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CARDYADS SIGNED

Controlling Cardiomyocyte Dyadic Structure

Total Cost €

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EC-Contrib. €

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Partnership

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 CARDYADS project word cloud

Explore the words cloud of the CARDYADS project. It provides you a very rough idea of what is the project "CARDYADS" about.

em    serca    hearts    experimentally    membrane    surface    patients    clem    myocytes    throughput    models    heart    cell    disease    transgenic    healthy    arrangement    release    sodium    stretch    anticipated    structure    imaging    altering    myocyte    group    dependent    function    adult    integrity    dyads    mathematical    precise    contraction    explanted    ventricular    maintenance    unprecedented    therapeutic    labels    break    triggers    manipulated    critically    sarcoplasmic    failing    dimensional    wall    yield    gene    left    ryanodine    gradually    determined    tissue    proteins    tested    invaginations    formed    receptor    genes    tomography    nature    unclear    responsible    employing    controllers    examine    reverse    normal    sequencing    exchanger    homeostasis    animals    cytosol    mice    tubules    reticulum    functional    candidate    signals    fluorescent    channel    disruption    human    modeling    relaxation    junctions    adulthood    removal    efficient    calcium    dyadic    accomplished    cardiac    palm    performing    stress    regulation    model   

Project "CARDYADS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITETET I OSLO 

Organization address
address: PROBLEMVEIEN 5-7
city: OSLO
postcode: 313
website: www.uio.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITETET I OSLO NO (OSLO) coordinator 2˙000˙000.00

Map

 Project objective

Contraction and relaxation of cardiac myocytes, and thus the whole heart, are critically dependent on dyads. These functional junctions between t-tubules, which are invaginations of the surface membrane, and the sarcoplasmic reticulum allow efficient control of calcium release into the cytosol, and also its removal. Dyads are formed gradually during development and break down during disease. However, the precise nature of dyadic structure is unclear, even in healthy adult cardiac myocytes, as are the triggers and consequences of altering dyadic integrity. In this proposal, my group will investigate the precise 3-dimensional arrangement of dyads and their proteins during development, adulthood, and heart failure by employing CLEM imaging (PALM and EM tomography). This will be accomplished by developing transgenic mice with fluorescent labels on four dyadic proteins (L-type calcium channel, ryanodine receptor, sodium-calcium exchanger, SERCA), and by imaging tissue from explanted normal and failing human hearts. The signals responsible for controlling dyadic formation, maintenance, and disruption will be determined by performing high-throughput sequencing to identify novel genes involved with these processes in several established model systems. Particular focus will be given to investigating left ventricular wall stress and stretch-dependent gene regulation as controllers of dyadic integrity. Candidate genes will be manipulated in cell models and transgenic animals to promote dyadic formation and maintenance, and reverse dyadic disruption in heart failure. The consequences of dyadic structure for function will be tested experimentally and with mathematical modeling to examine effects on cardiac myocyte calcium homeostasis and whole-heart function. The results of this project are anticipated to yield unprecedented insight into dyadic structure, regulation, and function, and to identify novel therapeutic targets for heart disease patients.

