Explore the words cloud of the SHUFFLE project. It provides you a very rough idea of what is the project "SHUFFLE" about.
The following table provides information about the project.
THE JAMES HUTTON INSTITUTE
|Coordinator Country||United Kingdom [UK]|
|Total cost||2˙499˙980 €|
|EC max contribution||2˙499˙980 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-10-01 to 2020-09-30|
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|1||THE JAMES HUTTON INSTITUTE||UK (DUNDEE)||coordinator||2˙499˙980.00|
During meiosis, recombination (crossing-over, CO) drives the exchange of genetic materials and releases genetic diversity by creating new combinations of alleles within and among chromosomes. CO is exploited in plant breeding through the generation of large populations of recombinants from which genetically improved individuals are selected. However in some economically important crops such as barley, the rate of improvement has plateaued. One hypothesis is that this is due to constraints on the locations of CO. In large genome cereals CO is restricted to the ends of chromosomes, excluding approximately two thirds of the genome from the breeding process.
This project focuses on three critically important questions about CO in barley: Why is it restricted to the telomeric ends of chromosomes? What proteins are the key players and what are their roles in controlling CO? And, what strategies can be established to effectively increase or redistribute CO in CO-poor regions?
I will address these questions in four Work Packages. In WP1 I will induce, identify and molecularly characterise putative meiotic mutants both phenotypically (at the plant level) and molecularly by captured exome sequencing. In WP2 I will characterise these mutants cytologically, genetically and by complementation to understand how the mutations affect recombination. In WPs 3 and 4, I will apply novel methods to isolate the specific cells undergoing meiosis, and use transcriptomics, targeted proteomics and pull-down assays to investigate how meiosis is regulated. I will focus on complexes that mark the sites of DNA double strand break (DSB) formation that identify where CO will occur. I will characterise these sites according to those resolved as either crossing-over or non-crossing-over events and relate their physical location to COs observed in population genetic data. Finally, I will evaluate strategies for modifying the distribution of recombination, and application in plant breeding
|year||authors and title||journal||last update|
Abdellah Barakate, Jennifer Stephens
An Overview of CRISPR-Based Tools and Their Improvements: New Opportunities in Understanding Plantâ€“Pathogen Interactions for Better Crop Protection
published pages: 765, ISSN: 1664-462X, DOI: 10.3389/fpls.2016.00765
|Frontiers in Plant Science 7||2019-07-04|
Isabelle Colas, Malcolm Macaulay, James D. Higgins, Dylan Phillips, Abdellah Barakate, Markus Posch, Susan J. Armstrong, F. Chris H. Franklin, Claire Halpin, Robbie Waugh, Luke Ramsay
A spontaneous mutation in MutL-Homolog 3 (HvMLH3) affects synapsis and crossover resolution in the barley desynaptic mutant des10
published pages: 693-707, ISSN: 0028-646X, DOI: 10.1111/nph.14061
|New Phytologist 212/3||2019-07-04|
Isabelle Colas, Katie Baker, Andrew Flavell
Cytology and Microscopy: Immunolocalization of Covalently Modified Histone Marks on Barley Mitotic Chromosomes
published pages: , ISSN: 2331-8325, DOI: 10.21769/BioProtoc.1841
Isabelle Colas, Benoit Darrier, Mikel Arrieta, Sybille U. Mittmann, Luke Ramsay, Pierre Sourdille, Robbie Waugh
Observation of Extensive Chromosome Axis Remodeling during the â€œDiffuse-Phaseâ€ of Meiosis in Large Genome Cereals
published pages: , ISSN: 1664-462X, DOI: 10.3389/fpls.2017.01235
|Frontiers in Plant Science 8||2019-05-14|
Colas I, Macaulay M, Higgins JD, Phillips D, Barakate A, Posch M, Armstrong SJ, Franklin FC, Halpin C, Waugh R, Ramsay L
published pages: 348-348, ISSN: 0028-646X, DOI: 10.1111/nph.15402
|New Phytologist 220/1||2019-05-14|
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