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Development of biomaterials through mimesis of plant defensive interfaces to fight wound infections

Total Cost €


EC-Contrib. €






 MIMESIS project word cloud

Explore the words cloud of the MIMESIS project. It provides you a very rough idea of what is the project "MIMESIS" about.

defence    effect    immunocompromised    similarities    polyester    anti    potentially    extracting    assembly    excellent    barrier    film    combined    forming    chemical    lipid    roles    ubiquitous    fighting    epidermal    medicine    evidences    material    chronic    adhesion    population    constitute    cosmetics    primary    invasion    polymer    record       prone    land    biocompatible    microbial    area    native    antimicrobial    biopolyesters    healing    combine    skin    extraction    infections    macromolecular    opportunistic    group    pathogens    million    pathogenic    materials    places    plants    situ    fungal    hampering    dressing    ex    genetics    risk    devastating    hence    abundant    films    vision    diabetic    biological    biochemistry    infect    humans    limit    century    broad    provoked    world    plant    wound    structure    patients    composition    biofouling    breached    determines    infection    mimicking    push    physiological    exist    inherent    wounds    display    reconstituted    polyesters    pathogen    ca    progress    shows    fungi    crossover    barriers    formulations    layer    biomaterials    preserves    position    candidate    400    21st    regeneration   

Project "MIMESIS" data sheet

The following table provides information about the project.


There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country Portugal [PT]
 Project website
 Total cost 1˙795˙967 €
 EC max contribution 1˙795˙967 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2020-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE NOVA DE LISBOA PT (LISBOA) coordinator 1˙795˙967.00


 Project objective

Fighting microbial infection of wounds, especially in immunocompromised patients, is a major challenge in the 21st century. The skin barrier is the primary defence against microbial (opportunistic) pathogens. When this barrier is breached even non-pathogenic fungi may cause devastating infections, most of which provoked by crossover fungi able to infect both plant and humans. Hence, diabetic patients (ca. 6.4% of the world population), who are prone to develop chronic non-healing wounds, constitute a major risk group. My research is driven by the vision of mimicking the functionality of plant polyesters to develop wound dressing biomaterials that combine antimicrobial and skin regeneration properties.

Land plants have evolved through more than 400 million years, developing defence polyester barriers that limit pathogen adhesion and invasion. Biopolyesters are ubiquitous in plants and are the third most abundant plant polymer. The unique chemical composition of the plant polyester and its macromolecular assembly determines its physiological roles. This lipid-based polymer shows important similarities to the epidermal skin layer; hence it is an excellent candidate for a wound-dressing material. While evidences of their skin regeneration properties exist in cosmetics formulations and in traditional medicine, extracting polyesters from plants results in the loss of both native structure and inherent barrier properties hampering progress in this area.

We have developed a biocompatible extraction method that preserves the plant polyester film forming abilities and their inherent biological properties. The ex-situ reconstituted polyester films display the native barrier properties, including potentially broad antimicrobial and anti-biofouling effect. This, combined with our established record in fungal biochemistry/genetics, places us in a unique position to push the development of plant polyester materials to be applied in wounds, in particular diabetic chronic wounds.


year authors and title journal last update
List of publications.
2016 Diego O. Hartmann, Marija Petkovic, Cristina Silva Pereira
Ionic Liquids as Unforeseen Assets to Fight Life-Threatening Mycotic Diseases
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2016.00111
Frontiers in Microbiology 7 2019-06-06
2016 Paula C. Alves, Diego O. Hartmann, Oscar Núñez, Isabel Martins, Teresa L. Gomes, Helga Garcia, Maria Teresa Galceran, Richard Hampson, Jörg D. Becker, Cristina Silva Pereira
Transcriptomic and metabolomic profiling of ionic liquid stimuli unveils enhanced secondary metabolism in Aspergillus nidulans
published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-016-2577-6
BMC Genomics 17/1 2019-06-06

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The information about "MIMESIS" are provided by the European Opendata Portal: CORDIS opendata.

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