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MIMESIS SIGNED

Development of biomaterials through mimesis of plant defensive interfaces to fight wound infections

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MIMESIS project word cloud

Explore the words cloud of the MIMESIS project. It provides you a very rough idea of what is the project "MIMESIS" about.

prone    crossover    inherent    shows    mimicking    similarities    polyester    physiological    display    opportunistic    infection    macromolecular    assembly    ex    biochemistry    risk    century    roles    excellent    reconstituted    diabetic    push    polymer    plants    fungi    record    fungal    patients    preserves    film    evidences    wound    dressing    ubiquitous    effect    places    pathogenic    biofouling    antimicrobial    primary    chemical    exist    composition    vision    infect    combine    land    chronic    situ    hence    microbial    ca    hampering    healing    million    cosmetics    films    biological    barriers    potentially    materials    regeneration    pathogens    native    world    skin    breached    biopolyesters    extracting    21st    barrier    combined    invasion    extraction       limit    400    lipid    humans    layer    wounds    progress    infections    position    material    forming    biomaterials    formulations    immunocompromised    polyesters    abundant    devastating    pathogen    area    broad    adhesion    anti    medicine    genetics    determines    constitute    candidate    plant    structure    population    biocompatible    fighting    group    epidermal    provoked    defence   

Project "MIMESIS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDADE NOVA DE LISBOA 

There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country Portugal [PT]
 Project website http://www.itqb.unl.pt/research/biology/applied-and-environmental-mycology/
 Total cost 1˙795˙967 €
 EC max contribution 1˙795˙967 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE NOVA DE LISBOA PT (LISBOA) coordinator 1˙795˙967.00
2    INSTITUTO DE TECNOLOGIA QUIMICA E BIOLOGICA - UNIVERSIDADE NOVA DE LISBOA PT (OEIRAS) coordinator 0.00

Map

 Project objective

Fighting microbial infection of wounds, especially in immunocompromised patients, is a major challenge in the 21st century. The skin barrier is the primary defence against microbial (opportunistic) pathogens. When this barrier is breached even non-pathogenic fungi may cause devastating infections, most of which provoked by crossover fungi able to infect both plant and humans. Hence, diabetic patients (ca. 6.4% of the world population), who are prone to develop chronic non-healing wounds, constitute a major risk group. My research is driven by the vision of mimicking the functionality of plant polyesters to develop wound dressing biomaterials that combine antimicrobial and skin regeneration properties.

Land plants have evolved through more than 400 million years, developing defence polyester barriers that limit pathogen adhesion and invasion. Biopolyesters are ubiquitous in plants and are the third most abundant plant polymer. The unique chemical composition of the plant polyester and its macromolecular assembly determines its physiological roles. This lipid-based polymer shows important similarities to the epidermal skin layer; hence it is an excellent candidate for a wound-dressing material. While evidences of their skin regeneration properties exist in cosmetics formulations and in traditional medicine, extracting polyesters from plants results in the loss of both native structure and inherent barrier properties hampering progress in this area.

We have developed a biocompatible extraction method that preserves the plant polyester film forming abilities and their inherent biological properties. The ex-situ reconstituted polyester films display the native barrier properties, including potentially broad antimicrobial and anti-biofouling effect. This, combined with our established record in fungal biochemistry/genetics, places us in a unique position to push the development of plant polyester materials to be applied in wounds, in particular diabetic chronic wounds.

 Publications

year authors and title journal last update
List of publications.
2016 Diego O. Hartmann, Marija Petkovic, Cristina Silva Pereira
Ionic Liquids as Unforeseen Assets to Fight Life-Threatening Mycotic Diseases
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2016.00111
Frontiers in Microbiology 7 2019-06-06
2016 Paula C. Alves, Diego O. Hartmann, Oscar Núñez, Isabel Martins, Teresa L. Gomes, Helga Garcia, Maria Teresa Galceran, Richard Hampson, Jörg D. Becker, Cristina Silva Pereira
Transcriptomic and metabolomic profiling of ionic liquid stimuli unveils enhanced secondary metabolism in Aspergillus nidulans
published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-016-2577-6
BMC Genomics 17/1 2019-06-06

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The information about "MIMESIS" are provided by the European Opendata Portal: CORDIS opendata.

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