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Nicotine actions on beta cell function in health and disease

Total Cost €


EC-Contrib. €






 NACHO project word cloud

Explore the words cloud of the NACHO project. It provides you a very rough idea of what is the project "NACHO" about.

nicotinic    lacking    considerable    mechanisms    therapy    model    stable    gene    personalized    chrnb2    metabolically    wt    suggests    secretion    proliferation    signaling    cessation    human    crispr    risk    h2    nicotine    healthy    medicine    humans    cells    tolerance    elevates    impairs    nachrs    diabetes    precise    receptors    modulate    critical    host    cas9    exposure    laboratory    acutely    attributed    t2d    acetylcholine    extended    determined    influences    clones    desensitization    calcium    animals    tobacco    aid    nacho    mice    obese    islets    plasma    nachr    molecular    dysfunction    alleles    mafa    insulin    cell    accumulating    activates    diet    glucose    diabetic    addictive    chewing    compound    membrane    activation    function    ex    vivo    mutant    exocytosis    expression    influx    smoking    endoc    effect    beta    modulates    cigarettes    compromised    sodium    immunohistochemistry    adaptability    clinical    receptor    generating    abuse   

Project "NACHO" data sheet

The following table provides information about the project.


Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 185˙857.00


 Project objective

Tobacco abuse elevates the risk of developing type 2 diabetes (T2D). This effect is attributed to nicotine, the major addictive compound in cigarettes and chewing tobacco. Nicotine acutely activates nicotinic receptors (nAchRs) while extended exposure results in receptor desensitization. Accumulating evidence suggests that long-term exposure to nicotine impairs beta cell function. Recent results (host laboratory) demonstrate that nicotine acutely modulates insulin secretion and that reduced nAchR expression in beta cells results in an increased risk for developing T2D. This suggests that activation of nAchRs is critical for beta cell function. However, the precise mechanisms to modulate beta cell function upon long-term exposure to nicotine in healthy and metabolically compromised conditions, have not been determined yet.

NACHO will investigate the effects of nicotine on insulin secretion using MafA mutant animals (model for beta cell dysfunction lacking specific nAchRs (Chrnb2/4)) and human islets. Molecular mechanisms by which nicotine affect insulin secretion will be studied by generating stable clones (CRISPR/Cas9) of human beta cells (EndoC-βH2) lacking CHRNB2/4 and evaluating cell signaling responses (calcium/sodium influx, exocytosis, plasma membrane potential) to nicotine/acetylcholine. The role of long-term nicotine exposure on beta cell adaptability will be assessed in diet-induced obese WT and MafA mutant mice treated with nicotine and evaluating beta cell function and proliferation in vivo (glucose tolerance) and ex vivo (insulin secretion and immunohistochemistry). The clinical impact of specific nAchR gene risk alleles and nicotinic signaling on insulin secretion will be evaluated in non-diabetic humans. Understanding how nicotine influences beta cell function in diabetes development is of considerable clinical interest since tobacco abuse is common and smoking cessation therapy is widely used. NACHO will aid to develop personalized medicine.

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The information about "NACHO" are provided by the European Opendata Portal: CORDIS opendata.

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