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ENLIGHT-TEN SIGNED

European Network linking informatics and genomics of helper T cells

Total Cost €

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EC-Contrib. €

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Partnership

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 ENLIGHT-TEN project word cloud

Explore the words cloud of the ENLIGHT-TEN project. It provides you a very rough idea of what is the project "ENLIGHT-TEN" about.

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Project "ENLIGHT-TEN" data sheet

The following table provides information about the project.

Coordinator
HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH 

Organization address
address: INHOFFENSTRASSE 7
city: BRAUNSCHWEIG
postcode: 38124
website: www.helmholtz-hzi.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.enlight-ten.eu
 Total cost 3˙354˙685 €
 EC max contribution 3˙354˙685 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2019-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH DE (BRAUNSCHWEIG) coordinator 498˙432.00
2    THE BABRAHAM INSTITUTE UK (CAMBRIDGE) participant 546˙575.00
3    INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES PT (LISBOA) participant 476˙712.00
4    GENOME RESEARCH LIMITED UK (LONDON) participant 273˙287.00
5    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 273˙287.00
6    TURUN YLIOPISTO FI (Turku) participant 269˙145.00
7    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 262˙875.00
8    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) participant 255˙934.00
9    Bayer Pharma AG DE (Berlin) participant 249˙216.00
10    QIAGEN AARHUS AS DK (AARHUS) participant 249˙216.00
11    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) participant 0.00
12    Abcam plc UK (Cambridge) partner 0.00
13    AFFIRIS AG AT (WIEN) partner 0.00
14    CRISPR Therapeutics Limited UK (Stevenage) partner 0.00
15    EAGLE GENOMICS LIMITED UK (CAMBRIDGE) partner 0.00
16    Genomatix Software GmbH DE (Muenchen) partner 0.00
17    NOVIMMUNE SA CH (PLAN LES OUATES GENEVE) partner 0.00

Map

 Project objective

ENLIGHT-TEN is a European Network Linking Informatics and Genomics of Helper T cells: our mission is to provide cross-disciplinary training in cellular immunology and big data analysis such that we train a new generation of researchers to fully exploit the power of emerging technological platforms. Our network of TEN beneficiaries combines T cell expertise with state-of-the-art technologies such as next generation sequencing (NGS), bioinformatics, multi-colour flow cytometry, preclinical models and tailored genome editing. Trainees will acquire a comprehensive knowledge in T cell immunology and the capacity to generate and interrogate big data sets as well as expertise in identifying novel biomarkers and developing therapeutic concepts. As such the training programme will provide an ideal stepping-stone for creative and innovative early stage researchers (ESRs) to enter and strengthen Europe’s academia as well as pharmaceutical and bioinformatics companies. The research focus of the network lies in the identification of extrinsic and intrinsic factors that control development, differentiation and plasticity of helper T cell subsets with particular emphasis on how T cell differentiation impacts on human diseases. The generation of large data sets is an emerging and challenging field, and there is high demand in both the academic sector as well as pharmaceutical companies for researchers to be able to analyse, integrate and exploit this rich source of information. ENLIGHT-TEN will combine the individual strengths of innovative laboratories and enterprises from complementary disciplines to provide unique interdisciplinary training for 13 ESRs, placing them at the forefront of this emerging field. Trainees will be empowered to perform cutting-edge analysis of the steadily increasing number of different T cell subsets, which play highly diverse and critical roles in the development of autoimmune diseases, making them a key target for pharmaceutical companies.