 Publications

year authors and title journal last update
List of publications.
2019 D. B. Lipsett, M. Frisk, J. M. Aronsen, E. S. Nordén, O. R. Buonarati, A. Cataliotti, J. W. Hell, I. Sjaastad, G. Christensen, W. E. Louch
Cardiomyocyte substructure reverts to an immature phenotype during heart failure
published pages: 1833-1853, ISSN: 0022-3751, DOI: 10.1113/jp277273
The Journal of Physiology 597/7 2020-03-05
2018 Kylie S. Foo, Miia L. Lehtinen, Chuen Yan Leung, Xiaojun Lian, Jiejia Xu, Wendy Keung, Lin Geng, Terje R.S. Kolstad, Sebastian Thams, Andy On-tik Wong, Nicodemus Wong, Kristine Bylund, Chikai Zhou, Xiaobing He, Shao-Bo Jin, Jonathan Clarke, Urban Lendahl, Ronald A. Li, William E. Louch, Kenneth R. Chien
Human ISL1 + Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction
published pages: 1644-1659, ISSN: 1525-0016, DOI: 10.1016/j.ymthe.2018.02.012
Molecular Therapy 26/7 2020-03-05
2019 William E. Louch
Channel surfing: new insights into plasticity of excitation‐contraction coupling
published pages: 2119-2120, ISSN: 0022-3751, DOI: 10.1113/jp277783
The Journal of Physiology 597/8 2020-03-05
2018 Xin Shen, Jonas den Brink, Yufeng Hou, Dylan Colli, Christopher Le, Terje R. Kolstad, Niall MacQuaide, Cathrine R. Carlson, Peter M. Kekenes‐Huskey, Andrew G. Edwards, Christian Soeller, William E. Louch
3D dSTORM imaging reveals novel detail of ryanodine receptor localization in rat cardiac myocytes
published pages: 399-418, ISSN: 0022-3751, DOI: 10.1113/JP277360
The Journal of Physiology 597/2 2020-03-05
2018 Åsmund T Røe, Marianne Ruud, Emil K Espe, Ornella Manfra, Stefano Longobardi, Jan M Aronsen, Einar Sjaastad Nordén, Trygve Husebye, Terje R S Kolstad, Alessandro Cataliotti, Geir Christensen, Ole M Sejersted, Steven A Niederer, Geir Øystein Andersen, Ivar Sjaastad, William E Louch
Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression
published pages: 752-764, ISSN: 0008-6363, DOI: 10.1093/cvr/cvy257
Cardiovascular Research 115/4 2020-03-05
2019 Anett H. Ottesen, Cathrine R. Carlson, Olav Søvik Eken, Mani Sadredini, Peder L. Myhre, Xin Shen, Bjørn Dalhus, Derek R. Laver, Per Kristian Lunde, Jouni Kurola, Marianne Lunde, Jon Erik Hoff, Kristin Godang, Ivar Sjaastad, Ville Pettilä, Mats Stridsberg, Stephan E. Lehnart, Andrew G. Edwards, Ida G. Lunde, Torbjørn Omland, Mathis K. Stokke, Geir Christensen, Helge Røsjø, William E. Louch
Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca 2+ -Dependent Arrhythmia
published pages: , ISSN: 1941-3149, DOI: 10.1161/CIRCEP.118.007045
Circulation: Arrhythmia and Electrophysiology 12/4 2020-03-05
2019 Martin Laasmaa, Pengfei Lu, Mladen Veletić, William E. Louch, Jacob Bergsland, Ilangko Balasingham, Marko Vendelin
Energy-efficiency of Cardiomyocyte Stimulation with Rectangular Pulses
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-49791-w
Scientific Reports 9/1 2020-03-05
2018 Peter P. Jones, Niall MacQuaide, William E. Louch
Dyadic Plasticity in Cardiomyocytes
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.01773
Frontiers in Physiology 9 2020-03-05
2018 Terje R Kolstad, Jonas van den Brink, Niall MacQuaide, Per Kristian Lunde, Michael Frisk, Jan Magnus Aronsen, Einar S Norden, Alessandro Cataliotti, Ivar Sjaastad, Ole M Sejersted, Andrew G Edwards, Glenn Terje Lines, William E Louch
Ryanodine receptor dispersion disrupts Ca2+ release in failing cardiac myocytes
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.39427
eLife 7 2020-03-05
2017 Ornella Manfra, Michael Frisk, William E. Louch
Regulation of Cardiomyocyte T-Tubular Structure: Opportunities for Therapy
published pages: 167-178, ISSN: 1546-9530, DOI: 10.1007/s11897-017-0329-9
Current Heart Failure Reports 14/3 2019-06-06
2017 Mary M Maleckar, Andrew G Edwards, William E Louch, Glenn T Lines
Studying dyadic structure–function relationships: a review of current modeling approaches and new insights into Ca 2+ (mis)handling
published pages: 117954681769860, ISSN: 1179-5468, DOI: 10.1177/1179546817698602
Clinical Medicine Insights: Cardiology 11 2019-06-06
2017 Shan S. Parikh, Daniel J. Blackwell, Nieves Gomez-Hurtado, Michael Frisk, Lili Wang, Kyungsoo Kim, Christen P. Dahl, Arnt Fiane, Theis Tønnessen, Dmytro O. Kryshtal, William E. Louch, Bjorn C. Knollmann
Thyroid and Glucocorticoid Hormones Promote Functional T-Tubule Development in Human-Induced Pluripotent Stem Cell–Derived CardiomyocytesNovelty and Significance
published pages: 1323-1330, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.117.311920
Circulation Research 121/12 2019-06-06
2017 Åsmund T. Røe, Jan Magnus Aronsen, Kristine Skårdal, Nazha Hamdani, Wolfgang A. Linke, Håvard E. Danielsen, Ole M. Sejersted, Ivar Sjaastad, William E. Louch
Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy
published pages: 1161-1172, ISSN: 0008-6363, DOI: 10.1093/cvr/cvx087
Cardiovascular Research 113/10 2019-06-06
2016 Michael Frisk, Marianne Ruud, Emil K. S. Espe, Jan Magnus Aronsen, Åsmund T. Røe, Lili Zhang, Per Andreas Norseng, Ole M. Sejersted, Geir A. Christensen, Ivar Sjaastad, William E. Louch
Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis
published pages: 443-451, ISSN: 0008-6363, DOI: 10.1093/cvr/cvw111
Cardiovascular Research 112/1 2019-06-06
2017 William E. Louch, Stanley Nattel
T-tubular collagen: a new player in mechanosensing and disease?
published pages: 839-840, ISSN: 0008-6363, DOI: 10.1093/cvr/cvx091
Cardiovascular Research 113/8 2019-06-06
2017 Sara Gattoni, Åsmund Treu Røe, Jan Magnus Aronsen, Ivar Sjaastad, William E. Louch, Nicolas P. Smith, Steven A. Niederer
Compensatory and decompensatory alterations in cardiomyocyte Ca 2+ dynamics in hearts with diastolic dysfunction following aortic banding
published pages: 3867-3889, ISSN: 0022-3751, DOI: 10.1113/JP273879
The Journal of Physiology 595/12 2019-06-06
2017 Andrew G Edwards, William E Louch
Species-Dependent Mechanisms of Cardiac Arrhythmia: A Cellular Focus
published pages: 117954681668606, ISSN: 1179-5468, DOI: 10.1177/1179546816686061
Clinical Medicine Insights: Cardiology 11 2019-06-06

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