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NACHO SIGNED

Nicotine actions on beta cell function in health and disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NACHO project word cloud

Explore the words cloud of the NACHO project. It provides you a very rough idea of what is the project "NACHO" about.

desensitization    mafa    mutant    obese    critical    cells    laboratory    gene    sodium    activation    nachrs    acutely    stable    nicotinic    risk    human    membrane    precise    immunohistochemistry    host    tolerance    calcium    elevates    mice    clinical    expression    ex    diabetic    addictive    therapy    attributed    cigarettes    endoc    beta    function    effect    smoking    suggests    abuse    considerable    nicotine    molecular    aid    signaling    proliferation    diabetes    modulates    animals    impairs    glucose    h2    alleles    insulin    model    compromised    determined    metabolically    adaptability    accumulating    t2d    healthy    cell    influx    generating    influences    compound    cas9    wt    personalized    activates    modulate    humans    exocytosis    vivo    receptor    secretion    extended    plasma    islets    crispr    dysfunction    tobacco    receptors    nacho    cessation    chrnb2    diet    mechanisms    nachr    exposure    medicine    lacking    chewing    acetylcholine    clones   

Project "NACHO" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 185˙857.00

Map

 Project objective

Tobacco abuse elevates the risk of developing type 2 diabetes (T2D). This effect is attributed to nicotine, the major addictive compound in cigarettes and chewing tobacco. Nicotine acutely activates nicotinic receptors (nAchRs) while extended exposure results in receptor desensitization. Accumulating evidence suggests that long-term exposure to nicotine impairs beta cell function. Recent results (host laboratory) demonstrate that nicotine acutely modulates insulin secretion and that reduced nAchR expression in beta cells results in an increased risk for developing T2D. This suggests that activation of nAchRs is critical for beta cell function. However, the precise mechanisms to modulate beta cell function upon long-term exposure to nicotine in healthy and metabolically compromised conditions, have not been determined yet.

NACHO will investigate the effects of nicotine on insulin secretion using MafA mutant animals (model for beta cell dysfunction lacking specific nAchRs (Chrnb2/4)) and human islets. Molecular mechanisms by which nicotine affect insulin secretion will be studied by generating stable clones (CRISPR/Cas9) of human beta cells (EndoC-βH2) lacking CHRNB2/4 and evaluating cell signaling responses (calcium/sodium influx, exocytosis, plasma membrane potential) to nicotine/acetylcholine. The role of long-term nicotine exposure on beta cell adaptability will be assessed in diet-induced obese WT and MafA mutant mice treated with nicotine and evaluating beta cell function and proliferation in vivo (glucose tolerance) and ex vivo (insulin secretion and immunohistochemistry). The clinical impact of specific nAchR gene risk alleles and nicotinic signaling on insulin secretion will be evaluated in non-diabetic humans. Understanding how nicotine influences beta cell function in diabetes development is of considerable clinical interest since tobacco abuse is common and smoking cessation therapy is widely used. NACHO will aid to develop personalized medicine.

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The information about "NACHO" are provided by the European Opendata Portal: CORDIS opendata.

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