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VMHCIRCUITS

Deciphering central role of VMH circuits in regulating energy balance

Total Cost €

0

EC-Contrib. €

0

Partnership

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 VMHCIRCUITS project word cloud

Explore the words cloud of the VMHCIRCUITS project. It provides you a very rough idea of what is the project "VMHCIRCUITS" about.

least    disorders    incidence    pharmacological    corresponding    body    glucose    mediating    obesity    optogenetics    stores    genetic    mechanisms    virus    diagram    vmh    physiological    hypothalamus    connections    regulation    energy    alterations    steadily    negative    co    animal    relatively    synaptic    understand    altered    dissect    little    tracers    decades    underlying    downstream    functional    electrophysiology    morphological    circuit    balance    behavioral    weight    regulate    central    intake    distributed    input    wiring    genes    manipulations    cardiovascular    combining    subset    regions    observations    upstream    retrograde    adiposity    basis    circulating    significance    tightly    collectively    shown    expressed    neurons    last    treatment    brain    feeding    neuronal    signals    portion    driving    mapping    techniques    few    basics    human    diseases    circuits    point    monitor    homeostasis    morbidities    electrical    diabetes    patients    obese    morbidly    vivo    models    metabolic    food    screens    heavily    ventromedial    acute    dramatic   

Project "VMHCIRCUITS" data sheet

The following table provides information about the project.

Coordinator
ISTANBUL MEDIPOL UNIVERSITESI VAFKI 

Organization address
address: ATATURK BULVARI 27 FAITH KASAPDEMIRHUN MAHALLESI
city: ISTANBUL
postcode: 34083
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Turkey [TR]
 Project website http://denizatasoylab.com
 Total cost 145˙845 €
 EC max contribution 145˙845 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ISTANBUL MEDIPOL UNIVERSITESI VAFKI TR (ISTANBUL) coordinator 145˙845.00

Map

 Project objective

Incidence of obesity has been steadily increasing for the last few decades. A corresponding rise in the obesity associated co-morbidities such as cardiovascular diseases and type-2 diabetes makes it an acute priority to understand the mechanisms underlying body weight regulation. It is well established that distributed brain circuits tightly monitor and regulate energy stores. Of particular interest, electrical and pharmacological manipulations to ventromedial portion of the hypothalamus (VMH), results in dramatic alterations in food intake, adiposity and glucose homeostasis in animal models. Furthermore, human genetic screens have shown that, at least for a subset of morbidly obese patients, genes that are heavily expressed in VMH are altered. Collectively these observations point to a central role for VMH in driving negative energy balance, yet relatively little is known how VMH neurons achieve this. To identify novel mechanisms for controlling energy balance, we propose to determine the following: 1) identify signals that regulate VMH neuronal activity, this includes synaptic input as well as circulating signals, 2) dissect out immediate downstream and upstream synaptic targets of VMH neurons mediating food intake and glucose homeostasis. To achieve this, we will use state of the art neuronal circuit mapping techniques involving virus based retrograde tracers and optogenetics. By combining functional electrophysiology and morphological approaches we will determine brain regions that has connections to and from VMH and evaluate behavioral and physiological significance each of these connections in-vivo. Understanding the basics of the functional VMH-wiring diagram will help determine how these neuronal circuits change under the conditions of metabolic and feeding disorders and will provide basis of targeted approaches for treatment.

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The information about "VMHCIRCUITS" are provided by the European Opendata Portal: CORDIS opendata.

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