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MEDICIS-produced radioisotope beams for medicine

Total Cost €


EC-Contrib. €






 MEDICIS-PROMED project word cloud

Explore the words cloud of the MEDICIS-PROMED project. It provides you a very rough idea of what is the project "MEDICIS-PROMED" about.

xofigo    difficult    physics    frequent    deadliest    aided    poor    network    isolde    11carbon    discovery    region    personalized    generation    radiopharmaceuticals    hadron    nanomaterial    functional    emitting    pet    accelerator    prognosis    radioactivity    laser    cyclotrons    radioisotope    imaging    severe    233francium    radioactive    cern    alpha    combine    treatments    fundamental    particles    pear    supply    drug    online    therapy    plays    multidisciplinary    medicine    isotopes    nuclear    223radium    purification    bone    chloride    ovarian    central    lack    reg    mass    shown    medicis    separated    accelerated    intersectorial    2013    nature    promed    technologies    intense    nuclei    damages    medical    shaped    irradiate    treatment    treat    cancer    either    shortage    separation    99mtechnetium    train    cancers    world    coupling    beam    metastasis    coherent    combining    subsystems    expand    collateral    women    pure    separators    isotope    exotic    collaborative    ion    scientists    beams    sources    contribution    unknown    radioisotopes    structure    18fluorine   

Project "MEDICIS-PROMED" data sheet

The following table provides information about the project.


Organization address
city: GENEVA 23
postcode: 1211

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website
 Total cost 2˙829˙269 €
 EC max contribution 2˙829˙269 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2014
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2019-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
2    INSTITUTO SUPERIOR TECNICO PT (LISBOA) participant 476˙712.00
4    Advanced Accelerator Applications FR (Saint Genis Pouilly) participant 262˙875.00
5    LEMER PAX FR (CARQUEFOU) participant 262˙875.00
10    EBG (Entwicklungs- und Betriebsgesellschaft) MedAustron GmbH AT (Wiener Neustadt) partner 0.00
14    Isis Innovation Ltd UK (Oxford) partner 0.00


 Project objective

Pure accelerated radioisotope beams have been used for 50 years in fundamental physics R&D, e.g. for nuclear structure studies (pear shaped exotic nuclei, Nature 2013); CERN-ISOLDE plays a central role in developing accelerator technologies and fostering collaborative approaches to advance this field of isotope mass separation online. Our most recent contribution was the use of nanomaterial targets for more intense and reliable beam production, and laser ion sources for their purification (discovery of yet unknown 233Francium). Radioisotopes are widely used for functional imaging in medicine, based on 99mTechnetium or on 18Fluorine. This field is expected to rapidly expand, when coupling imaging with new cancer treatments, with isotopes emitting different type of radioactivity, e.g. alpha particles. This is shown with the recently introduced 223Radium chloride (Xofigo®) used as a treatment drug in advanced bone cancers. However, either shortage in the supply of 99mTechnetium or lack of access to new radioisotope with adequate properties is a severe treat to develop personalized treatment that combine functional imaging and therapy. Ovarian cancers have poor prognosis, are the second most frequent cancer for women and one of the deadliest. They are difficult to treat, because of possible presence of metastasis, and because this region is difficult to irradiate without collateral damages. MEDICIS-PROMED will train a new generation of scientists to develop systems for personalized Medicine combining functional imaging and treatments based on radioactive ion beam mass-separation. This will be done across a coherent intersectorial multidisciplinary network with world-leading scientists in their field. Subsystems for the development of new radiopharmaceuticals, of isotope mass separators at medical cyclotrons, and of mass separated 11Carbon for PET-aided hadron therapy will be specifically developed to treat the ovarian cancer.


