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Bioactive AdrenoMedullin is a Novel Outstanding Marker to Predict and Prevent Septic Shock

Total Cost €


EC-Contrib. €






 PreventSepticShock project word cloud

Explore the words cloud of the PreventSepticShock project. It provides you a very rough idea of what is the project "PreventSepticShock" about.

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Project "PreventSepticShock" data sheet

The following table provides information about the project.


Organization address
postcode: 16556
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 2˙137˙500 €
 EC max contribution 2˙137˙500 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SMEINST-2-2014
 Funding Scheme SME-2
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SPHINGOTEC GMBH DE (HOHEN NEUENDORF) coordinator 2˙137˙500.00


 Project objective

Sepsis is a life-threatening condition that arises when the body's response to an infection damages its own tissues and organs. Although sepsis is initiated by infection, it is not the infection per se, which kills the patient, but rather the body’s response to it, in particular, the development of a shock, which is initiated by deterioration of the blood vessel system, hypotension, insufficient oxygenation of organs and finally their functional breakdown. For a clinician this situation occurs suddenly and there is no diagnostic tool to predict this event early enough to initiate adequate measures to guide the patient and prevent its death. Despite of large efforts and developments in the last decade septic shock is still the world biggest killer causing 5-6 million deaths a year worldwide. Thus the prediction of septic shock and stratification of high risk patients is still an unmet medical need. The novel bioreactive Adrenomedullin (bio-ADM) assay of Sphingotec is the first unprecedented analytical assay which stratified in a pilot study sepsis patients who have the risk to die from a septic shock with very high confidentiality. Thus adequate measures to restore blood pressure can be introduced in time and life can be saved. Feasibility studies elucidating all clinical and commercialisation aspects have given excellent prospects for bio-ADM. Thus, in the project the bio-ADM assay will be used in an observation study with 1000 ICU patients suffering from sepsis to validate the power of the novel biomarker and to indicate a cut-off for bio-ADM. Furthermore, the project is dedicated to conduct technical work to bring the marker to automation and point of care platforms of diagnostic partners to guarantee broad application after the project, and to carry out measures to disseminate and explore the project results to ensure quick penetration of an up to 500 million € diagnostic market. In this way the project will initiate dynamic and robust growth of the applicant.


List of deliverables.
Ethical documents Documents, reports 2019-07-25 12:58:35
CE labelling Other 2019-07-25 12:58:35
PreventSepticShock marketing website Websites, patent fillings, videos etc. 2019-07-25 12:58:34
Presentation of PreventSepticShock Documents, reports 2019-07-25 12:58:35
Scientific dissemination material Documents, reports 2019-07-25 12:58:35

Take a look to the deliverables list in detail:  detailed list of PreventSepticShock deliverables.


year authors and title journal last update
List of publications.
2016 Rudovich N1, Pivovarova O, Bernigau W, Sparwasser A, Tacke C, Murahovshi V, Mertes G, Birkenfeld AL, Bergmann A, Weickert MO, Pfeiffer AF.
Modulation of circulating vasoactive peptides and extracellular matrix proteins are two novel mechanisms in the cardioprotective action of acarbose.
published pages: , ISSN: , DOI:
Minerva Endocrinol. 2016 Dec;41(4):456-68. Epub 2016 Mar 23. 2019-07-25
2017 Mattia Arrigo, Quynh A. Truong, Jackie Szymonifka, Mercedes Rivas-Lasarte, Heli Tolppanen, Malha Sadoune, Etienne Gayat, Alain Cohen-Solal, Frank Ruschitzka, James L. Januzzi, Jagmeet P. Singh, Alexandre Mebazaa
Mid-regional pro-atrial natriuretic peptide to predict clinical course in heart failure patients undergoing cardiac resynchronization therapy
published pages: , ISSN: 1099-5129, DOI: 10.1093/europace/euw305
EP Europace 2019-07-25
2017 Heli Tolppanen, Mercedes Rivas-Lasarte, Johan Lassus, Jordi Sans-Roselló, Oliver Hartmann, Matias Lindholm, Mattia Arrigo, Tuukka Tarvasmäki, Lars Köber, Holger Thiele, Kari Pulkki, Jindrich Spinar, John Parissis, Marek Banaszewski, Jose Silva-Cardoso, Valentina Carubelli, Alessandro Sionis, Veli-Pekka Harjola, Alexandre Mebazaa
Adrenomedullin: a marker of impaired hemodynamics, organ dysfunction, and poor prognosis in cardiogenic shock
published pages: , ISSN: 2110-5820, DOI: 10.1186/s13613-016-0229-2
Annals of Intensive Care 7/1 2019-07-25
2017 Tim-Philipp Simon, Lukas Martin, Sabine Doemming, Andreas Humbs, Christian Bruells, Ruedger Kopp, Oliver Hartmann, Joachim Struck, Andreas Bergmann, Gernot Marx, Tobias Schuerholz
Plasma adrenomedullin in critically ill patients with sepsis after major surgery: A pilot study
published pages: 68-72, ISSN: 0883-9441, DOI: 10.1016/j.jcrc.2016.10.017
Journal of Critical Care 38 2019-07-25
2015 Matthew F. Yuyun, Hafid K. Narayan, Leong L. Ng
Prognostic Significance of Adrenomedullin in Patients With Heart Failure and With Myocardial Infarction
published pages: 986-991, ISSN: 0002-9149, DOI: 10.1016/j.amjcard.2015.01.027
The American Journal of Cardiology 115/7 2019-07-25
2015 Abraham Schoe, Emile F. Schippers, Joachim Struck, Stefan Ebmeyer, Robert J.M. Klautz, Evert de Jonge, Jaap T. van Dissel
Postoperative Pro-Adrenomedullin Levels Predict Mortality in Thoracic Surgery Patients
published pages: 373-381, ISSN: 0090-3493, DOI: 10.1097/CCM.0000000000000709
Critical Care Medicine 43/2 2019-07-25
2017 Pietro Caironi, Roberto Latini, Joachim Struck, Oliver Hartmann, Andreas Bergmann, Giuseppe Maggio, Marco Cavana, Gianni Tognoni, Antonio Pesenti, Luciano Gattinoni, Serge Masson
Circulating biologically active adrenomedullin (bio-ADM) predicts hemodynamic support requirement and mortality during sepsis
published pages: , ISSN: 0012-3692, DOI: 10.1016/j.chest.2017.03.035
Chest 2019-07-25
2016 Wesley H. Self, Alan B. Storrow, Oliver Hartmann, Tyler W. Barrett, Gregory J. Fermann, Alan S. Maisel, Joachim Struck, Andreas Bergmann, Sean P. Collins
Plasma bioactive adrenomedullin as a prognostic biomarker in acute heart failure
published pages: 257-262, ISSN: 0735-6757, DOI: 10.1016/j.ajem.2015.10.033
The American Journal of Emergency Medicine 34/2 2019-07-25
2017 Matthew F. Yuyun, Hafid K. Narayan, Paulene A. Quinn, Joachim Struck, Andreas Bergmann, Oliver Hartmann, Leong L. Ng
Prognostic value of human mature adrenomedullin in patients with acute myocardial infarction
published pages: 42-50, ISSN: 1558-2027, DOI: 10.2459/JCM.0000000000000299
Journal of Cardiovascular Medicine 18/1 2019-07-25
2016 Chris Berrie
Adrenomedullin Plasma Levels Predictive of Mortality in Intensive Care Unit: Presented at ISICEM
published pages: , ISSN: , DOI:

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