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MIMESIS SIGNED

Development of biomaterials through mimesis of plant defensive interfaces to fight wound infections

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MIMESIS project word cloud

Explore the words cloud of the MIMESIS project. It provides you a very rough idea of what is the project "MIMESIS" about.

plants    regeneration    evidences    extraction    position    risk    biofouling    skin    land    hampering    microbial    chemical    vision    biological    biochemistry    constitute    record    shows    ca    effect    wound    native    extracting    candidate    combined    combine    21st    polyester    formulations    antimicrobial    broad    dressing    reconstituted    400       world    provoked    structure    pathogenic    population    abundant    prone    million    polyesters    patients    ubiquitous    assembly    exist    immunocompromised    infection    mimicking    barrier    chronic    adhesion    area    infections    lipid    push    places    defence    invasion    polymer    barriers    composition    epidermal    genetics    infect    films    healing    excellent    potentially    crossover    ex    similarities    hence    humans    preserves    biopolyesters    diabetic    fighting    devastating    layer    cosmetics    inherent    fungi    pathogens    limit    progress    wounds    film    biomaterials    material    pathogen    group    fungal    medicine    physiological    determines    materials    forming    display    plant    breached    roles    opportunistic    situ    century    anti    biocompatible    primary    macromolecular   

Project "MIMESIS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDADE NOVA DE LISBOA 

There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country Portugal [PT]
 Project website http://www.itqb.unl.pt/research/biology/applied-and-environmental-mycology/
 Total cost 1˙795˙967 €
 EC max contribution 1˙795˙967 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE NOVA DE LISBOA PT (LISBOA) coordinator 1˙795˙967.00
2    INSTITUTO DE TECNOLOGIA QUIMICA E BIOLOGICA - UNIVERSIDADE NOVA DE LISBOA PT (OEIRAS) coordinator 0.00

Map

 Project objective

Fighting microbial infection of wounds, especially in immunocompromised patients, is a major challenge in the 21st century. The skin barrier is the primary defence against microbial (opportunistic) pathogens. When this barrier is breached even non-pathogenic fungi may cause devastating infections, most of which provoked by crossover fungi able to infect both plant and humans. Hence, diabetic patients (ca. 6.4% of the world population), who are prone to develop chronic non-healing wounds, constitute a major risk group. My research is driven by the vision of mimicking the functionality of plant polyesters to develop wound dressing biomaterials that combine antimicrobial and skin regeneration properties.

Land plants have evolved through more than 400 million years, developing defence polyester barriers that limit pathogen adhesion and invasion. Biopolyesters are ubiquitous in plants and are the third most abundant plant polymer. The unique chemical composition of the plant polyester and its macromolecular assembly determines its physiological roles. This lipid-based polymer shows important similarities to the epidermal skin layer; hence it is an excellent candidate for a wound-dressing material. While evidences of their skin regeneration properties exist in cosmetics formulations and in traditional medicine, extracting polyesters from plants results in the loss of both native structure and inherent barrier properties hampering progress in this area.

We have developed a biocompatible extraction method that preserves the plant polyester film forming abilities and their inherent biological properties. The ex-situ reconstituted polyester films display the native barrier properties, including potentially broad antimicrobial and anti-biofouling effect. This, combined with our established record in fungal biochemistry/genetics, places us in a unique position to push the development of plant polyester materials to be applied in wounds, in particular diabetic chronic wounds.

 Publications

year authors and title journal last update
List of publications.
2016 Diego O. Hartmann, Marija Petkovic, Cristina Silva Pereira
Ionic Liquids as Unforeseen Assets to Fight Life-Threatening Mycotic Diseases
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2016.00111
Frontiers in Microbiology 7 2019-06-06
2016 Paula C. Alves, Diego O. Hartmann, Oscar Núñez, Isabel Martins, Teresa L. Gomes, Helga Garcia, Maria Teresa Galceran, Richard Hampson, Jörg D. Becker, Cristina Silva Pereira
Transcriptomic and metabolomic profiling of ionic liquid stimuli unveils enhanced secondary metabolism in Aspergillus nidulans
published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-016-2577-6
BMC Genomics 17/1 2019-06-06

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The information about "MIMESIS" are provided by the European Opendata Portal: CORDIS opendata.

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