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ELASTISLET

Tailored Elastin-like Recombinamers as Advanced Systems for Cell Therapies in Diabetes Mellitus: a Synthetic Biology Approach towards a Bioeffective and Immunoisolated Biosimilar Islet/Cell Niche

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EC-Contrib. €

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 ELASTISLET project word cloud

Explore the words cloud of the ELASTISLET project. It provides you a very rough idea of what is the project "ELASTISLET" about.

linking    biology    core    biologically    fulfils    basic    extracellular    elastin    first    treatment    capsule    elastislet    scaffolding    ideal    biomimetic    intense    synergistically    immune    relies    inner    recombinamers    directed    interfaces    cutting    diabetes    innovative    functional    elrs    cloak    niche    tissue    interact    interface    hosts    materials    fuse    procuring    biocompatibility    breakthrough    environment    foreign    implanted    surrounding    immediately    family    material    coating    lbl    matrix    cell    starting    outer    hostile    ideas    physical    content    encapsulation    edge    cellular    continuity    grafting    permselectivity    versatile    isolate    nutrient    nanobiotechnology    optimal    combined    supply    transplantation    perceiving    combine    talk    synthetic    cells    create    integrate    point    islet    implant    biomaterials    isolation    tissues    generate    technologies    superior    therapy    cargo    cross    rejection    molecular    therapies    function    islets    survive    biomaterial    unusual    reactive    physiologically    simultaneously   

Project "ELASTISLET" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE VALLADOLID 

Organization address
address: PLAZA SANTA CRUZ 8 PALACIO DE SANTA CRUZ
city: VALLADOLID
postcode: 47002
website: www.uva.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://www.elastislet.eu/en/
 Total cost 6˙214˙495 €
 EC max contribution 6˙214˙495 € (100%)
 Programme 1. H2020-EU.2.1.3.1. (Cross-cutting and enabling materials technologies)
 Code Call H2020-NMP-2014-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2019-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE VALLADOLID ES (VALLADOLID) coordinator 1˙773˙555.00
2    UPPSALA UNIVERSITET SE (UPPSALA) participant 831˙597.00
3    UNIVERSITA DEGLI STUDI DI PERUGIA IT (PERUGIA) participant 688˙579.00
4    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) participant 645˙750.00
5    TECHNICAL PROTEINS NANOBIOTECHNOLOGY SL ES (VALLADOLID) participant 489˙000.00
6    UNIVERSIDADE DE AVEIRO PT (AVEIRO) participant 354˙940.00
7    NCARDIA AG DE (KOLN) participant 341˙875.00
8    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) participant 303˙125.00
9    UNIVERSIDADE DO MINHO PT (BRAGA) participant 301˙121.00
10    Promoscience srl IT (TRIESTE) participant 262˙450.00
11    ASPHALION SL ES (BARCELONA) participant 222˙500.00
12    UNIVERSITAT BASEL CH (BASEL) participant 0.00

Map

 Project objective

ELASTISLET aims to create a breakthrough development in encapsulation technology and its use in cell and tissue therapies for the treatment of type 1 and 2 diabetes. ELASTISLET will combine leading technologies in biomaterial design, production and processing, cross-linking/grafting technology and cell therapy, to synergistically integrate them into a new immune-isolation and biomimetic scaffolding approach for islet and cell transplantation in diabetes treatment. ELASTISLET’s starting point is a highly innovative and versatile family of superior biomaterials, the Elastin-like Recombinamers (ELRs). Those innovative materials will be combined with the most cutting-edge encapsulation technologies, such as reactive LbL. ELASTISLET relies on the most innovative ideas taken from synthetic biology, nanobiotechnology and molecular and cellular biology to build the ideal niche for islet/cell encapsulation and transplantation. ELASTISLET main objective is to achieve a functional coating that fulfils, first, the basic requirements of optimal biocompatibility and physical properties (permselectivity) but, second, generate a capsule that can promote an intense and directed cross talk through all cell-material interfaces involved: the implant-surrounding tissue (outer) interface and cargo cells-capsule (inner) interface. At the end, a capsule that is able not only to cloak its content and isolate it from the immune rejection but that it is able to biologically interact with the surrounding tissues and its cargo simultaneously in a way that the implanted capsule will immediately interact and fuse with the surrounding tissues creating a real continuity of the extracellular matrix from the core of the capsule to the surrounding hosts tissues and procuring adequate nutrient supply. That will provide a physiologically ideal biomimetic environment for the implanted islets/cells to survive and function in the long term without perceiving a foreign, unusual or hostile environment.

