Explore the words cloud of the EVOLHGT project. It provides you a very rough idea of what is the project "EVOLHGT" about.
The following table provides information about the project.
THE UNIVERSITY OF LIVERPOOL
|Coordinator Country||United Kingdom [UK]|
|Total cost||1˙820˙865 €|
|EC max contribution||1˙820˙865 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-06-01 to 2020-05-31|
Take a look of project's partnership.
|1||THE UNIVERSITY OF LIVERPOOL||UK (LIVERPOOL)||coordinator||1˙515˙740.00|
|2||INSTITUTE OF SCIENCE AND TECHNOLOGYAUSTRIA||AT (KLOSTERNEUBURG)||participant||305˙124.00|
Horizontal gene transfer (HGT) is a form of genic inheritance that occurs between individuals in a population or between species rather than from parent to offspring. HGT is most prevalent in bacteria, where it is an important source of novel metabolic pathways, pathogenicity factors, and antibiotic resistance.
In spite of the importance of HGT, we understand little about the evolutionary barriers to HGT. This proposal will outline a systematic experimental approach to elucidate factors that select for or against horizontally transferred genes, by pursuing three objectives. The first is to quantify intrinsic selection acting on newly transferred genes, by experimentally transferring and expressing several hundred genes across species boundaries. We will be able to systematically classify genes as resistant or permissive to transfer, examine the effect of the function and position in metabolic and regulatory networks on resistance to transfer, as well as identify any genes with substantial intrinsic benefits. The second objective is to examine the effect of evolutionary divergence on HGT, by determining whether genes from closely related species are more permissive to transfer than those from more divergent species. The final objective is to determine the role of the environment in shaping these selective effects. Understanding how robust the selective effects are to different environmental conditions will aid in evaluating the relative roles of genetics and the environment as factors in the evolutionary outcomes of HGT . Overall, this work will provide a systematic analysis of the roles of different factors in affecting the outcomes of horizontal gene transfer. Understanding this process in a quantitative fashion is critical to understanding bacterial adaptation and diversity.
|year||authors and title||journal||last update|
Rodrigo A. F. Redondo, Harold P. de Vladar, Tomasz WÅ‚odarski, Jonathan P. Bollback
Evolutionary interplay between structure, energy and epistasis in the coat protein of the Ï•X 174 phage family
published pages: 20160139, ISSN: 1742-5689, DOI: 10.1098/rsif.2016.0139
|Journal of The Royal Society Interface 14/126||2019-06-06|
Mato Lagator, Srdjan Sarikas, Hande Acar, Jonathan P Bollback, CÄƒlin C Guet
Regulatory network structure determines patterns of intermolecular epistasis
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.28921
Mato Lagator, Tiago PaixÃ£o, Nicholas H Barton, Jonathan P Bollback, CÄƒlin C Guet
On the mechanistic nature of epistasis in a canonical cis-regulatory element
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.25192
Pavel Payne, Lukas Geyrhofer, Nicholas H Barton, Jonathan P Bollback
CRISPR-based herd immunity can limit phage epidemics in bacterial populations
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.32035
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