List of deliverables.
Radiometal and 11C –based bioligands synthesis for target receptors of ovarian cancer Documents, reports 2019-07-23 16:46:39
Collection of mass separated 11CO/CO2/CH4 at high efficiency Documents, reports 2019-07-23 16:46:44
Preclinical Imaging and Animal Models – Clinical Translation on ovarian cancer Documents, reports 2019-07-23 16:15:36
99Mo/Tc production with metal uranium/graphene targets at CERN-MEDICIS Documents, reports 2019-07-23 16:15:37
Summary of charge breeding investigations for a future 11C treatment facility Documents, reports 2019-07-23 16:46:51
Open training event (summer school) Other 2019-07-23 16:47:45
Cell-nucleus targeting with bioligands for Auger-thera Documents, reports 2019-07-23 16:47:54
Production of theranostics 149/152Tb at CERN-MEDICIS and shipping Documents, reports 2019-07-23 16:15:44
Cyclotron production and mass-separation of 47/48/49Sc Documents, reports 2019-07-23 16:15:43
Remote laser ion source operation system for installation at medical cyclotrons Documents, reports 2019-07-23 15:46:32
Laser molecular break-up in RFQ cooler for beam purification Documents, reports 2019-07-23 16:15:54
Personnalized 11C PET aided hadron therapy Documents, reports 2019-07-23 15:46:25
New robot-assisted instruments and delivery methods for brachytherapy Documents, reports 2019-07-23 16:47:46
Website Websites, patent fillings, videos etc. 2019-07-10 14:13:58
Public lecture Other 2019-07-10 14:13:58
Enrolment in PhD program Other 2019-07-10 14:13:58
Investigation of imaging probes for ovarian cancer in animal models Documents, reports 2019-07-10 14:13:58
Design of new containers for theranostic isotope pairs transportation Documents, reports 2019-07-10 14:13:58

Take a look to the deliverables list in detail:  detailed list of MEDICIS-PROMED deliverables.