 Deliverables

List of deliverables.
Report on existing standards and standardization landscape Documents, reports 2020-03-05 08:32:04
Project website Websites, patent fillings, videos etc. 2020-03-05 08:32:04
Report and management activities Documents, reports 2020-03-05 08:32:04
Communication and dissemination plan Documents, reports 2020-03-05 08:32:04
Quality and contingency Documents, reports 2020-03-05 08:32:04

Take a look to the deliverables list in detail:  detailed list of ELASTISLET deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Luis Quintanilla-Sierra, Carmen García-Arévalo, J.C. Rodriguez-Cabello
Self-assembly in Elastin-Like Recombinamers: a Mechanism to Mimic Natural Complexity
published pages: 100007, ISSN: 2590-0064, DOI: 10.1016/j.mtbio.2019.100007
Materials Today Bio 2020-03-05
2019 Juan Gonzalez-Valdivieso, Alessandra Girotti, Raquel Muñoz, J. Carlos Rodriguez-Cabello, F. Javier Arias
Self-Assembling ELR-Based Nanoparticles as Smart Drug-Delivery Systems Modulating Cellular Growth via Akt
published pages: 1996-2007, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.9b00206
Biomacromolecules 20/5 2020-03-05
2019 Leander Poocza, Filippo Cipriani, Matilde Alonso, José Carlos Rodríguez-Cabello
Hydrophobic Cholesteryl Moieties Trigger Substrate Cell–Membrane Interaction of Elastin–Mimetic Protein Coatings in Vitro
published pages: 10818-10827, ISSN: 2470-1343, DOI: 10.1021/acsomega.9b00548
ACS Omega 4/6 2020-03-05
2019 Tatjana Flora, I González de Torre, M Alonso, J Carlos Rodríguez-Cabello
Use of proteolytic sequences with different cleavage kinetics as a way to generate hydrogels with preprogrammed cell-infiltration patterns imparted over their given 3D spatial structure
published pages: 35008, ISSN: 1758-5090, DOI: 10.1088/1758-5090/ab10a5
Biofabrication 11/3 2020-03-05
2018 Roni Lehmann-Werman, Judith Magenheim, Joshua Moss, Daniel Neiman, Ofri Abraham, Sheina Piyanzin, Hai Zemmour, Ilana Fox, Talya Dor, Markus Grompe, Giora Landesberg, Bao-Li Loza, Abraham Shaked, Kim Olthoff, Benjamin Glaser, Ruth Shemer, Yuval Dor
Monitoring liver damage using hepatocyte-specific methylation markers in cell-free circulating DNA
published pages: , ISSN: 2379-3708, DOI: 10.1172/jci.insight.120687
JCI Insight 3/12 2020-03-05
2018 M Putzu, F Causa, Manuel Parente, Israel González de Torre, J C Rodriguez-Cabello, P A Netti
Silk-ELR co-recombinamer covered stents obtained by electrospinning
published pages: 21-28, ISSN: 2056-3418, DOI: 10.1093/rb/rby022
Regenerative Biomaterials 6/1 2020-03-05
2019 Ana M. Testera, Mercedes Santos, Alessandra Girotti, F. Javier Arias, J. Manuel Báñez, Matilde Alonso, J. Carlos Rodríguez-Cabello
A novel lipase-catalyzed method for preparing ELR-based bioconjugates
published pages: 752-759, ISSN: 0141-8130, DOI: 10.1016/j.ijbiomac.2018.10.028
International Journal of Biological Macromolecules 121 2020-03-05
2016 Mariana B. Oliveira, Javad Hatami, João F. Mano
Coating Strategies Using Layer-by-layer Deposition for Cell Encapsulation
published pages: 1753-1764, ISSN: 1861-4728, DOI: 10.1002/asia.201600145
Chemistry - An Asian Journal 11/12 2020-03-05
2018 Joshua Moss, Judith Magenheim, Daniel Neiman, Hai Zemmour, Netanel Loyfer, Amit Korach, Yaacov Samet, Myriam Maoz, Henrik Druid, Peter Arner, Keng-Yeh Fu, Endre Kiss, Kirsty L. Spalding, Giora Landesberg, Aviad Zick, Albert Grinshpun, A. M. James Shapiro, Markus Grompe, Avigail Dreazan Wittenberg, Benjamin Glaser, Ruth Shemer, Tommy Kaplan, Yuval Dor
Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease
published pages: 1-12, ISSN: 2041-1723, DOI: 10.1038/s41467-018-07466-6
Nature Communications 9/1 2020-03-05
2019 Rui R. Costa, Diana Soares da Costa, Rui L. Reis, Iva Pashkuleva
