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iNEXT SIGNED

Infrastructure for NMR, EM and X-rays for translational research

Total Cost €

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EC-Contrib. €

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Partnership

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 iNEXT project word cloud

Explore the words cloud of the iNEXT project. It provides you a very rough idea of what is the project "iNEXT" about.

nmr    revealing    attract    structure    mechanisms    translational    smes    drug    structural    biomaterials    vaccines    brings    multimodal    medicine    biomedical    chemistry    hindered    enzymes    biology    centers    life    engaging    full    training    protein    instrumentation    sites    imaging    synchrotron    network    ess    innovative    collection    light    first    cellular    lack    inext    biotechnological    molecular    infrastructure    screening    time    provides    microscopy    em    electron    engineered    potent    biological    neutron    bioimaging    world    provider    membrane    facility    forms    openscreen    joint    atomic    data    alike    ultra    rays    enhanced    inclusive    instruct    cells    procedure    class    fundamental    networking    organizational    drugs    modes    transnational    benefit    architecture    instruments    innovations    umbrella    whereby    translate    biotechnology    industries    resolution    expertise    facilities    interdisciplinary    suitability    expert    academics    esfri    audit    fragment   

Project "iNEXT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT UTRECHT 

Organization address
address: HEIDELBERGLAAN 8
city: UTRECHT
postcode: 3584 CS
website: www.uu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.inext-eu.org
 Total cost 9˙999˙534 €
 EC max contribution 9˙999˙534 € (100%)
 Programme 1. H2020-EU.1.4.1.2. (Integrating and opening existing national and regional  research infrastructures of European interest)
 Code Call H2020-INFRAIA-2014-2015
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT UTRECHT NL (UTRECHT) coordinator 999˙724.00
2    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) participant 2˙395˙127.00
3    DIAMOND LIGHT SOURCE LIMITED UK (DIDCOT) participant 1˙155˙074.00
4    CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLO PROTEINE IT (FIRENZE) participant 740˙695.00
5    JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN DE (FRANKFURT AM MAIN) participant 684˙776.00
6    STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS NL (AMSTERDAM) participant 683˙500.00
7    Masarykova univerzita CZ (BRNO STRED) participant 470˙672.00
8    FORSCHUNGSVERBUND BERLIN EV DE (BERLIN) participant 438˙609.00
9    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 428˙600.00
10    SYNCHROTRON SOLEIL SOCIETE CIVILE FR (SAINT AUBIN) participant 385˙925.00
11    LUNDS UNIVERSITET SE (LUND) participant 312˙925.00
12    UNIVERSITEIT LEIDEN NL (LEIDEN) participant 272˙968.00
13    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 223˙562.00
14    EUROPEAN SYNCHROTRON RADIATION FACILITY FR (GRENOBLE) participant 203˙250.00
15    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 179˙625.00
16    INSTRUCT ACADEMIC SERVICES LIMITED UK (OXFORD) participant 128˙500.00
17    AARHUS UNIVERSITET DK (AARHUS C) participant 92˙750.00
18    EUROPEAN SPALLATION SOURCE ERIC SE (LUND) participant 47˙000.00
19    EOTVOS LORAND TUDOMANYEGYETEM HU (BUDAPEST) participant 31˙250.00
20    OULUN YLIOPISTO FI (OULU) participant 31˙250.00
21    PANEPISTIMIO PATRON EL (RIO PATRAS) participant 31˙250.00
22    UNIVERSIDADE NOVA DE LISBOA PT (LISBOA) participant 31˙250.00
23    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) participant 31˙250.00
24    EUROPEAN SPALLATION SOURCE ESS AB SE (LUND) participant 0.00
25    INSTITUTO DE TECNOLOGIA QUIMICA E BIOLOGICA - UNIVERSIDADE NOVA DE LISBOA PT (OEIRAS) participant 0.00

Map

 Project objective

Structural biology provides insight into the molecular architecture of cells up to atomic resolution, revealing the biological mechanisms that are fundamental to life. It is thus key to many innovations in chemistry, biotechnology and medicine such as engineered enzymes, new potent drugs, innovative vaccines and novel biomaterials. iNEXT (infrastructure for NMR, EM and X-rays for Translational research) will provide high-end structural biology instrumentation and expertise, facilitating expert and non-expert European users to translate their fundamental research into biomedical and biotechnological applications. iNEXT brings together leading European structural biology facilities under one interdisciplinary organizational umbrella and includes synchrotron sites for X-rays, NMR centers with ultra-high field instruments, and, for the first time, advanced electron microscopy and light imaging facilities. Together with key partners in biological and biomedical institutions, partners focusing on training and dissemination activities, and ESFRI projects (Instruct, Euro-BioImaging, EU-OPENSCREEN and future neutron-provider ESS), iNEXT forms an inclusive European network of world class. iNEXT joint research projects (fragment screening for drug development, membrane protein structure, and multimodal cellular imaging) and networking, training and transnational access activities will be important for SMEs, established industries and academics alike. In particular, iNEXT will provide novel access modes to attract new and non-expert users, which are often hindered from engaging in structural biology projects through lack of instrumentation and expertise: a Structural Audit procedure, whereby a sample is assessed for its suitability for structural studies; Enhanced Project Support, allowing users to get expert help in an iNEXT facility; and High-End Data Collection, enabling experienced users to take full benefit of the iNEXT state-of-the-art equipment.

 Deliverables

List of deliverables.
15 structure validation projects through biophysics facility Documents, reports 2020-03-06 16:01:12
Delivery of 144 days of access to Titan KRIO cyro-EM at NeCEN Documents, reports 2020-03-06 14:56:44
Protocols for RNA sample optimization and DNA/RNA delivery into bacterial and mammalian cells. for in-cell NMR studies Documents, reports 2020-03-06 14:57:07
Reports on feasibility studies on the promising translational targets Documents, reports 2020-03-06 14:56:54
Delivery of 750 hours of access to the BioMAX beamline at MAXIV Documents, reports 2020-03-06 14:56:24
Delivery of 192 supervised access days to EMCF at EMBL-HD Documents, reports 2020-03-06 14:54:15
Delivery of 120 samples through the Structural Audit procedure at NKI Documents, reports 2020-03-06 14:56:44
Delivery of 75 days of access to Cryo-EM at CSIC Documents, reports 2020-03-06 16:01:05
Secondary screening of a set of derivatives around an initial hit making use of the EU-OPENSCREEN library Documents, reports 2020-03-06 14:56:35
Characterization of 120 “SAXS x-audit” samples at EMBL-HH Documents, reports 2020-03-06 14:48:42
120 samples through “Structural Audit” Documents, reports 2020-03-06 16:01:09
Delivery of 2720 hours of access to Beam MX/SAXS at SOLEIL Documents, reports 2020-03-06 14:56:25
Delivery of 10 days of Structural Audit to NMR at CERM/CIRMMP Documents, reports 2020-03-06 14:48:27
Delivery of 20 projects for biophysical characterisation at NKI Documents, reports 2020-03-06 14:56:57
Delivery of 212 days of access to NMR at FVB-FMP Documents, reports 2020-03-06 14:56:32
Delivery of 78 days of full service ‘Protein to XTAL’at EMBL-HH Documents, reports 2020-03-06 14:48:22
Summary report on networking activities with industry Documents, reports 2020-03-06 16:17:01
Access to NMR probe(s) optimized for the investigation of membrane proteins (binding studies/,screening) Documents, reports 2020-03-06 14:56:32
Delivery of 70 days of access to Integrated Macromolecular Crystallography service at EMBL-GR Documents, reports 2020-03-06 14:54:05
Data management system for a EM workflows, extending ISPyB Documents, reports 2020-03-06 16:55:30
Delivery of 10 days of access as Structural Audit to SONNMRLSF at UU Documents, reports 2020-03-06 14:56:56
Delivery of 775 hours of access to SAXS beamtime at EMBL-HH Documents, reports 2020-03-06 14:54:14
Delivery of 110 days of access to cryo-EM at Diamond Documents, reports 2020-03-06 14:48:13
Report on the organization of annual user meetings Documents, reports 2020-03-06 16:55:32
Draft sustainability plan Documents, reports 2020-03-06 16:01:25
Delivery of 100 days of Enhanced Support to NMR at CERM/CIRMMP Documents, reports 2020-03-06 16:00:53
Delivery of 100 days of access as Enhanced Support to SONNMRLSF at UU Documents, reports 2020-03-06 14:56:54
Delivery of 130 days of access to cryo-EM at CEITEC Documents, reports 2020-03-06 14:54:13
Delivery of 145 days of access to NMR at CEITEC Documents, reports 2020-03-06 14:54:16
Delivery of 346 days of High-End Data Acquisition to NMR at CERM/CIRMMP Documents, reports 2020-03-06 14:48:28
Delivery of 1555 hours of access to MX beamtime at EMBL-HH Documents, reports 2020-03-06 14:48:22
Delivery of access to 10 screening campaigns at Diamond Documents, reports 2020-03-06 14:54:25
Delivery of access for 60 mail-in SAXS sessions at Diamond Documents, reports 2020-03-06 14:54:22
Delivery of 5450 supervised access hours to ALMF at EMBL-HD Documents, reports 2020-03-06 14:54:19
Delivery of 305 days of High-End Data Acquisition to NMR at BMRZ Documents, reports 2020-03-06 14:48:11
Delivery of 10 days of Structural Audit to NMR at BMRZ Documents, reports 2020-03-06 14:48:08
Delivery of 30 samples analysed for Structural Audit at CSIC Documents, reports 2020-03-06 14:48:06
Report on Coordination activities with PDBe and Elixir Documents, reports 2020-03-06 16:55:33
Delivery of 36 days of accessto Integrated fragment screening by MX at EMBL-GR Documents, reports 2020-03-06 14:54:12
Delivery of 100 days of Enhanced Support to NMR at BMRZ Documents, reports 2020-03-06 14:48:19
Report on Coordination activities with Virtual Research Environments Documents, reports 2020-03-06 16:17:02
Delivery of 110 days of access to NMR at RALF-NMR Documents, reports 2020-03-06 14:56:36
Delivery of 76 days of full service ‘Protein to SAXS at EMBL-HH Documents, reports 2020-03-06 14:54:18
Delivery of 2389 hours of access to Beam MX at Diamond Documents, reports 2020-03-06 14:48:28
Delivery of 14 days of access to Integrated compound screening (focused libraries) by MX at EMBL-GR Documents, reports 2020-03-06 14:48:22
5 integrated structure validation projects through combined access in biophysics and imaging Documents, reports 2020-03-06 14:48:07
Report on the organization of TDC workshops Documents, reports 2020-03-06 16:55:32
Protocols for correlative fluorescent labeling of proteins in vitro and in situ Documents, reports 2020-03-06 16:01:31
15 structure validation projects through advanced imaging facility Documents, reports 2020-03-06 16:01:18
Delivery of 370 days of access as High-end Data Acquisition to SONNMRLSF at UU Documents, reports 2020-03-06 14:56:45
Report on novel biophysical methods Documents, reports 2020-03-06 14:57:10
Automation of the on-line SEC setups at the partner SAXS beamlines Documents, reports 2019-11-22 17:51:28
Protocols and tools for protein interactions in mammalian cells by NMR Documents, reports 2019-11-22 17:51:28
Protocols for preparing ssNMR samples in bacterial and mammalian cell fractions and cells Documents, reports 2019-11-22 17:51:28
Automated SAXS pipeline for membrane proteins, integrated into ISPyB Documents, reports 2019-11-22 17:51:28
Protocols for membrane protein structure determination by solid-state NMR Documents, reports 2019-11-22 17:51:28
Fragment library distributed to partners Documents, reports 2019-11-22 17:51:28
Second report on conferences and meetings with iNEXT representation Documents, reports 2019-11-22 17:51:27
Fully automatic screening, large scale X-ray data collection pipelines Documents, reports 2019-11-22 17:51:28
Best practice workflows for cryo electron tomography specimen preparation Documents, reports 2019-11-22 17:51:28
Protocols for data acquisition for correlative CLEXM Documents, reports 2019-11-22 17:51:28
Start of TA access to HT fragment screening by NMR Documents, reports 2019-11-22 17:51:28
Report on a model for future structural biology access in Europe Documents, reports 2019-11-22 17:51:28
Storage and queuing facilities at ESRF Documents, reports 2019-11-22 17:51:28
Representation on RI bodies or Committees Documents, reports 2019-11-22 17:51:28
Protocols and tools for using ssNMR to study protein complexes associated with cellular compartments Documents, reports 2019-11-22 17:51:28
Report on financial sustainability Documents, reports 2019-11-22 17:51:28
Fluorophore knock in cell lines for structural studies Documents, reports 2019-11-22 17:51:28
Second summary report on networking activities Documents, reports 2019-11-22 17:51:27
Automated pipelines for NMR-based structure determination accessible online Documents, reports 2019-11-22 17:51:28
Access to an integrated miniaturized HT-SEC-SAXS set-up Documents, reports 2019-11-22 17:51:28
CRIMS support for ligand and fragment screening Documents, reports 2019-11-22 17:51:28
Data management system for ligand and fragment screening, extending ISPyB Documents, reports 2019-11-22 17:51:28
Setup for lower background for diffraction data on membrane proteins Documents, reports 2019-11-22 17:51:28
Storage and queuing facilities at Diamond Documents, reports 2019-11-22 17:51:28
Start of TA to HT integrated fragment screening in Grenoble Documents, reports 2019-11-22 17:51:28
Start of TA to HT integrated fragment screening at Diamond Documents, reports 2019-11-22 17:51:28
Workflow for EM-based determination of membrane protein structures Documents, reports 2019-11-22 17:51:28
Second report on the interaction with industrial parties Documents, reports 2019-11-22 17:51:27
Second report on outreach activities Documents, reports 2019-11-22 17:51:28
Automatic EM Image Processing workflow in the absence of structural flexibility Documents, reports 2019-11-22 17:51:27
Optimized protocols for reconstitution of membrane proteins Documents, reports 2019-11-22 17:51:28
Optimized workflows for ligand screening by NMR Documents, reports 2019-11-22 17:51:28
Integrated submission system operational Documents, reports 2019-11-22 17:51:24
First report on conferences and meetings with iNEXT representation Documents, reports 2019-11-22 17:51:24
First report on outreach activities Documents, reports 2019-11-22 17:51:24
TA access to HT crystallization and crystal mounting Documents, reports 2019-11-22 17:51:24
First summary report on networking activities Documents, reports 2019-11-22 17:51:24
First report on the interaction with industrial parties Documents, reports 2019-11-22 17:51:24
Report on demands of the user community Documents, reports 2019-11-22 17:51:24
Start of TA to integrated screening for focused libraries at EMBL-GR/ESRF Documents, reports 2019-11-22 17:51:24
Report on comparative analysis of data models in all disciplines and strategy for integration Documents, reports 2019-11-22 17:51:24
Hiring a Project Manager Documents, reports 2019-11-22 17:51:24
SONICC-based centring of membrane protein crystals Documents, reports 2019-11-22 17:51:26
Protocols for cooperation with ESFRI BMS RIs Documents, reports 2019-11-22 17:51:26
Management Guidelines Documents, reports 2019-11-22 17:51:24