 Deliverables

List of deliverables.
Midterm review meeting Other 2020-04-07 20:07:59

Take a look to the deliverables list in detail:  detailed list of ENLIGHT-TEN deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Yi-Ling Chen, Tomas Gomes, Clare S. Hardman, Felipe A. Vieira Braga, Danuta Gutowska-Owsiak, Maryam Salimi, Nicki Gray, David A. Duncan, Gary Reynolds, David Johnson, Mariolina Salio, Vincenzo Cerundolo, Jillian L. Barlow, Andrew N.J. McKenzie, Sarah A. Teichmann, Muzlifah Haniffa, Graham Ogg
Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation
published pages: , ISSN: 0022-1007, DOI: 10.1084/jem.20190811
The Journal of Experimental Medicine 217/3 2020-04-07
2019 Tomás Gomes, Sarah A. Teichmann, Carlos Talavera-López
Immunology Driven by Large-Scale Single-Cell Sequencing
published pages: 1011-1021, ISSN: 1471-4906, DOI: 10.1016/j.it.2019.09.004
Trends in Immunology 40/11 2020-04-07
2018 Daniel J. Kunz, Tomás Gomes, Kylie R. James
Immune Cell Dynamics Unfolded by Single-Cell Technologies
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01435
Frontiers in Immunology 9 2020-04-07
2018 Ekaterina Minskaia, Barbara C. Saraiva, Maria M. V. Soares, Rita I. Azevedo, Ruy M. Ribeiro, Saumya D. Kumar, Ana I. S. Vieira, João F. Lacerda
Molecular Markers Distinguishing T Cell Subtypes With TSDR Strand-Bias Methylation
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02540
Frontiers in Immunology 9 2020-04-07
2018 Lina Petersone, Natalie M. Edner, Vitalijs Ovcinnikovs, Frank Heuts, Ellen M. Ross, Elisavet Ntavli, Chun J. Wang, Lucy S. K. Walker
T Cell/B Cell Collaboration and Autoimmunity: An Intimate Relationship
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01941
Frontiers in Immunology 9 2020-04-07
2019 Thomas Faux, Kalle T. Rytkönen, Asta Laiho, Laura L. Elo
RepViz: a replicate-driven R tool for visualizing genomic regions
published pages: , ISSN: 1756-0500, DOI: 10.1186/s13104-019-4473-z
BMC Research Notes 12/1 2020-04-07
2018 Marisa Stebegg, Saumya D. Kumar, Alyssa Silva-Cayetano, Valter R. Fonseca, Michelle A. Linterman, Luis Graca
Regulation of the Germinal Center Response
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02469
Frontiers in Immunology 9 2020-04-07
2018 Jhuma Pramanik, Xi Chen, Gozde Kar, Johan Henriksson, Tomás Gomes, Jong-Eun Park, Kedar Natarajan, Kerstin B. Meyer, Zhichao Miao, Andrew N. J. McKenzie, Bidesh Mahata, Sarah A. Teichmann
Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation
published pages: , ISSN: 1756-994X, DOI: 10.1186/s13073-018-0589-3
Genome Medicine 10/1 2020-04-07
2017 Tomi Suomi, Fatemeh Seyednasrollah, Maria K. Jaakkola, Thomas Faux, Laura L. Elo
ROTS: An R package for reproducibility-optimized statistical testing
published pages: e1005562, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1005562
PLOS Computational Biology 13/5 2020-04-07
2017 Verena Brucklacher-Waldert, Cristina Ferreira, Marisa Stebegg, Olivier Fesneau, Silvia Innocentin, Julien C. Marie, Marc Veldhoen
Cellular Stress in the Context of an Inflammatory Environment Supports TGF-β-Independent T Helper-17 Differentiation
published pages: 2357-2370, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.05.052
Cell Reports 19/11 2020-04-07
2019 Marisa Stebegg, Alyssa Silva-Cayetano, Silvia Innocentin, Timothy P. Jenkins, Cinzia Cantacessi, Colin Gilbert, Michelle A. Linterman
Heterochronic faecal transplantation boosts gut germinal centres in aged mice
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-10430-7
Nature Communications 10/1 2020-04-07
2019 Vitalijs Ovcinnikovs, Ellen M. Ross, Lina Petersone, Natalie M. Edner, Frank Heuts, Elisavet Ntavli, Alexandros Kogimtzis, Alan Kennedy, Chun Jing Wang, Clare L. Bennett, David M. Sansom, Lucy S. K. Walker
CTLA-4–mediated transendocytosis of costimulatory molecules primarily targets migratory dendritic cells
published pages: eaaw0902, ISSN: 2470-9468, DOI: 10.1126/sciimmunol.aaw0902
Science Immunology 4/35 2020-04-07

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