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VMHCIRCUITS

Deciphering central role of VMH circuits in regulating energy balance

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 VMHCIRCUITS project word cloud

Explore the words cloud of the VMHCIRCUITS project. It provides you a very rough idea of what is the project "VMHCIRCUITS" about.

weight    physiological    pharmacological    vivo    input    animal    altered    regions    regulate    relatively    negative    combining    disorders    mediating    tracers    adiposity    diseases    acute    optogenetics    genetic    basics    portion    alterations    circuit    energy    expressed    hypothalamus    mechanisms    incidence    homeostasis    co    dramatic    vmh    electrophysiology    virus    feeding    stores    upstream    synaptic    decades    central    few    observations    connections    corresponding    patients    downstream    metabolic    dissect    regulation    last    manipulations    treatment    driving    retrograde    distributed    models    little    circulating    diabetes    point    neurons    morphological    morbidly    circuits    steadily    heavily    brain    mapping    subset    balance    glucose    obesity    cardiovascular    human    least    intake    tightly    body    monitor    techniques    genes    electrical    shown    ventromedial    diagram    functional    screens    neuronal    obese    understand    significance    wiring    signals    basis    behavioral    collectively    morbidities    food    underlying   

Project "VMHCIRCUITS" data sheet

The following table provides information about the project.

Coordinator
ISTANBUL MEDIPOL UNIVERSITESI VAFKI 

Organization address
address: ATATURK BULVARI 27 FAITH KASAPDEMIRHUN MAHALLESI
city: ISTANBUL
postcode: 34083
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Turkey [TR]
 Project website http://denizatasoylab.com
 Total cost 145˙845 €
 EC max contribution 145˙845 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ISTANBUL MEDIPOL UNIVERSITESI VAFKI TR (ISTANBUL) coordinator 145˙845.00

Map

 Project objective

Incidence of obesity has been steadily increasing for the last few decades. A corresponding rise in the obesity associated co-morbidities such as cardiovascular diseases and type-2 diabetes makes it an acute priority to understand the mechanisms underlying body weight regulation. It is well established that distributed brain circuits tightly monitor and regulate energy stores. Of particular interest, electrical and pharmacological manipulations to ventromedial portion of the hypothalamus (VMH), results in dramatic alterations in food intake, adiposity and glucose homeostasis in animal models. Furthermore, human genetic screens have shown that, at least for a subset of morbidly obese patients, genes that are heavily expressed in VMH are altered. Collectively these observations point to a central role for VMH in driving negative energy balance, yet relatively little is known how VMH neurons achieve this. To identify novel mechanisms for controlling energy balance, we propose to determine the following: 1) identify signals that regulate VMH neuronal activity, this includes synaptic input as well as circulating signals, 2) dissect out immediate downstream and upstream synaptic targets of VMH neurons mediating food intake and glucose homeostasis. To achieve this, we will use state of the art neuronal circuit mapping techniques involving virus based retrograde tracers and optogenetics. By combining functional electrophysiology and morphological approaches we will determine brain regions that has connections to and from VMH and evaluate behavioral and physiological significance each of these connections in-vivo. Understanding the basics of the functional VMH-wiring diagram will help determine how these neuronal circuits change under the conditions of metabolic and feeding disorders and will provide basis of targeted approaches for treatment.

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The information about "VMHCIRCUITS" are provided by the European Opendata Portal: CORDIS opendata.

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