year authors and title journal last update
List of publications.
2019 R. Formento-Cavaier, U. Köster, B. Crepieux, V.M. Gadelshin, F. Haddad, T. Stora, K. Wendt
Very high specific activity erbium 169Er production for potential receptor-targeted radiotherapy
published pages: , ISSN: 0168-583X, DOI: 10.1016/j.nimb.2019.04.022
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 2019-10-08
2019 V.M. Gadelshin, V. Barozier, T.E. Cocolios, V.N. Fedosseev, R. Formento-Cavaier, F. Haddad, B. Marsh, S. Marzari, S. Rothe, T. Stora, D. Studer, F. Weber, K. Wendt
MELISSA: Laser ion source setup at CERN-MEDICIS facility. Blueprint
published pages: , ISSN: 0168-583X, DOI: 10.1016/j.nimb.2019.04.024
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 2019-07-30
2018 M. Breitenfeldt, F. di Lorenzo, A. Pikin, J. Pitters, F. Wenander
MEDeGUN commissioning results
published pages: 40004, ISSN: , DOI: 10.1063/1.5053278
AIP Conference Proceedings volume 2011 2019-07-30
2019 H. Verhoeven, T.E. Cocolios, K. Dockx, G.J. Farooq-Smith, O. Felden, R. Formento-Cavaier, R. Gebel, U. Köster, B. Neumaier, B. Scholten, I. Spahn, S. Spellerberg, M.E. Stamati, S. Stegemann
Measurement of spallation cross sections for the production of terbium radioisotopes for medical applications from tantalum targets
published pages: , ISSN: 0168-583X, DOI: 10.1016/j.nimb.2019.04.071
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 2019-07-30
2018 Ernesto Amato, Francesco Cicone, Lucrezia Auditore, Sergio Baldari, John O. Prior, Silvano Gnesin
A Monte Carlo model for the internal dosimetry of choroid plexuses in nuclear medicine procedures
published pages: 52-57, ISSN: 1120-1797, DOI: 10.1016/j.ejmp.2018.05.005
Physica Medica 49 2019-07-30
2017 Francesco Cicone, Giuseppe Minniti, Maria Antonietta Oliva, Luciano Carideo, John O. Prior, Francesco Scopinaro, Felice Giangaspero, Antonietta Arcella
Expression of large neutral amino acid transporters LAT1 and LAT2 in medulloblastoma
published pages: 179-181, ISSN: 1433-7398, DOI: 10.1007/s10014-017-0296-6
Brain Tumor Pathology 34/4 2019-07-30
2017 Caroline Stokke, Pablo Minguez Gabiña, Pavel Solný, Francesco Cicone, Mattias Sandström, Katarina Sjögreen Gleisner, Carlo Chiesa, Emiliano Spezi, Maria Paphiti, Mark Konijnenberg, Matt Aldridge, Jill Tipping, Michael Wissmeyer, Boudewijn Brans, Klaus Bacher, Carsten Kobe, Glenn Flux
Dosimetry-based treatment planning for molecular radiotherapy: a summary of the 2017 report from the Internal Dosimetry Task Force
published pages: , ISSN: 2197-7364, DOI: 10.1186/s40658-017-0194-3
EJNMMI Physics 4/1 2019-07-30
2016 Giuseppe Minniti, Claudia Scaringi, Sergio Paolini, Enrico Clarke, Francesco Cicone, Vincenzo Esposito, Andrea Romano, Mattia Osti, Riccardo Maurizi Enrici
Repeated stereotactic radiosurgery for patients with progressive brain metastases
published pages: 91-97, ISSN: 0167-594X, DOI: 10.1007/s11060-015-1937-4
Journal of Neuro-Oncology 126/1 2019-07-30
2018 H. Pahl, V. Bencini, M. Breitenfeldt, A.R. Granadeiro Costa, A. Pikin, J. Pitters, F. Wenander
A low energy ion beamline for TwinEBIS
published pages: P08012-P08012, ISSN: 1748-0221, DOI: 10.1088/1748-0221/13/08/p08012
Journal of Instrumentation 13/08 2019-07-30
2018 Luciano Carideo, Giuseppe Minniti, Marcelo Mamede, Claudia Scaringi, Ivana Russo, Francesco Scopinaro, Francesco Cicone
18 F-DOPA uptake parameters in glioma: effects of patients’ characteristics and prior treatment history
published pages: 20170847, ISSN: 0007-1285, DOI: 10.1259/bjr.20170847
The British Journal of Radiology 2019-07-30
2019 A. Ringvall Moberg, S. Warren, C. Muñoz Pequeño, J. Cruikshank, T. Giles, D. Hanstorp
Time-of-Flight study of molecular beams extracted from the ISOLDE RFQ cooler and buncher
published pages: , ISSN: 0168-583X, DOI: 10.1016/j.nimb.2019.03.014
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 2019-07-30
2018 F. Cicone, M. G. Santaguida, G. My, G. Mancuso, A. Papa, R. Persechino, C. Virili, N. Brusca, A. Tofani, F. Scopinaro, M. Centanni
