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CHARME

Growing bone fast and cost-effective

Total Cost €

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EC-Contrib. €

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Partnership

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 CHARME project word cloud

Explore the words cloud of the CHARME project. It provides you a very rough idea of what is the project "CHARME" about.

defect    induces    autograft    limited    endpoints    bone    allograft    operative    site    trl    procedure    channel    trl6    200    charme    stem    seduces    submission    adverse    processed    clinically    xpand    manufacture    structure    data    quantities    life    pain    market    regulatory    marketing    maturity    strategy    cells    exceptional    generates    situ    infrastructure    put    commercialisation    standard    stimulate    billion    autologous    patients    inducing    surface    generation    materials    establishment    golden    regeneration    position    2017    synthetic    bv    biotechnology    faster    nano    patented    graft    unlike    commercial    acceptance    launch    attracting    body    million    property    successful    quality    orthopaedic    cell    patient    plan    tissue    spinal    technological    extra    technologies    superior    epitaxos    replace    disadvantages    markets    form    true    approval    material    dental    superiority    abundant    epitaxo    innovative    quantity   

Project "CHARME" data sheet

The following table provides information about the project.

Coordinator
KUROS BIOSCIENCES BV 

Organization address
address: PROFESSOR BRONKHORSTLAAN 10 G 48
city: BILTHOVEN
postcode: 3723 MB
website: www.xpand-biotech.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.charme-horizon.nl
 Total cost 2˙630˙845 €
 EC max contribution 1˙841˙591 € (70%)
 Programme 1. H2020-EU.2.3.1. (Mainstreaming SME support, especially through a dedicated instrument)
2. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
 Code Call H2020-SMEINST-2-2014
 Funding Scheme SME-2
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2017-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KUROS BIOSCIENCES BV NL (BILTHOVEN) coordinator 1˙841˙591.00

Map

 Project objective

XPAND Biotechnology BV has developed a new generation of orthopaedic materials: the EpitaxOs bone regeneration material.

EpitaxOs (TRL 6) is unique: a) it seduces the body to form bone b) is as effective as the golden standard autograft without its disadvantages (extra operative procedure, pain, limited quantity available) c) it is superior to other synthetic bone graft materials, allograft, growth factors and cell-based technologies d) it is available in abundant quantities e) it increases the quality of life for patients as the use of EpitaxOs has no adverse effects on the patient. The innovative property of EpitaxOs is its patented surface nano-structure, which induces the formation of bone by attracting the patient’s own stem cells to the defect site and stimulate them to make autologous bone (in situ bone tissue regeneration). Similar to autograft and growth factors and unlike other synthetic materials, EpitaxOs is a true bone inducing material, but generates bone much faster

EpitaxOs is targeted at the €4 billion spinal market and the €200 million dental market. The exceptional bone inducing properties of EpitaxOs put it in a unique position to replace autograft, (processed) allograft and growth factors.

The CHARME project aims at bringing EpitaxOs from technological maturity level TRL6 to a successful commercial/ production launch at level TRL 8/9 (in 2017). The objectives are: 1. Development of a commercial scale production infrastructure 2. Regulatory submission of EpitaxOs in key markets 3. Providing evidence-based data to demonstrate product superiority and facilitate product launch & market acceptance 4. Establishment of a marketing channel and development of a strategy for commercialisation of EpitaxOs

The endpoints of the CHARME project will be EpitaxO, a commercial scale infrastructure, to manufacture EpitaxOs, regulatory submission, approval in Europe, clinically relevant study data, a marketing channel, plan for the commercialisation

 Deliverables

List of deliverables.
Distribution targeted information letters to dedicated groups Other 2019-07-25 13:42:30
Scientific articles Documents, reports 2019-07-25 13:42:30
Brochures for patients, surgeons, hospitals Other 2019-07-25 13:42:30
Establish an interactive CHARME webpage. Other 2019-07-25 13:42:30

Take a look to the deliverables list in detail:  detailed list of CHARME deliverables.

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The information about "CHARME" are provided by the European Opendata Portal: CORDIS opendata.

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