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INPACT

Innovative peptides against cancer and pathogenic bacteria, with advances in science, biopharmaceutical drug development, product market targeting, training , and communication.

Total Cost €

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EC-Contrib. €

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Partnership

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Project "INPACT" data sheet

The following table provides information about the project.

Coordinator
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES 

Organization address
address: AVENIDA PROF EGAS MONIZ
city: LISBOA
postcode: 1649 028
website: www.imm.ul.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Project website https://rise-inpact.com/
 Total cost 1˙390˙500 €
 EC max contribution 850˙500 € (61%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2014
 Funding Scheme MSCA-RISE
 Starting year 2015
 Duration (year-month-day) from 2015-02-01   to  2019-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES PT (LISBOA) coordinator 463˙500.00
2    UNIVERSIDAD POMPEU FABRA ES (BARCELONA) participant 180˙000.00
3    PROTEODESIGN SL ES (BARCELONA) participant 72˙000.00
4    UNIVERSIDAD DE NAVARRA ES (PAMPLONA) participant 49˙500.00
5    CENTRO ATLANTICO DEL MEDICAMENTO, SA ES (SAN CRISTOBAL DE LA LAGUNA TENERIFE) participant 45˙000.00
6    TECHNOPHAGE INVESTIGACAO E DESENVOLVIMENTO EM BIOTECNOLOGIA SA PT (LISBOA) participant 40˙500.00
7    BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY US (STANFORD) partner 0.00
8    INSTITUTO CIENCIA HOJE-ICH BR (RIO DE JANEIRO) partner 0.00
9    THE UNIVERSITY OF QUEENSLAND AU (BRISBANE) partner 0.00
10    UNIVERSIDADE FEDERAL DO RIO DE JANEIRO BR (RIO DE JANEIRO) partner 0.00

Map

 Project objective

INPACT aims at the pre-clinical development of innovative drugs and drug formulations against selected cancers (eg prostate cancer) and pathogenic bacteria (eg S. aureus). The INPACT consortium allies the expertise of both academic and industrial R&D partners that contribute with their own unique technologies to achieve new drugs that are only possible to develop in an integrative effort. Academic partners have unique knowledge and technologies on supercharged viral proteins-derived cell-penetrating peptides (eg from Dengue virus) and ultra-resistant cyclic peptides that may be transferred to the industrial partners, which in turn have specialized proprietary technologies on anticancer and/or peptide drugs’ technologies. The judicious exchange of knowledge among partners will lead to new resistant peptides for trans-barrier delivery of drugs (eg cyclic peptide-drug chimeras) and bacterial killing (both planktonic and biofilms). INPACT includes four leading academic partners (from Portugal, Spain, Australia, and Brazil) and three consolidated biotech SMEs (one from Portugal and two Spain). In addition to the R&D project itself, INPACT involves at the highest possible level a top business school in Europe (IESE, Barcelona, Spain), a consolidated media partner specialised in science communication (Ciencia Hoje, Rio de Janeiro, Brazil) and experts in international science funding from one of the top US universities (University of Stanford). The consortium will be the perfect environment for young researchers to acquire knowledge and skills in science, technology, entrepreneurship, business, and communication so they can pro-actively tailor their career path in a life-long learning perspective. This is a contribution towards the advancement of Europe through the use of research and education for societal development and economic growth.

 Deliverables

List of deliverables.
Training and career development Other 2019-09-02 14:01:24
Outreaching Outputs Other 2019-09-02 14:01:24
Products Other 2019-09-02 14:01:24
Dissemination Outputs Other 2019-09-02 14:01:24