Hyperhomocysteinemia in acute iatrogenic hypothyroidism: the relevance of thyroid autoimmunity
published pages: 831-837, ISSN: 1720-8386, DOI: 10.1007/s40618-017-0811-y
Journal of Endocrinological Investigation 41/7 2019-07-30
2019 J. Pitters, M. Breitenfeldt, H. Pahl, A. Pikin, F. Wenander
Challenges in 11C charge breeding
published pages: , ISSN: 0168-583X, DOI: 10.1016/j.nimb.2019.05.046
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 2019-07-30
2019 Mahabub A. Bhuiyan, Zakhar R. Kudrynskyi, Debarati Mazumder, Jake D. G. Greener, Oleg Makarovsky, Christopher J. Mellor, Evgeny E. Vdovin, Benjamin A. Piot, Inna I. Lobanova, Zakhar D. Kovalyuk, Marina Nazarova, Artem Mishchenko, Kostya S. Novoselov, Yang Cao, Laurence Eaves, Go Yusa, Amalia Patanè
Photoquantum Hall Effect and Light-Induced Charge Transfer at the Interface of Graphene/InSe Heterostructures
published pages: 1805491, ISSN: 1616-301X, DOI: 10.1002/adfm.201805491
Advanced Functional Materials 29/3 2019-07-30
2017 Katarina Sjögreen Gleisner, Emiliano Spezi, Pavel Solny, Pablo Minguez Gabina, Francesco Cicone, Caroline Stokke, Carlo Chiesa, Maria Paphiti, Boudewijn Brans, Mattias Sandström, Jill Tipping, Mark Konijnenberg, Glenn Flux
Variations in the practice of molecular radiotherapy and implementation of dosimetry: results from a European survey
published pages: , ISSN: 2197-7364, DOI: 10.1186/s40658-017-0193-4
EJNMMI Physics 4/1 2019-07-30
2017 Robert J. Young, T. Jonathan Yang, Vaios Hatzoglou, Gary Ulaner, Antonio Omuro
“Comment on Hatzoglou et al.: Dynamic contrast-enhanced MRI perfusion vs 18FDG PET/CT in differentiating brain tumor progression from radiation injury”-Reply
published pages: now286, ISSN: 1522-8517, DOI: 10.1093/neuonc/now286
Neuro-Oncology 2019-07-30
2017 Giuseppe Minniti, Sergio Paolini, Giancarlo D’Andrea, Gaetano Lanzetta, Francesco Cicone, Veronica Confaloni, Alessandro Bozzao, Vincenzo Esposito, Mattia Osti
Outcomes of postoperative stereotactic radiosurgery to the resection cavity versus stereotactic radiosurgery alone for melanoma brain metastases
published pages: 455-462, ISSN: 0167-594X, DOI: 10.1007/s11060-017-2394-z
Journal of Neuro-Oncology 132/3 2019-07-30
2016 Giuseppe Minniti, Claudia Scaringi, Sergio Paolini, Gaetano Lanzetta, Andrea Romano, Francesco Cicone, Mattia Osti, Riccardo Maurizi Enrici, Vincenzo Esposito
Single-Fraction Versus Multifraction (3 × 9 Gy) Stereotactic Radiosurgery for Large (>2 cm) Brain Metastases: A Comparative Analysis of Local Control and Risk of Radiation-Induced Brain Necrosis
published pages: 1142-1148, ISSN: 0360-3016, DOI: 10.1016/j.ijrobp.2016.03.013
International Journal of Radiation Oncology*Biology*Physics 95/4 2019-07-30
2017 Christian P. Filss, Francesco Cicone, Nadim Jon Shah, Norbert Galldiks, Karl-Josef Langen
Amino acid PET and MR perfusion imaging in brain tumours
published pages: 209-223, ISSN: 2281-5872, DOI: 10.1007/s40336-017-0225-z
Clinical and Translational Imaging 5/3 2019-07-30
2018 M. Nazarova, T. Stora, A.A. Zhukov, K. Huang, R.R. Nair, Y.B. Wang, J. Yin, M. Holwill, Z. Wang, A. Mishchenko, K.S. Novoselov
Growth of graphene on tantalum and its protective properties
published pages: 29-34, ISSN: 0008-6223, DOI: 10.1016/j.carbon.2018.06.027
Carbon 139 2019-07-30
2019 D. Leimbach, S. Rothe, L. Bengtsson, A. Ringvall-Moberg, J. Sundberg, K. Wendt, D. Hanstorp
Upgrades of the GANDALPH photodetachment detector towards the determination of the electron affinity of astatine
published pages: , ISSN: 0168-583X, DOI: 10.1016/j.nimb.2019.05.015
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 2019-07-30
2018 J. Pitters, M. Breitenfeldt, F. Wenander
Charge breeding of CO+ beams at REX-ISOLDE
published pages: 70012, ISSN: , DOI: 10.1063/1.5053354
AIP Conference Proceedings volume 2011 2019-07-30
2018 Silvano Gnesin, Francesco Cicone, Periklis Mitsakis, Axel Van der Gucht, Sébastien Baechler, Raymond Miralbell, Valentina Garibotto, Thomas Zilli, John O. Prior
First in-human radiation dosimetry of the gastrin-releasing peptide (GRP) receptor antagonist 68Ga-NODAGA-MJ9
