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Innovative training network: Immunoprofile-directed stratification of patients with the autoimmune disorder thrombotic thrombocytopenic purpura

Total Cost €


EC-Contrib. €






Project "PROFILE" data sheet

The following table provides information about the project.


Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website
 Total cost 1˙464˙397 €
 EC max contribution 1˙464˙397 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-EID
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2019-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
2    Stichting Sanquin Bloedvoorziening NL (Amsterdam) participant 510˙748.00
3    ICOSAGEN AS EE (TARTU) participant 226˙264.00
4    PROTOBIOS OU EE (TALLINN) participant 226˙264.00
6    Biokit ES (LLIÇA D´AMUNT) partner 0.00
7    Dutch TTP patient organization NL (Hoogland) partner 0.00
9    Immudex Aps DK (Copenhagen) partner 0.00


 Project objective

The PROFILE Innovative European Industrial Doctoral programme will develop improved tools for stratification of patients with the autoimmune disorder acquired thrombotic thrombocytopenic purpura (TTP). Patient stratification is needed in order to further develop personalized medicine approaches for human disorders. Therefore, a detailed understanding of the disease at the molecular level is needed. Furthermore, implementation of a robust set of novel biomarkers is essential for stratification of patients. Also, highly flexible platforms to rapidly develop novel therapeutics are crucial to further boost the field of personalized medicine. The research program is embedded in a unique translational training program, which emphasizes clinical needs as a driving force for development of novel, innovative diagnostics and therapeutics (for personalized medicine). There is intersectoral knowledge transfer between academia and companies at the European level as 6 different EU Member states are involved in the network either as beneficiary or partner organization. The PROFILE network will allow 6 early stage researchers to follow this unique translational training. They will be trained in the clinic to identify clinical needs, in academia where they will contribute to a scientifically ambitious project and in the non-academic sector where they will be trained in a novel technologies and commercializing bioassays endowing them with an unique PROFILE for further advancing personalized medicine in Europe.


List of deliverables.
Scientific WP(1-4).6 Other 2020-02-12 16:53:57
Training 5.4 Other 2020-02-07 12:50:52
Scientific WP(1-4).2 Documents, reports 2020-02-07 12:50:50
Scientific WP(1-4).5 Other 2020-02-07 12:50:54
Scientific WP(1-4).3 Documents, reports 2020-02-07 12:50:54
Scientific WP(1-4).4 Other 2020-02-07 12:50:55
Communication 6.1 Websites, patent fillings, videos etc. 2019-07-09 17:09:32
Training 5.3 Other 2019-07-09 17:09:32

Take a look to the deliverables list in detail:  detailed list of PROFILE deliverables.


