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GENEVOSYN SIGNED

Reshuffling genes and genomes: from experimental evolution to synthetic biology in plants

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EC-Contrib. €

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Project "GENEVOSYN" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.mpimp-golm.mpg.de/1997016/2_5_Million_Euro_for_innovative_plant_research
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 2˙500˙000.00

Map

 Project objective

GENEVOSYN has three highly ambitious objectives that will enable the engineering of new generations of crop plants. The project consists of three complementary workpackages (WPs) and will use both synthetic genomes and naturally available genomes as raw material for novel biotechnology and synthetic biology approaches. It will employ experimental gene and genome transfer as well as recently discovered natural (horizontal) genome transfer processes to generate new crop varieties and species. In WP1, the plastid (chloroplast) will be developed as a highly efficient platform for synthetic biology applications in plants. This will be accomplished by pursuing bottom-up and top-down synthetic biology approaches. They include the construction of large synthetic multigene operons towards introducing new complex metabolic pathways into plants, and the design, synthesis, assembly and booting up of radically redesigned synthetic genomes that ultimately will allow us to expand the genetic code and thereby the amino acid repertoire of plant cells. In WP2, GENEVOSYN aims at developing a technology for mitochondrial genome engineering in plants. The possibility to alter the genetic information in plant mitochondria by transformation would revolutionize both basic and applied research on plant mitochondria, and pave the way to harnessing the enormous potential of mitochondrial biotechnology. Finally, WP3 will exploit recently discovered horizontal genome transfer processes for the creation of novel crop species and the improvement of existing ones. To this end, we will use grafting-assisted horizontal genome transfer between crop species in the nightshade family (Solanaceae) to (i) generate new combinations of nuclear and plastid genomes and determine the impact of the plastid genome and specific plastid genes on plant growth and stress tolerance, and (ii) produce novel (synthetic) species that arise from the combination of entire nuclear genomes of existing species.

 Publications

year authors and title journal last update
List of publications.
2019 Zhichao Li, Ralph Bock
Rapid functional activation of a horizontally transferred eukaryotic gene in a bacterial genome in the absence of selection
published pages: 6351-6359, ISSN: 0305-1048, DOI: 10.1093/nar/gkz370
Nucleic Acids Research 47/12 2020-04-15
2019 Stephanie Ruf, Joachim Forner, Claudia Hasse, Xenia Kroop, Stefanie Seeger, Laura Schollbach, Anne Schadach, Ralph Bock
High-efficiency generation of fertile transplastomic Arabidopsis plants
published pages: 282-289, ISSN: 2055-0278, DOI: 10.1038/s41477-019-0359-2
Nature Plants 5/3 2020-04-15
2018 Christian R Boehm, Ralph Bock
Recent advances and current challenges in synthetic biology of the plastid genetic system and metabolism
published pages: pp.00767.2018, ISSN: 0032-0889, DOI: 10.1104/pp.18.00767
Plant Physiology 2019-04-03
2018 Zhichao Li, Ralph Bock
Replication of bacterial plasmids in the nucleus of the red alga Porphyridium purpureum
published pages: 1-8, ISSN: 2041-1723, DOI: 10.1038/s41467-018-05651-1
Nature Communications 9/1 2019-04-03
2018 Iman Tabatabaei, Cristina Dal Bosco, Marta Bednarska, Stephanie Ruf, Jörg Meurer, Ralph Bock
A highly efficient sulfadiazine selection system for the generation of transgenic plants and algae
published pages: 1-12, ISSN: 1467-7644, DOI: 10.1111/pbi.13004
Plant Biotechnology Journal 2019-04-03

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