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NACHO SIGNED

Nicotine actions on beta cell function in health and disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 NACHO project word cloud

Explore the words cloud of the NACHO project. It provides you a very rough idea of what is the project "NACHO" about.

risk    tobacco    human    clinical    compromised    cell    personalized    activation    sodium    mechanisms    alleles    adaptability    signaling    laboratory    receptor    nicotine    cas9    lacking    cessation    insulin    nicotinic    cells    exocytosis    plasma    clones    considerable    stable    modulate    precise    vivo    elevates    aid    glucose    islets    determined    molecular    function    extended    nacho    desensitization    impairs    acetylcholine    nachr    diabetic    host    smoking    receptors    beta    ex    influences    proliferation    mutant    therapy    gene    wt    humans    chrnb2    diet    exposure    healthy    membrane    addictive    chewing    abuse    model    attributed    critical    mafa    h2    accumulating    obese    suggests    influx    animals    cigarettes    diabetes    generating    tolerance    endoc    nachrs    t2d    secretion    crispr    medicine    effect    compound    calcium    mice    metabolically    activates    expression    dysfunction    immunohistochemistry    acutely    modulates   

Project "NACHO" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 185˙857.00

Map

 Project objective

Tobacco abuse elevates the risk of developing type 2 diabetes (T2D). This effect is attributed to nicotine, the major addictive compound in cigarettes and chewing tobacco. Nicotine acutely activates nicotinic receptors (nAchRs) while extended exposure results in receptor desensitization. Accumulating evidence suggests that long-term exposure to nicotine impairs beta cell function. Recent results (host laboratory) demonstrate that nicotine acutely modulates insulin secretion and that reduced nAchR expression in beta cells results in an increased risk for developing T2D. This suggests that activation of nAchRs is critical for beta cell function. However, the precise mechanisms to modulate beta cell function upon long-term exposure to nicotine in healthy and metabolically compromised conditions, have not been determined yet.

NACHO will investigate the effects of nicotine on insulin secretion using MafA mutant animals (model for beta cell dysfunction lacking specific nAchRs (Chrnb2/4)) and human islets. Molecular mechanisms by which nicotine affect insulin secretion will be studied by generating stable clones (CRISPR/Cas9) of human beta cells (EndoC-βH2) lacking CHRNB2/4 and evaluating cell signaling responses (calcium/sodium influx, exocytosis, plasma membrane potential) to nicotine/acetylcholine. The role of long-term nicotine exposure on beta cell adaptability will be assessed in diet-induced obese WT and MafA mutant mice treated with nicotine and evaluating beta cell function and proliferation in vivo (glucose tolerance) and ex vivo (insulin secretion and immunohistochemistry). The clinical impact of specific nAchR gene risk alleles and nicotinic signaling on insulin secretion will be evaluated in non-diabetic humans. Understanding how nicotine influences beta cell function in diabetes development is of considerable clinical interest since tobacco abuse is common and smoking cessation therapy is widely used. NACHO will aid to develop personalized medicine.

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The information about "NACHO" are provided by the European Opendata Portal: CORDIS opendata.

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