Take a look to the deliverables list in detail:  detailed list of iNEXT deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Sunil Kumar Saini, Tripti Tamhane, Raghavendra Anjanappa, Ankur Saikia, Sofie Ramskov, Marco Donia, Inge Marie Svane, Søren Nyboe Jakobsen, Maria Garcia-Alai, Martin Zacharias, Rob Meijers, Sebastian Springer, Sine Reker Hadrup
Empty peptide-receptive MHC class I molecules for efficient detection of antigen-specific T cells
published pages: eaau9039, ISSN: 2470-9468, DOI: 10.1126/sciimmunol.aau9039
Science Immunology 4/37 2020-03-06
2019 Arne Raasakka, Salla Ruskamo, Robert Barker, Oda C. Krokengen, Guro H. Vatne, Cecilie K. Kristiansen, Erik I. Hallin, Maximilian W. A. Skoda, Ulrich Bergmann, Hanna Wacklin-Knecht, Nykola C. Jones, Søren V. Hoffmann, Petri Kursula
Neuropathy-related mutations alter the membrane binding properties of the human myelin protein P0 cytoplasmic tail
published pages: e0216833, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0216833
PLOS ONE 14/6 2020-03-06
2018 The Quyen Nguyen, Mélanie Chenon, Fernando Vilela, Christophe Velours, Magali Aumont-Nicaise, Jessica Andreani, Paloma F. Varela, Paola Llinas, Julie Ménétrey
Correction: Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain
published pages: e0197193, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0197193
PLOS ONE 13/5 2020-03-06
2019 Panagis Polykretis, Francesca Cencetti, Chiara Donati, Enrico Luchinat, Lucia Banci
Cadmium effects on superoxide dismutase 1 in human cells revealed by NMR
published pages: 101102, ISSN: 2213-2317, DOI: 10.1016/j.redox.2019.101102
Redox Biology 21 2020-03-06
2018 Amaya Jiménez, Slavica Jonic, Tomas Majtner, Joaquín Otón, Jose Luis Vilas, David Maluenda, Javier Mota, Erney Ramírez-Aportela, Marta Martínez, Yaiza Rancel, Joan Segura, Ruben Sánchez-García, Roberto Melero, Laura del Cano, Pablo Conesa, Lars Skjaerven, Roberto Marabini, Jose M Carazo, Carlos Oscar S Sorzano
Validation of electron microscopy initial models via small angle X-ray scattering curves
published pages: 2427-2433, ISSN: 1367-4803, DOI: 10.1093/bioinformatics/bty985
Bioinformatics 35/14 2020-03-06
2019 Francesca Camponeschi, Lucia Banci
Metal cofactors trafficking and assembly in the cell: a molecular view
published pages: 231-245, ISSN: 0033-4545, DOI: 10.1515/pac-2018-0720
Pure and Applied Chemistry 91/2 2020-03-06
2019 Yovana Cabrera, Leire Dublang, José Angel Fernández-Higuero, David Albesa-Jové, Maria Lucas, Ana Rosa Viguera, Marcelo E. Guerin, Jose M.G. Vilar, Arturo Muga, Fernando Moro
Regulation of Human Hsc70 ATPase and Chaperone Activities by Apg2: Role of the Acidic Subdomain
published pages: 444-461, ISSN: 0022-2836, DOI: 10.1016/j.jmb.2018.11.026
Journal of Molecular Biology 431/2 2020-03-06
2019 Petros Giastas, Margarete Neu, Paul Rowland, Efstratios Stratikos
High-Resolution Crystal Structure of Endoplasmic Reticulum Aminopeptidase 1 with Bound Phosphinic Transition-State Analogue Inhibitor
published pages: 708-713, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.9b00002
ACS Medicinal Chemistry Letters 10/5 2020-03-06
2019 Raquel Saborano, Zuhal Eraslan, Jennie Roberts, Farhat L. Khanim, Patricia F. Lalor, Michelle A. C. Reed, Ulrich L. Günther
A framework for tracer-based metabolism in mammalian cells by NMR
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-37525-3
Scientific Reports 9/1 2020-03-06
2019 Marcus Oscarsson, Antonia Beteva, David Flot, Elspeth Gordon, Matias Guijarro, Gordon Leonard, Sean McSweeney, Stephanie Monaco, Christoph Mueller-Dieckmann, Max Nanao, Didier Nurizzo, Alexander N. Popov, David von Stetten, Olof Svensson, Vicente Rey-Bakaikoa, Idrissou Chado, Leonard M. G. Chavas, Laurent Gadea, Patrick Gourhant, Tatiana Isabet, Pierre Legrand, Martin Savko, Serena Sirigu, William
MXCuBE2 : the dawn of MXCuBE Collaboration
published pages: 393-405, ISSN: 1600-5775, DOI: 10.1107/s1600577519001267
Journal of Synchrotron Radiation 26/2 2020-03-06
2019 Erney Ramírez-Aportela, Javier Mota, Pablo Conesa, Jose Maria Carazo, Carlos Oscar S. Sorzano
DeepRes : a new deep-learning- and aspect-based local resolution method for electron-microscopy maps
published pages: , ISSN: 2052-2525, DOI: 10.1107/s2052252519011692
IUCrJ 6/6 2020-03-06
2019 Maarten W. Tuijtel, Abraham J. Koster, Stefan Jakobs, Frank G. A. Faas, Thomas H. Sharp
Correlative cryo super-resolution light and electron microscopy on mammalian cells using fluorescent proteins
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-37728-8
Scientific Reports 9/1 2020-03-06
2019 Mo’men Abdelkareem, Charlotte Saint-André, Maria Takacs, Gabor Papai, Corinne Crucifix, Xieyang Guo, Julio Ortiz, Albert Weixlbaumer
Structural Basis of Transcription: RNA Polymerase Backtracking and Its Reactivation
published pages: 298-309.e4, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2019.04.029
Molecular Cell 75/2 2020-03-06
2019 Cristina Machón, Montserrat Fàbrega-Ferrer, Daming Zhou, Ana Cuervo, José L. Carrascosa, David I. Stuart, Miquel Coll
Atomic structure of the Epstein-Barr virus portal
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-11706-8
Nature Communications 10/1 2020-03-06
2019 Lynn Radamaker, Yin-Hsi Lin, Karthikeyan Annamalai, Stefanie Huhn, Ute Hegenbart, Stefan O. Schönland, Günter Fritz, Matthias Schmidt, Marcus Fändrich
Cryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09032-0
Nature Communications 10/1 2020-03-06
2019 Linda Cerofolini, Stefano Giuntini, Enrico Ravera, Claudio Luchinat, Francesco Berti, Marco Fragai
Structural characterization of a protein adsorbed on aluminum hydroxide adjuvant in vaccine formulation
published pages: , ISSN: 2059-0105, DOI: 10.1038/s41541-019-0115-7
npj Vaccines 4/1 2020-03-06
2019 Isaac Santos-Pérez, Diego Charro, David Gil-Carton, Mikel Azkargorta, Felix Elortza, Dennis H. Bamford, Hanna M. Oksanen, Nicola G. A. Abrescia
Structural basis for assembly of vertical single β-barrel viruses
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-08927-2
Nature Communications 10/1 2020-03-06
2019 Rana Abdelnabi, James A. Geraets, Yipeng Ma, Carmen Mirabelli, Justin W. Flatt, Aušra Domanska, Leen Delang, Dirk Jochmans, Timiri Ajay Kumar, Venkatesan Jayaprakash, Barij Nayan Sinha, Pieter Leyssen, Sarah J. Butcher, Johan Neyts
A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses
published pages: e3000281, ISSN: 1545-7885, DOI: 10.1371/journal.pbio.3000281
PLOS Biology 17/6 2020-03-06
2019 Erney Ramírez-Aportela, Jose Luis Vilas, Alisa Glukhova, Roberto Melero, Pablo Conesa, Marta Martínez, David Maluenda, Javier Mota, Amaya Jiménez, Javier Vargas, Roberto Marabini, Patrick M Sexton, Jose Maria Carazo, Carlos Oscar S Sorzano
Automatic local resolution-based sharpening of cryo-EM maps
published pages: , ISSN: 1367-4803, DOI: 10.1093/bioinformatics/btz671
Bioinformatics 2020-03-06
2019 Jiri Wald, Marion Pasin, Martina Richter, Christin Walther, Neann Mathai, Johannes Kirchmair, Vadim A. Makarov, Nikolaus Goessweiner-Mohr, Thomas C. Marlovits, Irene Zanella, Antonio Real-Hohn, Nuria Verdaguer, Dieter Blaas, Michaela Schmidtke
Cryo-EM structure of pleconaril-resistant rhinovirus-B5 complexed to the antiviral OBR-5-340 reveals unexpected binding site
published pages: 19109-19115, ISSN: 0027-8424, DOI: 10.1073/pnas.1904732116
Proceedings of the National Academy of Sciences 116/38 2020-03-06
2019 Michaela Krafcikova, Simon Dzatko, Coralie Caron, Anton Granzhan, Radovan Fiala, Tomas Loja, Marie-Paule Teulade-Fichou, Tomas Fessl, Robert Hänsel-Hertsch, Jean-Louis Mergny, Silvie Foldynova-Trantirkova, Lukas Trantirek
Monitoring DNA–Ligand Interactions in Living Human Cells Using NMR Spectroscopy
published pages: 13281-13285, ISSN: 0002-7863, DOI: 10.1021/jacs.9b03031
Journal of the American Chemical Society 141/34 2020-03-06
2018 Roman I. Koning, Abraham J. Koster, Thomas H. Sharp
Advances in cryo-electron tomography for biology and medicine
published pages: 82-96, ISSN: 0940-9602, DOI: 10.1016/j.aanat.2018.02.004
Annals of Anatomy - Anatomischer Anzeiger 217 2020-03-06
2019 Linda Cerofolini, Stefano Giuntini, Letizia Barbieri, Matteo Pennestri, Anna Codina, Marco Fragai, Lucia Banci, Enrico Luchinat, Enrico Ravera
Real-Time Insights into Biological Events: In-Cell Processes and Protein-Ligand Interactions
published pages: 239-247, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2018.11.3132
Biophysical Journal 116/2 2020-03-06
2019 Albert Escobedo, Busra Topal, Micha B. A. Kunze, Juan Aranda, Giulio Chiesa, Daniele Mungianu, Ganeko Bernardo-Seisdedos, Bahareh Eftekharzadeh, Margarida Gairí, Roberta Pierattelli, Isabella C. Felli, Tammo Diercks, Oscar Millet, Jesús García, Modesto Orozco, Ramon Crehuet, Kresten Lindorff-Larsen, Xavier Salvatella
Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09923-2
Nature Communications 10/1 2020-03-06
2019 Christian Pichlo, Linda Juetten, Fabian Wojtalla, Magdalena Schacherl, Dolores Diaz, Ulrich Baumann
Molecular determinants of the mechanism and substrate specificity of Clostridium difficile proline-proline endopeptidase-1
published pages: 11525-11535, ISSN: 0021-9258, DOI: 10.1074/jbc.ra119.009029
Journal of Biological Chemistry 294/30 2020-03-06
2019 Andreas Moritz, Raghavendra Anjanappa, Claudia Wagner, Sebastian Bunk, Martin Hofmann, Gabriele Pszolla, Ankur Saikia, Maria Garcia-Alai, Rob Meijers, Hans-Georg Rammensee, Sebastian Springer, Dominik Maurer
High-throughput peptide-MHC complex generation and kinetic screenings of TCRs with peptide-receptive HLA-A*02:01 molecules
published pages: eaav0860, ISSN: 2470-9468, DOI: 10.1126/sciimmunol.aav0860
Science Immunology 4/37 2020-03-06
2019 Ieva Goldberga, Rui Li, Wing Ying Chow, David G. Reid, Ulyana Bashtanova, Rakesh Rajan, Anna Puszkarska, Hartmut Oschkinat, Melinda J. Duer
Detection of nucleic acids and other low abundance components in native bone and osteosarcoma extracellular matrix by isotope enrichment and DNP-enhanced NMR
published pages: 26686-26690, ISSN: 2046-2069, DOI: 10.1039/c9ra03198g
RSC Advances 9/46 2020-03-06
2019 Azzurra Carlon, Enrico Ravera, Giacomo Parigi, Garib N. Murshudov, Claudio Luchinat
Joint X-ray/NMR structure refinement of multidomain/multisubunit systems
published pages: 265-278, ISSN: 0925-2738, DOI: 10.1007/s10858-018-0212-3
Journal of Biomolecular NMR 73/6-7 2020-03-06
