Explore the words cloud of the EXODUS project. It provides you a very rough idea of what is the project "EXODUS" about.
The following table provides information about the project.
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
|Coordinator Country||Germany [DE]|
|Total cost||1˙998˙063 €|
|EC max contribution||1˙998˙063 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-09-01 to 2020-08-31|
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|1||KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN||DE (MUENCHEN)||coordinator||1˙998˙063.00|
The incidence of autoimmune diseases including multiple sclerosis is dramatically increasing. While there is a genetically defined “bedrock” susceptibility to develop T cell mediated autoimmunity, environmental cues likely determine the threshold for disease development. Yet, little is known on how environmental cues sensed at body/environment interfaces are translated into immunopathology in distant organs like the central nervous system (CNS). Here, we raise the hypothesis that immune cells must be activated at epithelial surfaces and then physically migrate to distant organs in order to induce autoimmunity. Furthermore, we propose that the “state of activation” of (either lymphoid or myeloid) immune cells can be interrogated by IL-6 production since IL-6 deficiency confers resistance to virtually any organ specific autoimmune disease and we have contributed fundamentally in defining the role of IL-6 for the generation of Th17 cells that are highly associated with autoimmune tissue inflammation. In EXODUS, we will develop ground-breaking next generation reporter tools in order to test these hypotheses. A split Cre recombinase protein, which dimerizes and is activated by blue light, will be used to genetically label cells (and their progeny) in a topologically defined manner (“compartment reporter”). Furthermore, we have developed a novel type of Cre-inducible in vivo IL-6 reporter (“activation reporter”). The combination of these tools will enable us to trace the anatomical compartment of activation of immune cells without limitations in lag time. Thus, site specific photogenetic co-induction of a fluorescence and IL-6 reporter will be used to probe peripheral sites for their potency to licence immune cells to travel to the CNS (Forward). Vice versa, labeling of cells in the CNS (through a thinned skull window) will allow for studying immune cell exodus from the CNS in homeostasis and during inflammation (Reverse).
|year||authors and title||journal||last update|
Thomas Korn, Axel Kallies
T cell responses in the central nervous system
published pages: 179-194, ISSN: 1474-1733, DOI: 10.1038/nri.2016.144
|Nature Reviews Immunology 17/3||2020-04-23|
Sylvia Heink, Nir Yogev, Christoph Garbers, Marina Herwerth, Lilian Aly, Christiane Gasperi, Veronika Husterer, Andrew L Croxford, Katja MÃ¶ller-Hackbarth, Harald S Bartsch, Karl Sotlar, Stefan Krebs, Tommy Regen, Helmut Blum, Bernhard Hemmer, Thomas Misgeld, Thomas F Wunderlich, Juan Hidalgo, Mohamed Oukka, Stefan Rose-John, Marc Schmidt-Supprian, Ari Waisman, Thomas Korn
Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells
published pages: 74-85, ISSN: 1529-2908, DOI: 10.1038/ni.3632
|Nature Immunology 18/1||2020-04-23|
Andreas Muschaweckh, Franziska Petermann, Thomas Korn
IL-1Î² and IL-23 Promote Extrathymic Commitment of CD27 + CD122 âˆ’ Î³Î´ T Cells to Î³Î´T17 Cells
published pages: 2668-2679, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1700287
|The Journal of Immunology 199/8||2020-04-23|
Christoph Garbers, Sylvia Heink, Thomas Korn, Stefan Rose-John
Interleukin-6: designing specific therapeutics for a complex cytokine
published pages: , ISSN: 1474-1776, DOI: 10.1038/nrd.2018.45
|Nature Reviews Drug Discovery ePub ahead of print||2020-04-23|
Anna-Lena Vogel, Benjamin Knier, Katja Lammens, Sudhakar Reddy Kalluri, Tanja Kuhlmann, Jeffrey L. Bennett, Thomas Korn
Deletional tolerance prevents AQP4-directed autoimmunity in mice
published pages: 458-469, ISSN: 0014-2980, DOI: 10.1002/eji.201646855
|European Journal of Immunology 47/3||2020-04-23|
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