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PlugBioIn SIGNED

Plug and play enzymes for an accelerated uptake of Biocatalysis in the Pharmaceutical Industry

Total Cost €

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EC-Contrib. €

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Partnership

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Project "PlugBioIn" data sheet

The following table provides information about the project.

Coordinator
C-LECTA GMBH 

Organization address
address: PERLICKSTRASSE 5
city: LEIPZIG
postcode: 4103
website: www.c-LEcta.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.c-lecta.com/products-services/products/customized-enzyme-c-lections/c-lecta-plug-play-biocats/
 Total cost 681˙125 €
 EC max contribution 476˙787 € (70%)
 Programme 1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
2. H2020-EU.2.3.1. (Mainstreaming SME support, especially through a dedicated instrument)
 Code Call H2020-SMEINST-2-2014
 Funding Scheme SME-2
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2017-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    C-LECTA GMBH DE (LEIPZIG) coordinator 476˙787.00

Map

 Project objective

At present there is a mismatch between the extensive interest of the pharmaceutical industry to utilize enzyme technology in their production processes and the number of such processes commercially implemented. To overcome this mismatch c-LEcta aims at offering a smart platform of Plug & Play enzymes for the three most relevant enzyme classes (alcohol dehydrogenase, transaminases, and nitrilase). The platform will address the needs of the pharma industry for performing essential biocatalytic reactions suitable for the production of million fold applied chiral active pharmaceutical ingredients (APIs) like Atorvastatin, Rosuvastatin and Duloxetine. The API market is valued at $101.08 billion in 2010. The unique selling proposition of this platform is to comprise ~100 high quality enzymes per class, which are pre-qualified for a wide range of important structural patterns, applicable for synthesis processes and easily scalable. Therefore, the business opportunity is to take advantage of the great potential of biocatalysis since the platform allows matching timelines and cost requirements. Up to now such service was not available without contract signing and extensive development timelines and costs. The development cost may be reduced up to ~80% by using the new platform technology compared to the conventional work flow. In manufacturing, the total production cost of a product will be typically reduced by > 30%. The platform will be promoted to a medium volume market with high growth rates. c-LEcta will address the global market, which is going to be widened step-by-step. Subject matter of Phase 2 c-LEcta is to refine the design of the enzyme platform, to scale up the enzyme production, synthesis process development and pilot-scale application in order to demonstrate and to assure rapid availability of enzymes in pharma development and for subsequent commercialization.

 Deliverables

List of deliverables.
Website for online ordering Websites, patent fillings, videos etc. 2019-05-30 12:54:33
Webinar on enzyme platform Websites, patent fillings, videos etc. 2019-05-30 12:54:26

Take a look to the deliverables list in detail:  detailed list of PlugBioIn deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 Michael Burns, Carlos A. Martinez, Brian Vanderplas, Richard Wisdom, Shu Yu, Robert A. Singer
A Chemoenzymatic Route to Chiral Intermediates Used in the Multikilogram Synthesis of a Gamma Secretase Inhibitor
published pages: 871-877, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.7b00096
Organic Process Research & Development 21/6 2019-07-08
2017 Tim Börner, Sebastian Rämisch, Sebastian Bartsch, Andreas Vogel, Patrick Adlercreutz, Carl Grey
Three in One: Temperature, Solvent and Catalytic Stability by Engineering the Cofactor-Binding Element of Amine Transaminase
published pages: 1482-1486, ISSN: 1439-4227, DOI: 10.1002/cbic.201700236
ChemBioChem 18/15 2019-07-08
2017 Konrad B. Otte, Elena Maurer, Marko Kirtz, Daniela Grabs, Eric Althoff, Sebastian Bartsch, Andreas Vogel, Bettina M. Nestl, Bernhard Hauer
Synthesis of Sebacic Acid Using a De Novo Designed Retro-Aldolase as a Key Catalyst
published pages: 1378-1382, ISSN: 1867-3880, DOI: 10.1002/cctc.201601551
ChemCatChem 9/8 2019-07-08

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The information about "PLUGBIOIN" are provided by the European Opendata Portal: CORDIS opendata.

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