2019 Linda Cerofolini, Marco Fragai, Enrico Ravera, Christoph A. Diebolder, Ludovic Renault, Vito Calderone
Integrative Approaches in Structural Biology: A More Complete Picture from the Combination of Individual Techniques
published pages: 370, ISSN: 2218-273X, DOI: 10.3390/biom9080370
Biomolecules 9/8 2020-03-06
2019 Falk Liberta, Sarah Loerch, Matthies Rennegarbe, Angelika Schierhorn, Per Westermark, Gunilla T. Westermark, Bouke P. C. Hazenberg, Nikolaus Grigorieff, Marcus Fändrich, Matthias Schmidt
Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09033-z
Nature Communications 10/1 2020-03-06
2019 Pawel Dubiela, Rebecca Del Conte, Francesca Cantini, Tomasz Borowski, Roberta Aina, Christian Radauer, Merima Bublin, Karin Hoffmann-Sommergruber, Stefano Alessandri
Impact of lipid binding on the tertiary structure and allergenic potential of Jug r 3, the non-specific lipid transfer protein from walnut
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-38563-1
Scientific Reports 9/1 2020-03-06
2019 Emiliana Giacomello, Paolo Ronchi, Rainer Pepperkok
GM130 and p115 play a key role in the organisation of the early secretory pathway during skeletal muscle differentiation
published pages: jcs222083, ISSN: 0021-9533, DOI: 10.1242/jcs.222083
Journal of Cell Science 132/2 2020-03-06
2018 Borja Mateos, Robert Konrat, Roberta Pierattelli, Isabella C. Felli
NMR Characterization of Long‐Range Contacts in Intrinsically Disordered Proteins from Paramagnetic Relaxation Enhancement in 13 C Direct‐Detection Experiments
published pages: 335-339, ISSN: 1439-4227, DOI: 10.1002/cbic.201800539
ChemBioChem 20/3 2020-03-06
2019 Bart van Beusekom, Natasja Wezel, Maarten L. Hekkelman, Anastassis Perrakis, Paul Emsley, Robbie P. Joosten
Building and rebuilding N-glycans in protein structure models
published pages: 416-425, ISSN: 2059-7983, DOI: 10.1107/s2059798319003875
Acta Crystallographica Section D Structural Biology 75/4 2020-03-06
2018 Nusrat Shahin Qureshi, Jasleen Kaur Bains, Sridhar Sreeramulu, Harald Schwalbe, Boris Fürtig
Conformational switch in the ribosomal protein S1 guides unfolding of structured RNAs for translation initiation
published pages: , ISSN: 0305-1048, DOI: 10.1093/nar/gky746
Nucleic Acids Research 2020-03-06
2019 Aušra Domanska, Justin W. Flatt, Joonas J. J. Jukonen, James A. Geraets, Sarah J. Butcher
A 2.8-Angstrom-Resolution Cryo-Electron Microscopy Structure of Human Parechovirus 3 in Complex with Fab from a Neutralizing Antibody
published pages: , ISSN: 0022-538X, DOI: 10.1128/jvi.01597-18
Journal of Virology 93/4 2020-03-06
2019 Nada Essawy, Camille Samson, Ambre Petitalot, Sophie Moog, Anne Bigot, Isaline Herrada, Agathe Marcelot, Ana-Andreea Arteni, Catherine Coirault, Sophie Zinn-Justin
An Emerin LEM-Domain Mutation Impairs Cell Response to Mechanical Stress
published pages: 570, ISSN: 2073-4409, DOI: 10.3390/cells8060570
Cells 8/6 2020-03-06
2019 Claudia Cattoglio, Iryna Pustova, Nike Walther, Jaclyn J Ho, Merle Hantsche-Grininger, Carla J Inouye, M Julius Hossain, Gina M Dailey, Jan Ellenberg, Xavier Darzacq, Robert Tjian, Anders S Hansen
Determining cellular CTCF and cohesin abundances to constrain 3D genome models
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.40164
eLife 8 2020-03-06
2019 S. Nader, J. Pérard, P. Carpentier, L. Arnaud, S. Crouzy, I. Michaud-Soret
New insights into the tetrameric family of the Fur metalloregulators
published pages: 501-519, ISSN: 0966-0844, DOI: 10.1007/s10534-019-00201-8
BioMetals 32/3 2020-03-06
2019 Daniel Merk, Sridhar Sreeramulu, Denis Kudlinzki, Krishna Saxena, Verena Linhard, Santosh L. Gande, Fabian Hiller, Christina Lamers, Ewa Nilsson, Anna Aagaard, Lisa Wissler, Niek Dekker, Krister Bamberg, Manfred Schubert-Zsilavecz, Harald Schwalbe
Molecular tuning of farnesoid X receptor partial agonism
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-10853-2
Nature Communications 10/1 2020-03-06
2018 Shu Zhou, Pontus Pettersson, Peter Brzezinski, Pia Ädelroth, Lena Mäler
NMR Study of Rcf2 Reveals an Unusual Dimeric Topology in Detergent Micelles
published pages: 444-447, ISSN: 1439-4227, DOI: 10.1002/cbic.201700664
ChemBioChem 19/5 2020-03-06
2019 Joan Segura, Ruben Sanchez-Garcia, C O S Sorzano, J M Carazo
3DBIONOTES v3.0: crossing molecular and structural biology data with genomic variations
published pages: 3512-3513, ISSN: 1367-4803, DOI: 10.1093/bioinformatics/btz118
Bioinformatics 35/18 2020-03-06
2019 Ana Cuervo, Montserrat Fàbrega-Ferrer, Cristina Machón, José Javier Conesa, Francisco J. Fernández, Rosa Pérez-Luque, Mar Pérez-Ruiz, Joan Pous, M. Cristina Vega, José L. Carrascosa, Miquel Coll
Structures of T7 bacteriophage portal and tail suggest a viral DNA retention and ejection mechanism
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-11705-9
Nature Communications 10/1 2020-03-06
2019 Alvaro Mallagaray, Robert Creutznacher, Jasmin Dülfer, Philipp H. O. Mayer, Lena Lisbeth Grimm, Jose Maria Orduña, Esben Trabjerg, Thilo Stehle, Kasper D. Rand, Bärbel S. Blaum, Charlotte Uetrecht, Thomas Peters
A post-translational modification of human Norovirus capsid protein attenuates glycan binding
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09251-5
Nature Communications 10/1 2020-03-06
2019 Liubov A. Dadinova, Yurii M. Chesnokov, Roman A. Kamyshinsky, Ivan A. Orlov, Maxim V. Petoukhov, Andrey A. Mozhaev, Ekaterina Yu. Soshinskaya, Vassili N. Lazarev, Valentin A. Manuvera, Anton S. Orekhov, Alexander L. Vasiliev, Eleonora V. Shtykova
Protective Dps–DNA co‐crystallization in stressed cells: an in vitro structural study by small‐angle X‐ray scattering and cryo‐electron tomography
published pages: 1360-1371, ISSN: 0014-5793, DOI: 10.1002/1873-3468.13439
FEBS Letters 593/12 2020-03-06
2019 Andreas Luxenburger, Dorian Schmidt, Chiara Ianes, Christian Pichlo, Marc Krüger, Thorsten von Drathen, Elena Brunstein, Graeme Gainsford, Ulrich Baumann, Uwe Knippschild, Christian Peifer
Design, Synthesis and Biological Evaluation of Isoxazole-Based CK1 Inhibitors Modified with Chiral Pyrrolidine Scaffolds
published pages: 873, ISSN: 1420-3049, DOI: 10.3390/molecules24050873
Molecules 24/5 2020-03-06
2018 J.L. Vilas, N. Tabassum, J. Mota, D. Maluenda, A. Jiménez-Moreno, T. Majtner, J.M. Carazo, S.T. Acton, C.O.S. Sorzano
Advances in image processing for single-particle analysis by electron cryomicroscopy and challenges ahead
published pages: 127-145, ISSN: 0959-440X, DOI: 10.1016/j.sbi.2018.11.004
Current Opinion in Structural Biology 52 2020-03-06
2019 Chao Qi, Simona Sorrentino, Ohad Medalia, Volodymyr M. Korkhov
The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein
published pages: 389-394, ISSN: 0036-8075, DOI: 10.1126/science.aav0778
Science 364/6438 2020-03-06
2019 Yi Yang, Catherine R. Back, Melissa A. Gräwert, Ayla A. Wahid, Harriet Denton, Rebecca Kildani, Joshua Paulin, Kristin Wörner, Wolgang Kaiser, Dmitri I. Svergun, Asel Sartbaeva, Andrew G. Watts, Kevin J. Marchbank, Jean M. H. van den Elsen
Utilization of Staphylococcal Immune Evasion Protein Sbi as a Novel Vaccine Adjuvant
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.03139
Frontiers in Immunology 9 2020-03-06
2019 Ferdinand Krupp, Nelly Said, Yong-Heng Huang, Bernhard Loll, Jörg Bürger, Thorsten Mielke, Christian M.T. Spahn, Markus C. Wahl
Structural Basis for the Action of an All-Purpose Transcription Anti-termination Factor
published pages: 143-157.e5, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2019.01.016
Molecular Cell 74/1 2020-03-06
2019 Johann Holzmann, Antonio Z Politi, Kota Nagasaka, Merle Hantsche-Grininger, Nike Walther, Birgit Koch, Johannes Fuchs, Gerhard Dürnberger, Wen Tang, Rene Ladurner, Roman R Stocsits, Georg A Busslinger, Béla Novák, Karl Mechtler, Iain Finley Davidson, Jan Ellenberg, Jan-Michael Peters
Absolute quantification of cohesin, CTCF and their regulators in human cells
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.46269
eLife 8 2020-03-06
2019 Joel B. Heim, Vesna Hodnik, Julie E. Heggelund, Gregor Anderluh, Ute Krengel
Crystal structures of cholera toxin in complex with fucosylated receptors point to importance of secondary binding site
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-48579-2
Scientific Reports 9/1 2020-03-06
2019 Enrico Ravera, Giacomo Parigi, Claudio Luchinat
What are the methodological and theoretical prospects for paramagnetic NMR in structural biology? A glimpse into the crystal ball
published pages: 173-179, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2019.07.027
Journal of Magnetic Resonance 306 2020-03-06
2019 C. O. S. Sorzano, A. Jiménez, J. Mota, J. L. Vilas, D. Maluenda, M. Martínez, E. Ramírez-Aportela, T. Majtner, J. Segura, R. Sánchez-García, Y. Rancel, L. del Caño, P. Conesa, R. Melero, S. Jonic, J. Vargas, F. Cazals, Z. Freyberg, J. Krieger, I. Bahar, R. Marabini, J. M. Carazo
Survey of the analysis of continuous conformational variability of biological macromolecules by electron microscopy
published pages: 19-32, ISSN: 2053-230X, DOI: 10.1107/s2053230x18015108
Acta Crystallographica Section F Structural Biology Communications 75/1 2020-03-06
2019 Joao Ramos, Jayaraman Muthukumaran, Filipe Freire, João Paquete-Ferreira, Ana Otrelo-Cardoso, Dmitri Svergun, Alejandro Panjkovich, Teresa Santos-Silva
Shedding Light on the Interaction of Human Anti-Apoptotic Bcl-2 Protein with Ligands through Biophysical and in Silico Studies
published pages: 860, ISSN: 1422-0067, DOI: 10.3390/ijms20040860
International Journal of Molecular Sciences 20/4 2020-03-06
2019 Chiara Marabelli, Biagina Marrocco, Simona Pilotto, Sagar Chittori, Sarah Picaud, Sara Marchese, Giuseppe Ciossani, Federico Forneris, Panagis Filippakopoulos, Guy Schoehn, Daniela Rhodes, Sriram Subramaniam, Andrea Mattevi
A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex
published pages: 387-399.e7, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.03.061
Cell Reports 27/2 2020-03-06
2019 Yonca Ural-Blimke, Ali Flayhan, Jan Strauss, Vasileios Rantos, Kim Bartels, Rolf Nielsen, Els Pardon, Jan Steyaert, Jan Kosinski, Esben M. Quistgaard, Christian Löw
Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1
published pages: 2404-2412, ISSN: 0002-7863, DOI: 10.1021/jacs.8b11343
Journal of the American Chemical Society 141/6 2020-03-06