Take a look to the deliverables list in detail:  detailed list of INPACT deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Bárbara Gomes, Marcelo T. Augusto, Mário R. Felício, Axel Hollmann, Octávio L. Franco, Sónia Gonçalves, Nuno C. Santos
Designing improved active peptides for therapeutic approaches against infectious diseases
published pages: 415-429, ISSN: 0734-9750, DOI: 10.1016/j.biotechadv.2018.01.004
Biotechnology Advances 36/2 2019-09-02
2018 Marco Cavaco, Miguel A. R. B. Castanho, Vera Neves
Peptibodies: An elegant solution for a long-standing problem
published pages: e23095, ISSN: 2475-8817, DOI: 10.1002/bip.23095
Peptide Science 110/1 2019-09-02
2019 Luz N. Irazazabal, William F. Porto, Isabel C.M. Fensterseifer, Eliane S.F. Alves, Carolina O. Matos, Antônio C.S. Menezes, Mário R. Felício, Sónia Gonçalves, Nuno C. Santos, Suzana M. Ribeiro, Vincent Humblot, Luciano M. Lião, Ali Ladram, Octavio L. Franco
Fast and potent bactericidal membrane lytic activity of PaDBS1R1, a novel cationic antimicrobial peptide
published pages: 178-190, ISSN: 0005-2736, DOI: 10.1016/j.bbamem.2018.08.001
Biochimica et Biophysica Acta (BBA) - Biomembranes 1861/1 2019-09-02
2018 Clara Pérez-Peinado, Susana Almeida Dias, Marco M. Domingues, Aurélie H. Benfield, João Miguel Freire, Gandhi Rádis-Baptista, Diana Gaspar, Miguel A. R. B. Castanho, David J. Craik, Sónia Troeira Henriques, Ana Salomé Veiga, David Andreu
Mechanisms of bacterial membrane permeabilization by crotalicidin (Ctn) and its fragment Ctn(15–34), antimicrobial peptides from rattlesnake venom
published pages: 1536-1549, ISSN: 0021-9258, DOI: 10.1074/jbc.ra117.000125
Journal of Biological Chemistry 293/5 2019-09-02
2017 Juliana Perazzo, Miguel A. R. B. Castanho, Sónia Sá Santos
Pharmacological Potential of the Endogenous Dipeptide Kyotorphin and Selected Derivatives
published pages: , ISSN: 1663-9812, DOI: 10.3389/fphar.2016.00530
Frontiers in Pharmacology 7 2019-09-02
2017 Sara Neves-Coelho, Rute Eleutério, Francisco Enguita, Vera Neves, Miguel Castanho
A New Noncanonical Anionic Peptide That Translocates a Cellular Blood–Brain Barrier Model
published pages: 1753, ISSN: 1420-3049, DOI: 10.3390/molecules22101753
Molecules 22/10 2019-09-02
2016 Vera Neves, Frederico Aires-da-Silva, Sofia Corte-Real, Miguel A.R.B. Castanho
Antibody Approaches To Treat Brain Diseases
published pages: 36-48, ISSN: 0167-7799, DOI: 10.1016/j.tibtech.2015.10.005
Trends in Biotechnology 34/1 2019-09-02
2015 João M. Freire, Nuno C. Santos, Ana Salomé Veiga, Andrea T. Da Poian, Miguel A. R. B. Castanho
Rethinking the capsid proteins of enveloped viruses: multifunctionality from genome packaging to genome transfection
published pages: 2267-2278, ISSN: 1742-464X, DOI: 10.1111/febs.13274
FEBS Journal 282/12 2019-09-02
2015 João M. Freire, Diana Gaspar, Ana Salomé Veiga, Miguel A. R. B. Castanho
Shifting gear in antimicrobial and anticancer peptides biophysical studies: from vesicles to cells
published pages: 178-185, ISSN: 1075-2617, DOI: 10.1002/psc.2741
Journal of Peptide Science 21/3 2019-09-02
2016 Suzana M. Ribeiro, Mário R. Felício, Esther Vilas Boas, Sónia Gonçalves, Fabrício F. Costa, Ramar Perumal Samy, Nuno C. Santos, Octávio L. Franco
New frontiers for anti-biofilm drug development
published pages: 133-144, ISSN: 0163-7258, DOI: 10.1016/j.pharmthera.2016.02.006
Pharmacology & Therapeutics 160 2019-09-02
