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ChromatidCohesion SIGNED

Establishment of Sister Chromatid Cohesion

Total Cost €

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EC-Contrib. €

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Project "ChromatidCohesion" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙120˙099 €
 EC max contribution 2˙120˙099 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 2˙120˙099.00

Map

 Project objective

Following their synthesis during DNA replication, sister chromatids remain paired by the cohesin complex, which forms the basis for their faithful segregation during cell division. Cohesin is a large ring-shaped protein complex, incorporating an ABC-type ATPase module. Despite its importance for genome stability, the molecular mechanism of cohesin action remains as intriguing as it remains poorly understood. How is cohesin topologically loaded onto chromatin? How is it unloaded again? What happens to cohesin during DNA replication in S-phase, so that it establishes cohesion between newly synthesized sister chromatids? We propose to capitalise on our recent success in the biochemical reconstitution of topological cohesin loading onto DNA. This lays the foundation for a work programme encompassing a combination of biochemical, single molecule, structural and genetic approaches to address the above questions. Five work packages will investigate cohesin’s molecular behaviour during its life-cycle on chromosomes, including the ATP binding and hydrolysis-dependent conformational changes that make this molecular machine work. It will be complemented by mechanistic analyses of the cofactors that help cohesin to load onto chromosomes and establish sister chromatid cohesion. The insight gained will not only advance our molecular knowledge of sister chromatid cohesion. It will more generally advance our understanding of the ubiquitous family of chromosomal SMC ATPases, of which cohesin is a member, and their activity of shaping and segregating genomes.

 Publications

year authors and title journal last update
List of publications.
2018 Yasuto Murayama, Catarina P. Samora, Yumiko Kurokawa, Hiroshi Iwasaki, Frank Uhlmann
Establishment of DNA-DNA Interactions by the Cohesin Ring
published pages: 465-477.e15, ISSN: 0092-8674, DOI: 10.1016/j.cell.2017.12.021
Cell 172/3 2020-04-06
2016 Frank Uhlmann
SMC complexes: from DNA to chromosomes
published pages: 399-412, ISSN: 1471-0072, DOI: 10.1038/nrm.2016.30
Nature Reviews Molecular Cell Biology 17/7 2020-04-06
2018 Yasutaka Kakui, Frank Uhlmann
SMC complexes orchestrate the mitotic chromatin interaction landscape
published pages: 335-339, ISSN: 0172-8083, DOI: 10.1007/s00294-017-0755-y
Current Genetics 64/2 2020-04-06
2017 Yasuto Murayama, Frank Uhlmann
An in vitro assay for monitoring topological DNA entrapment by the chromosomal cohesin complex
published pages: 23-35, ISSN: , DOI: 10.1007/978-1-4939-6545-8_2
Methods in Molecular Biology 1515 2020-04-06
2015 Yasuto Murayama, Frank Uhlmann
DNA Entry into and Exit out of the Cohesin Ring by an Interlocking Gate Mechanism
published pages: 1628-1640, ISSN: 0092-8674, DOI: 10.1016/j.cell.2015.11.030
Cell 163/7 2020-04-06
2016 Maria Ocampo-Hafalla, Sofía Muñoz, Catarina P. Samora, Frank Uhlmann
Evidence for cohesin sliding along budding yeast chromosomes
published pages: 150178, ISSN: 2046-2441, DOI: 10.1098/rsob.150178
Open Biology 6/6 2020-04-06
2016 Catarina P. Samora, Julie Saksouk, Panchali Goswami, Ben O. Wade, Martin R. Singleton, Paul A. Bates, Armelle Lengronne, Alessandro Costa, Frank Uhlmann
Ctf4 Links DNA Replication with Sister Chromatid Cohesion Establishment by Recruiting the Chl1 Helicase to the Replisome
published pages: 371-384, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2016.05.036
Molecular Cell 63/3 2020-04-06
2018 Rahul Thadani, Julia Kamenz, Sebastian Heeger, Sofía Muñoz, Frank Uhlmann
Cell-Cycle Regulation of Dynamic Chromosome Association of the Condensin Complex
published pages: 2308-2317, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.04.082
Cell Reports 23/8 2020-04-06

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