Bioinspired baroplastic glycosaminoglycan sealants for soft tissues
published pages: 108-117, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2019.01.040
Acta Biomaterialia 87 2020-03-05
2019 Tatjana Flora, I. González de Torre, M. Alonso, J. Carlos Rodríguez-Cabello
Tethering QK peptide to enhance angiogenesis in elastin-like recombinamer (ELR) hydrogels
published pages: , ISSN: 0957-4530, DOI: 10.1007/s10856-019-6232-z
Journal of Materials Science: Materials in Medicine 30/2 2020-03-05
2018 Tatjana Flora, I. González de Torre, Luis Quintanilla, M. Alonso, J. Carlos Rodríguez-Cabello
Spatial control and cell adhesion selectivity on model gold surfaces grafted with elastin-like recombinamers
published pages: 19-29, ISSN: 0014-3057, DOI: 10.1016/j.eurpolymj.2018.06.026
European Polymer Journal 106 2020-03-05
2018 Hai Zemmour, David Planer, Judith Magenheim, Joshua Moss, Daniel Neiman, Dan Gilon, Amit Korach, Benjamin Glaser, Ruth Shemer, Giora Landesberg, Yuval Dor
Non-invasive detection of human cardiomyocyte death using methylation patterns of circulating DNA
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03961-y
Nature Communications 9/1 2020-03-05
2019 Filippo Cipriani, Dominik Bernhagen, Carmen García-Arévalo, Israel González de Torre, Peter Timmerman, José Carlos Rodríguez-Cabello
Bicyclic RGD peptides with high integrin α v β 3 and α 5 β 1 affinity promote cell adhesion on elastin-like recombinamers
published pages: 35009, ISSN: 1748-605X, DOI: 10.1088/1748-605x/aafd83
Biomedical Materials 14/3 2020-03-05
2018 Mercedes Santos, Sofia Serrano-Ducar, Juan Gonzalez-Valdivieso, Reinaldo Vallejo, Alessandra Girotti, Purificacion Cuadrado, Francisco Javier Arias
Genetically Engineered Elastin-based Biomaterials for Biomedical Applications
published pages: 1-28, ISSN: 0929-8673, DOI: 10.2174/0929867325666180508094637
Current Medicinal Chemistry 25 2020-03-05
2017 Javad Hatami, Sandra Silva, Mariana Oliveira, Rui Costa, Rui Reis, João Mano
Multilayered Films Produced by Layer-by-Layer Assembly of Chitosan and Alginate as a Potential Platform for the Formation of Human Adipose-Derived Stem Cell aggregates
published pages: 440, ISSN: 2073-4360, DOI: 10.3390/polym9090440
Polymers 9/12 2020-03-05
2016 Mercedes Vila, Ana García, Alessandra Girotti, Matilde Alonso, Jose Carlos Rodríguez-Cabello, Arlyng González-Vázquez, Josep A. Planell, Elisabeth Engel, Julia Buján, Natalio García-Honduvilla, María Vallet-Regí
3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicine
published pages: 349-356, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2016.09.016
Acta Biomaterialia 45 2020-03-05
2019 Constancio Gonzalez-Obeso, Alessandra Girotti, J. Carlos Rodriguez-Cabello
A transferrin receptor-binding mucoadhesive elastin-like recombinamer: In vitro and in vivo characterization
published pages: 241-250, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2019.02.027
Acta Biomaterialia 88 2020-03-05
2015 Karla E. Inostroza-Brito, Estelle Collin, Orit Siton-Mendelson, Katherine H. Smith, Amàlia Monge-Marcet, Daniela S. Ferreira, Raúl Pérez Rodríguez, Matilde Alonso, José Carlos Rodríguez-Cabello, Rui L. Reis, Francesc Sagués, Lorenzo Botto, Ronit Bitton, Helena S. Azevedo, Alvaro Mata
Co-assembly, spatiotemporal control and morphogenesis of a hybrid protein–peptide system
published pages: 897-904, ISSN: 1755-4330, DOI: 10.1038/nchem.2349
Nature Chemistry 7/11 2020-03-05
2018 Israel González de Torre, Arturo Ibáñez-Fonseca, Luis Quintanilla, Matilde Alonso, José-Carlos Rodríguez-Cabello
Random and oriented electrospun fibers based on a multicomponent, in situ clickable elastin-like recombinamer system for dermal tissue engineering