2019 Marila Alfano, Julien Pérard, Philippe Carpentier, Christian Basset, Barbara Zambelli, Jennifer Timm, Serge Crouzy, Stefano Ciurli, Christine Cavazza
The carbon monoxide dehydrogenase accessory protein CooJ is a histidine-rich multidomain dimer containing an unexpected Ni(II)-binding site
published pages: 7601-7614, ISSN: 0021-9258, DOI: 10.1074/jbc.ra119.008011
Journal of Biological Chemistry 294/19 2020-03-06
2019 Siddarth Narasimhan, Stephan Scherpe, Alessandra Lucini Paioni, Johan van der Zwan, Gert E. Folkers, Huib Ovaa, Marc Baldus
DNP-Supported Solid-State NMR Spectroscopy of Proteins Inside Mammalian Cells
published pages: 12969-12973, ISSN: 1433-7851, DOI: 10.1002/anie.201903246
Angewandte Chemie International Edition 58/37 2020-03-06
2019 Vadim Kotov, Kim Bartels, Katharina Veith, Inokentijs Josts, Udaya K. Tiruttani Subhramanyam, Christian Günther, Jörg Labahn, Thomas C. Marlovits, Isabel Moraes, Henning Tidow, Christian Löw, Maria M. Garcia-Alai
High-throughput stability screening for detergent-solubilized membrane proteins
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-46686-8
Scientific Reports 9/1 2020-03-06
2018 Meytal Galilee, Akram Alian
The structure of FIV reverse transcriptase and its implications for non-nucleoside inhibitor resistance
published pages: e1006849, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1006849
PLOS Pathogens 14/1 2019-11-22
2018 Beatriz Trastoy, Erik Klontz, Jared Orwenyo, Alberto Marina, Lai-Xi Wang, Eric J. Sundberg, Marcelo E. Guerin
Structural basis for the recognition of complex-type N-glycans by Endoglycosidase S
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04300-x
Nature Communications 9/1 2019-11-22
2018 Kinga Nyíri, Haydyn D. T. Mertens, Borbála Tihanyi, Gergely N. Nagy, Bianka Kőhegyi, Judit Matejka, Matthew J. Harris, Judit E. Szabó, Veronika Papp-Kádár, Veronika Németh-Pongrácz, Olivér Ozohanics, Károly Vékey, Dmitri I. Svergun, Antoni J. Borysik, Beáta G. Vértessy
Structural model of human dUTPase in complex with a novel proteinaceous inhibitor
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-22145-8
Scientific Reports 8/1 2019-11-22
2018 Sándor Kun, Jaida Begum, Efthimios Kyriakis, Evgenia C.V. Stamati, Thomas A. Barkas, Eszter Szennyes, Éva Bokor, Katalin E. Szabó, George A. Stravodimos, Ádám Sipos, Tibor Docsa, Pál Gergely, Colin Moffatt, Myrto S. Patraskaki, Maria C. Kokolaki, Alkistis Gkerdi, Vassiliki T. Skamnaki, Demetres D. Leonidas, László Somsák, Joseph M. Hayes
A multidisciplinary study of 3-(β- d -glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis, crystallography and kinetics reveal new potent inhibitors
published pages: 266-278, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2018.01.095
European Journal of Medicinal Chemistry 147 2019-11-22
2018 Anna Niesteruk, Hendrik R. A. Jonker, Christian Richter, Verena Linhard, Sridhar Sreeramulu, Harald Schwalbe
The domain architecture of PtkA, the first tyrosine kinase from Mycobacterium tuberculosis , differs from the conventional kinase architecture
published pages: 11823-11836, ISSN: 0021-9258, DOI: 10.1074/jbc.RA117.000120
Journal of Biological Chemistry 293/30 2019-11-22
2018 Birgit Koch, Bianca Nijmeijer, Moritz Kueblbeck, Yin Cai, Nike Walther, Jan Ellenberg
Generation and validation of homozygous fluorescent knock-in cells using CRISPR–Cas9 genome editing
published pages: 1465-1487, ISSN: 1754-2189, DOI: 10.1038/nprot.2018.042
Nature Protocols 13/6 2019-11-22
2018 Anna Kluza, Ewa Niedzialkowska, Katarzyna Kurpiewska, Zuzanna Wojdyla, Matthew Quesne, Ewa Kot, Przemyslaw J. Porebski, Tomasz Borowski
Crystal structure of thebaine 6-O-demethylase from the morphine biosynthesis pathway
published pages: 229-235, ISSN: 1047-8477, DOI: 10.1016/j.jsb.2018.01.007
Journal of Structural Biology 202/3 2019-11-22
2018 Nelly R. Hajizadeh, Daniel Franke, Cy M. Jeffries, Dmitri I. Svergun
Consensus Bayesian assessment of protein molecular mass from solution X-ray scattering data
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-25355-2
Scientific Reports 8/1 2019-11-22
2018 Fabrizio Martino, Mohinder Pal, Hugo Muñoz-Hernández, Carlos F. Rodríguez, Rafael Núñez-Ramírez, David Gil-Carton, Gianluca Degliesposti, J. Mark Skehel, S. Mark Roe, Chrisostomos Prodromou, Laurence H. Pearl, Oscar Llorca
RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03942-1
Nature Communications 9/1 2019-11-22
2018 Simon Dzatko, Michaela Krafcikova, Robert Hänsel-Hertsch, Tomas Fessl, Radovan Fiala, Tomas Loja, Daniel Krafcik, Jean-Louis Mergny, Silvie Foldynova-Trantirkova, Lukas Trantirek
Evaluation of the Stability of DNA i-Motifs in the Nuclei of Living Mammalian Cells
published pages: 2165-2169, ISSN: 1433-7851, DOI: 10.1002/anie.201712284
Angewandte Chemie International Edition 57/8 2019-11-22
2018 Stuart C Howes, Roman I Koning, Abraham J Koster
Correlative microscopy for structural microbiology
published pages: 132-138, ISSN: 1369-5274, DOI: 10.1016/j.mib.2018.01.009
Current Opinion in Microbiology 43 2019-11-22
2018 Yury B. Slonimskiy, Eugene G. Maksimov, Evgeny P. Lukashev, Marcus Moldenhauer, Cy M. Jeffries, Dmitri I. Svergun, Thomas Friedrich, Nikolai N. Sluchanko
Functional interaction of low-homology FRPs from different cyanobacteria with Synechocystis OCP
published pages: 382-393, ISSN: 0005-2728, DOI: 10.1016/j.bbabio.2018.03.001
Biochimica et Biophysica Acta (BBA) - Bioenergetics 1859/5 2019-11-22
2018 Daniel Franke, Cy M. Jeffries, Dmitri I. Svergun
Machine Learning Methods for X-Ray Scattering Data Analysis from Biomacromolecular Solutions
published pages: 2485-2492, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2018.04.018
Biophysical Journal 114/11 2019-11-22
2018 Sébastien Igonet, Claire Raingeval, Erika Cecon, Maja Pučić-Baković, Gordan Lauc, Olivier Cala, Maciej Baranowski, Javier Perez, Ralf Jockers, Isabelle Krimm, Anass Jawhari
Enabling STD-NMR fragment screening using stabilized native GPCR: A case study of adenosine receptor
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-26113-0
Scientific Reports 8/1 2019-11-22
2018 Verity A. Jackson, Dimphna H. Meijer, Maria Carrasquero, Laura S. van Bezouwen, Edward D. Lowe, Colin Kleanthous, Bert J. C. Janssen, Elena Seiradake
Structures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03460-0
Nature Communications 9/1 2019-11-22
2018 Michael J. Capper, Gareth S. A. Wright, Letizia Barbieri, Enrico Luchinat, Eleonora Mercatelli, Luke McAlary, Justin J. Yerbury, Paul M. O’Neill, Svetlana V. Antonyuk, Lucia Banci, S. Samar Hasnain
The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04114-x
Nature Communications 9/1 2019-11-22
2018 Bart van Beusekom, Wouter G. Touw, Mahidhar Tatineni, Sandeep Somani, Gunaretnam Rajagopal, Jinquan Luo, Gary L. Gilliland, Anastassis Perrakis, Robbie P. Joosten
Homology-based hydrogen bond information improves crystallographic structures in the PDB
published pages: 798-808, ISSN: 0961-8368, DOI: 10.1002/pro.3353
Protein Science 27/3 2019-11-22
2018 Petr V. Konarev, Dmitri I. Svergun
Direct shape determination of intermediates in evolving macromolecular solutions from small-angle scattering data
published pages: 402-409, ISSN: 2052-2525, DOI: 10.1107/S2052252518005900
IUCrJ 5/4 2019-11-22
2018 Alexandra Louka, Irina Matlahov, Stefano Giuntini, Linda Cerofolini, Andrea Cavallo, Serena Pillozzi, Enrico Ravera, Marco Fragai, Annarosa Arcangeli, Ayyalusamy Ramamoorthy, Gil Goobes, Claudio Luchinat
Engineering l -asparaginase for spontaneous formation of calcium phosphate bioinspired microreactors
published pages: 12719-12726, ISSN: 1463-9076, DOI: 10.1039/c8cp00419f
Physical Chemistry Chemical Physics 20/18 2019-11-22
2018 Abdullah Basoglu, Ismail Sen, Gaia Meoni, Leonardo Tenori, Amir Naseri
NMR-Based Plasma Metabolomics at Set Intervals in Newborn Dairy Calves with Severe Sepsis
published pages: 1-12, ISSN: 0962-9351, DOI: 10.1155/2018/8016510
Mediators of Inflammation 2018 2019-11-22
2017 The Quyen Nguyen, Mélanie Chenon, Fernando Vilela, Christophe Velours, Magali Aumont-Nicaise, Jessica Andreani, Paloma F. Varela, Paola Llinas, Julie Ménétrey
Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain
published pages: 1-20, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0186354.s004
PLOS ONE October 16, 2017 2019-11-22
2018 Sven Falke, Karsten Dierks, Clement Blanchet, Melissa Graewert, Florent Cipriani, Rob Meijers, Dmitri Svergun, Christian Betzel
Multi-channel in situ dynamic light scattering instrumentation enhancing biological small-angle X-ray scattering experiments at the PETRA III beamline P12
published pages: 361-372, ISSN: 1600-5775, DOI: 10.1107/S1600577517017568
Journal of Synchrotron Radiation 25/2 2019-11-22
2018 Flayhan A, Mertens HDT, Ural-Blimke Y, Martinez Molledo M, Svergun DI, Löw C
Saposin Lipid Nanoparticles: A Highly Versatile and Modular Tool for Membrane Protein Research
published pages: 345-355, ISSN: 0969-2126, DOI: 10.1016/j.str.2018.01.007
Structure 26 2019-11-22
2017 Tanmay A. M. Bharat, Danguole Kureisaite-Ciziene, Gail G. Hardy, Ellen W. Yu, Jessica M. Devant, Wim J. H. Hagen, Yves V. Brun, John A. G. Briggs, Jan Löwe
Structure of the hexagonal surface layer on Caulobacter crescentus cells
published pages: 17059, ISSN: 2058-5276, DOI: 10.1038/nmicrobiol.2017.59
Nature Microbiology 2 2019-11-22
2018 Ilektra-Chara Giassa, Jan Rynes, Tomas Fessl, Silvie Foldynova-Trantirkova, Lukas Trantirek
Advances in the cellular structural biology of nucleic acids
published pages: 1997-2011, ISSN: 0014-5793, DOI: 10.1002/1873-3468.13054
FEBS Letters 592/12 2019-11-22
2018 Friedemann Flügge, Thomas Peters
Complete assignment of Ala, Ile, Leu, Met and Val methyl groups of human blood group A and B glycosyltransferases using lanthanide-induced pseudocontact shifts and methyl–methyl NOESY
published pages: 245-259, ISSN: 0925-2738, DOI: 10.1007/s10858-018-0183-4
Journal of Biomolecular NMR 70/4 2019-11-22
2018 Julien Marquevielle, M. V. Vasantha Kumar, Jean-Louis Mergny, Gilmar F. Salgado
1H, 13C, and 15N chemical shift assignments of a G-quadruplex forming sequence within the KRAS proto-oncogene promoter region
published pages: 123-127, ISSN: 1874-2718, DOI: 10.1007/s12104-017-9793-0
Biomolecular NMR Assignments 12/1 2019-11-22