2016 Ludovico Migliolo, Mário R. Felício, Marlon H. Cardoso, Osmar N. Silva, Mary-Ann E. Xavier, Diego O. Nolasco, Adeliana Silva de Oliveira, Ignasi Roca-Subira, Jordi Vila Estape, Leandro D. Teixeira, Sonia M. Freitas, Anselmo J. Otero-Gonzalez, Sónia Gonçalves, Nuno C. Santos, Octavio L. Franco
Structural and functional evaluation of the palindromic alanine-rich antimicrobial peptide Pa-MAP2
published pages: 1488-1498, ISSN: 0005-2736, DOI: 10.1016/j.bbamem.2016.04.003
Biochimica et Biophysica Acta (BBA) - Biomembranes 1858/7 2019-09-02
2017 Vera Neves , Frederico Aires-da-Silva, Maurício Morais, Lurdes Gano, Elisabete Ribeiro, Antónia Pinto, Sandra Aguiar, Diana Gaspar, Célia Fernandes, João D. G. Correia, and Miguel A. R. B. Castanho
Novel Peptides Derived from Dengue Virus Capsid Protein Translocate Reversibly the Blood–Brain Barrier through a Receptor-Free Mechanism
published pages: , ISSN: 1554-8929, DOI: 10.1021/acschembio.7b00087
ACS Chemical Biology 2019-09-02
2016 Marlon H. Cardoso, Suzana M. Ribeiro, Diego O. Nolasco, César de la Fuente-Núñez, Mário R. Felício, Sónia Gonçalves, Carolina O. Matos, Luciano M. Liao, Nuno C. Santos, Robert E. W. Hancock, Octávio L. Franco, Ludovico Migliolo
A polyalanine peptide derived from polar fish with anti-infectious activities
published pages: 21385, ISSN: 2045-2322, DOI: 10.1038/srep21385
Scientific Reports 6 2019-09-02
2017 Susana A. Dias, João M. Freire, Clara Pérez-Peinado, Marco M. Domingues, Diana Gaspar, Nuno Vale, Paula Gomes, David Andreu, Sónia T. Henriques, Miguel A. R. B. Castanho, Ana S. Veiga
New Potent Membrane-Targeting Antibacterial Peptides from Viral Capsid Proteins
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2017.00775
Frontiers in Microbiology 8 2019-09-02
2017 Sónia Gonçalves, Patrícia M. Silva, Mário R. Felício, Luciano N. de Medeiros, Eleonora Kurtenbach, Nuno C. Santos
Psd1 Effects on Candida albicans Planktonic Cells and Biofilms
published pages: , ISSN: 2235-2988, DOI: 10.3389/fcimb.2017.00249
Frontiers in Cellular and Infection Microbiology 7 2019-09-02
2017 Mário R. Felício, Osmar N. Silva, Sônia Gonçalves, Nuno C. Santos, Octávio L. Franco
Peptides with Dual Antimicrobial and Anticancer Activities
published pages: , ISSN: 1664-302X, DOI: 10.3389/fchem.2017.00005
Frontiers in Chemistry 5 2019-09-02
2016 Juliana Perazzo, Mônica Lopes-Ferreira, Sónia Sá Santos, Isa Serrano, Antónia Pinto, Carla Lima, Eduard Bardaji, Isaura Tavares, Montserrat Heras, Katia Conceição, Miguel A. R. B. Castanho
Endothelium-Mediated Action of Analogues of the Endogenous Neuropeptide Kyotorphin (Tyrosil-Arginine): Mechanistic Insights from Permeation and Effects on Microcirculation
published pages: 1130-1140, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.6b00099
ACS Chemical Neuroscience 7/8 2019-09-02
2017 Juliana Perazzo, Carla Lima, Montserrat Heras, Eduard Bardají, Mônica Lopes-Ferreira, Miguel Castanho
Neuropeptide Kyotorphin Impacts on Lipopolysaccharide-Induced Glucocorticoid-Mediated Inflammatory Response. A Molecular Link to Nociception, Neuroprotection, and Anti-Inflammatory Action
published pages: 1663-1667, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.7b00007
ACS Chemical Neuroscience 8/8 2019-09-02
2017 Tiago N. Figueira, Filipa D. Oliveira, Inês Almeida, Érica O. Mello, Valdirene M. Gomes, Miguel A. R. B. Castanho, Diana Gaspar
Challenging metastatic breast cancer with the natural defensin PvD 1
published pages: 16887-16899, ISSN: 2040-3364, DOI: 10.1039/c7nr05872a
Nanoscale 9/43 2019-09-02

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