published pages: 137-149, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.03.027
Acta Biomaterialia 72 2020-03-05
2017 Yuping Li, Jose Carlos Rodriguez-Cabello, Conrado Aparicio
Intrafibrillar Mineralization of Self-Assembled Elastin-Like Recombinamer Fibrils
published pages: 5838-5846, ISSN: 1944-8244, DOI: 10.1021/acsami.6b15285
ACS Applied Materials & Interfaces 9/7 2020-03-05
2017 Jeevan Govindharajulu, Xi Chen, Yuping Li, Jose Rodriguez-Cabello, Mrinal Battacharya, Conrado Aparicio
Chitosan-Recombinamer Layer-by-Layer Coatings for Multifunctional Implants
published pages: 369, ISSN: 1422-0067, DOI: 10.3390/ijms18020369
International Journal of Molecular Sciences 18/2 2020-03-05
2017 Sebastian Manuel Staubli, Giulia Cerino, Israel Gonzalez De Torre, Matilde Alonso, Daniel Oertli, Friedrich Eckstein, Katharina Glatz, José Carlos Rodríguez Cabello, Anna Marsano
Control of angiogenesis and host response by modulating the cell adhesion properties of an Elastin-Like Recombinamer-based hydrogel
published pages: 30-41, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2017.04.047
Biomaterials 135 2020-03-05
2018 J. Carlos Rodríguez-Cabello, I. González de Torre, A. Ibañez-Fonseca, M. Alonso
Bioactive scaffolds based on elastin-like materials for wound healing
published pages: 118-133, ISSN: 0169-409X, DOI: 10.1016/j.addr.2018.03.003
Advanced Drug Delivery Reviews 129 2020-03-05
2017 David Pescador, Arturo Ibáñez-Fonseca, Fermín Sánchez-Guijo, Jesús G. Briñón, Francisco Javier Arias, Sandra Muntión, Cristina Hernández, Alessandra Girotti, Matilde Alonso, María Consuelo del Cañizo, José Carlos Rodríguez-Cabello, Juan Francisco Blanco
Regeneration of hyaline cartilage promoted by xenogeneic mesenchymal stromal cells embedded within elastin-like recombinamer-based bioactive hydrogels
published pages: 115, ISSN: 0957-4530, DOI: 10.1007/s10856-017-5928-1
Journal of Materials Science: Materials in Medicine 28/8 2020-03-05
2017 Esen Sayin, Rosti Hama Rashid, José Carlos Rodríguez-Cabello, Ahmed Elsheikh, Erkan Türker Baran, Vasif Hasirci
Human adipose derived stem cells are superior to human osteoblasts (HOB) in bone tissue engineering on a collagen-fibroin-ELR blend
published pages: 71-81, ISSN: 2452-199X, DOI: 10.1016/j.bioactmat.2017.04.001
Bioactive Materials 2/2 2020-03-05
2018 Boris L. Gala-Lopez, Daniel Neiman, Tatsuya Kin, Doug O’Gorman, Andrew R. Pepper, Andrew J. Malcolm, Sheina Pianzin, Peter A. Senior, Patricia Campbell, Benjamin Glaser, Yuval Dor, Ruth Shemer, A.M. James Shapiro
Beta Cell Death by Cell-free DNA and Outcome After Clinical Islet Transplantation
published pages: 978-985, ISSN: 0041-1337, DOI: 10.1097/TP.0000000000002083
Transplantation 102/6 2020-03-05
2017 Karla E. Inostroza-Brito, Estelle C. Collin, Anna Majkowska, Sherif Elsharkawy, Alistair Rice, Armando E. del Río Hernández, Xin Xiao, José Rodríguez-Cabello, Alvaro Mata
Cross-linking of a biopolymer-peptide co-assembling system
published pages: 80-89, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.05.043
Acta Biomaterialia 58 2020-03-05
2018 Rui R. Costa, Miguel González-Pérez, Marcos Herrero-Gutiérrez, Ricardo A. Pires, Matilde Alonso, J. Carlos Rodriguez-Cabello, Rui L. Reis, Iva Pashkuleva
Tuning the stiffness of surfaces by assembling genetically engineered polypeptides with tailored amino acid sequence
published pages: , ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b00723
Biomacromolecules 2020-03-05
2017 Maria P. Sousa, Israel Gonzalez de Torre, Mariana B. Oliveira, José C. Rodríguez-Cabello, João F. Mano
Biomimetic click assembled multilayer coatings exhibiting responsive properties
published pages: 150-163, ISSN: 2468-5194, DOI: 10.1016/j.mtchem.2017.04.001
Materials Today Chemistry 4 2020-03-05