2018 Barbara Wienen-Schmidt, Hendrik R. A. Jonker, Tobias Wulsdorf, Hans-Dieter Gerber, Krishna Saxena, Denis Kudlinzki, Sridhar Sreeramulu, Giacomo Parigi, Claudio Luchinat, Andreas Heine, Harald Schwalbe, Gerhard Klebe
Paradoxically, Most Flexible Ligand Binds Most Entropy-Favored: Intriguing Impact of Ligand Flexibility and Solvation on Drug–Kinase Binding
published pages: 5922-5933, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.8b00105
Journal of Medicinal Chemistry 61/14 2019-11-22
2018 Florian Delbart, Marijke Brams, Fabian Gruss, Sam Noppen, Steve Peigneur, Sandro Boland, Patrick Chaltin, Jose Brandao-Neto, Frank von Delft, Wouter G. Touw, Robbie P. Joosten, Sandra Liekens, Jan Tytgat, Chris Ulens
An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein
published pages: 2534-2545, ISSN: 0021-9258, DOI: 10.1074/jbc.M117.815316
Journal of Biological Chemistry 293/7 2019-11-22
2018 Antonio Z Politi, Yin Cai, Nike Walther, M Julius Hossain, Birgit Koch, Malte Wachsmuth, Jan Ellenberg
Quantitative mapping of fluorescently tagged cellular proteins using FCS-calibrated four-dimensional imaging
published pages: 1445-1464, ISSN: 1754-2189, DOI: 10.1038/nprot.2018.040
Nature Protocols 13/6 2019-11-22
2018 Carlos Sacristan, Misbha Ud Din Ahmad, Jenny Keller, Job Fermie, Vincent Groenewold, Eelco Tromer, Alexander Fish, Roberto Melero, José María Carazo, Judith Klumperman, Andrea Musacchio, Anastassis Perrakis, Geert JPL Kops
Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis
published pages: 800-810, ISSN: 1465-7392, DOI: 10.1038/s41556-018-0130-3
Nature Cell Biology 20/7 2019-11-22
2018 Franziska Kappert, Sridhar Sreeramulu, Hendrik R. A. Jonker, Christian Richter, Vladimir V. Rogov, Ewgenij Proschak, Bruno Hargittay, Krishna Saxena, Harald Schwalbe
Structural Characterization of the Interaction of the Fibroblast Growth Factor Receptor with a Small Molecule Allosteric Inhibitor
published pages: 7861-7865, ISSN: 0947-6539, DOI: 10.1002/chem.201801770
Chemistry - A European Journal 24/31 2019-11-22
2018 Aurore Cabanettes, Lukas Perkams, Carolina Spies, Carlo Unverzagt, Annabelle Varrot
Recognition of Complex Core-Fucosylated N-Glycans by a Mini Lectin
published pages: 10178-10181, ISSN: 1433-7851, DOI: 10.1002/anie.201805165
Angewandte Chemie International Edition 57/32 2019-11-22
2018 Sissy Kalayil, Sagar Bhogaraju, Florian Bonn, Donghyuk Shin, Yaobin Liu, Ninghai Gan, Jérôme Basquin, Paolo Grumati, Zhao-Qing Luo, Ivan Dikic
Insights into catalysis and function of phosphoribosyl-linked serine ubiquitination
published pages: 734-738, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0145-8
Nature 557/7707 2019-11-22
2018 Amparo Garcia-Lopez, Francesca Tessaro, Hendrik R. A. Jonker, Anna Wacker, Christian Richter, Arnaud Comte, Nikolaos Berntenis, Roland Schmucki, Klas Hatje, Olivier Petermann, Gianpaolo Chiriano, Remo Perozzo, Daniel Sciarra, Piotr Konieczny, Ignacio Faustino, Guy Fournet, Modesto Orozco, Ruben Artero, Friedrich Metzger, Martin Ebeling, Peter Goekjian, Benoît Joseph, Harald Schwalbe, Leonardo Scapozza
Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04110-1
Nature Communications 9/1 2019-11-22
2018 Zhou S, Pettersson P, Huang J, Sjöholm J, Sjöstrand D, Pomès R, Högbom M, Brzezinski P, Mäler L, Ädelroth P
Solution NMR structure of yeast Rcf1, a protein involved in respiratory supercomplex formation
published pages: 3048-3053, ISSN: 0027-8424, DOI:
Proc Natl Acad Sci U S A 115(12) 2019-11-22
2018 Shu Zhou, Pontus Pettersson, Jingjing Huang, Johannes Sjöholm, Dan Sjöstrand, Régis Pomès, Martin Högbom, Peter Brzezinski, Lena Mäler, Pia Ädelroth
Solution NMR structure of yeast Rcf1, a protein involved in respiratory supercomplex formation
published pages: 3048-3053, ISSN: 0027-8424, DOI: 10.1073/pnas.1712061115
Proceedings of the National Academy of Sciences 115/12 2019-11-22
2018 Guillermo Abascal-Palacios, Ewan Phillip Ramsay, Fabienne Beuron, Edward Morris, Alessandro Vannini
Structural basis of RNA polymerase III transcription initiation
published pages: 301-306, ISSN: 0028-0836, DOI: 10.1038/nature25441
Nature 553/7688 2019-11-22
2018 Michael Graf, Paul Huter, Cristina Maracci, Miroslav Peterek, Marina V. Rodnina, Daniel N. Wilson
Visualization of translation termination intermediates trapped by the Apidaecin 137 peptide during RF3-mediated recycling of RF1
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05465-1
Nature Communications 9/1 2019-11-22
2018 Nelly R. Hajizadeh, Daniel Franke, Dmitri I. Svergun
Integrated beamline control and data acquisition for small-angle X-ray scattering at the P12 BioSAXS beamline at PETRAIII storage ring DESY
published pages: 906-914, ISSN: 1600-5775, DOI: 10.1107/S1600577518005398
Journal of Synchrotron Radiation 25/3 2019-11-22
2018 Yi-Han Lin, María Lucas, Timothy R. Evans, Guillermo Abascal-Palacios, Alexandra G. Doms, Nicole A. Beauchene, Adriana L. Rojas, Aitor Hierro, Matthias P. Machner
RavN is a member of a previously unrecognized group of Legionella pneumophila E3 ubiquitin ligases
published pages: e1006897, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1006897
PLOS Pathogens 14/2 2019-11-22
2018 Po-chia Chen, Pawel Masiewicz, Vladimir Rybin, Dmitri Svergun, Janosch Hennig
A General Small-Angle X-ray Scattering-Based Screening Protocol Validated for Protein–RNA Interactions
published pages: 197-202, ISSN: 2156-8952, DOI: 10.1021/acscombsci.8b00007
ACS Combinatorial Science 20/4 2019-11-22
2018 iNEXT Consortium
iNEXT: a European facility network to stimulate translational structural biology
published pages: , ISSN: 0014-5793, DOI: 10.1002/1873-3468.13062
FEBS Letters 2019-11-22
2017 Alejandro Panjkovich, Dmitri I Svergun
CHROMIXS: automatic and interactive analysis of chromatography-coupled small-angle X-ray scattering data
published pages: 1-3, ISSN: 1367-4803, DOI: 10.1093/bioinformatics/btx846
Bioinformatics 28 December 2017 2019-11-22
2017 Sigrun Rumpel, Enrico Ravera, Constanze Sommer, Edward Reijerse, Christophe Farès, Claudio Luchinat, Wolfgang Lubitz
1 H NMR Spectroscopy of [FeFe] Hydrogenase: Insight into the Electronic Structure of the Active Site
published pages: 131-134, ISSN: 0002-7863, DOI: 10.1021/jacs.7b11196
Journal of the American Chemical Society 140/1 2019-11-22
2018 Martin A. Schroer, Clement E. Blanchet, Andrey Yu. Gruzinov, Melissa A. Gräwert, Martha E. Brennich, Nelly R. Hajizadeh, Cy M. Jeffries, Dmitri I. Svergun
Smaller capillaries improve the small-angle X-ray scattering signal and sample consumption for biomacromolecular solutions
published pages: 1113-1122, ISSN: 1600-5775, DOI: 10.1107/S1600577518007907
Journal of Synchrotron Radiation 25/4 2019-11-22
2018 Anne Diehl, Yvette Roske, Linda Ball, Anup Chowdhury, Matthias Hiller, Noel Molière, Regina Kramer, Daniel Stöppler, Catherine L. Worth, Brigitte Schlegel, Martina Leidert, Nils Cremer, Natalja Erdmann, Daniel Lopez, Heike Stephanowitz, Eberhard Krause, Barth-Jan van Rossum, Peter Schmieder, Udo Heinemann, Kürşad Turgay, Ümit Akbey, Hartmut Oschkinat
Structural changes of TasA in biofilm formation of Bacillus subtilis
published pages: 3237-3242, ISSN: 0027-8424, DOI: 10.1073/pnas.1718102115
Proceedings of the National Academy of Sciences 115/13 2019-11-22
2018 Martinez Molledo M, Quistgaard EM, Flayhan A, Pieprzyk J, Löw C
Multispecific Substrate Recognition in a Proton-Dependent Oligopeptide Transporter.
published pages: 467-476, ISSN: 0969-2126, DOI:
Structure Mar 6;26(3) 2019-11-22
2018 M. Alfano, J. Pérard, R. Miras, P. Catty, C. Cavazza
Biophysical and structural characterization of the putative nickel chaperone CooT from Carboxydothermus hydrogenoformans
published pages: 809-817, ISSN: 0949-8257, DOI: 10.1007/s00775-018-1576-2
JBIC Journal of Biological Inorganic Chemistry 23/5 2019-11-22
2018 Anna Niesteruk, Marie Hutchison, Sridhar Sreeramulu, Hendrik R.A. Jonker, Christian Richter, Rupert Abele, Christoph Bock, Harald Schwalbe
Structural characterization of the intrinsically disordered domain of Mycobacterium tuberculosis protein tyrosine kinase A
published pages: 1233-1245, ISSN: 0014-5793, DOI: 10.1002/1873-3468.13022
FEBS Letters 592/7 2019-11-22
2018 Thomas Hermanns, Christian Pichlo, Ilka Woiwode, Karsten Klopffleisch, Katharina F. Witting, Huib Ovaa, Ulrich Baumann, Kay Hofmann
A family of unconventional deubiquitinases with modular chain specificity determinants
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03148-5
Nature Communications 9/1 2019-11-22
2018 Bart van Beusekom, Krista Joosten, Maarten L. Hekkelman, Robbie P. Joosten, Anastassis Perrakis
Homology-based loop modeling yields more complete crystallographic protein structures
published pages: 585-594, ISSN: 2052-2525, DOI: 10.1107/s2052252518010552
IUCrJ 5/5 2019-11-22
2018 Alessandro Emendato, Remo Guerrini, Erika Marzola, Hans Wienk, Rolf Boelens, Serena Leone, Delia Picone
Disordered Peptides Looking for Their Native Environment: Structural Basis of CB1 Endocannabinoid Receptor Binding to Pepcans
published pages: , ISSN: 2296-889X, DOI: 10.3389/fmolb.2018.00100
Frontiers in Molecular Biosciences 5 2019-11-22
2018 Gareth S. A. Wright, Akane Saeki, Takaaki Hikima, Yoko Nishizono, Tamao Hisano, Misaki Kamaya, Kohei Nukina, Hideo Nishitani, Hiro Nakamura, Masaki Yamamoto, Svetlana V. Antonyuk, S. Samar Hasnain, Yoshitsugu Shiro, Hitomi Sawai
Architecture of the complete oxygen-sensing FixL-FixJ two-component signal transduction system
published pages: eaaq0825, ISSN: 1937-9145, DOI: 10.1126/scisignal.aaq0825
Science Signaling 11/525 2019-11-22
2018 Cecilia Pinto, Deni Mance, Tessa Sinnige, Mark Daniëls, Markus Weingarth, Marc Baldus
Formation of the β-barrel assembly machinery complex in lipid bilayers as seen by solid-state NMR
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06466-w
Nature Communications 9/1 2019-11-22
2018 Yin Cai, M. Julius Hossain, Jean-Karim Hériché, Antonio Z. Politi, Nike Walther, Birgit Koch, Malte Wachsmuth, Bianca Nijmeijer, Moritz Kueblbeck, Marina Martinic-Kavur, Rene Ladurner, Stephanie Alexander, Jan-Michael Peters, Jan Ellenberg
Experimental and computational framework for a dynamic protein atlas of human cell division
published pages: 411-415, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0518-z
Nature 561/7723 2019-11-22
2018 Alexander Marchanka, Jan Stanek, Guido Pintacuda, Teresa Carlomagno
Rapid access to RNA resonances by proton-detected solid-state NMR at >100 kHz MAS
