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Paediatric LMS

Non-Invasive Quantitative Magnetic Resonance for Obese Children – the Paediatric LiverMultiScan Test

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Paediatric LMS project word cloud

Explore the words cloud of the Paediatric LMS project. It provides you a very rough idea of what is the project "Paediatric LMS" about.

first    causal    diagnostic    modification    market    nation    fraction    multicentre    viability    oxford    subsequent    plan    fatty    liver    solid    rates    insensitive    adults    paediatric    performance    life    engineering    adult    effectiveness    grading    definition    efficacy    experts    chronic    livermultiscan    costly    business    overweight    mri    obese    disease    marked    opportunity    substantial    assessing    diagnosis    trial    diagnose    obtain    economic    adolescents    disproportionate    alcoholic    techniques    presenting    samples    monitor    network    reproducibility    size    burden    steatohepatitis    recruitment    impose    health    estimates    diagnostics    standard    trials    spin    poor    benefit    inadequately    thresholds    quick    founded    painful    tiny    ce    perspectum    site    optimization    pathology    precise    children    world    lms    sites    invasive    accurately    presentation    excellent    huge    obesity    as    least    university    biopsy    chance    healthcare    clinical    feasibility   

Project "Paediatric LMS" data sheet

The following table provides information about the project.

Coordinator
PERSPECTUM DIAGNOSTICS LTD 

Organization address
address: 23-38 HYTHE BRIDGE STREET BEAVER HOUSE
city: OXFORD
postcode: OX1 2ET
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.perspectumdiagnostics.com
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SMEINST-1-2014
 Funding Scheme SME-1
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2015-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    PERSPECTUM DIAGNOSTICS LTD UK (OXFORD) coordinator 50˙000.00

Map

 Project objective

As for adults, chronic liver disease is children is a major, rapidly growing health problem. The main causal factor is obesity, leading to fatty liver disease and non-alcoholic steatohepatitis. Inadequately treated children with liver disease will impose a disproportionate life-long burden on a nation’s healthcare system. In the EU, one third of adolescents is overweight/obese. Current techniques to diagnose and monitor liver disease in children are poor, insensitive or invasive. Liver biopsy is painful, costly, and samples only a tiny fraction of the liver. Perspectum Diagnostics is a University of Oxford spin-out founded by world-leading clinical and engineering experts in MRI. They have developed a quick, non-invasive MRI test that measures accurately the main features of liver pathology. Clinical trials in adults show excellent diagnostic performance and reproducibility. Perspectum’s first product, LiverMultiScan (LMS), is CE-marked for diagnosis of adult liver disease. We propose substantial modification of LMS for liver disease in children/adolescents. This requires adaptation and optimization of the methods in LMS, not least definition of thresholds and grading of disease, and analysis/presentation of results. A multicentre clinical trial is needed to obtain solid clinical evidence of diagnostic efficacy and cost-effectiveness of Paediatric LMS. We will develop a study design with a clinical trials unit; establish a network of EU clinical sites; ensure recruitment and technical feasibility at each site; cost the clinical study; establish economic viability; obtain more precise estimates of market size and growth rates, as well as the economic benefit to users. Paediatric LMS can become the standard test for assessing chronic liver disease in children, presenting not only a huge economic opportunity, but also the chance to greatly improve liver health in EU children. We will deliver a business plan for a subsequent phase 2 application.

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The information about "PAEDIATRIC LMS" are provided by the European Opendata Portal: CORDIS opendata.

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