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TASCMAR SIGNED

Tools And Strategies to access to original bioactive compounds from Cultivation of MARine invertebrates and associated symbionts

Total Cost €

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EC-Contrib. €

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Partnership

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 TASCMAR project word cloud

Explore the words cloud of the TASCMAR project. It provides you a very rough idea of what is the project "TASCMAR" about.

strategies    extraction    entire    environmental    metabolomic    vivo    modulating    compounds    chemicals    zone    bioremediation    exploited    societal    supply    trade    economical    instrumentation    flow    pilot    zippertex    biomass    vitro    deriving    prototypes    prioritisation    characterization    catalytic    bio    compromise    bottlenecks    bioactive    platotex    nutraceuticals    metabolites    databases    validated    biomolecules    cosmeceuticals    symbionts    reaching    mesophotic    discovering    sustainable    analytical    industrial    holistic    readiness    overcome    innovative    bioassays    constantly    panel    profiling    cultivation    reveal    improvements    fine    organisms    pharmaceuticals    industries    enzymes    constructed    underutilized    technological    added    cell    biocatalysts    lab    filtering    bioactivity    secondary    employed    frame    aspires    tascmar    house    dereplication    biodiscovery    marine    combined    extracts    anti    pure    invertebrates    valuable    tools    candidates    angiogenesis    libraries    conjunction    ovo    ageing   

Project "TASCMAR" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://www.tascmar.eu
 Total cost 6˙758˙452 €
 EC max contribution 6˙755˙950 € (100%)
 Programme 1. H2020-EU.3.2. (SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy)
 Code Call H2020-BG-2014-2
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2019-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙442˙248.00
2    ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON EL (ATHINA) participant 801˙250.00
3    CRELUX GMBH DE (MARTINSRIED) participant 801˙212.00
4    PIERRE GUERIN SAS FR (NIORT) participant 800˙015.00
5    TEL AVIV UNIVERSITY IL (TEL AVIV) participant 400˙278.00
6    UNIVERSITE DE LA REUNION FR (SAINT DENIS DE LA REUNION CEDEX 9) participant 399˙917.00
7    APIVITA KALLYNTIKA DIAITITIKA FARMAKA ANONYMI EMPORIKI KAI VIOTECHNIKI ETAIREIA EL (MARKOPOULO) participant 399˙687.00
8    ASSOCIATION ECO OCEAN IL (TEL AVIV YAFFO) participant 349˙635.00
9    BICT SRL IT (LODI LO) participant 320˙875.00
10    CHULALONGKORN UNIVERSITY TH (BANGKOK) participant 299˙975.00
11    IMARE NATURAL SL ES (MOTRIL GRANADA) participant 299˙956.00
12    ASTAREAL AB SE (GUSTAVSBERG) participant 232˙900.00
13    T6 ECOSYSTEMS SRL IT (ROMA) participant 208˙000.00

Map

 Project objective

TASCMAR project aspires to develop new tools and strategies in order to overcome existing bottlenecks in the biodiscovery and industrial exploitation of novel marine derived biomolecules (secondary metabolites and enzymes) with applications in the pharmaceuticals, nutraceuticals, cosmeceuticals and fine chemicals industries. Exploitation of neglected and underutilized marine invertebrates and symbionts from mesophotic zone will be combined with innovative approaches for the cultivation and extraction of marine organisms from lab to pilot-scale, using the unique prototypes Platotex™ and Zippertex™, both reaching the Technology Readiness Level 7. Thus, marine dedicated cultivation and extraction equipment will be built and validated. These unique improvements will ensure sustainable supply of biomass and promote the production of high added value bioactive marine compounds. An integrated, holistic technological metabolomic approach will be applied, in conjunction with bioactivity profiling, as filtering and bio-prioritisation tools. Moreover, state-of-the-art analytical instrumentation and in-house databases will be employed for the dereplication and characterization of valuable compounds. A panel of libraries (marine organisms, extracts, pure metabolites and biocatalysts) will be constructed and exploited throughout the project. A focused panel of in-vitro, cell-based, in-ovo and in-vivo bioassays for discovering metabolites with anti-ageing and/or angiogenesis modulating activity will frame the entire work-flow and will reveal the lead compounds. In addition, the catalytic potential of mesophotic symbionts and deriving enzymes candidates will be evaluated in fine chemicals and bioremediation industries. The project activities will be constantly assessed via effective management for their societal, economical and environmental impact in order to find the best compromise between industrial development and sustainable growth.