published pages: 8972-8975, ISSN: 1359-7345, DOI: 10.1039/c8cc04437f
Chemical Communications 54/65 2019-11-22
2018 Daniel Stöppler, Alex Macpherson, Susanne Smith-Penzel, Nicolas Basse, Fabien Lecomte, Hervé Deboves, Richard D. Taylor, Tim Norman, John Porter, Lorna C. Waters, Marta Westwood, Ben Cossins, Katharine Cain, James White, Robert Griffin, Christine Prosser, Sebastian Kelm, Amy H. Sullivan, David Fox, Mark D. Carr, Alistair Henry, Richard Taylor, Beat H. Meier, Hartmut Oschkinat, Alastair D. Lawson
Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR
published pages: e2006192, ISSN: 1545-7885, DOI: 10.1371/journal.pbio.2006192
PLOS Biology 16/5 2019-11-22
2018 Nikolai N. Sluchanko, Yury B. Slonimskiy, Evgeny A. Shirshin, Marcus Moldenhauer, Thomas Friedrich, Eugene G. Maksimov
OCP–FRP protein complex topologies suggest a mechanism for controlling high light tolerance in cyanobacteria
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06195-0
Nature Communications 9/1 2019-11-22
2017 Luca Mazzei, Michele Cianci, Umberto Contaldo, Francesco Musiani, Stefano Ciurli
Urease Inhibition in the Presence of N -( n -Butyl)thiophosphoric Triamide, a Suicide Substrate: Structure and Kinetics
published pages: 5391-5404, ISSN: 0006-2960, DOI: 10.1021/acs.biochem.7b00750
Biochemistry 56/40 2019-11-22
2018 Sarah Clark, Janette B Myers, Ashleigh King, Radovan Fiala, Jiri Novacek, Grant Pearce, Jörg Heierhorst, Steve L Reichow, Elisar J Barbar
Multivalency regulates activity in an intrinsically disordered transcription factor
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.36258
eLife 7 2019-11-22
2018 J. Pérard, S. Nader, M. Levert, L. Arnaud, P. Carpentier, C. Siebert, F. Blanquet, C. Cavazza, P. Renesto, D. Schneider, M. Maurin, J. Coves, S. Crouzy, I. Michaud-Soret
Structural and functional studies of the metalloregulator Fur identify a promoter-binding mechanism and its role in Francisella tularensis virulence
published pages: , ISSN: 2399-3642, DOI: 10.1038/s42003-018-0095-6
Communications Biology 1/1 2019-11-22
2018 Caillan Crowe-McAuliffe, Michael Graf, Paul Huter, Hiraku Takada, Maha Abdelshahid, Jiří Nováček, Victoriia Murina, Gemma C. Atkinson, Vasili Hauryliuk, Daniel N. Wilson
Structural basis for antibiotic resistance mediated by the Bacillus subtilis ABCF ATPase VmlR
published pages: 8978-8983, ISSN: 0027-8424, DOI: 10.1073/pnas.1808535115
Proceedings of the National Academy of Sciences 115/36 2019-11-22
2017 Cecilia Pinto, Deni Mance, Manon Julien, Mark Daniels, Markus Weingarth, Marc Baldus
Studying assembly of the BAM complex in native membranes by cellular solid-state NMR spectroscopy
published pages: , ISSN: 1047-8477, DOI: 10.1016/j.jsb.2017.11.015
Journal of Structural Biology 2019-11-22
2018 Ana Rita Costa, Rita Pinto-Costa, Sara Castro Sousa, Mónica Mendes Sousa
The Regulation of Axon Diameter: From Axonal Circumferential Contractility to Activity-Dependent Axon Swelling
published pages: , ISSN: 1662-5099, DOI: 10.3389/fnmol.2018.00319
Frontiers in Molecular Neuroscience 11 2019-11-22
2018 Wing Ying Chow, Rui Li, Ieva Goldberga, David G. Reid, Rakesh Rajan, Jonathan Clark, Hartmut Oschkinat, Melinda J. Duer, Robert Hayward, Catherine M. Shanahan
Essential but sparse collagen hydroxylysyl post-translational modifications detected by DNP NMR
published pages: 12570-12573, ISSN: 1359-7345, DOI: 10.1039/c8cc04960b
Chemical Communications 54/89 2019-11-22
2018 Nadav Elad, Szilvia Baron, Yoav Peleg, Shira Albeck, Jacob Grunwald, Gal Raviv, Zippora Shakked, Oren Zimhony, Ron Diskin
Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 Å resolution
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06440-6
Nature Communications 9/1 2019-11-22
2018 R. Marabini, M. Kazemi, C.O.S. Sorzano, J.M. Carazo
Map challenge: Analysis using a pair comparison method based on Fourier shell correlation
published pages: 527-542, ISSN: 1047-8477, DOI: 10.1016/j.jsb.2018.09.009
Journal of Structural Biology 204/3 2019-11-22
2019 Inga Songailiene, Marius Rutkauskas, Tomas Sinkunas, Elena Manakova, Sabine Wittig, Carla Schmidt, Virginijus Siksnys, Ralf Seidel
Decision-Making in Cascade Complexes Harboring crRNAs of Altered Length
published pages: 3157-3166.e4, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.08.033
Cell Reports 28/12 2019-11-22
2018 Gustavo Fuertes, Niccolo Banterle, Kiersten M. Ruff, Aritra Chowdhury, Rohit V. Pappu, Dmitri I. Svergun, Edward A. Lemke
Comment on “Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water”
published pages: eaau8230, ISSN: 0036-8075, DOI: 10.1126/science.aau8230
Science 361/6405 2019-11-22
2018 Alberto Marra, Jiajia Dong, Tiancheng Ma, Stefano Giuntini, Elisa Crescenzo, Linda Cerofolini, Marco Martinucci, Claudio Luchinat, Marco Fragai, Cristina Nativi, Alessandro Dondoni
Protein Glycosylation through Sulfur Fluoride Exchange (SuFEx) Chemistry: The Key Role of a Fluorosulfate Thiolactoside
published pages: 18981-18987, ISSN: 0947-6539, DOI: 10.1002/chem.201803912
Chemistry - A European Journal 24/71 2019-11-22
2018 Marta Compte, Seandean Lykke Harwood, Ines G. Muñoz, Rocio Navarro, Manuela Zonca, Gema Perez-Chacon, Ainhoa Erce-Llamazares, Nekane Merino, Antonio Tapia-Galisteo, Angel M. Cuesta, Kasper Mikkelsen, Eduardo Caleiras, Natalia Nuñez-Prado, M. Angela Aznar, Simon Lykkemark, Jorge Martínez-Torrecuadrada, Ignacio Melero, Francisco J. Blanco, Jorge Bernardino de la Serna, Juan M. Zapata, Laura Sanz, Luis Alvarez-Vallina
A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07195-w
Nature Communications 9/1 2019-11-22
2018 J. Bernard Heymann, Roberto Marabini, Mohsen Kazemi, Carlos Oscar S. Sorzano, Maya Holmdahl, Joshua H. Mendez, Scott M. Stagg, Slavica Jonic, Eugene Palovcak, Jean-Paul Armache, Jianhua Zhao, Yifan Cheng, Grigore Pintilie, Wah Chiu, Ardan Patwardhan, Jose-Maria Carazo
The first single particle analysis Map Challenge: A summary of the assessments
published pages: 291-300, ISSN: 1047-8477, DOI: 10.1016/j.jsb.2018.08.010
Journal of Structural Biology 204/2 2019-11-22
2018 Bettina Böttcher, Michael Nassal
Structure of Mutant Hepatitis B Core Protein Capsids with Premature Secretion Phenotype
published pages: 4941-4954, ISSN: 0022-2836, DOI: 10.1016/j.jmb.2018.10.018
Journal of Molecular Biology 430/24 2019-11-22
2018 Sylwia Berbeć, Robert Dec, Dmitry Molodenskiy, Beata Wielgus-Kutrowska, Christian Johannessen, Agnieszka Hernik-Magoń, Fernando Tobias, Agnieszka Bzowska, Grzegorz Ścibisz, Timothy A. Keiderling, Dmitri Svergun, Wojciech Dzwolak
β 2 -Type Amyloidlike Fibrils of Poly- l -glutamic Acid Convert into Long, Highly Ordered Helices upon Dissolution in Dimethyl Sulfoxide
published pages: 11895-11905, ISSN: 1520-6106, DOI: 10.1021/acs.jpcb.8b08308
The Journal of Physical Chemistry B 122/50 2019-11-22
2018 J. Gómez-Blanco, J.M. de la Rosa-Trevín, R. Marabini, L. del Cano, A. Jiménez, M. Martínez, R. Melero, T. Majtner, D. Maluenda, J. Mota, Y. Rancel, E Ramírez-Aportela, J.L. Vilas, M. Carroni, S. Fleischmann, E. Lindahl, A.W. Ashton, M. Basham, D.K. Clare, K. Savage, C.A. Siebert, G.G. Sharov, C.O.S. Sorzano, P. Conesa, J.M. Carazo
Using Scipion for stream image processing at Cryo-EM facilities
published pages: 457-463, ISSN: 1047-8477, DOI: 10.1016/j.jsb.2018.10.001
Journal of Structural Biology 204/3 2019-11-22
2018 Barbara Wienen-Schmidt, Tobias Wulsdorf, Hendrik R. A. Jonker, Krishna Saxena, Denis Kudlinzki, Verena Linhard, Sridhar Sreeramulu, Andreas Heine, Harald Schwalbe, Gerhard Klebe
On the Implication of Water on Fragment-to-Ligand Growth in Kinase Binding Thermodynamics
published pages: 1988-1996, ISSN: 1860-7179, DOI: 10.1002/cmdc.201800438
ChemMedChem 13/18 2019-11-22
2018 Nasrollah Rezaei-Ghaleh, Giacomo Parigi, Andrea Soranno, Andrea Holla, Stefan Becker, Benjamin Schuler, Claudio Luchinat, Markus Zweckstetter
Local and Global Dynamics in Intrinsically Disordered Synuclein
published pages: 15262-15266, ISSN: 1433-7851, DOI: 10.1002/anie.201808172
Angewandte Chemie International Edition 57/46 2019-11-22
2018 Maryam Faridounnia, Gert Folkers, Rolf Boelens
Function and Interactions of ERCC1-XPF in DNA Damage Response
published pages: 3205, ISSN: 1420-3049, DOI: 10.3390/molecules23123205
Molecules 23/12 2019-11-22
2018 Giedrius Sasnauskas, Elena Manakova, Kęstutis Lapėnas, Kotryna Kauneckaitė, Virginijus Siksnys
DNA recognition by Arabidopsis transcription factors ABI3 and NGA1
published pages: 4041-4059, ISSN: 1742-464X, DOI: 10.1111/febs.14649
The FEBS Journal 285/21 2019-11-22
2018 Hajizadeh NR, Pieprzyk J, Skopintsev P, Flayhan A, Svergun DI, Löw C
Probing the Architecture of a Multi-PDZ Domain Protein: Structure of PDZK1 in Solution
published pages: 1522-1533.e5, ISSN: 0969-2126, DOI: 10.1016/j.str.2018.07.016
Structure 26/11 2019-11-22
2018 Marta Sanz-Murillo, Jun Xu, Georgiy A. Belogurov, Olga Calvo, David Gil-Carton, María Moreno-Morcillo, Dong Wang, Carlos Fernández-Tornero
Structural basis of RNA polymerase I stalling at UV light-induced DNA damage
published pages: 8972-8977, ISSN: 0027-8424, DOI: 10.1073/pnas.1802626115
Proceedings of the National Academy of Sciences 115/36 2019-11-22
2018 Maria Martinez Molledo, Esben M. Quistgaard, Christian Löw
Tripeptide binding in a proton-dependent oligopeptide transporter
published pages: 3239-3247, ISSN: 0014-5793, DOI: 10.1002/1873-3468.13246
FEBS Letters 592/19 2019-11-22
2018 Joshua Hutchings, Viktoriya Stancheva, Elizabeth A. Miller, Giulia Zanetti
Subtomogram averaging of COPII assemblies reveals how coat organization dictates membrane shape
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06577-4
Nature Communications 9/1 2019-11-22
2018 Sabrina Santarsia, Ana Sofia Grosso, Filipa Trovão, Jesús Jiménez-Barbero, Ana Luísa Carvalho, Cristina Nativi, Filipa Marcelo
Molecular Recognition of a Thomsen-Friedenreich Antigen Mimetic Targeting Human Galectin-3
published pages: 2030-2036, ISSN: 1860-7179, DOI: 10.1002/cmdc.201800525
ChemMedChem 13/19 2019-11-22
2018 Lucia Gigli, Witold Andrałojć, Arina Dalaloyan, Giacomo Parigi, Enrico Ravera, Daniella Goldfarb, Claudio Luchinat
Assessing protein conformational landscapes: integration of DEER data in Maximum Occurrence analysis
published pages: 27429-27438, ISSN: 1463-9076, DOI: 10.1039/c8cp06195e
Physical Chemistry Chemical Physics 20/43 2019-11-22
