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Cell-type specific mechanisms regulating rhythms in leukocyte homing

Total Cost €


EC-Contrib. €






Project "CIRCODE" data sheet

The following table provides information about the project.


Organization address
postcode: 80539

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 1˙497˙688 €
 EC max contribution 1˙497˙688 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2020-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Leukocytes are the key components of the immune system that fight infections and provide tissue repair, yet their migration patterns throughout the body over the course of a day are completely unknown. Circadian, ~24 hour rhythms are emerging as important novel regulators of immune cell migration and function, which impacts inflammatory diseases such as myocardial infarction and sepsis. Altering leukocyte tissue infiltration and activation at the proper times provides an option for therapy that would maximize the clinical impact of drugs and vaccinations and minimize side effects. We aim to create a four-dimensional map of leukocyte migration to organs in time and space and investigate with epigenetics techniques the molecular mechanisms that regulate cell-type specific rhythms. We will functionally define the daily oscillating molecular signature(s) of leukocytes and endothelial cells with novel proteomics approaches and thus identify a circadian traffic code that dictates the rhythmic migration of leukocyte subsets to specific organs under steady-state and inflammatory conditions with pharmacological and genetic tools. We will assess the impact of lineage-specific arrhythmicities on immune homeostasis and leukocyte trafficking using an innovative combination of novel genetic tools. Based on these data we will create a model predicting circadian leukocyte migration to tissues. The project combines the disciplines of immunology and chronobiology by obtaining unprecedented information in time and space of circadian leukocyte trafficking and investigating how immune-cell specific oscillations are generated at the molecular level, which is of broad impact for both fields. Our extensive experience in the rhythmic control of the immune system makes us well poised to characterize the molecular components that orchestrate circadian leukocyte distribution across the body.


year authors and title journal last update
List of publications.
2020 Sophia Hergenhan, Stephan Holtkamp, Christoph Scheiermann
Molecular Interactions Between Components of the Circadian Clock and the Immune System
published pages: , ISSN: 0022-2836, DOI: 10.1016/j.jmb.2019.12.044
Journal of Molecular Biology 2020-04-01
2019 Robert Pick, Wenyan He, Chien-Sin Chen, Christoph Scheiermann
Time-of-Day-Dependent Trafficking and Function of Leukocyte Subsets
published pages: 524-537, ISSN: 1471-4906, DOI: 10.1016/
Trends in Immunology 40/6 2020-04-01
2019 Alba de Juan, Louise Madeleine Ince, Robert Pick, Chien-Sin Chen, Filippo Molica, Gabriele Zuchtriegel, Chen Wang, Dachuan Zhang, David Druzd, Maximilian E.T. Hessenauer, Graziano Pelli, Isa Kolbe, Henrik Oster, Colette Prophete, Sophia Martina Hergenhan, Urs Albrecht, Jürgen Ripperger, Eloi Montanez, Christoph A. Reichel, Oliver Soehnlein, Brenda R. Kwak, Paul S. Frenette, Christoph Scheiermann
Artery-Associated Sympathetic Innervation Drives Rhythmic Vascular Inflammation of Arteries and Veins
published pages: 1100-1114, ISSN: 0009-7322, DOI: 10.1161/circulationaha.119.040232
Circulation 140/13 2020-04-01
2019 Louise M. Ince, Jasmin Weber, Christoph Scheiermann
Control of Leukocyte Trafficking by Stress-Associated Hormones
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.03143
Frontiers in Immunology 9 2019-04-25
2018 Wenyan He, Stephan Holtkamp, Sophia Martina Hergenhan, Kerstin Kraus, Alba de Juan, Jasmin Weber, Paul Bradfield, Julien Martin Pierre Grenier, Jeoffrey Pelletier, David Druzd, Chien-Sin Chen, Louise Madeleine Ince, Susanne Bierschenk, Robert Pick, Markus Sperandio, Michel Aurrand-Lions, Christoph Scheiermann
Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues
published pages: 1175-1190.e7, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2018.10.007
Immunity 49/6 2019-04-25
2016 Steffens, S; Drechsler, M.; C. Weber; Duchene, J.; Scheiermann, C.; Horckmans, M; Nitz, K.; Bidzhekov, K.; Schloss, M.J.; Soehnlein, O.
The time-of-day of myocardial infarction onset affects healing through oscillations in cardiac neutrophil recruitment
published pages: 937-948, ISSN: 1757-4684, DOI: 10.15252/emmm.201506083
EMBO Molecular Medicine 8 2019-06-04
2018 Christoph Scheiermann, Julie Gibbs, Louise Ince, Andrew Loudon
Clocking in to immunity
published pages: 423-437, ISSN: 1474-1733, DOI:
Nature Reviews Immunology 18/7 2019-06-04
2017 Druzd D, Matveeva O, Ince L, Harrison U, He W, Schmal C, Herzel H, Tsang AH, Kawakami N, Leliavski A, Uhl O, Yao L, Sander LE, Chen CS, Kraus K, de Juan A, Hergenhan SM, Ehlers M, Koletzko B, Haas R, Solbach W, Oster H, Scheiermann C.
Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses
published pages: Pages 120–132, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2016.12.011
Immunity Volume 46, Issue 1 2019-06-04

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