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STEMMING-FROM-NERVE SIGNED

Targeted Cell Recruitment During Organogenesis And Regeneration: Glia Makes The Tooth

Total Cost €

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EC-Contrib. €

0

Partnership

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 STEMMING-FROM-NERVE project word cloud

Explore the words cloud of the STEMMING-FROM-NERVE project. It provides you a very rough idea of what is the project "STEMMING-FROM-NERVE" about.

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Project "STEMMING-FROM-NERVE" data sheet

The following table provides information about the project.

Coordinator
MEDIZINISCHE UNIVERSITAET WIEN 

Organization address
address: SPITALGASSE 23
city: WIEN
postcode: 1090
website: www.meduniwien.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Austria [AT]
 Project website http://www.adameykolab.eu/
 Total cost 1˙964˙338 €
 EC max contribution 1˙964˙338 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-08-01   to  2020-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) coordinator 1˙964˙338.00

Map

 Project objective

Recently we discovered an entirely new phenomenon in developmental biology – targeted recruitment of stem cells from the pervasive peripheral nerves. For example, we demonstrated that majority of melanocytes – our pigment cells, are born from peripheral glial cells. To further extend this far-reaching principle we will use tooth development as a model. Current opinion holds that sensory innervation of the tooth has a minor or no role in making a structure of the tooth during development and adulthood. On the contrary, our preliminary data strongly suggest that sensory nerve contributes pulp cells and matrix-producing cells of odontoblast lineage to the growing tooth. Our hypothesis implies that nerve-associated glial cells can be recruited from the nerve by unknown molecules presented inside of the tooth environment, and that these recruited cells are capable of producing pulp cells and odontoblasts.

WE PROPOSE TO ADDRESS THE ROLE OF A SENSORY NERVE AS A PROVIDER OF DENTAL STEM CELLS DURING THE DEVELOPMENT, ADULTHOOD AND REGENERATION.

To experimentally address our hypothesis we developed innovative and powerful approaches: we will use advanced genetics tracing with multicolor reporters, completely novel unconventional individual cell transcriptome analysis, transgenic mice with cell type-specific modifications in signaling, microsurgery and grafting, and, finally, 3D-imaging of developing tooth structures.

This project is interesting to a wide community of scientists because it addresses a novel function of peripheral nervous system which is contributing stem cells as building blocks to local tissues in development and regeneration. The MEDICAL IMPLICATION of this project will include better understanding of tooth regeneration providing new approaches to dentin recovery and tooth restoration following trauma.

 Publications

year authors and title journal last update
List of publications.
2017 Maria Eleni Kastriti, Igor Adameyko
Specification, plasticity and evolutionary origin of peripheral glial cells
published pages: 196-202, ISSN: 0959-4388, DOI: 10.1016/j.conb.2017.11.004
Current Opinion in Neurobiology 47 2020-04-07
2017 Marketa Kaucka, Igor Adameyko
Evolution and development of the cartilaginous skull: From a lancelet towards a human face
published pages: , ISSN: 1084-9521, DOI: 10.1016/j.semcdb.2017.12.007
Seminars in Cell & Developmental Biology 2020-04-07
2018 Alessandro Furlan, Igor Adameyko
Schwann cell precursor: a neural crest cell in disguise?
published pages: , ISSN: 0012-1606, DOI: 10.1016/j.ydbio.2018.02.008
Developmental Biology 2020-04-07
2017 Alessandro Furlan, Vyacheslav Dyachuk, Maria Eleni Kastriti, Laura Calvo-Enrique, Hind Abdo, Saida Hadjab, Tatiana Chontorotzea, Natalia Akkuratova, Dmitry Usoskin, Dmitry Kamenev, Julian Petersen, Kazunori Sunadome, Fatima Memic, Ulrika Marklund, Kaj Fried, Piotr Topilko, Francois Lallemend, Peter V. Kharchenko, Patrik Ernfors, Igor Adameyko
Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla
published pages: eaal3753, ISSN: 0036-8075, DOI: 10.1126/science.aal3753
Science 357/6346 2020-04-07
2017 Julian Petersen, Igor Adameyko
Nerve-associated neural crest: peripheral glial cells generate multiple fates in the body
published pages: 10-14, ISSN: 0959-437X, DOI: 10.1016/j.gde.2017.02.006
Current Opinion in Genetics & Development 45 2020-04-07
2017 Jan Krivanek, Igor Adameyko, Kaj Fried
Heterogeneity and Developmental Connections between Cell Types Inhabiting Teeth
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2017.00376
Frontiers in Physiology 8 2020-04-07

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