2018 Wout Oosterheert, Laura S. van Bezouwen, Remco N. P. Rodenburg, Joke Granneman, Friedrich Förster, Andrea Mattevi, Piet Gros
Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06817-7
Nature Communications 9/1 2019-11-22
2018 Jonas Aretz, Upendra R. Anumala, Felix F. Fuchsberger, Narges Molavi, Nandor Ziebart, Hengxi Zhang, Marc Nazaré, Christoph Rademacher
Allosteric Inhibition of a Mammalian Lectin
published pages: 14915-14925, ISSN: 0002-7863, DOI: 10.1021/jacs.8b08644
Journal of the American Chemical Society 140/44 2019-11-22
2018 Spyridon Gourdoupis, Veronica Nasta, Vito Calderone, Simone Ciofi-Baffoni, Lucia Banci
IBA57 Recruits ISCA2 to Form a [2Fe-2S] Cluster-Mediated Complex
published pages: 14401-14412, ISSN: 0002-7863, DOI: 10.1021/jacs.8b09061
Journal of the American Chemical Society 140/43 2019-11-22
2018 Ulrike Blaschke, Beneditta Suwono, Sachli Zafari, Ingo Ebersberger, Evelyn Skiebe, Cy M. Jeffries, Dmitri I. Svergun, Gottfried Wilharm
Recombinant production of A1S_0222 from Acinetobacter baumannii ATCC 17978 and confirmation of its DNA-(adenine N6)-methyltransferase activity
published pages: 78-85, ISSN: 1046-5928, DOI: 10.1016/j.pep.2018.06.009
Protein Expression and Purification 151 2019-11-22
2018 Doris Popovic, Birgit Koch, Moritz Kueblbeck, Jan Ellenberg, Lucas Pelkmans
Multivariate Control of Transcript to Protein Variability in Single Mammalian Cells
published pages: 398-411.e6, ISSN: 2405-4712, DOI: 10.1016/j.cels.2018.09.001
Cell Systems 7/4 2019-11-22
2018 Tom Reichenbach, Dayanand Kalyani, Rosaria Gandini, Olov Svartström, Henrik Aspeborg, Christina Divne
Structural and biochemical characterization of the Cutibacterium acnes exo-β-1,4-mannosidase that targets the N-glycan core of host glycoproteins
published pages: e0204703, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0204703
PLOS ONE 13/9 2019-11-22
2018 Alix Tröster, Stephanie Heinzlmeir, Benedict-Tilman Berger, Santosh L. Gande, Krishna Saxena, Sridhar Sreeramulu, Verena Linhard, Amir H. Nasiri, Michael Bolte, Susanne Müller, Bernhard Kuster, Guillaume Médard, Denis Kudlinzki, Harald Schwalbe
NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family
published pages: 1629-1633, ISSN: 1860-7179, DOI: 10.1002/cmdc.201800398
ChemMedChem 13/16 2019-11-22
2016 Marta A Uzarska, Veronica Nasta, Benjamin D Weiler, Farah Spantgar, Simone Ciofi-Baffoni, Maria Rosaria Saviello, Leonardo Gonnelli, Ulrich Mühlenhoff, Lucia Banci, Roland Lill
Mitochondrial Bol1 and Bol3 function as assembly factors for specific iron-sulfur proteins
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.16673
eLife 5 2019-11-22
2017 Emily Smith, Gwyndaf Evans, James Foadi
An effective introduction to structural crystallography using 1D Gaussian atoms
published pages: 65501, ISSN: 0143-0807, DOI: 10.1088/1361-6404/aa8188
European Journal of Physics 38/6 2019-11-22
2017 Anastasia Mylona, Stephen Carr, Pierre Aller, Isabel Moraes, Richard Treisman, Gwyndaf Evans, James Foadi
A Novel Approach to Data Collection for Difficult Structures: Data Management for Large Numbers of Crystals with the BLEND Software
published pages: 242, ISSN: 2073-4352, DOI: 10.3390/cryst7080242
Crystals 7/8 2019-11-22
2017 Massimiliano Aschi, Argante Bozzi, Carla Luzi, Nadia Bouchemal, Marco Sette
Crabrolin, a natural antimicrobial peptide: structural properties
published pages: , ISSN: 1075-2617, DOI: 10.1002/psc.3013
Journal of Peptide Science June 5 2019-11-22
2018 Gergő Gógl, Beáta Biri-Kovács, Ádám L. Póti, Henrietta Vadászi, Bálint Szeder, Andrea Bodor, Gitta Schlosser, András Ács, Lilla Turiák, László Buday, Anita Alexa, László Nyitray, Attila Reményi
Dynamic control of RSK complexes by phosphoswitch-based regulation
published pages: 46-71, ISSN: 1742-464X, DOI: 10.1111/febs.14311
The FEBS Journal 285/1 2019-11-22
2017 Katharina Veith, Maria Martinez Molledo, Yasser Almeida Hernandez, Inokentijs Josts, Julius Nitsche, Christian Löw, Henning Tidow
Lipid-like Peptides can Stabilize Integral Membrane Proteins for Biophysical and Structural Studies
published pages: 1735-1742, ISSN: 1439-4227, DOI: 10.1002/cbic.201700235
ChemBioChem 18/17 2019-11-22
2018 Linda Cerofolini, Tommaso Staderini, Stefano Giuntini, Enrico Ravera, Marco Fragai, Giacomo Parigi, Roberta Pierattelli, Claudio Luchinat
Long-range paramagnetic NMR data can provide a closer look on metal coordination in metalloproteins
published pages: 71-80, ISSN: 0949-8257, DOI: 10.1007/s00775-017-1511-y
JBIC Journal of Biological Inorganic Chemistry 23/1 2019-11-22
2017 Pau Martin-Malpartida, Marta Batet, Zuzanna Kaczmarska, Regina Freier, Tiago Gomes, Eric Aragón, Yilong Zou, Qiong Wang, Qiaoran Xi, Lidia Ruiz, Angela Vea, José A. Márquez, Joan Massagué, Maria J. Macias
Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02054-6
Nature Communications 8/1 2019-11-22
2017 Miguel Romano-Moreno, Adriana L. Rojas, Chad D. Williamson, David C. Gershlick, María Lucas, Michail N. Isupov, Juan S. Bonifacino, Matthias P. Machner, Aitor Hierro
Molecular mechanism for the subversion of the retromer coat by the Legionella effector RidL
published pages: E11151-E11160, ISSN: 0027-8424, DOI: 10.1073/pnas.1715361115
Proceedings of the National Academy of Sciences 114/52 2019-11-22
2016 Abdullah Basoglu, Nuri Baspinar, Leonardo Tenori, Alessia Vignoli, Ramazan Yildiz
Plasma metabolomics in calves with acute bronchopneumonia
published pages: , ISSN: 1573-3882, DOI: 10.1007/s11306-016-1074-x
Metabolomics 12/8 2019-11-22
2017 Yizhou Liu, Joshua S. Sharp, Duc H-T. Do, Richard A. Kahn, Harald Schwalbe, Florian Buhr, James H. Prestegard
Mistakes in translation: Reflections on mechanism
published pages: e0180566, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0180566
PLOS ONE 12/6 2019-11-22
2017 Andrea Bertarello, Tobias Schubeis, Carmelo Fuccio, Enrico Ravera, Marco Fragai, Giacomo Parigi, Lyndon Emsley, Guido Pintacuda, Claudio Luchinat
Paramagnetic Properties of a Crystalline Iron–Sulfur Protein by Magic-Angle Spinning NMR Spectroscopy
published pages: 6624-6629, ISSN: 0020-1669, DOI: 10.1021/acs.inorgchem.7b00674
Inorganic Chemistry 56/11 2019-11-22
2016 Xander Nuttle, Giuliana Giannuzzi, Michael H. Duyzend, Joshua G. Schraiber, Iñigo Narvaiza, Peter H. Sudmant, Osnat Penn, Giorgia Chiatante, Maika Malig, John Huddleston, Chris Benner, Francesca Camponeschi, Simone Ciofi-Baffoni, Holly A. F. Stessman, Maria C. N. Marchetto, Laura Denman, Lana Harshman, Carl Baker, Archana Raja, Kelsi Penewit, Nicolette Janke, W. Joyce Tang, Mario Ventura, Lucia Banci, Francesca Antonacci, Joshua M. Akey, Chris T. Amemiya, Fred H. Gage, Alexandre Reymond, Evan E. Eichler
Emergence of a Homo sapiens-specific gene family and chromosome 16p11.2 CNV susceptibility
published pages: 205-209, ISSN: 0028-0836, DOI: 10.1038/nature19075
Nature 536/7615 2019-11-22
2017 Esben M. Quistgaard, Maria Martinez Molledo, Christian Löw
Structure determination of a major facilitator peptide transporter: Inward facing PepTSt from Streptococcus thermophilus crystallized in space group P3121
published pages: , ISSN: 1932-6203, DOI: 10.1371/journal.pone.0173126
PLOS one 2019-11-22
2017 Michael Graf, Stefan Arenz, Paul Huter, Alexandra Dönhöfer, Jiří Nováček, Daniel N. Wilson
Cryo-EM structure of the spinach chloroplast ribosome reveals the location of plastid-specific ribosomal proteins and extensions
published pages: gkw1272, ISSN: 0305-1048, DOI: 10.1093/nar/gkw1272
Nucleic Acids Research 2019-11-22
2017 Ajasja Ljubetič, Fabio Lapenta, Helena Gradišar, Igor Drobnak, Jana Aupič, Žiga Strmšek, Duško Lainšček, Iva Hafner-Bratkovič, Andreja Majerle, Nuša Krivec, Mojca Benčina, Tomaž Pisanski, Tanja Ćirković Veličković, Adam Round, José María Carazo, Roberto Melero, Roman Jerala
Design of coiled-coil protein-origami cages that self-assemble in vitro and in vivo
published pages: 1094-1101, ISSN: 1087-0156, DOI: 10.1038/nbt.3994
Nature Biotechnology 35(11) 2019-11-22
2017 Robbin Schnieders, Christian Richter, Sven Warhaut, Vanessa de Jesus, Sara Keyhani, Elke Duchardt-Ferner, Heiko Keller, Jens Wöhnert, Lars T. Kuhn, Alexander L. Breeze, Wolfgang Bermel, Harald Schwalbe, Boris Fürtig
Evaluation of 15N-detected H–N correlation experiments on increasingly large RNAs
published pages: 31-44, ISSN: 0925-2738, DOI: 10.1007/s10858-017-0132-7
Journal of Biomolecular NMR 69/1 2019-11-22
2016 Viktor Farkas, Imre Jákli, Gábor K. Tóth, András Perczel
Aromatic Cluster Sensor of Protein Folding: Near-UV Electronic Circular Dichroism Bands Assigned to Fold Compactness
published pages: 13871-13883, ISSN: 0947-6539, DOI: 10.1002/chem.201602455
Chemistry - A European Journal 22/39 2019-11-22
2017 Haydyn D.T. Mertens, Dmitri I. Svergun
Combining NMR and small angle X-ray scattering for the study of biomolecular structure and dynamics
published pages: 33-41, ISSN: 0003-9861, DOI: 10.1016/j.abb.2017.05.005
Archives of Biochemistry and Biophysics 628 2019-11-22
2018 Baker LA, Sinnige T, Schellenberger P, de Keyzer J, Siebert CA, Driessen AJM, Baldus M, Grünewald K
Combined 1H-Detected Solid-State NMR Spectroscopy and Electron Cryotomography to Study Membrane Proteins across Resolutions in Native Environments
published pages: 161-170.e3, ISSN: 0969-2126, DOI:
Structure 26/1 2019-11-22
2017 D. Franke, M. V. Petoukhov, P. V. Konarev, A. Panjkovich, A. Tuukkanen, H. D. T. Mertens, A. G. Kikhney, N. R. Hajizadeh, J. M. Franklin, C. M. Jeffries, D. I. Svergun
ATSAS 2.8 : a comprehensive data analysis suite for small-angle scattering from macromolecular solutions
published pages: , ISSN: 1600-5767, DOI: 10.1107/S1600576717007786
Journal of Applied Crystallography 50/4 2019-11-22
2017 Stefano Giuntini, Linda Cerofolini, Enrico Ravera, Marco Fragai, Claudio Luchinat
Atomic structural details of a protein grafted onto gold nanoparticles
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-18109-z
Scientific Reports 7/1 2019-11-22
2017 Stefano Giuntini, Evita Balducci, Linda Cerofolini, Enrico Ravera, Marco Fragai, Francesco Berti, Claudio Luchinat
Characterization of the Conjugation Pattern in Large Polysaccharide-Protein Conjugates by NMR Spectroscopy
published pages: 14997-15001, ISSN: 1433-7851, DOI: 10.1002/anie.201709274
Angewandte Chemie International Edition 56/47 2019-11-22
