ChromatidCohesion SIGNED
Establishment of Sister Chromatid Cohesion
Total Cost €
0EC-Contrib. €
0Partnership
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0ChromatidCohesion project word cloud
Explore the words cloud of the ChromatidCohesion project. It provides you a very rough idea of what is the project "ChromatidCohesion" about.
Project "ChromatidCohesion" data sheet
The following table provides information about the project.
| Coordinator |
THE FRANCIS CRICK INSTITUTE LIMITED
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Total cost | 2˙120˙099 € |
| EC max contribution | 2˙120˙099 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-ADG |
| Funding Scheme | ERC-ADG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-10-01 to 2020-09-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE FRANCIS CRICK INSTITUTE LIMITED | UK (LONDON) | coordinator | 2˙120˙099.00 |
Map
Project objective
Following their synthesis during DNA replication, sister chromatids remain paired by the cohesin complex, which forms the basis for their faithful segregation during cell division. Cohesin is a large ring-shaped protein complex, incorporating an ABC-type ATPase module. Despite its importance for genome stability, the molecular mechanism of cohesin action remains as intriguing as it remains poorly understood. How is cohesin topologically loaded onto chromatin? How is it unloaded again? What happens to cohesin during DNA replication in S-phase, so that it establishes cohesion between newly synthesized sister chromatids? We propose to capitalise on our recent success in the biochemical reconstitution of topological cohesin loading onto DNA. This lays the foundation for a work programme encompassing a combination of biochemical, single molecule, structural and genetic approaches to address the above questions. Five work packages will investigate cohesin’s molecular behaviour during its life-cycle on chromosomes, including the ATP binding and hydrolysis-dependent conformational changes that make this molecular machine work. It will be complemented by mechanistic analyses of the cofactors that help cohesin to load onto chromosomes and establish sister chromatid cohesion. The insight gained will not only advance our molecular knowledge of sister chromatid cohesion. It will more generally advance our understanding of the ubiquitous family of chromosomal SMC ATPases, of which cohesin is a member, and their activity of shaping and segregating genomes.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Yasuto Murayama, Catarina P. Samora, Yumiko Kurokawa, Hiroshi Iwasaki, Frank Uhlmann Establishment of DNA-DNA Interactions by the Cohesin Ring published pages: 465-477.e15, ISSN: 0092-8674, DOI: 10.1016/j.cell.2017.12.021 |
Cell 172/3 | 2020-04-06 |
| 2016 |
Frank Uhlmann SMC complexes: from DNA to chromosomes published pages: 399-412, ISSN: 1471-0072, DOI: 10.1038/nrm.2016.30 |
Nature Reviews Molecular Cell Biology 17/7 | 2020-04-06 |
| 2018 |
Yasutaka Kakui, Frank Uhlmann SMC complexes orchestrate the mitotic chromatin interaction landscape published pages: 335-339, ISSN: 0172-8083, DOI: 10.1007/s00294-017-0755-y |
Current Genetics 64/2 | 2020-04-06 |
| 2017 |
Yasuto Murayama, Frank Uhlmann An in vitro assay for monitoring topological DNA entrapment by the chromosomal cohesin complex published pages: 23-35, ISSN: , DOI: 10.1007/978-1-4939-6545-8_2 |
Methods in Molecular Biology 1515 | 2020-04-06 |
| 2015 |
Yasuto Murayama, Frank Uhlmann DNA Entry into and Exit out of the Cohesin Ring by an Interlocking Gate Mechanism published pages: 1628-1640, ISSN: 0092-8674, DOI: 10.1016/j.cell.2015.11.030 |
Cell 163/7 | 2020-04-06 |
| 2016 |
Maria Ocampo-Hafalla, SofÃa Muñoz, Catarina P. Samora, Frank Uhlmann Evidence for cohesin sliding along budding yeast chromosomes published pages: 150178, ISSN: 2046-2441, DOI: 10.1098/rsob.150178 |
Open Biology 6/6 | 2020-04-06 |
| 2016 |
Catarina P. Samora, Julie Saksouk, Panchali Goswami, Ben O. Wade, Martin R. Singleton, Paul A. Bates, Armelle Lengronne, Alessandro Costa, Frank Uhlmann Ctf4 Links DNA Replication with Sister Chromatid Cohesion Establishment by Recruiting the Chl1 Helicase to the Replisome published pages: 371-384, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2016.05.036 |
Molecular Cell 63/3 | 2020-04-06 |
| 2018 |
Rahul Thadani, Julia Kamenz, Sebastian Heeger, SofÃa Muñoz, Frank Uhlmann Cell-Cycle Regulation of Dynamic Chromosome Association of the Condensin Complex published pages: 2308-2317, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.04.082 |
Cell Reports 23/8 | 2020-04-06 |
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