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Nicotine actions on beta cell function in health and disease

Total Cost €


EC-Contrib. €






 NACHO project word cloud

Explore the words cloud of the NACHO project. It provides you a very rough idea of what is the project "NACHO" about.

clinical    extended    accumulating    mafa    glucose    function    vivo    therapy    mechanisms    membrane    cell    nachr    host    personalized    immunohistochemistry    secretion    nacho    addictive    nicotinic    abuse    cigarettes    elevates    attributed    diabetic    islets    healthy    cells    mice    stable    tolerance    modulates    modulate    activates    tobacco    acutely    precise    acetylcholine    chewing    smoking    exposure    clones    model    dysfunction    influences    crispr    obese    generating    risk    laboratory    molecular    animals    receptor    diet    medicine    beta    influx    ex    compromised    plasma    lacking    nachrs    expression    aid    endoc    gene    calcium    adaptability    cas9    signaling    compound    effect    human    metabolically    chrnb2    h2    nicotine    receptors    diabetes    exocytosis    proliferation    t2d    determined    critical    activation    suggests    wt    impairs    alleles    insulin    cessation    humans    mutant    considerable    sodium    desensitization   

Project "NACHO" data sheet

The following table provides information about the project.


Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 185˙857.00


 Project objective

Tobacco abuse elevates the risk of developing type 2 diabetes (T2D). This effect is attributed to nicotine, the major addictive compound in cigarettes and chewing tobacco. Nicotine acutely activates nicotinic receptors (nAchRs) while extended exposure results in receptor desensitization. Accumulating evidence suggests that long-term exposure to nicotine impairs beta cell function. Recent results (host laboratory) demonstrate that nicotine acutely modulates insulin secretion and that reduced nAchR expression in beta cells results in an increased risk for developing T2D. This suggests that activation of nAchRs is critical for beta cell function. However, the precise mechanisms to modulate beta cell function upon long-term exposure to nicotine in healthy and metabolically compromised conditions, have not been determined yet.

NACHO will investigate the effects of nicotine on insulin secretion using MafA mutant animals (model for beta cell dysfunction lacking specific nAchRs (Chrnb2/4)) and human islets. Molecular mechanisms by which nicotine affect insulin secretion will be studied by generating stable clones (CRISPR/Cas9) of human beta cells (EndoC-βH2) lacking CHRNB2/4 and evaluating cell signaling responses (calcium/sodium influx, exocytosis, plasma membrane potential) to nicotine/acetylcholine. The role of long-term nicotine exposure on beta cell adaptability will be assessed in diet-induced obese WT and MafA mutant mice treated with nicotine and evaluating beta cell function and proliferation in vivo (glucose tolerance) and ex vivo (insulin secretion and immunohistochemistry). The clinical impact of specific nAchR gene risk alleles and nicotinic signaling on insulin secretion will be evaluated in non-diabetic humans. Understanding how nicotine influences beta cell function in diabetes development is of considerable clinical interest since tobacco abuse is common and smoking cessation therapy is widely used. NACHO will aid to develop personalized medicine.

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The information about "NACHO" are provided by the European Opendata Portal: CORDIS opendata.

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