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EPIGENHEART

Epigenetic control of retinoic acid-dependent genes during heart development

Total Cost €

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EC-Contrib. €

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Partnership

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Project "EPIGENHEART" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE D'AIX MARSEILLE 

Organization address
address: Boulevard Charles Livon 58
city: Marseille
postcode: 13284
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://www.zaffranlab.com/cardiogenese_en.html
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2017-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE D'AIX MARSEILLE FR (Marseille) coordinator 173˙076.00

Map

 Project objective

EPIGENHEART proposes a unique and competitive training for heart development research centred on congenital heart diseases (CHD), a leading cause of death in Europe . Defects in the pathways involved in myocardial lineages at the venous pole of the heart are found to be the origin of CHD and atrial arrhythmias. Epigenetic gene regulation has influence in maintenance of cellular identity, differentiation, and is deregulated in many diseases. The involvement of epigenetic dysregulation in CHD is poorly described, much of the mechanistic detail involved in triggering these events in the context of heart development remains unclear. RA signalling is preferentially active in the venous pole region of the embryonic heart. A deregulation of the retinoic acid (RA) has been implicated in venous pole defects in patients. How RA signalling takes part in the genetic and epigenetic network regulating the venous pole lineage decisions needs to be studied in details. With the use of in vitro, ex vivo and in vivo approaches in transgenic and deficient mouse embryos combined with transcriptomic and chromatin profiling, the two interacting research lines of EPIGENHEART fulfils this goal. EPIGENHEART is expected to increase the knowledge on the genetic and epigenetic network regulating the formation of the venous pole, which will contribute to better understand the associated heart diseases. Apart from the impact on human health, the project will contribute to ER´s future career prospects and European scientific excellence and competitiveness.

 Publications

year authors and title journal last update
List of publications.
2017 Sonia Stefanovic, Stéphane Zaffran
Mechanisms of retinoic acid signaling during cardiogenesis
published pages: 9-19, ISSN: 0925-4773, DOI: 10.1016/j.mod.2016.12.002
Mechanisms of Development 143 2019-07-24
2017 Marine Roux, Brigitte Laforest, Nathalie Eudes, Nicolas Bertrand, Sonia Stefanovic, Stéphane Zaffran
Hoxa1 and Hoxb1 are required for pharyngeal arch artery development
published pages: 1-8, ISSN: 0925-4773, DOI: 10.1016/j.mod.2016.11.006
Mechanisms of Development 143 2019-07-24

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The information about "EPIGENHEART" are provided by the European Opendata Portal: CORDIS opendata.

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