Opendata, web and dolomites

EVOLHGT SIGNED

Selective Barriers to Horizontal Gene Transfer

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "EVOLHGT" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF LIVERPOOL 

Organization address
address: BROWNLOW HILL 765 FOUNDATION BUILDING
city: LIVERPOOL
postcode: L69 7ZX
website: www.liverpool.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.evolutioninaction.net/funding
 Total cost 1˙820˙865 €
 EC max contribution 1˙820˙865 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) coordinator 1˙515˙740.00
2    INSTITUTE OF SCIENCE AND TECHNOLOGYAUSTRIA AT (KLOSTERNEUBURG) participant 305˙124.00

Map

 Project objective

Horizontal gene transfer (HGT) is a form of genic inheritance that occurs between individuals in a population or between species rather than from parent to offspring. HGT is most prevalent in bacteria, where it is an important source of novel metabolic pathways, pathogenicity factors, and antibiotic resistance.

In spite of the importance of HGT, we understand little about the evolutionary barriers to HGT. This proposal will outline a systematic experimental approach to elucidate factors that select for or against horizontally transferred genes, by pursuing three objectives. The first is to quantify intrinsic selection acting on newly transferred genes, by experimentally transferring and expressing several hundred genes across species boundaries. We will be able to systematically classify genes as resistant or permissive to transfer, examine the effect of the function and position in metabolic and regulatory networks on resistance to transfer, as well as identify any genes with substantial intrinsic benefits. The second objective is to examine the effect of evolutionary divergence on HGT, by determining whether genes from closely related species are more permissive to transfer than those from more divergent species. The final objective is to determine the role of the environment in shaping these selective effects. Understanding how robust the selective effects are to different environmental conditions will aid in evaluating the relative roles of genetics and the environment as factors in the evolutionary outcomes of HGT . Overall, this work will provide a systematic analysis of the roles of different factors in affecting the outcomes of horizontal gene transfer. Understanding this process in a quantitative fashion is critical to understanding bacterial adaptation and diversity.

 Publications

year authors and title journal last update
List of publications.
2017 Rodrigo A. F. Redondo, Harold P. de Vladar, Tomasz WÅ‚odarski, Jonathan P. Bollback
Evolutionary interplay between structure, energy and epistasis in the coat protein of the Ï•X 174 phage family
published pages: 20160139, ISSN: 1742-5689, DOI: 10.1098/rsif.2016.0139
Journal of The Royal Society Interface 14/126 2019-06-06
2017 Mato Lagator, Srdjan Sarikas, Hande Acar, Jonathan P Bollback, Călin C Guet
Regulatory network structure determines patterns of intermolecular epistasis
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.28921
eLife 6 2019-06-06
2017 Mato Lagator, Tiago Paixão, Nicholas H Barton, Jonathan P Bollback, Călin C Guet
On the mechanistic nature of epistasis in a canonical cis-regulatory element
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.25192
eLife 6 2019-06-06
2018 Pavel Payne, Lukas Geyrhofer, Nicholas H Barton, Jonathan P Bollback
CRISPR-based herd immunity can limit phage epidemics in bacterial populations
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.32035
eLife 7 2019-06-06

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EVOLHGT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EVOLHGT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

PROGRESS (2019)

The Enemy of the Good: Towards a Theory of Moral Progress

Read More  

DISINTEGRATION (2019)

The Mass Politics of Disintegration

Read More  

HOLI (2019)

Deep Learning for Holistic Inference

Read More