2017 Pawel Dubiela, Roberta Aina, Dominika Polak, Sabine Geiselhart, Piotr Humeniuk, Barbara Bohle, Stefano Alessandri, Rebecca Del Conte, Francesca Cantini, Tomasz Borowski, Merima Bublin, Karin Hoffmann-Sommergruber
Enhanced Pru p 3 IgE-binding activity by selective free fatty acid-interaction
published pages: 1728-1731.e10, ISSN: 0091-6749, DOI: 10.1016/j.jaci.2017.06.016
Journal of Allergy and Clinical Immunology 140/6 2019-11-22
2017 Paul Huter, Stefan Arenz, Lars V. Bock, Michael Graf, Jan Ole Frister, Andre Heuer, Lauri Peil, Agata L. Starosta, Ingo Wohlgemuth, Frank Peske, Jiří Nováček, Otto Berninghausen, Helmut Grubmüller, Tanel Tenson, Roland Beckmann, Marina V. Rodnina, Andrea C. Vaiana, Daniel N. Wilson
Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P
published pages: 515-527.e6, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2017.10.014
Molecular Cell 68/3 2019-11-22
2017 Tanja Florin, Cristina Maracci, Michael Graf, Prajwal Karki, Dorota Klepacki, Otto Berninghausen, Roland Beckmann, Nora Vázquez-Laslop, Daniel N Wilson, Marina V Rodnina, Alexander S Mankin
An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome
published pages: 752-757, ISSN: 1545-9993, DOI: 10.1038/nsmb.3439
Nature Structural & Molecular Biology 24/9 2019-11-22
2016 Diego Brancaccio, Angelo Gallo, Mario Piccioli, Ettore Novellino, Simone Ciofi-Baffoni, Lucia Banci
[4Fe-4S] Cluster Assembly in Mitochondria and Its Impairment by Copper
published pages: , ISSN: 0002-7863, DOI: 10.1021/jacs.6b09567
Journal of the American Chemical Society 2019-11-22
2017 Joaquín Otón, Eva Pereiro, José J. Conesa, Francisco J. Chichón, Daniel Luque, Javier M. Rodríguez, Ana J. Pérez-Berná, Carlos Oscar S. Sorzano, Joanna Klukowska, Gabor T. Herman, Javier Vargas, Roberto Marabini, José L. Carrascosa, José M. Carazo
XTEND: Extending the depth of field in cryo soft X-ray tomography
published pages: 45808, ISSN: 2045-2322, DOI: 10.1038/srep45808
Scientific Reports 7 2019-11-22
2017 Simon Erlendsson, Kamil Gotfryd, Flemming Hofmann, Larsen Jonas, Sigurd Mortensen, Michel-Andreas Geiger, Barth-Jan van Rossum, Hartmut Oschkinat, Ulrik Gether, Kaare Teilum, Claus J Loland
Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.19314.001
eLife 2019-11-22
2017 Panteleimon G. Takis, Leonardo Tenori, Enrico Ravera, Claudio Luchinat
Gelified Biofluids for High-Resolution Magic Angle Spinning 1H NMR Analysis: The Case of Urine
published pages: , ISSN: 0003-2700, DOI: 10.1021/acs.analchem.6b04318
Analytical Chemistry 2019-11-22
2016 Enrico Ravera, Linda Cerofolini, Tommaso Martelli, Alexandra Louka, Marco Fragai, Claudio Luchinat
1H-detected solid-state NMR of proteins entrapped in bioinspired silica: a new tool for biomaterials characterization
published pages: 27851, ISSN: 2045-2322, DOI: 10.1038/srep27851
Scientific Reports 6 2019-11-22
2017 Sumera Perveen, Naeem Rashid, Xiao-Feng Tang, Tadayuki Imanaka, Anastassios C. Papageorgiou
Anthranilate phosphoribosyltransferase from the hyperthermophilic archaeon Thermococcus kodakarensis shows maximum activity with zinc and forms a unique dimeric structure
published pages: 1217-1230, ISSN: 2211-5463, DOI: 10.1002/2211-5463.12264
FEBS Open Bio 7/8 2019-11-22
2016 Paula Yagüe, Joost Willemse, Roman I. Koning, Beatriz Rioseras, María T. López-García, Nathaly Gonzalez-Quiñonez, Carmen Lopez-Iglesias, Pavel V. Shliaha, Adelina Rogowska-Wrzesinska, Abraham J. Koster, Ole N. Jensen, Gilles P. van Wezel, Ángel Manteca
Subcompartmentalization by cross-membranes during early growth of Streptomyces hyphae
published pages: 12467, ISSN: 2041-1723, DOI: 10.1038/ncomms12467
Nature Communications 7 2019-11-22
2017 Francesca Camponeschi, Simone Ciofi-Baffoni, Lucia Banci
Anamorsin/Ndor1 Complex Reduces [2Fe–2S]-MitoNEET via a Transient Protein–Protein Interaction
published pages: 9479-9482, ISSN: 0002-7863, DOI: 10.1021/jacs.7b05003
Journal of the American Chemical Society 139/28 2019-11-22
2017 Abdullah Basoglu, Nuri Baspinar, Leonardo Tenori, Alessia Vignoli, Erdem Gulersoy
Effects of Boron Supplementation on Peripartum Dairy Cows\' Health.
published pages: , ISSN: 0163-4984, DOI: 10.1007/s12011-017-0971-9
Biological Trace Element Research 2019-11-22
2016 Anne T. Tuukkanen, Gerard J. Kleywegt, Dmitri I. Svergun
Resolution of ab initio shapes determined from small-angle scattering
published pages: 440-447, ISSN: 2052-2525, DOI: 10.1107/S2052252516016018
IUCrJ 3/6 2019-11-22
2017 Ignacio Fernández, Irina Cornaciu, Mariela del Carmen Carrica, Emiko Uchikawa, Guillaume Hoffmann, Rodrigo Sieira, José Antonio Márquez, Fernando A. Goldbaum
Three-Dimensional Structure of Full-Length NtrX, an Unusual Member of the NtrC Family of Response Regulators
published pages: , ISSN: 0022-2836, DOI: 10.1016/j.jmb.2016.12.022
Journal of Molecular Biology 2019-11-22
2016 Mohammed Kaplan, Siddarth Narasimhan, Cecilia de Heus, Deni Mance, Sander van Doorn, Klaartje Houben, Dušan Popov-Čeleketić, Reinier Damman, Eugene A. Katrukha, Purvi Jain, Willie J.C. Geerts, Albert J.R. Heck, Gert E. Folkers, Lukas C. Kapitein, Simone Lemeer, Paul M.P. van Bergen en Henegouwen, Marc Baldus
EGFR Dynamics Change during Activation in Native Membranes as Revealed by NMR
published pages: , ISSN: 0092-8674, DOI: 10.1016/j.cell.2016.10.038
Cell 167 2019-11-22
2016 Ulrich Zander, Guillaume Hoffmann, Irina Cornaciu, Jean-Pierre Marquette, Gergely Papp, Christophe Landret, Gaël Seroul, Jérémy Sinoir, Martin Röwer, Frank Felisaz, Sonia Rodriguez-Puente, Vincent Mariaule, Peter Murphy, Magali Mathieu, Florent Cipriani, José Antonio Márquez
Automated harvesting and processing of protein crystals through laser photoablation
published pages: 454-466, ISSN: 2059-7983, DOI: 10.1107/S2059798316000954
Acta Crystallographica Section D Structural Biology 72/4 2019-11-22
2017 Florian Lehner, Denis Kudlinzki, Christian Richter, Henrike M. Müller-Werkmeister, Katharina B. Eberl, Jens Bredenbeck, Harald Schwalbe, Robert Silvers
Impact of Azidohomoalanine Incorporation on Protein Structure and Ligand Binding
published pages: 2340-2350, ISSN: 1439-4227, DOI: 10.1002/cbic.201700437
ChemBioChem 18/23 2019-11-22
2018 Letizia Barbieri, Enrico Luchinat, Lucia Banci
Intracellular metal binding and redox behavior of human DJ-1
published pages: 61-69, ISSN: 0949-8257, DOI: 10.1007/s00775-017-1509-5
JBIC Journal of Biological Inorganic Chemistry 23/1 2019-11-22
2017 Sina Reckel, Charlotte Gehin, Delphine Tardivon, Sandrine Georgeon, Tim Kükenshöner, Frank Löhr, Akiko Koide, Lena Buchner, Alejandro Panjkovich, Aline Reynaud, Sara Pinho, Barbara Gerig, Dmitri Svergun, Florence Pojer, Peter Güntert, Volker Dötsch, Shohei Koide, Anne-Claude Gavin, Oliver Hantschel
Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02313-6
Nature Communications 8/1 2019-11-22
2017 Enrico Luchinat, Letizia Barbieri, Lucia Banci
A molecular chaperone activity of CCS restores the maturation of SOD1 fALS mutants
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-17815-y
Scientific Reports 7/1 2019-11-22
2017 Joren S. Retel, Andrew J. Nieuwkoop, Matthias Hiller, Victoria A. Higman, Emeline Barbet-Massin, Jan Stanek, Loren B. Andreas, W. Trent Franks, Barth-Jan van Rossum, Kutti R. Vinothkumar, Lieselotte Handel, Gregorio Giuseppe de Palma, Benjamin Bardiaux, Guido Pintacuda, Lyndon Emsley, Werner Kühlbrandt, Hartmut Oschkinat
Structure of outer membrane protein G in lipid bilayers
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02228-2
Nature Communications 8/1 2019-11-22
2016 Roberta Spadaccini, Serena Leone, Michele Fortunato Rega, Christian Richter, Delia Picone
Influence of pH on structure and stability of the sweet protein MNEI
published pages: , ISSN: 0014-5793, DOI: 10.1002/1873-3468.12437
FEBS Letters Sept 29, 2016 2019-11-22
2017 Joseph A. Lyons, Andreas Bøggild, Poul Nissen, Jens Frauenfeld
Saposin-Lipoprotein Scaffolds for Structure Determination of Membrane Transporters
published pages: 85-99, ISSN: , DOI: 10.1016/bs.mie.2017.06.035
Methods in Enzymology 19/07/2017 2019-11-22
2017 David Albesa-Jové, M. Ángela Sainz-Polo, Alberto Marina, Marcelo E. Guerin
Structural Snapshots of α-1,3-Galactosyltransferase with Native Substrates: Insight into the Catalytic Mechanism of Retaining Glycosyltransferases
published pages: 14853-14857, ISSN: 1433-7851, DOI: 10.1002/anie.201707922
Angewandte Chemie International Edition 56/47 2019-11-22
2017 Daniel A. Holdbrook, Björn M. Burmann, Roland G. Huber, Maxim V. Petoukhov, Dmitri I. Svergun, Sebastian Hiller, Peter J. Bond
A Spring-Loaded Mechanism Governs the Clamp-like Dynamics of the Skp Chaperone
published pages: 1079-1088.e3, ISSN: 0969-2126, DOI: 10.1016/j.str.2017.05.018
Structure 25/7 2019-11-22
2017 Veronica Nasta, Andrea Giachetti, Simone Ciofi-Baffoni, Lucia Banci
Structural insights into the molecular function of human [2Fe-2S] BOLA1-GRX5 and [2Fe-2S] BOLA3-GRX5 complexes
published pages: 2119-2131, ISSN: 0304-4165, DOI: 10.1016/j.bbagen.2017.05.005
Biochimica et Biophysica Acta (BBA) - General Subjects 1861/8 2019-11-22
2016 Marıa Lucas, David C. Gershlick, Ander Vidaurrazaga, Adriana L. Rojas, Juan S. Bonifacino, Aitor Hierro
Structural Mechanism for Cargo Recognition by the Retromer Complex
published pages: , ISSN: 0092-8674, DOI: 10.1016/j.cell.2016.10.056
Cell 2019-11-22
2016 Katherine Celler, Roman I. Koning, Joost Willemse, Abraham J. Koster, Gilles P. van Wezel
Cross-membranes orchestrate compartmentalization and morphogenesis in Streptomyces
published pages: ncomms11836, ISSN: 2041-1723, DOI: 10.1038/ncomms11836
Nature Communications 7 2019-11-22
2017 Julia Wirmer-Bartoschek, Lars Erik Bendel, Hendrik R. A. Jonker, J. Tassilo Grün, Francesco Papi, Carla Bazzicalupi, Luigi Messori, Paola Gratteri, Harald Schwalbe
Solution NMR Structure of a Ligand/Hybrid-2-G-Quadruplex Complex Reveals Rearrangements that Affect Ligand Binding
published pages: , ISSN: 1433-7851, DOI: 10.1002/anie.201702135
Angewandte Chemie International Edition 2019-11-22
2016 S. Lange, W. T. Franks, N. Rajagopalan, K. Do ring, M. A. Geiger, A. Linden, B.-J. van Rossum, G. Kramer, B. Bukau, H. Oschkinat
Structural analysis of a signal peptide inside the ribosome tunnel by DNP MAS NMR
published pages: e1600379-e160037, ISSN: 2375-2548, DOI: 10.1126/sciadv.1600379
Science Advances 2/8 2019-11-22

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