2018 Sherif Elsharkawy, Maisoon Al-Jawad, Maria F. Pantano, Esther Tejeda-Montes, Khushbu Mehta, Hasan Jamal, Shweta Agarwal, Kseniya Shuturminska, Alistair Rice, Nadezda V. Tarakina, Rory M. Wilson, Andy J. Bushby, Matilde Alonso, Jose C. Rodriguez-Cabello, Ettore Barbieri, Armando del Río Hernández, Molly M. Stevens, Nicola M. Pugno, Paul Anderson, Alvaro Mata
Protein disorder–order interplay to guide the growth of hierarchical mineralized structures
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04319-0
Nature Communications 9/1 2020-03-05
2018 Arturo Ibáñez-Fonseca, Teresa L. Ramos, Israel González de Torre, Luis Ignacio Sánchez-Abarca, Sandra Muntión, Francisco Javier Arias, María Consuelo del Cañizo, Matilde Alonso, Fermín Sánchez-Guijo, José Carlos Rodríguez-Cabello
Biocompatibility of two model elastin-like recombinamer-based hydrogels formed through physical or chemical cross-linking for various applications in tissue engineering and regenerative medicine
published pages: e1450-e1460, ISSN: 1932-6254, DOI: 10.1002/term.2562
Journal of Tissue Engineering and Regenerative Medicine 12/3 2020-03-05
2018 Alicia Fernández-Colino, Frederic Wolf, Hans Keijdener, Stephan Rütten, Thomas Schmitz-Rode, Stefan Jockenhoevel, J. Carlos Rodríguez-Cabello, Petra Mela
Macroporous click-elastin-like hydrogels for tissue engineering applications
published pages: 140-147, ISSN: 0928-4931, DOI: 10.1016/j.msec.2018.03.013
Materials Science and Engineering: C 88 2020-03-05
2018 Ayse Selcen Alagoz, Jose Carlos Rodriguez-Cabello, Vasif Hasirci
PHBV wet spun scaffold coated with ELR-REDV improves vascularization for bone tissue engineering
published pages: , ISSN: 1748-6041, DOI: 10.1088/1748-605X/aad139
Biomedical Materials 2020-03-05
2016 Erik Korsgren, Olle Korsgren
Glucose Effectiveness
published pages: 111-115, ISSN: 0041-1337, DOI: 10.1097/TP.0000000000000900
Transplantation 100/1 2020-03-05
2017 Mohamed Hamed Misbah, Mercedes Santos, Luis Quintanilla, Christina Günter, Matilde Alonso, Andreas Taubert, José Carlos Rodríguez-Cabello
Recombinant DNA technology and click chemistry: a powerful combination for generating a hybrid elastin-like-statherin hydrogel to control calcium phosphate mineralization
published pages: 772-783, ISSN: 2190-4286, DOI: 10.3762/bjnano.8.80
Beilstein Journal of Nanotechnology 8 2020-03-05
2018 Per-Ola Carlsson, Daniel Espes, Amir Sedigh, Avi Rotem, Baruch Zimerman, Helena Grinberg, Tali Goldman, Uriel Barkai, Yuval Avni, Gunilla T. Westermark, Lina Carlbom, Håkan Ahlström, Olof Eriksson, Johan Olerud, Olle Korsgren
Transplantation of macroencapsulated human islets within the bioartificial pancreas βAir to patients with type 1 diabetes mellitus
published pages: 1735-1744, ISSN: 1600-6135, DOI: 10.1111/ajt.14642
American Journal of Transplantation 18/7 2020-03-05
2017 Arturo Ibáñez-Fonseca, Matilde Alonso, Francisco Javier Arias, José Carlos Rodríguez-Cabello
Förster Resonance Energy Transfer-Paired Hydrogel Forming Silk-Elastin-Like Recombinamers by Recombinant Conjugation of Fluorescent Proteins
published pages: 828-835, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.6b00738
Bioconjugate Chemistry 28/3 2020-03-05
2017 Olle Korsgren
Islet Encapsulation: Physiological Possibilities and Limitations
published pages: 1748-1754, ISSN: 0012-1797, DOI: 10.2337/db17-0065
Diabetes 66/7 2020-03-05
2017 Andrea Grosso, Maximilian G. Burger, Alexander Lunger, Dirk J. Schaefer, Andrea Banfi, Nunzia Di Maggio
It Takes Two to Tango: Coupling of Angiogenesis and Osteogenesis for Bone Regeneration
published pages: 68, ISSN: 2296-4185, DOI: 10.3389/fbioe.2017.00068
Frontiers in Bioengineering and Biotechnology 5 2020-03-05

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