream synaptic targets of VMH neurons mediating food intake and glucose homeostasis. To achieve this, we will use state of the art neuronal circuit mapping techniques involving virus based retrograde tracers and optogenetics. By combining functional electrophysiology and morphological approaches we will determine brain regions that has connections to and from VMH and evaluate behavioral and physiological significance each of these connections in-vivo. Understanding the basics of the functional VMH-wiring diagram will help determine how these neuronal circuits change under the conditions of metabolic and feeding disorders and will provide basis of targeted approaches for treatment.

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The information about "VMHCIRCUITS" are provided by the European Opendata Portal: CORDIS opendata.

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