year authors and title journal last update
List of publications.
2019 Kanin Wichapong, Hessel Poelman, Bogac Ercig, Johana Hrdinova, Xiaosong Liu, Esther Lutgens, Gerry AF Nicolaes
Rational modulator design by exploitation of protein–protein complex structures
published pages: 1015-1033, ISSN: 1756-8919, DOI: 10.4155/fmc-2018-0433
Future Medicinal Chemistry 11/9 2019-10-03
2019 Anastasis Petri, Hyo Jung Kim, Yaoxian Xu, Rens de Groot, Chan Li, Aline Vandenbulcke, Karen Vanhoorelbeke, Jonas Emsley, James T. B. Crawley
Crystal structure and substrate-induced activation of ADAMTS13
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-11474-5
Nature Communications 10/1 2019-10-03
2019 Lara Zafrani, Charlotte Dekimpe, Bérangère. S. Joly, Elien Roose, Fabienne Fieux, Elie Azoulay, Marie-Noëlle Peraldi, Antoine Durrbach, Paul Coppo, Karen Vanhoorelbeke, Agnès Veyradier
Transfer of ADAMTS13 antibody-mediated thrombotic thrombocytopenic purpura via kidney transplantation
published pages: e277-e280, ISSN: 0390-6078, DOI: 10.3324/haematol.2019.219063
Haematologica 104/6 2019-10-03
2018 Bérangère S. Joly, X. Long Zheng, Agnès Veyradier
Understanding thrombotic microangiopathies in children
published pages: 1536-1538, ISSN: 0342-4642, DOI: 10.1007/s00134-018-5059-2
Intensive Care Medicine 44/9 2019-10-03
2018 Bogac Ercig, Kanin Wichapong, Chris Reutelingsperger, Karen Vanhoorelbeke, Jan Voorberg, Gerry Nicolaes
Insights into 3D Structure of ADAMTS13: A Stepping Stone towards Novel Therapeutic Treatment of Thrombotic Thrombocytopenic Purpura
published pages: 028-041, ISSN: 0340-6245, DOI: 10.1160/th17-06-0404
Thrombosis and Haemostasis 118/01 2019-07-09
2018 E. Roose, A. S. Schelpe, B. S. Joly, M. Peetermans, P. Verhamme, J. Voorberg, A. Greinacher, H. Deckmyn, S. F. De Meyer, P. Coppo, A. Veyradier, K. Vanhoorelbeke
An open conformation of ADAMTS-13 is a hallmark of acute acquired thrombotic thrombocytopenic purpura
published pages: 378-388, ISSN: 1538-7933, DOI: 10.1111/jth.13922
Journal of Thrombosis and Haemostasis 16/2 2019-07-09
2018 Bérangère Joly, Pierre Boisseau, Elien Roose, Alain Stepanian, Nathalie Biebuyck, Julien Hogan, François Provot, Yahsou Delmas, Céline Garrec, Karen Vanhoorelbeke, Paul Coppo, Agnès Veyradier
ADAMTS13 Gene Mutations Influence ADAMTS13 Conformation and Disease Age-Onset in the French Cohort of Upshaw–Schulman Syndrome
published pages: 1902-1917, ISSN: 0340-6245, DOI: 10.1055/s-0038-1673686
Thrombosis and Haemostasis 118/11 2019-07-09
2018 Johana Hrdinová, Fabian C. Verbij, Paul H.P. Kaijen, Robin B. Hartholt, Floris van Alphen, Neubury Lardy, Anja ten Brinke, Karen Vanhoorelbeke, Pooja J. Hindocha, Anne S. De Groot, Alexander B. Meijer, Jan Voorberg, Ivan Peyron
Mass spectrometry-assisted identification of ADAMTS13-derived peptides presented on HLA-DR and HLA-DQ
published pages: 1083-1092, ISSN: 0390-6078, DOI: 10.3324/haematol.2017.179119
Haematologica 103/6 2019-07-09
2018 Johana Hrdinová, Silvia D’Angelo, Nuno A. G. Graça, Bogac Ercig, Karen Vanhoorelbeke, Agnès Veyradier, Jan Voorberg, Paul Coppo
Dissecting the pathophysiology of immune thrombotic thrombocytopenic purpura: interplay between genes and environmental triggers
published pages: 1099-1109, ISSN: 0390-6078, DOI: 10.3324/haematol.2016.151407
Haematologica 103/7 2019-07-09
2018 Matthieu Jestin, Ygal Benhamou, An-Sofie Schelpe, Elien Roose, François Provôt, Lionel Galicier, Miguel Hié, Claire Presne, Pascale Poullin, Alain Wynckel, Samir Saheb, Christophe Deligny, Aude Servais, Stéphane Girault, Yahsou Delmas, Tarik Kanouni, Alexandre Lautrette, Dominique Chauveau, Christiane Mousson, Pierre Perez, Jean-Michel Halimi, Anne Charvet-Rumpler, Mohamed Hamidou, Pascal Cathébras, Karen Vanhoorelbeke, Agnès Veyradier, Paul Coppo
Preemptive rituximab prevents long-term relapses in immune-mediated thrombotic thrombocytopenic purpura
published pages: 2143-2153, ISSN: 0006-4971, DOI: 10.1182/blood-2018-04-840090
Blood 132/20 2019-07-09
2018 An-Sofie Schelpe, Christelle Orlando, Bogac Ercig, Chloë Geeroms, Inge Pareyn, Nele Vandeputte, Leydi Carolina Velásquez Pereira, Elien Roose, Karel Fostier, Gerry A.F. Nicolaes, Hans Deckmyn, Simon F. De Meyer, Karen Vanhoorelbeke, Kristin Jochmans
Child-onset thrombotic thrombocytopenic purpura caused by p.R498C and p.G259PfsX133 mutations in ADAMTS13
published pages: 191-199, ISSN: 0902-4441, DOI: 10.1111/ejh.13094
European Journal of Haematology 101/2 2019-07-09
2018 Elien Roose, Gestur Vidarsson, Kadri Kangro, Onno Verhagen, Ilaria Mancini, Linda Desender, Inge Pareyn, Nele Vandeputte, Aline Vandenbulcke, Chiara Vendramin, An-Sofie Schelpe, Jan Voorberg, Marie-Agnès Azerad, Laurent Gilardin, Marie Scully, Daan Dierickx, Hans Deckmyn, Simon De Meyer, Flora Peyvandi, Karen Vanhoorelbeke
Anti-ADAMTS13 Autoantibodies against Cryptic Epitopes in Immune-Mediated Thrombotic Thrombocytopenic Purpura
published pages: 1729-1742, ISSN: 0340-6245, DOI: 10.1055/s-0038-1669459
Thrombosis and Haemostasis 118/10 2019-07-09
2017 Johanna A. Kremer Hovinga, Paul Coppo, Bernhard Lämmle, Joel L. Moake, Toshiyuki Miyata, Karen Vanhoorelbeke
Thrombotic thrombocytopenic purpura
published pages: 17020, ISSN: 2056-676X, DOI: 10.1038/nrdp.2017.20
Nature Reviews Disease Primers 3 2019-07-09
2017 Bérangère S. Joly, Karen Vanhoorelbeke, Agnès Veyradier
Understanding therapeutic targets in thrombotic thrombocytopenic purpura
published pages: 1398-1400, ISSN: 0342-4642, DOI: 10.1007/s00134-016-4662-3
Intensive Care Medicine 43/9 2019-07-09
2017 Ralf J. Ludwig, Karen Vanhoorelbeke, Frank Leypoldt, Ziya Kaya, Katja Bieber, Sandra M. McLachlan, Lars Komorowski, Jie Luo, Otavio Cabral-Marques, Christoph M. Hammers, Jon M. Lindstrom, Peter Lamprecht, Andrea Fischer, Gabriela Riemekasten, Claudia Tersteeg, Peter Sondermann, Basil Rapoport, Klaus-Peter Wandinger, Christian Probst, Asmaa El Beidaq, Enno Schmidt, Alan Verkman, Rudolf A. Manz, Falk Nimmerjahn
Mechanisms of Autoantibody-Induced Pathology
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.00603
Frontiers in Immunology 8 2019-07-09

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