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Troy Stem Cells SIGNED

Troy+ stomach stem cells in homeostasis, repair and pathogenesis

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EC-Contrib. €

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Project "Troy Stem Cells" data sheet

The following table provides information about the project.

Coordinator
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH 

Organization address
address: DR BOHRGASSE 3
city: WIEN
postcode: 1030
website: www.imba.oeaw.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website http://www.stemcells.cam.ac.uk/research/pis/koo
 Total cost 1˙570˙398 €
 EC max contribution 1˙570˙398 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-08-01   to  2020-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH AT (WIEN) coordinator 570˙478.00
2    THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 715˙398.00
3    TECHNISCHE UNIVERSITAET DRESDEN DE (DRESDEN) participant 284˙522.00

Map

 Project objective

The adult mammalian stomach can be divided into three distinct parts: From the proximal fore-stomach over the corpus to the distal pylorus. Due to constant exposure to mechanical stress and to hostile contents of the lumen, highly specialized cell types have to be constantly reproduced in order to maintain the function of the gastrointestinal tract. Recently, the applicant identified Troy chief cells as a novel stem cell population in the corpus epithelium. Troy chief cells displayed a very low proliferation rate indicating their quiescent nature compared to other known gastro-intestinal tract stem cells. Interestingly, these stem cells can actively divide upon tissue damage, suggesting distinctive statuses under conditions of homeostasis and injury.

As Troy stomach stem cells exhibit interconvertible characteristics i.e. quiescent and proliferative, they represent a unique model of adult stem cells with which we can study 1) the dynamics of stem cell propagation in homeostasis and regeneration and the underlying mechanism of this switch by analysing molecular and epigenetic profiles. Subsequently, by analysing mRNA expression profiles and epigenetic changes in Troy stem cells between homeostasis and injury repair, we will generate a list of genes with potentially interesting functions in cell fate decisions. We will therefore investigate 2) the stomach stem cell programme in homeostasis and regeneration using in vitro and in vivo functional genetics. Lastly, we will characterise 3) human stomach stem cells in normal and pathological conditions.

Here we pursue three main aims: - Investigating Troy stem cell dynamics during homeostasis and injury repair - Unmasking the stomach stem cell programme using in vitro and in vivo functional genetics - Characterising human stomach stem cells

 Publications

year authors and title journal last update
List of publications.
2018 Maureen Spit, Bon-Kyoung Koo, Madelon M. Maurice
Tales from the crypt: intestinal niche signals in tissue renewal, plasticity and cancer
published pages: 180120, ISSN: 2046-2441, DOI: 10.1098/rsob.180120
Open Biology 8/9 2019-06-06
2019 Szu-Hsien (Sam) Wu, Ji-Hyun Lee, and Bon-Kyoung Koo
Lineage Tracing: Computational Reconstruction Goes Beyond the Limit of Imaging
published pages: , ISSN: 0219-1032, DOI: 10.14348/molcells.2019.0006
Molecules and Cells 2019-06-06
2017 Amanda Andersson-Rolf, Matthias Zilbauer, Bon-Kyoung Koo, Hans Clevers
Stem Cells in Repair of Gastrointestinal Epithelia
published pages: 278-289, ISSN: 1548-9213, DOI: 10.1152/physiol.00005.2017
Physiology 32/4 2019-06-06
2019 Therese Seidlitz, Sebastian R Merker, Alexander Rothe, Falk Zakrzewski, Cläre von Neubeck, Konrad Grützmann, Ulrich Sommer, Christine Schweitzer, Sebastian Schölch, Heike Uhlemann, Anne-Marlene Gaebler, Kristin Werner, Mechthild Krause, Gustavo B Baretton, Thilo Welsch, Bon-Kyoung Koo, Daniela E Aust, Barbara Klink, Jürgen Weitz, Daniel E Stange
Human gastric cancer modelling using organoids
published pages: 207-217, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2017-314549
Gut 68/2 2019-06-06
2018 Juergen Fink, Seungmin Han, David J. Jörg, Sebastian R. Merker, Eunmin Lee, Min Kyu Yum, Ji-Hyun Lee, Manon Josserand, Teodora Trendafilova, Amanda Andersson-Rolf, Catherine Dabrowska, Hyunki Kim, Nobuo Sasaki, Richard Lester Mort, Onur Basak, Hans Clevers, Daniel E. Stange, Jong-Kyoung Kim, Benjamin D. Simons, Bonkyoung Koo
Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells
published pages: , ISSN: 1556-5068, DOI: 10.2139/ssrn.3213913
SSRN Electronic Journal 2019-06-06
2019 Jihoon Kim, Bon-Kyoung Koo, Ki-Jun Yoon
Modeling Host-Virus Interactions in Viral Infectious Diseases Using Stem-Cell-Derived Systems and CRISPR/Cas9 Technology
published pages: 124, ISSN: 1999-4915, DOI: 10.3390/v11020124
Viruses 11/2 2019-06-06

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