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CHARME

Growing bone fast and cost-effective

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

CHARME project word cloud

Explore the words cloud of the CHARME project. It provides you a very rough idea of what is the project "CHARME" about.

data life procedure faster channel abundant allograft patented maturity replace spinal seduces materials regeneration dental operative true technologies markets technological tissue graft superiority pain inducing trl6 generates launch biotechnology approval cells billion cell position autologous stem 2017 200 establishment quantity epitaxo exceptional regulatory extra million attracting successful bone plan clinically nano submission trl put processed induces standard limited endpoints quality bv superior golden defect infrastructure form surface body charme generation acceptance manufacture material market epitaxos synthetic patient quantities innovative commercial patients commercialisation property disadvantages xpand unlike stimulate structure autograft marketing situ site orthopaedic adverse strategy

Project "CHARME" data sheet

The following table provides information about the project.

Coordinator	KUROS BIOSCIENCES BV Organization address address: PROFESSOR BRONKHORSTLAAN 10 G 48 city: BILTHOVEN postcode: 3723 MB website: www.xpand-biotech.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://www.charme-horizon.nl
Total cost	2˙630˙845 €
EC max contribution	1˙841˙591 € (70%)
Programme	1. H2020-EU.2.3.1. (Mainstreaming SME support, especially through a dedicated instrument) 2. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
Code Call	H2020-SMEINST-2-2014
Funding Scheme	SME-2
Starting year	2015
Duration (year-month-day)	from 2015-07-01 to 2017-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KUROS BIOSCIENCES BV KUROS BIOSCIENCES BV Organization address address: PROFESSOR BRONKHORSTLAAN 10 G 48 city: BILTHOVEN postcode: 3723 MB website: www.xpand-biotech.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (BILTHOVEN)	coordinator	1˙841˙591.00

Map

Project objective

XPAND Biotechnology BV has developed a new generation of orthopaedic materials: the EpitaxOs bone regeneration material.

EpitaxOs (TRL 6) is unique: a) it seduces the body to form bone b) is as effective as the golden standard autograft without its disadvantages (extra operative procedure, pain, limited quantity available) c) it is superior to other synthetic bone graft materials, allograft, growth factors and cell-based technologies d) it is available in abundant quantities e) it increases the quality of life for patients as the use of EpitaxOs has no adverse effects on the patient. The innovative property of EpitaxOs is its patented surface nano-structure, which induces the formation of bone by attracting the patient’s own stem cells to the defect site and stimulate them to make autologous bone (in situ bone tissue regeneration). Similar to autograft and growth factors and unlike other synthetic materials, EpitaxOs is a true bone inducing material, but generates bone much faster

EpitaxOs is targeted at the €4 billion spinal market and the €200 million dental market. The exceptional bone inducing properties of EpitaxOs put it in a unique position to replace autograft, (processed) allograft and growth factors.

The CHARME project aims at bringing EpitaxOs from technological maturity level TRL6 to a successful commercial/ production launch at level TRL 8/9 (in 2017). The objectives are: 1. Development of a commercial scale production infrastructure 2. Regulatory submission of EpitaxOs in key markets 3. Providing evidence-based data to demonstrate product superiority and facilitate product launch & market acceptance 4. Establishment of a marketing channel and development of a strategy for commercialisation of EpitaxOs

The endpoints of the CHARME project will be EpitaxO, a commercial scale infrastructure, to manufacture EpitaxOs, regulatory submission, approval in Europe, clinically relevant study data, a marketing channel, plan for the commercialisation

Deliverables

List of deliverables.
Distribution targeted information letters to dedicated groups	Other	2019-07-25 13:42:30
Scientific articles	Documents, reports	2019-07-25 13:42:30
Brochures for patients, surgeons, hospitals	Other	2019-07-25 13:42:30
Establish an interactive CHARME webpage.	Other	2019-07-25 13:42:30

Take a look to the deliverables list in detail: detailed list of CHARME deliverables.

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The information about "CHARME" are provided by the European Opendata Portal: CORDIS opendata.

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