 Publications

year authors and title journal last update
List of publications.
2018 Eleni-Dimitra Papanagnou, Evangelos Terpos, Efstathios Kastritis, Issidora S. Papassideri, Ourania E. Tsitsilonis, Meletios A. Dimopoulos, Ioannis P. Trougakos
Molecular responses to therapeutic proteasome inhibitors in multiple myeloma patients are donor-, cell type- and drug-dependent
published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.24882
Oncotarget 9/25 2020-01-29
2017 Efstratios Nikolaivits, Maria Dimarogona, Nikolas Fokialakis, Evangelos Topakas
Marine-Derived Biocatalysts: Importance, Accessing, and Application in Aromatic Pollutant Bioremediation
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2017.00265
Frontiers in Microbiology 8 2020-01-29
2019 Zoi Evangelakou, Maria Manola, Sentiljana Gumeni, Ioannis P. Trougakos
Nutrigenomics as a tool to study the impact of diet on aging and age-related diseases: the Drosophila approach
published pages: , ISSN: 1555-8932, DOI: 10.1186/s12263-019-0638-6
Genes & Nutrition 14/1 2020-01-29
2019 James Davis Reimer, Hiroki Kise, Maria E. A. Santos, Dhugal John Lindsay, Richard L. Pyle, Joshua M. Copus, Brian W. Bowen, Masanori Nonaka, Takuo Higashiji, Yehuda Benayahu
Exploring the Biodiversity of Understudied Benthic Taxa at Mesophotic and Deeper Depths: Examples From the Order Zoantharia (Anthozoa: Hexacorallia)
published pages: , ISSN: 2296-7745, DOI: 10.3389/fmars.2019.00305
Frontiers in Marine Science 6 2020-01-29
2018 Ronen Liberman, Tom Shlesinger, Yossi Loya, Yehuda Benayahu
Octocoral Sexual Reproduction: Temporal Disparity Between Mesophotic and Shallow-Reef Populations
published pages: , ISSN: 2296-7745, DOI: 10.3389/fmars.2018.00445
Frontiers in Marine Science 5 2020-01-29
2018 Efstratios Nikolaivits, Maria Dimarogona, Ioanna Karagiannaki, Angelina Chalima, Ayelet Fishman, Evangelos Topakas
Versatile Fungal Polyphenol Oxidase with Chlorophenol Bioremediation Potential: Characterization and Protein Engineering
published pages: , ISSN: 0099-2240, DOI: 10.1128/aem.01628-18
Applied and Environmental Microbiology 84/23 2020-01-29
2018 Dewi Embong Bulan, Alisa Wilantho, Patcharaporn Krainara, Voranop Viyakarn, Suchana Chavanich, Naraporn Somboonna
Spatial and Seasonal Variability of Reef Bacterial Communities in the Upper Gulf of Thailand
published pages: , ISSN: 2296-7745, DOI: 10.3389/fmars.2018.00441
Frontiers in Marine Science 5 2020-01-29
2018 Dewi Embong Bulan, Alisa Wilantho, Sissades Tongsima, Voranop Viyakarn, Suchana Chavanich, Naraporn Somboonna
Microbial and Small Eukaryotes Associated With Reefs in the Upper Gulf of Thailand
published pages: , ISSN: 2296-7745, DOI: 10.3389/fmars.2018.00436
Frontiers in Marine Science 5 2020-01-29
2017 Yehuda Benayahu, Catherine S. McFadden, Erez Shoham, Leen P. van Ofwegen
Search for mesophotic octocorals (Cnidaria, Anthozoa) and their phylogeny. II. A new zooxanthellate species from Eilat, northern Red Sea
published pages: 1-12, ISSN: 1313-2989, DOI: 10.3897/zookeys.676.12751
ZooKeys 676 2020-01-29
2019 Erez Shoham, Thomas Prohaska, Zahava Barkay, Andreas Zitek, Yehuda Benayahu
Soft corals form aragonite-precipitated columnar spiculite in mesophotic reefs
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-37696-z
Scientific Reports 9/1 2020-01-29
2017 Sentiljana Gumeni, Zoi Evangelakou, Vassilis Gorgoulis, Ioannis Trougakos
Proteome Stability as a Key Factor of Genome Integrity
published pages: 2036, ISSN: 1422-0067, DOI: 10.3390/ijms18102036
International Journal of Molecular Sciences 18/10 2020-01-29
2017 Tsakiri, E.N.; Terpos, E.; Papanagnou, E.D.; Kastritis, E.; Brieudes, V.; Halabalaki, M.; Bagratuni, T.; Florea, B.I.; Overkleeft, H.S.; Scorrano, L.; Skaltsounis, A.L.; Dimopoulos, M.A.; Trougakos, I.P.
Milder degenerative effects of Carfilzomib &ITvs&IT. Bortezomib in the Drosophila model: a link to clinical adverse events
published pages: nature Publishin, ISSN: 2045-2322, DOI:
SCIENTIFIC REPORTS, 7 , 17802 1 2020-01-29
