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Paediatric LMS

Non-Invasive Quantitative Magnetic Resonance for Obese Children – the Paediatric LiverMultiScan Test

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Paediatric LMS project word cloud

Explore the words cloud of the Paediatric LMS project. It provides you a very rough idea of what is the project "Paediatric LMS" about.

adolescents    nation    mri    feasibility    presenting    engineering    diagnostic    obese    causal    as    multicentre    trial    world    economic    fraction    recruitment    disproportionate    life    paediatric    poor    standard    health    children    university    costly    impose    perspectum    subsequent    monitor    site    benefit    burden    thresholds    definition    size    pathology    liver    inadequately    opportunity    steatohepatitis    invasive    sites    performance    oxford    fatty    techniques    business    tiny    healthcare    overweight    spin    quick    trials    efficacy    market    diagnose    disease    network    assessing    effectiveness    huge    least    accurately    livermultiscan    optimization    ce    modification    obtain    insensitive    samples    precise    chance    founded    chronic    reproducibility    grading    painful    estimates    diagnosis    viability    adults    obesity    lms    marked    biopsy    substantial    diagnostics    excellent    rates    experts    alcoholic    adult    first    solid    plan    clinical    presentation   

Project "Paediatric LMS" data sheet

The following table provides information about the project.

Coordinator
PERSPECTUM DIAGNOSTICS LTD 

Organization address
address: 23-38 HYTHE BRIDGE STREET BEAVER HOUSE
city: OXFORD
postcode: OX1 2ET
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.perspectumdiagnostics.com
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SMEINST-1-2014
 Funding Scheme SME-1
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2015-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    PERSPECTUM DIAGNOSTICS LTD UK (OXFORD) coordinator 50˙000.00

Map

 Project objective

As for adults, chronic liver disease is children is a major, rapidly growing health problem. The main causal factor is obesity, leading to fatty liver disease and non-alcoholic steatohepatitis. Inadequately treated children with liver disease will impose a disproportionate life-long burden on a nation’s healthcare system. In the EU, one third of adolescents is overweight/obese. Current techniques to diagnose and monitor liver disease in children are poor, insensitive or invasive. Liver biopsy is painful, costly, and samples only a tiny fraction of the liver. Perspectum Diagnostics is a University of Oxford spin-out founded by world-leading clinical and engineering experts in MRI. They have developed a quick, non-invasive MRI test that measures accurately the main features of liver pathology. Clinical trials in adults show excellent diagnostic performance and reproducibility. Perspectum’s first product, LiverMultiScan (LMS), is CE-marked for diagnosis of adult liver disease. We propose substantial modification of LMS for liver disease in children/adolescents. This requires adaptation and optimization of the methods in LMS, not least definition of thresholds and grading of disease, and analysis/presentation of results. A multicentre clinical trial is needed to obtain solid clinical evidence of diagnostic efficacy and cost-effectiveness of Paediatric LMS. We will develop a study design with a clinical trials unit; establish a network of EU clinical sites; ensure recruitment and technical feasibility at each site; cost the clinical study; establish economic viability; obtain more precise estimates of market size and growth rates, as well as the economic benefit to users. Paediatric LMS can become the standard test for assessing chronic liver disease in children, presenting not only a huge economic opportunity, but also the chance to greatly improve liver health in EU children. We will deliver a business plan for a subsequent phase 2 application.

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The information about "PAEDIATRIC LMS" are provided by the European Opendata Portal: CORDIS opendata.

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