published pages: , ISSN: 2191-219X, DOI: 10.1186/s13550-018-0462-9
EJNMMI Research 8/1 2019-07-30
2016 Maria C Rossi Espagnet, Andrea Romano, Valeria Mancuso, Francesco Cicone, Antonio Napolitano, Claudia Scaringi, Giuseppe Minniti, Alessandro Bozzao
Multiparametric evaluation of low grade gliomas at follow-up: comparison between diffusion and perfusion MR with 18 F-FDOPA PET
published pages: 20160476, ISSN: 0007-1285, DOI: 10.1259/bjr.20160476
The British Journal of Radiology 89/1066 2019-07-30
2019 J. Pitters, M. Breitenfeldt, S. Duarte Pinto, H. Pahl, A. Pikin, A. Shornikov, F. Wenander
Pepperpot emittance measurements of ion beams from an electron beam ion source
published pages: 28-35, ISSN: 0168-9002, DOI: 10.1016/j.nima.2018.12.072
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 922 2019-07-30
2016 Francesco Cicone, Anna Clerico, Giuseppe Minniti, Milena Paiano, Luciano Carideo, Claudia Scaringi, Karl-Josef Langen, Francesco Scopinaro
18F-DOPA Positron Emission Tomography in Medulloblastoma: 2 Case Reports
published pages: 490.e7-490.e11, ISSN: 1878-8750, DOI: 10.1016/j.wneu.2016.06.058
World Neurosurgery 93 2019-07-30
2017 R. Formento Cavaier, F. Haddad, T. Sounalet, T. Stora, I. Zahi
Terbium Radionuclides for Theranostics Applications: A Focus On MEDICIS-PROMED
published pages: 157-163, ISSN: 1875-3892, DOI: 10.1016/j.phpro.2017.09.053
Physics Procedia 90 2019-07-30
2018 Y. Martinez Palenzuela, B.A. Marsh, J. Ballof, R. Catherall, K. Chrysalidis, T.E. Cocolios, B. Crepieux, T. Day Goodacre, V.N. Fedosseev, M.H. Huyse, P.B. Larmonier, J.P. Ramos, S. Rothe, J.D.A. Smith, T. Stora, P. Van Duppen, S. Wilkins
Enhancing the extraction of laser-ionized beams from an arc discharge ion source volume
published pages: 59-66, ISSN: 0168-583X, DOI: 10.1016/j.nimb.2018.06.006
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 431 2019-07-10
2017 M. Breitenfeldt, R. Mertzig, J. Pitters, A. Shornikov, F. Wenander
The TwinEBIS setup: Machine description
published pages: 139-146, ISSN: 0168-9002, DOI: 10.1016/j.nima.2016.12.037
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 856 2019-07-10
2017 V. Gadelshin, T. Cocolios, V. Fedoseev, R. Heinke, T. Kieck, B. Marsh, P. Naubereit, S. Rothe, T. Stora, D. Studer, P. Van Duppen, K. Wendt
Laser resonance ionization spectroscopy on lutetium for the MEDICIS project
published pages: , ISSN: 0304-3843, DOI: 10.1007/s10751-017-1406-x
Hyperfine Interactions 238/1 2019-07-10
2018 Thomas Elias Cocolios, Cristina Ferrari, Fiona Reid, Thierry Stora
MEDICIS-Promed: an Innovative Training Network for a new generation of professionals in nuclear medicine
published pages: 530-533, ISSN: , DOI: 10.1007/978-981-10-5122-7_133
IFMBE Proceedings 65 2019-07-10
2017 Robert Mertzig, M. Breitenfeldt, S. Mathot, J. Pitters, A. Shornikov, F. Wenander
A high-compression electron gun for C 6+ production: concept, simulations and mechanical design
published pages: 102-111, ISSN: 0168-9002, DOI: 10.1016/j.nima.2016.12.036
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 859 2019-07-10
2017 Silvano Gnesin, Periklis Mitsakis, Francesco Cicone, Emmanuel Deshayes, Vincent Dunet, Augusto F. Gallino, Marek Kosinski, Sébastien Baechler, Franz Buchegger, David Viertl, John O. Prior
First in-human radiation dosimetry of 68Ga-NODAGA-RGDyK
published pages: 43, ISSN: 2191-219X, DOI: 10.1186/s13550-017-0288-x
EJNMMI Research 7/1 2019-07-10
2017 Thomas Elias Cocolios, Kara M Lynch, Emma Nichols
The ISOLDE LEGO ® robot: building interest in frontier research
published pages: 44004, ISSN: 0031-9120, DOI: 10.1088/1361-6552/aa71e4
Physics Education 52/4 2019-07-10
2017 Francesco Cicone, David Viertl, Ana Maria Quintela Pousa, Thibaut Denoël, Silvano Gnesin, Francesco Scopinaro, Marie-Catherine Vozenin, John O. Prior
Cardiac Radionuclide Imaging in Rodents: A Review of Methods, Results, and Factors at Play
published pages: 35, ISSN: 2296-858X, DOI: 10.3389/fmed.2017.00035
Frontiers in Medicine 4 2019-07-10

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