2017 Yehuda Benayahu, Catherine S. McFadden, Erez Shoham
Search for mesophotic octocorals (Cnidaria, Anthozoa) and their phylogeny: I. A new sclerite-free genus from Eilat, northern Red Sea
published pages: 1-11, ISSN: 1313-2989, DOI: 10.3897/zookeys.680.12727
ZooKeys 680 2020-01-29
2019 Géraldine Le Goff, Philippe Lopes, Guillaume Arcile, Pinelopi Vlachou, Elsa Van Elslande, Pascal Retailleau, Jean-François Gallard, Michal Weis, Yehuda Benayahu, Nikolas Fokialakis, Jamal Ouazzani
Impact of the Cultivation Technique on the Production of Secondary Metabolites by Chrysosporium lobatum TM-237-S5, Isolated from the Sponge Acanthella cavernosa
published pages: 678, ISSN: 1660-3397, DOI: 10.3390/md17120678
Marine Drugs 17/12 2020-01-29
2019 Pierre-Eric Campos, Emmanuel Pichon, Céline Moriou, Patricia Clerc, Rozenn Trépos, Michel Frederich, Nicole De Voogd, Claire Hellio, Anne Gauvin-Bialecki, Ali Al-Mourabit
New Antimalarial and Antimicrobial Tryptamine Derivatives from the Marine Sponge Fascaplysinopsis reticulata
published pages: 167, ISSN: 1660-3397, DOI: 10.3390/md17030167
Marine Drugs 17/3 2020-01-29
2018 Eleni N. Tsakiri, Sentiljana Gumeni, Kalliopi K. Iliaki, Dimitra Benaki, Konstantinos Vougas, Gerasimos P. Sykiotis, Vassilis G. Gorgoulis, Emmanuel Mikros, Luca Scorrano, Ioannis P. Trougakos
Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation
published pages: e12845, ISSN: 1474-9718, DOI: 10.1111/acel.12845
Aging Cell 2020-01-29
2018 Aimilia Sklirou, Eleni-Dimitra Papanagnou, Nikolas Fokialakis, Ioannis P. Trougakos
Cancer chemoprevention via activation of proteostatic modules
published pages: 110-121, ISSN: 0304-3835, DOI: 10.1016/j.canlet.2017.10.034
Cancer Letters 413 2020-01-29
2019 Efstratios Nikolaivits, Andreas Agrafiotis, Aikaterini Termentzi, Kyriaki Machera, Géraldine Le Goff, Pedro Álvarez, Suchana Chavanich, Yehuda Benayahu, Jamal Ouazzani, Nikolas Fokialakis, Evangelos Topakas
Unraveling the Detoxification Mechanism of 2,4-Dichlorophenol by Marine-Derived Mesophotic Symbiotic Fungi Isolated from Marine Invertebrates
published pages: 564, ISSN: 1660-3397, DOI: 10.3390/md17100564
Marine Drugs 17/10 2020-01-29
2018 Amr El-Demerdash, Céline Moriou, Jordan Toullec, Marc Besson, Stéphanie Soulet, Nelly Schmitt, Sylvain Petek, David Lecchini, Cécile Debitus, Ali Al-Mourabit
Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis
published pages: 146, ISSN: 1660-3397, DOI: 10.3390/md16050146
Marine Drugs 16/5 2019-06-04
2018 ROB W.M. VAN SOEST, NICOLE J. DE VOOGD
Calcareous sponges of the Western Indian Ocean and Red Sea
published pages: 1, ISSN: 1175-5326, DOI: 10.11646/zootaxa.4426.1.1
Zootaxa 4426/1 2019-06-04
2017 Charlotte Leman-Loubière, Géraldine Le Goff, Pascal Retailleau, Cécile Debitus, Jamal Ouazzani
Sporothriolide-Related Compounds from the Fungus Hypoxylon monticulosum CLL-205 Isolated from a Sphaerocladina Sponge from the Tahiti Coast
published pages: 2850-2854, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.7b00714
Journal of Natural Products 80/10 2019-06-04
2017 Charlotte Leman-Loubière, Géraldine Le Goff, Cécile Debitus, Jamal Ouazzani
Sporochartines A–E, A New Family of Natural Products from the Marine Fungus Hypoxylon monticulosum Isolated from a Sphaerocladina Sponge
published pages: , ISSN: 2296-7745, DOI: 10.3389/fmars.2017.00399
Frontiers in Marine Science 4 2019-06-04
2016 Sentiljana Gumeni, Ioannis P. Trougakos
Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease
published pages: 1-24, ISSN: 1942-0900, DOI: 10.1155/2016/4587691
Oxidative Medicine and Cellular Longevity 2016 2019-06-04
2018 Pinelopi Vlachou, Géraldine Le Goff, Carolina Alonso, Pedro Álvarez, Jean-François Gallard, Nikolas Fokialakis, Jamal Ouazzani
Innovative Approach to Sustainable Marine Invertebrate Chemistry and a Scale-Up Technology for Open Marine Ecosystems
published pages: 152, ISSN: 1660-3397, DOI: 10.3390/md16050152
Marine Drugs 16/5 2019-06-04

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